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Conserved domains on  [gi|269847040|ref|NP_775858|]
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REST corepressor 2 isoform 1 [Homo sapiens]

Protein Classification

REST corepressor( domain architecture ID 10477716)

REST corepressor such as REST corepressor 1, which binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor) and plays a specific role in determining neural cell differentiation; contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  10449787|8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 46-98 4.05e-17

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


:

Pssm-ID: 460214  Cd Length: 53  Bit Score: 75.34  E-value: 4.05e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 269847040   46 IRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKE 98
Cdd:pfam01448   1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPNHNLPDRKLDEYLVVARS 53
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 134-178 4.83e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11661:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 46  Bit Score: 57.62  E-value: 4.83e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 269847040 134 EWTVEDKVLFEQAFGFHGKCFQRIQQ-MLPDKLIPSLVKYYYSWKK 178
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 331-374 7.22e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 7.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 269847040  331 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYR 374
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Gag_MA super family cl03116
Matrix protein (MA), p15; The matrix protein, p15, is encoded by the gag gene. MA is involved ...
 466-520 3.82e-03

Matrix protein (MA), p15; The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity.


The actual alignment was detected with superfamily member pfam01140:

Pssm-ID: 426076 [Multi-domain]  Cd Length: 126  Bit Score: 37.75  E-value: 3.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269847040  466 QPPPLQQGRFLQprlapnQPPPPLIRPALaaprHSARPGPQPPPTLIGTPLEPPA 520
Cdd:pfam01140  78 QVPYIVTWEALA------ADPPPWVRPFL----TPKPPPPQPPAAPGLRPPLPPA 122
 
Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 46-98 4.05e-17

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 75.34  E-value: 4.05e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 269847040   46 IRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKE 98
Cdd:pfam01448   1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPNHNLPDRKLDEYLVVARS 53
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 134-178 4.83e-11

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 57.62  E-value: 4.83e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 269847040 134 EWTVEDKVLFEQAFGFHGKCFQRIQQ-MLPDKLIPSLVKYYYSWKK 178
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 331-374 7.22e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 7.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 269847040  331 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYR 374
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 331-373 2.81e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.10  E-value: 2.81e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 269847040 331 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSY 373
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
331-376 4.51e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 43.75  E-value: 4.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 269847040   331 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSYRRR 376
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 134-177 3.84e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 38.25  E-value: 3.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 269847040  134 EWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWK 177
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
133-179 2.26e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 2.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 269847040   133 DEWTVEDKVLFEQAFGFHG-KCFQRIQQMLPDKLIPSLVKYYYSWKKT 179
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Gag_MA pfam01140
Matrix protein (MA), p15; The matrix protein, p15, is encoded by the gag gene. MA is involved ...
 466-520 3.82e-03

Matrix protein (MA), p15; The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity.


Pssm-ID: 426076 [Multi-domain]  Cd Length: 126  Bit Score: 37.75  E-value: 3.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269847040  466 QPPPLQQGRFLQprlapnQPPPPLIRPALaaprHSARPGPQPPPTLIGTPLEPPA 520
Cdd:pfam01140  78 QVPYIVTWEALA------ADPPPWVRPFL----TPKPPPPQPPAAPGLRPPLPPA 122
 
Name Accession Description Interval E-value
ELM2 pfam01448
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ...
 46-98 4.05e-17

ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.


Pssm-ID: 460214  Cd Length: 53  Bit Score: 75.34  E-value: 4.05e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 269847040   46 IRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKE 98
Cdd:pfam01448   1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPNHNLPDRKLDEYLVVARS 53
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 134-178 4.83e-11

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 57.62  E-value: 4.83e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 269847040 134 EWTVEDKVLFEQAFGFHGKCFQRIQQ-MLPDKLIPSLVKYYYSWKK 178
Cdd:cd11661    1 EWSESEAKLFEEGLRKYGKDFHDIRQdFLPWKSVGELVEFYYMWKK 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 331-374 7.22e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 7.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 269847040  331 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYR 374
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 331-373 2.81e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.10  E-value: 2.81e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 269847040 331 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSY 373
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
331-376 4.51e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 43.75  E-value: 4.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 269847040   331 RWTTDEQLLAVQAIRRYG-KDFGAIAEVIGNKTLTQVKTFFVSYRRR 376
Cdd:smart00717   3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_7 pfam15963
Myb DNA-binding like;
331-381 2.22e-04

Myb DNA-binding like;


Pssm-ID: 464956 [Multi-domain]  Cd Length: 85  Bit Score: 39.83  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 269847040  331 RWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKtffvsyrRRFNLEE 381
Cdd:pfam15963  10 RWSKEETELFYKALSMFGTDFSLIAQLFPGRTRRQIK-------LKFKREE 53
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 134-177 3.84e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 38.25  E-value: 3.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 269847040  134 EWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWK 177
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
133-179 2.26e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 2.26e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 269847040   133 DEWTVEDKVLFEQAFGFHG-KCFQRIQQMLPDKLIPSLVKYYYSWKKT 179
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 134-177 2.59e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 36.01  E-value: 2.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 269847040 134 EWTVEDKVLFEQAFGFHG-KCFQRIQQMLPDKLIPSLVKYYYSWK 177
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
Gag_MA pfam01140
Matrix protein (MA), p15; The matrix protein, p15, is encoded by the gag gene. MA is involved ...
 466-520 3.82e-03

Matrix protein (MA), p15; The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity.


Pssm-ID: 426076 [Multi-domain]  Cd Length: 126  Bit Score: 37.75  E-value: 3.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 269847040  466 QPPPLQQGRFLQprlapnQPPPPLIRPALaaprHSARPGPQPPPTLIGTPLEPPA 520
Cdd:pfam01140  78 QVPYIVTWEALA------ADPPPWVRPFL----TPKPPPPQPPAAPGLRPPLPPA 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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