NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27545418|ref|NP_775452|]
View 

zinc finger protein 689 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
29-88 3.20e-24

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.35  E-value: 3.20e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418     29 LKFADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGALGCAGPKPALITWLERNTDDW 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-466 1.18e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 159 PDLPALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVC--DQCGKRFSQRKNLSQHQVIHTGEKPY-HC 235
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 236 PDCGRCFRRSRSLANHRTTHT---GEKPHQCPSCGRRFaYPSLLAIHQRTHTGEKP-YTCLECSRRFRQRTALV------ 305
Cdd:COG5048  96 KSLPLSNSKASSSSLSSSSSNsndNNLLSSHSLPPSSR-DPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpan 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 306 -------------IHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTLLQHQLLHTGEKP 372
Cdd:COG5048 175 slskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 373 YPCPDCGRAFRRSGSLAIHRSTHTEE-------KLHACDDCGRRFAYPSLLASHRR--VHSGE--RPYACD--LCSKRFA 439
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFS 334

                       330       340
                ....*....|....*....|....*..
gi 27545418 440 QWSHLAQHQLLHTGEKPFPCLECGRCF 466
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLLNSSS 361
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
29-88 3.20e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.35  E-value: 3.20e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418     29 LKFADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGALGCAGPKPALITWLERNTDDW 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 31-69 4.74e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.43  E-value: 4.74e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27545418    31 FADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGALG 69
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 29-68 2.74e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 2.74e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27545418  29 LKFADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGAL 68
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-466 1.18e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 159 PDLPALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVC--DQCGKRFSQRKNLSQHQVIHTGEKPY-HC 235
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 236 PDCGRCFRRSRSLANHRTTHT---GEKPHQCPSCGRRFaYPSLLAIHQRTHTGEKP-YTCLECSRRFRQRTALV------ 305
Cdd:COG5048  96 KSLPLSNSKASSSSLSSSSSNsndNNLLSSHSLPPSSR-DPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpan 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 306 -------------IHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTLLQHQLLHTGEKP 372
Cdd:COG5048 175 slskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 373 YPCPDCGRAFRRSGSLAIHRSTHTEE-------KLHACDDCGRRFAYPSLLASHRR--VHSGE--RPYACD--LCSKRFA 439
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFS 334

                       330       340
                ....*....|....*....|....*..
gi 27545418 440 QWSHLAQHQLLHTGEKPFPCLECGRCF 466
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLLNSSS 361
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-244 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|....*.
gi 27545418   219 NLSQHQVIHTGEKPYHCPDCGRCFRR 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 204-251 6.75e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.75e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 27545418  204 PYVCDQCGKRFSQRKNLSQHqvIHTGEKPYHCPDCGRCFRRSRSLANH 251
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
29-88 3.20e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.35  E-value: 3.20e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418     29 LKFADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGALGCAGPKPALITWLERNTDDW 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 31-69 4.74e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.43  E-value: 4.74e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 27545418    31 FADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGALG 69
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 29-68 2.74e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 2.74e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 27545418  29 LKFADVAVYFSSEEWGRLRPAQRTLYRDVMRETYGLLGAL 68
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-466 1.18e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 159 PDLPALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVC--DQCGKRFSQRKNLSQHQVIHTGEKPY-HC 235
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 236 PDCGRCFRRSRSLANHRTTHT---GEKPHQCPSCGRRFaYPSLLAIHQRTHTGEKP-YTCLECSRRFRQRTALV------ 305
Cdd:COG5048  96 KSLPLSNSKASSSSLSSSSSNsndNNLLSSHSLPPSSR-DPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpan 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 306 -------------IHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACEHCEARFSQRSTLLQHQLLHTGEKP 372
Cdd:COG5048 175 slskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 373 YPCPDCGRAFRRSGSLAIHRSTHTEE-------KLHACDDCGRRFAYPSLLASHRR--VHSGE--RPYACD--LCSKRFA 439
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFS 334

                       330       340
                ....*....|....*....|....*..
gi 27545418 440 QWSHLAQHQLLHTGEKPFPCLECGRCF 466
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKLLNSSS 361
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-335 9.57e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 9.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 171 QNLKKPYPCPDCGRRFSYPSLLVSHRRA--HSGEC--PYVCD--QCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGRCF-- 242
Cdd:COG5048 284 KGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSkf 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 243 -----RRSRSLANHRTTHTGEKPHQC--PSCGRRFAYPSLLAIHQRTHTGEKP--YTCLECSRRFRQRTALVIHQRIHTg 313
Cdd:COG5048 364 spllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT- 442

                       170       180
                ....*....|....*....|..
gi 27545418 314 EKPYPCPDCERRFSSSSRLVSH 335
Cdd:COG5048 443 NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-408 1.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 176 PYPCPDCGRRFSYPSLLVSHRRAHSGEcPYVCDQCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTH 255
Cdd:COG5048 199 SSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNE 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 256 TGE-------KPHQCPSCGRRFAYPSLLAIHQRT--HTGEKPYTCLE----CSRRFRQRTALVIHQRIHTGEKPYPCPDC 322
Cdd:COG5048 278 SDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLL 357

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 323 ERRFSSSSRL-------VSHRRVHSGERPYACEH--CEARFSQRSTLLQHQLLHTGEKP--YPCPDCGRAFRRSGSLAIH 391
Cdd:COG5048 358 NSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPH 437

                       250
                ....*....|....*..
gi 27545418 392 RSTHTEEKLHACDDCGR 408
Cdd:COG5048 438 KKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 313-396 1.53e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 1.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 313 GEKPYPCP--DCERRFSSSSRLVSHRRvHSgerpyaceHCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRRSGSLAI 390
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 27545418 391 HRsTHT 396
Cdd:COG5189 417 HR-KHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-469 1.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 259 KPHQCPSCGRRFAYPSLLAIHQRTHTGEKPYTCLECSRRFRQRT--ALVIHQRIHTGEKPYPCPDCERRFSSSSRLVSHR 336
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 337 RVHSGE-RPYACEHCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFR-RSGSLAIHRSTHTEEKLHacddcgrRFAYPS 414
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLSK-------DPSSNL 184

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 27545418 415 LLASHRRVHSGERPYACDLCSKRFAQWSHLAQHQLLHTGEKPFPCLECGRCFRQR 469
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-244 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|....*.
gi 27545418   219 NLSQHQVIHTGEKPYHCPDCGRCFRR 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 5.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 27545418   303 ALVIHQRIHTGEKPYPCPDCERRFSS 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 9.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 27545418   247 SLANHRTTHTGEKPHQCPSCGRRFAY 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-447 1.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27545418 369 GEKPYPCP--DCGRAFRRSGSLAIHR-STHTEEKLHACDDcgrrfayPSllaSHRRVHSGERPYACDLCSKRFAQWSHLA 445
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMlHGHQNQKLHENPS-------PE---KMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ..
gi 27545418 446 QH 447
Cdd:COG5189 416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 2.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.48e-03
                          10        20
                  ....*....|....*....|....*
gi 27545418   416 LASHRRVHSGERPYACDLCSKRFAQ 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-384 2.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|....*
gi 27545418   360 LLQHQLLHTGEKPYPCPDCGRAFRR 384
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-300 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|....*
gi 27545418   276 LAIHQRTHTGEKPYTCLECSRRFRQ 300
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 204-251 6.75e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 6.75e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 27545418  204 PYVCDQCGKRFSQRKNLSQHqvIHTGEKPYHCPDCGRCFRRSRSLANH 251
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-468 7.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 27545418   443 HLAQHQLLHTGEKPFPCLECGRCFRQ 468
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH