|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
56-343 |
2.91e-47 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 170.91 E-value: 2.91e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 56 ILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 136 ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAA 215
Cdd:COG0666 83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 216 SGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLVNN 295
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI-VKLLLEA 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 157743284 296 GADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPL 343
Cdd:COG0666 242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
87-366 |
3.64e-46 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 167.82 E-value: 3.64e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 87 EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASL 166
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 167 NVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 247 CYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI-VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 157743284 327 QNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA 366
Cdd:COG0666 240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
21-301 |
8.10e-45 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 163.97 E-value: 8.10e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 21 VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADV 100
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 101 NARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 181 AFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN 260
Cdd:COG0666 161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 157743284 261 AGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
11-276 |
3.59e-44 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 162.05 E-value: 3.59e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVL 90
Cdd:COG0666 24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 91 GLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170
Cdd:COG0666 104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 171 KKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250
Cdd:COG0666 184 NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263
|
250 260
....*....|....*....|....*.
gi 157743284 251 QDAVAIELVNAGANVNQPNDKGFTPL 276
Cdd:COG0666 264 AALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
8-243 |
4.30e-42 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 155.88 E-value: 4.30e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNE 87
Cdd:COG0666 54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 88 KVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN 167
Cdd:COG0666 134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 168 VCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
Cdd:COG0666 214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
20-317 |
3.33e-37 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 146.71 E-value: 3.33e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 20 DVEEVRSLLSQKENINVLDQERRTPLHA--AAYVGDVP-ILQLLLMSGANVNAKDTLWLTPLHRAAASRN-EKVLGLLLA 95
Cdd:PHA03095 26 TVEEVRRLLAAGADVNFRGEYGKTPLHLylHYSSEKVKdIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIK 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 96 HSADVNARDKLWQTPLHVAaanratkcaealaplLSSLNVadrsgrsalhhavhsgHLETVNLLLNKGASLNVCDKKERQ 175
Cdd:PHA03095 106 AGADVNAKDKVGRTPLHVY---------------LSGFNI----------------NPKVIRLLLRKGADVNALDLYGMT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 176 PLHwaAFLGH----LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQI--EVVKYLLRMGAEIDEPNAFGNTALHIACYL 249
Cdd:PHA03095 155 PLA--VLLKSrnanVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMATG 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 250 G--QDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLvNNGADVNYQSKEGKSPLHMAAIHG 317
Cdd:PHA03095 233 SscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLI-ALGADINAVSSDGNTPLSLMVRNN 301
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
186-489 |
4.85e-37 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 141.24 E-value: 4.85e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 265
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 266 NQPNDKGFTPLHvAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHV 345
Cdd:COG0666 81 NAKDDGGNTLLH-AAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 346 AARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLlssgqlysivsslsnehvLSAGFDINTPDNLGRT 425
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL------------------LEAGADVNAKDNDGKT 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157743284 426 CLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Cdd:COG0666 222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
56-417 |
7.79e-37 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 149.06 E-value: 7.79e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 56 ILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN--ARDKLwqTPLHVAAANRATKCAEALAPLLSSL 133
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiiALDDL--SVLECAVDSKNIDTIKAIIDNRSNI 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 134 NVADRSgrsaLHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVL-KLLVARGADLGCKDRKGYGLLHT 212
Cdd:PHA02876 238 NKNDLS----LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYL 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 213 AAASG-QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDA-VAIELVNAGANVNQPNDKGFTPLHVAAVStNGALCLE 290
Cdd:PHA02876 314 MAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVR-NNVVIIN 392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 291 LLVNNGADVNYQSKEGKSPLHMaAIHGR--FTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL-LISTLMTNGADTAR 367
Cdd:PHA02876 393 TLLDYGADIEALSQKIGTALHF-ALCGTnpYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLdVIEMLLDNGADVNA 471
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 157743284 368 RGIHDMFPLHLAVlfGFSDCCRKLLSSGqlysivSSLSNEHVLSAGFDIN 417
Cdd:PHA02876 472 INIQNQYPLLIAL--EYHGIVNILLHYG------AELRDSRVLHKSLNDN 513
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
16-373 |
2.07e-33 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 134.71 E-value: 2.07e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 16 IFSRDVEEVRSLLSQKEN-INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLL 94
Cdd:PHA02874 9 IYSGDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 95 AHSADVNArdklwqtpLHVAAANRatkcaEALAPLLSS---LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 171
Cdd:PHA02874 89 DNGVDTSI--------LPIPCIEK-----DMIKTILDCgidVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
Cdd:PHA02874 156 NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 252 DAVAIELVNAGANVNQPNdkGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIH-GRFTRSQILIQNGS 330
Cdd:PHA02874 236 SAIELLINNASINDQDID--GSTPLHHAINPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYiNKDPVIKDIIANAV 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 157743284 331 EIDCADKFGNTPL--HVaaryghELLISTLMTNGADTARRGIHDM 373
Cdd:PHA02874 314 LIKEADKLKDSDFleHI------EIKDNKEFSDFIKECNEEIEDM 352
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
533-812 |
3.03e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 130.46 E-value: 3.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLD 612
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 613 VRDHKGRTALFLATERGSTECVEVLTAHGASALIKErKRKWTPLHAAAASGHTDSLHLLIDSGerADItDVMDAYGQTPL 692
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD-KDGETPLHLAAYNGNLEIVKLLLEAG--ADV-NAQDNDGNTPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 693 MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Cdd:COG0666 158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 157743284 773 LLQAALstdpLDAGVDYSGYSPMHWASYTGHEDCLELLLE 812
Cdd:COG0666 238 LLEAGA----DLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
289-622 |
3.56e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 130.07 E-value: 3.56e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 289 LELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARR 368
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 369 GIHDMFPLHLAVLFGFSDCCRKLLSsgqlysivsslsnehvlsAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 448
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLE------------------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDtyrraephtpsshdaeedeplkesrRKE 528
Cdd:COG0666 146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENG-------------------------HLE 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 529 AffcLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNclEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
Cdd:COG0666 201 I---VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD--LNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
|
330
....*....|....
gi 157743284 609 VNLDVRDHKGRTAL 622
Cdd:COG0666 276 LLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
668-998 |
1.30e-32 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 128.53 E-value: 1.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 668 LHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 747
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 748 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDpldaGVDYSGYSPMHWASYTGHEDCLELLLEHspfsylegnpftpl 827
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN----ARDKDGETPLHLAAYNGNLEIVKLLLEA-------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 828 hcavinnqdsttemllgalGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAV 907
Cdd:COG0666 143 -------------------GAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 908 EFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAEtqdLGLINATNSALQMPLHIAARNGLASVVQALLSHGATV 987
Cdd:COG0666 203 KLLLEAG-ADVNAKDNDGKTALDLAAENGNLEIVKLLLEA---GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278
|
330
....*....|.
gi 157743284 988 LAVDEEGHTPA 998
Cdd:COG0666 279 AAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
773-1015 |
2.44e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 121.98 E-value: 2.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIvN 852
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI-N 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLA 932
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 933 CSKGHEKCALMILAETQDlglINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLA 1012
Cdd:COG0666 161 AANGNLEIVKLLLEAGAD---VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKL 237
|
...
gi 157743284 1013 LIL 1015
Cdd:COG0666 238 LLE 240
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
706-1015 |
1.03e-29 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 120.06 E-value: 1.03e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDA 785
Cdd:COG0666 6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 786 GvdysGYSPMHWASYTGHEDCLELLLEHspfsylegnpftplhcavinnqdsttemllgalGAKiVNSRDAKGRTPLHAA 865
Cdd:COG0666 86 G----GNTLLHAAARNGDLEIVKLLLEA---------------------------------GAD-VNARDKDGETPLHLA 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 866 AFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMIL 945
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLL 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 946 AETQDlglINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
Cdd:COG0666 207 EAGAD---VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
588-860 |
2.07e-29 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 119.29 E-value: 2.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 588 PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAsALIKERKRKWTPLHAAAASGHTDS 667
Cdd:COG0666 24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DINAKDDGGNTLLHAAARNGDLEI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 668 LHLLIDSGerADItDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 747
Cdd:COG0666 103 VKLLLEAG--ADV-NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 748 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAgvdySGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPL 827
Cdd:COG0666 180 NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN----DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
|
250 260 270
....*....|....*....|....*....|...
gi 157743284 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRT 860
Cdd:COG0666 256 LLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
512-758 |
9.96e-29 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 117.36 E-value: 9.96e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 512 SHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCleDVESTIPVSPLHL 591
Cdd:COG0666 49 LADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV--NARDKDGETPLHL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKrKWTPLHAAAASGHTDSLHLL 671
Cdd:COG0666 127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 672 IDSGerADITDVmDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Cdd:COG0666 206 LEAG--ADVNAK-DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*..
gi 157743284 752 FKGRTPI 758
Cdd:COG0666 283 LDLLTLL 289
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
21-301 |
1.43e-28 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 119.77 E-value: 1.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 21 VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLH-----RAAASRNEKVLGLLLA 95
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 96 HSADVNARDKLWQTPLHVAAANratkcaealapllsslnvadrsgrsalhhavHSGHLETVNLLLNKGASLNVCDKKERQ 175
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISK-------------------------------KSNSYSIVEYLLDNGANVNIKNSDGEN 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 176 PLHWAAFLGH--LEVLKLLVARGADLGCKDRkgygllhtaaasgqievVKYLLRMGAEIDEPNAFGNTALHIACYlgqdA 253
Cdd:PHA03100 144 LLHLYLESNKidLKILKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVY----N 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 157743284 254 VAIELVNA----GANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNY 301
Cdd:PHA03100 203 NNPEFVKYlldlGANPNLVNKYGDTPLHIAILNNNKEI-FKLLLNNGPSIKT 253
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
656-956 |
3.21e-28 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 115.82 E-value: 3.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 656 LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCED 735
Cdd:COG0666 22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 736 CLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAgvdySGYSPMHWASYTGHEDCLELLLEHsp 815
Cdd:COG0666 102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN----DGNTPLHLAAANGNLEIVKLLLEA-- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 816 fsylegnpftplhcavinnqdsttemllgalGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Cdd:COG0666 176 -------------------------------GAD-VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743284 896 MTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINA 956
Cdd:COG0666 224 DLAAENGNLEIVKLLLEAG-ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
410-725 |
9.12e-28 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.28 E-value: 9.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Cdd:COG0666 41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 490 CSPLHYAAASDTYRRAEphtpsshdaeedeplkesrrkeaffcleFLLDNGADPSLRDRQGYTavhyaaaygnrqnlell 569
Cdd:COG0666 121 ETPLHLAAYNGNLEIVK----------------------------LLLEAGADVNAQDNDGNT----------------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 570 lemsfncledvestipvsPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKEr 649
Cdd:COG0666 156 ------------------PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD- 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITdvmDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLLLEAGADLNAK---DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
148-493 |
3.27e-27 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 118.63 E-value: 3.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 148 VHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Cdd:PHA02876 153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 228 MGAEIDEP-----NAFGNTALHiacylgqdaVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQ 302
Cdd:PHA02876 233 NRSNINKNdlsllKAIRNEDLE---------TSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAK 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 303 SKEGKSPLHMAAIHGRFTRS-QILIQNGSEIDCADKFGNTPLHVAARYG-HELLISTLMTNGADTARRGIHDMFPLHLAV 380
Cdd:PHA02876 304 NIKGETPLYLMAKNGYDTENiRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAA 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 381 LfgfsdccrkllssGQLYSIVSSLsnehvLSAGFDINTPDNLGRTCLHAAASGGN-VECLNLLLSSGADLRRRDKFGRTP 459
Cdd:PHA02876 384 V-------------RNNVVIINTL-----LDYGADIEALSQKIGTALHFALCGTNpYMSVKTLIDRGANVNSKNKDLSTP 445
|
330 340 350
....*....|....*....|....*....|....*
gi 157743284 460 LHYAAANG-SYQCAVTLVTAGAGVNEADCKGCSPL 493
Cdd:PHA02876 446 LHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
219-660 |
3.45e-27 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 116.66 E-value: 3.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 219 IEVVKYLLRMGAEIDEPNAFGNTALH--IACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNN 295
Cdd:PHA03095 27 VEEVRRLLAAGADVNFRGEYGKTPLHlyLHYSSEKVKDIVRlLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIKA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 296 GADVNYQskegksplhmaaihgrftrsqiliqngseidcaDKFGNTPLHVaaryghellistlmtngadtarrgihdmfp 375
Cdd:PHA03095 107 GADVNAK---------------------------------DKVGRTPLHV------------------------------ 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 376 lHLAvlfgfSDCCRkllssgqlYSIVSSLsnehvLSAGFDINTPDNLGRTCLHA--AASGGNVECLNLLLSSGADLRRRD 453
Cdd:PHA03095 124 -YLS-----GFNIN--------PKVIRLL-----LRKGADVNALDLYGMTPLAVllKSRNANVELLRLLIDAGADVYAVD 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 454 KFGRTPLHYAAAN--GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEphtpsshdaeedeplkesrrkeaff 531
Cdd:PHA03095 185 DRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSL------------------------- 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 532 cLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEM--SFNCLEDVESTipvsPLHLAAYNGH----------CE 599
Cdd:PHA03095 240 -VLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALgaDINAVSSDGNT----PLSLMVRNNNgravraalakNP 314
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743284 600 ALKTLAETLVNLDVRDHKGRTAlflaterGSTECVEVLTAHGASALIKERKRKwtpLHAAA 660
Cdd:PHA03095 315 SAETVAATLNTASVAGGDIPSD-------ATRLCVAKVVLRGAFSLLPEPIRA---YHADF 365
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
148-463 |
3.76e-24 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 106.97 E-value: 3.76e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 148 VHSGHLETV-NLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Cdd:PHA02874 9 IYSGDIEAIeKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 227 RMGAEidepnafgNTALHIACyLGQDAVAIeLVNAGANVNQPNDKGFTPLHVAaVSTNGALCLELLVNNGADVNYQSKEG 306
Cdd:PHA02874 89 DNGVD--------TSILPIPC-IEKDMIKT-ILDCGIDVNIKDAELKTFLHYA-IKKGDLESIKMLFEYGADVNIEDDNG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGfsd 386
Cdd:PHA02874 158 CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--- 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 387 ccrkllssgqlYSIVSSLSNEHvlsagfDINTPDNLGRTCLHAAAS-GGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Cdd:PHA02874 235 -----------RSAIELLINNA------SINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
15-198 |
4.10e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 103.59 E-value: 4.10e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 15 AIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAY--VGDVPILQLLLMSGANVNAKDTLWLTPLHRAAAS--RNEKVL 90
Cdd:PHA03100 80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESnkIDLKIL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 91 GLLLAHSADVNARDKLwqtplhvaaanratkcaEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170
Cdd:PHA03100 160 KLLIDKGVDINAKNRV-----------------NYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVN 222
|
170 180
....*....|....*....|....*...
gi 157743284 171 KKERQPLHWAAFLGHLEVLKLLVARGAD 198
Cdd:PHA03100 223 KYGDTPLHIAILNNNKEIFKLLLNNGPS 250
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
11-246 |
1.28e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 102.65 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLH-------------------------------AAAYVGDVPILQL 59
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHiickepnklgmkemirsinkcsvfytlvaikDAFNNRNVEIFKI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 60 LLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDK-LWQTPLHVAAANRATKCAEALAPLLSSLNVADR 138
Cdd:PHA02878 120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 139 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA-AFLGHLEVLKLLVARGADLGCKDR-KGYGLLHTAAAS 216
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKS 279
|
250 260 270
....*....|....*....|....*....|
gi 157743284 217 GQieVVKYLLRMGAEIDEPNAFGNTALHIA 246
Cdd:PHA02878 280 ER--KLKLLLEYGADINSLNSYKLTPLSSA 307
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
341-625 |
1.44e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 101.96 E-value: 1.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 341 TPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSI--VSSLSNEHV---LSAGFD 415
Cdd:PHA02874 37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlpIPCIEKDMIktiLDCGID 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 416 INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHY 495
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 496 AAASDTYRraephtpsshdaeedeplkesrrkeaffCLEFLLDNGADPSLRDRQGYTAVHYAAAYgNRQNLELLLEMSFN 575
Cdd:PHA02874 197 AAEYGDYA----------------------------CIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIELLINNASI 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 157743284 576 CLEDVESTipvSPLHLA-AYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625
Cdd:PHA02874 248 NDQDIDGS---TPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
75-358 |
2.93e-22 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 101.50 E-value: 2.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 75 LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAaanratkCAE----ALAPLLSSLNVADRS-GRSALHHAVH 149
Cdd:PHA02878 38 FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHII-------CKEpnklGMKEMIRSINKCSVFyTLVAIKDAFN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 150 SGHLETVN-LLLNKGASLNVCDKKERQPLHWAAFLgHLEVLKLLVARGADLGCKDR-KGYGLLHTAAASGQIEVVKYLLR 227
Cdd:PHA02878 111 NRNVEIFKiILTNRYKNIQTIDLVYIDKKSKDDII-EAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 228 MGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK-EG 306
Cdd:PHA02878 190 YGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYiLG 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 307 KSPLHMaAIHGRfTRSQILIQNGSEIDCADKFGNTPLHVAA--RYGHE---LLISTL 358
Cdd:PHA02878 270 LTALHS-SIKSE-RKLKLLLEYGADINSLNSYKLTPLSSAVkqYLCINigrILISNI 324
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
24-332 |
1.07e-21 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 101.29 E-value: 1.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDtlwltpLHRAAASRNEKVLGLLLAHSA--DVN 101
Cdd:PHA02876 194 VNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKND------LSLLKAIRNEDLETSLLLYDAgfSVN 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 102 ARDKLWQTPLHVAAanrATKCAEALAPLL----SSLNVADRSGRSALHHAVHSGH-LETVNLLLNKGASLNVCDKKERQP 176
Cdd:PHA02876 268 SIDDCKNTPLHHAS---QAPSLSRLVPKLlergADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITP 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 177 LHWAAFLG-HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVA 255
Cdd:PHA02876 345 LHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMS 424
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 256 IE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAihGRFTRSQILIQNGSEI 332
Cdd:PHA02876 425 VKtLIDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAEL 500
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
576-985 |
2.99e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 96.67 E-value: 2.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 576 CLEDVESTIPVSPLHLAAYNGHCEALKTLAETL---------------VNLDVRDHKGRTALFLATERGSTECVEVLTAH 640
Cdd:PHA02876 121 CIHILKEAISGNDIHYDKINESIEYMKLIKERIqqdelliaemlleggADVNAKDIYCITPIHYAAERGNAKMVNLLLSY 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 641 GASALIKERKrKWTPLHAAAASGHTDSLHLLIDSGERADITDVmdaygqtPLMLAIMNGHVDCVHLLLEKGSTADAADLR 720
Cdd:PHA02876 201 GADVNIIALD-DLSVLECAVDSKNIDTIKAIIDNRSNINKNDL-------SLLKAIRNEDLETSLLLYDAGFSVNSIDDC 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 721 GRTALHRGAVT-GCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH-TAVLRTLLQAalstdpldaGVDYSGYSPMHwa 798
Cdd:PHA02876 273 KNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIML---------GADVNAADRLY-- 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 799 sytghedclelllehspfsylegnpFTPLHCAVINNQDSTTEMLLGALGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLL 878
Cdd:PHA02876 342 -------------------------ITPLHQASTLDRNKDIVITLLELGAN-VNARDYCDKTPIHYAAVRNNVVIINTLL 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 879 QHQAEVNATDHTGRTALMTA--AENGQTaAVEFLLYRGkADLTVLDENKNTALHLACSKgheKCALMILAETQDLGL-IN 955
Cdd:PHA02876 396 DYGADIEALSQKIGTALHFAlcGTNPYM-SVKTLIDRG-ANVNSKNKDLSTPLHYACKK---NCKLDVIEMLLDNGAdVN 470
|
410 420 430
....*....|....*....|....*....|
gi 157743284 956 ATNSALQMPLHIAArnGLASVVQALLSHGA 985
Cdd:PHA02876 471 AINIQNQYPLLIAL--EYHGIVNILLHYGA 498
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
186-466 |
6.24e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 93.96 E-value: 6.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC---YLGQDAVAIE--LVN 260
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikYNLTDVKEIVklLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 261 AGANVNQPNDKGFTPLHVAAVSTNGALCL-ELLVNNGADVNYQSKEGKSPLHMAA--IHGRFTRSQILIQNGSEIDCADK 337
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISKKSNSYSIvEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 338 FgntplhvaaryghellistlmtngadtarrgihDMFplhlavlfgfsdccrkllssgqlysivsslsnehvLSAGFDIN 417
Cdd:PHA03100 175 V---------------------------------NYL-----------------------------------LSYGVPIN 186
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 157743284 418 TPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Cdd:PHA03100 187 IKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
10-233 |
1.29e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 92.81 E-value: 1.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 10 PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVG-----DVPILQLLLMSGANVNAKDTLWLTPLHRAAA- 83
Cdd:PHA03100 37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKynltdVKEIVKLLLEYGANVNAPDNNGITPLLYAISk 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 84 -SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKcAEALAPLLSS---LNVADRsgrsalhhavhsghletVNLL 159
Cdd:PHA03100 117 kSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKID-LKILKLLIDKgvdINAKNR-----------------VNYL 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157743284 160 LNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEID 233
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
589-898 |
2.01e-19 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 92.33 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 589 LHLAAYNGHCEALKTLAETLVN-LDVRDHKGRTALFLATERGSTECVEVLTAHGASalIKERKRKW-TPLHAAAASGHTD 666
Cdd:PHA02874 5 LRMCIYSGDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGAD--INHINTKIpHPLLTAIKIGAHD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 667 SLHLLIDSGERADITDVMDAYGQTplmlaimnghvdcVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746
Cdd:PHA02874 83 IIKLLIDNGVDTSILPIPCIEKDM-------------IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 747 VLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDpldagvDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNP 823
Cdd:PHA02874 150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEkgAYANVK------DNNGESPLHNAAEYGDYACIKLLIDHgNHIMNKCKNG 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 824 FTPLHCAVINNQdSTTEMLlgaLGAKIVNSRDAKGRTPLH-AAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTA 898
Cdd:PHA02874 224 FTPLHNAIIHNR-SAIELL---INNASINDQDIDGSTPLHhAINPPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
144-380 |
1.42e-18 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 90.32 E-value: 1.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAF----LGHLEVLKLLVARgaDLGCKDRKgyglLHTAAASGQI 219
Cdd:PHA02878 41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKepnkLGMKEMIRSINKC--SVFYTLVA----IKDAFNNRNV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 220 EVVKYLLrmgaeIDEPNAFGNTALHIACYLGQDAVaIE------LVNAGANVNQPN-DKGFTPLHVAAVSTNGALcLELL 292
Cdd:PHA02878 115 EIFKIIL-----TNRYKNIQTIDLVYIDKKSKDDI-IEaeitklLLSYGADINMKDrHKGNTALHYATENKDQRL-TELL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 293 VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL-LISTLMTNGAD-TARRGI 370
Cdd:PHA02878 188 LSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYdILKLLLEHGVDvNAKSYI 267
|
250
....*....|
gi 157743284 371 HDMFPLHLAV 380
Cdd:PHA02878 268 LGLTALHSSI 277
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
42-300 |
2.20e-18 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 88.89 E-value: 2.20e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 42 RTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSA--DVNARDKlwqtplhvaaanra 119
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDI-------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 120 tkcaealapllsslnvadrsgRSALHHAVHSGHLETVNLLLNKGASLN-VCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198
Cdd:PHA02875 69 ---------------------ESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGAD 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 199 LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHV 278
Cdd:PHA02875 128 PDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALC 207
|
250 260
....*....|....*....|..
gi 157743284 279 AAVSTNGALCLELLVNNGADVN 300
Cdd:PHA02875 208 YAIENNKIDIVRLFIKRGADCN 229
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
589-682 |
2.77e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 80.55 E-value: 2.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHgasALIKERKRKWTPLHAAAASGHTDSL 668
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 157743284 669 HLLIDSGERADITD 682
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
144-236 |
5.16e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 79.77 E-value: 5.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARgADLGCKDrKGYGLLHTAAASGQIEVVK 223
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157743284 224 YLLRMGAEIDEPN 236
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
654-1015 |
6.41e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 88.16 E-value: 6.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 654 TPLHAAAASGHTDSLHLLIDSGERADITDVM------------DAYGQTPLMLAIMNGHVDC---VHLLLEKGSTADAAD 718
Cdd:PHA03095 1 DEEDESVDIIMEAALYDYLLNASNVTVEEVRrllaagadvnfrGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 719 LRGRTALH---RGAVTgcEDCLAALLDHDAFVLCRDFKGRTPIH--LASACGHTAVLRTLLQAALSTDPLDAgvdySGYS 793
Cdd:PHA03095 81 RCGFTPLHlylYNATT--LDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDL----YGMT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 794 PMHwaSYTGHEDC----LELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEM-LLGALGAKiVNSRDAKGRTPLHAAAF 867
Cdd:PHA03095 155 PLA--VLLKSRNAnvelLRLLIDAgADVYAVDDRFRSLLHHHLQSFKPRARIVrELIRAGCD-PAATDMLGNTPLHSMAT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 868 ADNVSGLRM--LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMIL 945
Cdd:PHA03095 232 GSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALG-ADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743284 946 AETQDLGLINATnsalqmpLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKD-VADCLALIL 1015
Cdd:PHA03095 311 AKNPSAETVAAT-------LNTASVAGGDIPSDATRLCVAKVVLRGAFSLLPEPIRAYHADfIRECEAEIA 374
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
177-269 |
1.60e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 78.62 E-value: 1.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 177 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRmGAEIDEPNaFGNTALHIACYLGQDAVAI 256
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157743284 257 ELVNAGANVNQPN 269
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
521-929 |
1.78e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 87.81 E-value: 1.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 521 LKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLemSFNCLEDVESTIPVSPLHLAAYNGHCEA 600
Cdd:PHA02876 149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLL--SYGADVNIIALDDLSVLECAVDSKNIDT 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 601 LKTLAETLVNLDVRDhkgrTALFLATERGSTECVEVLTAHGASA-LIKERKRkwTPLHAAAasgHTDSLHLLIDS-GERA 678
Cdd:PHA02876 227 IKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAGFSVnSIDDCKN--TPLHHAS---QAPSLSRLVPKlLERG 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 679 DITDVMDAYGQTPLMLAIMNGH-VDCVHLLLEKGSTADAADLRGRTALHRGA-VTGCEDCLAALLDHDAFVLCRDFKGRT 756
Cdd:PHA02876 298 ADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQAStLDRNKDIVITLLELGANVNARDYCDKT 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 757 PIHLASACGHTAVLRTLLQAALSTDPLDAGVDysgySPMHWASYTghedclelllehspfsyleGNPFTPLHCAVINNQD 836
Cdd:PHA02876 378 PIHYAAVRNNVVIINTLLDYGADIEALSQKIG----TALHFALCG-------------------TNPYMSVKTLIDRGAN 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 837 sttemllgalgakiVNSRDAKGRTPLHAAAFAD-NVSGLRMLLQHQAEVNATDHTGRTALMTAAenGQTAAVEFLLYRGK 915
Cdd:PHA02876 435 --------------VNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA 498
|
410
....*....|....*.
gi 157743284 916 A--DLTVLDENKNTAL 929
Cdd:PHA02876 499 ElrDSRVLHKSLNDNM 514
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
599-907 |
3.08e-17 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 85.85 E-value: 3.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEV---LTAHGASALIKERKrKWTPLHAAAASGHT-DSLHLLIDS 674
Cdd:PHA03095 28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERC-GFTPLHLYLYNATTlDVIKLLIKA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 675 GerADITDVmDAYGQTPL--MLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH-----RGAvtgCEDCLAALLDHDAFV 747
Cdd:PHA03095 107 G--ADVNAK-DKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAvllksRNA---NVELLRLLIDAGADV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 748 LCRDFKGRTP--IHLASACGHTAVLRTLLqaALSTDPldAGVDYSGYSPMHwaSYTGHEDCLELLLehSPFsylegnpft 825
Cdd:PHA03095 181 YAVDDRFRSLlhHHLQSFKPRARIVRELI--RAGCDP--AATDMLGNTPLH--SMATGSSCKRSLV--LPL--------- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 826 plhcaVINNQDsttemllgalgakiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTA 905
Cdd:PHA03095 244 -----LIAGIS--------------INARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGR 304
|
..
gi 157743284 906 AV 907
Cdd:PHA03095 305 AV 306
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
111-203 |
3.12e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.85 E-value: 3.12e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 111 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKgASLNVCDKKeRQPLHWAAFLGHLEVLK 190
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157743284 191 LLVARGADLGCKD 203
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
11-198 |
4.26e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 85.04 E-value: 4.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNakDTLW---LTPLHRAAASRNE 87
Cdd:PHA02875 38 PIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAD--DVFYkdgMTPLHLATILKKL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 88 KVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLN 167
Cdd:PHA02875 116 DIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
|
170 180 190
....*....|....*....|....*....|..
gi 157743284 168 VCDKK-ERQPLHWAAFLGHLEVLKLLVARGAD 198
Cdd:PHA02875 196 YFGKNgCVAALCYAIENNKIDIVRLFIKRGAD 227
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
656-751 |
5.28e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 77.08 E-value: 5.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 656 LHAAAASGHTDSLHLLIDSGERADitdVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADaaDLRGRTALHRGAVTGCED 735
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADAN---LQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLE 75
|
90
....*....|....*.
gi 157743284 736 CLAALLDHDAFVLCRD 751
Cdd:pfam12796 76 IVKLLLEKGADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
533-730 |
6.80e-17 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 84.27 E-value: 6.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLleMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTL--AETLVN 610
Cdd:PHA02875 18 ARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLL--MKHGAIPDVKYPDIESELHDAVEEGDVKAVEELldLGKFAD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 611 lDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRkWTPLHAAAASGHTDSLHLLIDsgERAdITDVMDAYGQT 690
Cdd:PHA02875 96 -DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDK-FSPLHLAVMMGDIKGIELLID--HKA-CLDIEDCCGCT 170
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 157743284 691 PLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730
Cdd:PHA02875 171 PLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAI 210
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
210-302 |
1.73e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 75.54 E-value: 1.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNaGANVNqPNDKGFTPLHVAAVSTNGAlCL 289
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVN-LKDNGRTALHYAARSGHLE-IV 77
|
90
....*....|...
gi 157743284 290 ELLVNNGADVNYQ 302
Cdd:pfam12796 78 KLLLEKGADINVK 90
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
436-789 |
1.75e-16 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 83.54 E-value: 1.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 436 VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCA---VTLVTAGAGVNEADCKGCSPLHYAAasdtyrraephtpsS 512
Cdd:PHA03095 27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYL--------------Y 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 513 HDAEEDeplkesrrkeaffCLEFLLDNGADPSLRDRQGYTAVHyaaaygnrqnlelllemsfncledvestipvspLHLA 592
Cdd:PHA03095 93 NATTLD-------------VIKLLIKAGADVNAKDKVGRTPLH---------------------------------VYLS 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 593 AYNGHCEALKTLAETLVNLDVRDHKGRTAL--FLATERGSTECVEVLTAHGASALIKERKRKwTPLHAAAASGHTDS--L 668
Cdd:PHA03095 127 GFNINPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGADVYAVDDRFR-SLLHHHLQSFKPRAriV 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 669 HLLIDSGERADITDVmdaYGQTPLMLAIMngHVDCVHL----LLEKGSTADAADLRGRTALHRGAVTG----CEDCLAAL 740
Cdd:PHA03095 206 RELIRAGCDPAATDM---LGNTPLHSMAT--GSSCKRSlvlpLLIAGISINARNRYGQTPLHYAAVFNnpraCRRLIALG 280
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 157743284 741 LDhdafVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDY 789
Cdd:PHA03095 281 AD----INAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAATLNT 325
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
862-955 |
4.72e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 74.38 E-value: 4.72e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADltvLDENKNTALHLACSKGHEKCA 941
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 157743284 942 LMILAETQDLGLIN 955
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
247-563 |
1.01e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 80.78 E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 247 CYLGQDAVAIE--LVNAGANVNQPNDKGFTPLhVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 324
Cdd:PHA02874 8 CIYSGDIEAIEkiIKNKGNCINISVDETTTPL-IDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 325 LIQNGSE-----IDCADKfgntplhvaarygheLLISTLMTNGADTARRGIHDMFPLHLAVlfgfsdccrkllSSGQLYS 399
Cdd:PHA02874 87 LIDNGVDtsilpIPCIEK---------------DMIKTILDCGIDVNIKDAELKTFLHYAI------------KKGDLES 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 400 IvsslsnEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
Cdd:PHA02874 140 I------KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 480 AGVNEADCKGCSPLHYAAASDtyRRAEP-----HTPSSHDAEEDEPLKESRRkeaFFC----LEFLLDNGADPSLRDRQG 550
Cdd:PHA02874 214 NHIMNKCKNGFTPLHNAIIHN--RSAIEllinnASINDQDIDGSTPLHHAIN---PPCdidiIDILLYHKADISIKDNKG 288
|
330
....*....|...
gi 157743284 551 YTAVHYAAAYGNR 563
Cdd:PHA02874 289 ENPIDTAFKYINK 301
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
622-718 |
1.25e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 73.23 E-value: 1.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 622 LFLATERGSTECVEVLTAHGASALIKErKRKWTPLHAAAASGHTDSLHLLIDSGeRADITDvmdaYGQTPLMLAIMNGHV 701
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKD----NGRTALHYAARSGHL 74
|
90
....*....|....*..
gi 157743284 702 DCVHLLLEKGSTADAAD 718
Cdd:pfam12796 75 EIVKLLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
740-993 |
1.51e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 81.65 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 740 LLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ--AALSTDPLDagvdysGYSPMHWASYTGHEDCLELLLEHSpfS 817
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSygADVNIIALD------DLSVLECAVDSKNIDTIKAIIDNR--S 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 818 YLEGNPFTPLHcaVINNQDSTTEMLLGALGAKiVNSRDAKGRTPLHAAAFADNVSGL-RMLLQHQAEVNATDHTGRTALM 896
Cdd:PHA02876 236 NINKNDLSLLK--AIRNEDLETSLLLYDAGFS-VNSIDDCKNTPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLY 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 897 TAAENG-QTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAEtqdLGL-INATNSALQMPLHIAARNGLA 974
Cdd:PHA02876 313 LMAKNGyDTENIRTLIMLG-ADVNAADRLYITPLHQASTLDRNKDIVITLLE---LGAnVNARDYCDKTPIHYAAVRNNV 388
|
250
....*....|....*....
gi 157743284 975 SVVQALLSHGATVLAVDEE 993
Cdd:PHA02876 389 VIINTLLDYGADIEALSQK 407
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
12-194 |
1.55e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 80.39 E-value: 1.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLG 91
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 92 LLLAHSADVNARDKLWQTPLHVAAA-NRATkcaealAPLL---SSLNVADRSGRSALHHAVH-SGHLETVNLLLNKGASL 166
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAIIhNRSA------IELLinnASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281
|
170 180
....*....|....*....|....*....
gi 157743284 167 NVCDKKERQPLHWA-AFLGHLEVLKLLVA 194
Cdd:PHA02874 282 SIKDNKGENPIDTAfKYINKDPVIKDIIA 310
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
12-104 |
2.86e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.07 E-value: 2.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLmSGANVNAKDTLWlTPLHRAAASRNEKVLG 91
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNGR-TALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157743284 92 LLLAHSADVNARD 104
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
895-991 |
6.74e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.92 E-value: 6.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 895 LMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCAlMILAETQDLGLINATNSalqmPLHIAARNGLA 974
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRT----ALHYAARSGHL 74
|
90
....*....|....*..
gi 157743284 975 SVVQALLSHGATVLAVD 991
Cdd:pfam12796 75 EIVKLLLEKGADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
397-718 |
8.72e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 77.78 E-value: 8.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 397 LYSIVS-------SLSNEHVLSAGFDINTPDNLGRT-CLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Cdd:PHA03100 1 LYSYIVltksriiKVKNIKYIIMEDDLNDYSYKKPVlPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 469 YQCAVT-----LVTAGAGVNEADCKGCSPLHYAAasdtyrraephtpsshdaeedeplkeSRRKEAFFCLEFLLDNGADP 543
Cdd:PHA03100 81 NLTDVKeivklLLEYGANVNAPDNNGITPLLYAI--------------------------SKKSNSYSIVEYLLDNGANV 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 544 SLRDRQGYTAVHYAAAYgNRQNLELllemsfncledvestipvsplhlaaynghceaLKTLAETLVNLDVRDHkgrtalf 623
Cdd:PHA03100 135 NIKNSDGENLLHLYLES-NKIDLKI--------------------------------LKLLIDKGVDINAKNR------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 624 latergstecVEVLTAHGASALIKErKRKWTPLHAAAASGHTDSLHLLIDSGerADITDVMDaYGQTPLMLAIMNGHVDC 703
Cdd:PHA03100 175 ----------VNYLLSYGVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLG--ANPNLVNK-YGDTPLHIAILNNNKEI 240
|
330
....*....|....*
gi 157743284 704 VHLLLEKGSTADAAD 718
Cdd:PHA03100 241 FKLLLNNGPSIKTII 255
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
376-486 |
9.48e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.53 E-value: 9.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 376 LHLAVLFGFSDCCRKLLSSGqlysivsslsnehvlsagFDINTPDNLGRTCLHAAASGGNVECLNLLLSSgADLRRRDKf 455
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG------------------ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN- 60
|
90 100 110
....*....|....*....|....*....|.
gi 157743284 456 GRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Cdd:pfam12796 61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
8-199 |
1.05e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 78.57 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVG-DVPILQLLLMSGANVNAKDTLWLTPLHRAAASRN 86
Cdd:PHA02876 308 ETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNN 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 87 EKVLGLLLAHSADVNARDKLWQTPLHVA-AANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSG-HLETVNLLLNKGA 164
Cdd:PHA02876 388 VVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGA 467
|
170 180 190
....*....|....*....|....*....|....*
gi 157743284 165 SLNVCDKKERQPLHWAafLGHLEVLKLLVARGADL 199
Cdd:PHA02876 468 DVNAINIQNQYPLLIA--LEYHGIVNILLHYGAEL 500
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
427-547 |
1.36e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.14 E-value: 1.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGvnEADCKGCSPLHYAAasdtyrrae 506
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAA--------- 69
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 157743284 507 phtpsshdaeedeplkESRRKEaffCLEFLLDNGADPSLRD 547
Cdd:pfam12796 70 ----------------RSGHLE---IVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
692-775 |
1.43e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.14 E-value: 1.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHdaFVLCRDFKGRTPIHLASACGHTAVLR 771
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDNGRTALHYAARSGHLEIVK 78
|
....
gi 157743284 772 TLLQ 775
Cdd:pfam12796 79 LLLE 82
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
3-118 |
1.92e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 77.23 E-value: 1.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 3 ILSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLH-AAAYVGDVPILQLLLMSGANVNAKDT-LWLTPLHr 80
Cdd:PHA02878 196 IPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHiSVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH- 274
|
90 100 110
....*....|....*....|....*....|....*...
gi 157743284 81 aAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANR 118
Cdd:PHA02878 275 -SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQY 311
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
45-137 |
2.23e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.76 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 45 LHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHsADVNARDKLWqTPLHVAAANRATKCAE 124
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78
|
90
....*....|...
gi 157743284 125 ALAPLLSSLNVAD 137
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
74-284 |
4.33e-14 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 76.59 E-value: 4.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 74 WLTPLHRAAASRN-EKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL---APLLssLNVADRS----GRSALH 145
Cdd:cd22192 17 SESPLLLAAKENDvQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLmeaAPEL--VNEPMTSdlyqGETALH 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 146 HAVHSGHLETVNLLLNKGASL---------------NVCDKKErQPLHWAAFLGHLEVLKLLVARGADLGCKDRkgygll 210
Cdd:cd22192 95 IAVVNQNLNLVRELIARGADVvspratgtffrpgpkNLIYYGE-HPLSFAACVGNEEIVRLLIEHGADIRAQDS------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 211 htaaasgqievvkyllrmgaeidepnaFGNTALHI---------ACYL---------GQDAVAIELVnaganvnqPNDKG 272
Cdd:cd22192 168 ---------------------------LGNTVLHIlvlqpnktfACQMydlilsydkEDDLQPLDLV--------PNNQG 212
|
250
....*....|..
gi 157743284 273 FTPLHVAAVSTN 284
Cdd:cd22192 213 LTPFKLAAKEGN 224
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
596-872 |
1.22e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 74.26 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKwTPLHAAAASGHTDSLHLLIDSG 675
Cdd:PHA02875 13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE-SELHDAVEEGDVKAVEELLDLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 676 ERADitDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGR 755
Cdd:PHA02875 92 KFAD--DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGC 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 756 TPIHLASACGHTAVLRTLLQAAlstdpldAGVDYSGYSP----MHWASYTGHEDCLELLLEHSP----FSYLEGNPFTPL 827
Cdd:PHA02875 170 TPLIIAMAKGDIAICKMLLDSG-------ANIDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGAdcniMFMIEGEECTIL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 157743284 828 HcaVINNQDSTTEM-LLGALGAKIVNSRDAKgrTPLHAAAFADNVS 872
Cdd:PHA02875 243 D--MICNMCTNLESeAIDALIADIAIRIHKK--TIRRDEGFKNNMS 284
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
141-408 |
1.90e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 73.49 E-value: 1.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 220
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 221 VVKYLLRMGAEIDEpnafgntalhiACYlgqdavaielvnaganvnqpnDKGFTPLHVAAVSTNGALcLELLVNNGADVN 300
Cdd:PHA02875 83 AVEELLDLGKFADD-----------VFY---------------------KDGMTPLHLATILKKLDI-MKLLIARGADPD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 301 YQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADT---ARRGihDMFPLH 377
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIdyfGKNG--CVAALC 207
|
250 260 270
....*....|....*....|....*....|.
gi 157743284 378 LAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408
Cdd:PHA02875 208 YAIENNKIDIVRLFIKRGADCNIMFMIEGEE 238
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
48-284 |
2.78e-13 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 74.35 E-value: 2.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 48 AAYVGDVPILQLLLMSGA--NVNAKDTLWLTPLHRAAA-SRNEKVLGLLLAHSADVNARDKLwqtpLHVAAANRATKCAE 124
Cdd:TIGR00870 24 AAERGDLASVYRDLEEPKklNINCPDRLGRSALFVAAIeNENLELTELLLNLSCRGAVGDTL----LHAISLEYVDAVEA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 125 ALAPLL-------SSLNVADRS------GRSALHHAVHSGHLETVNLLLNKGASLNV------CDKKERQ--------PL 177
Cdd:TIGR00870 100 ILLHLLaafrksgPLELANDQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPAracgdfFVKSQGVdsfyhgesPL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 178 HWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHtaaasgqievvkyLLRMGAEidepNAFGNTALHIACY------LGQ 251
Cdd:TIGR00870 180 NAAACLGSPSIVALLSEDPADILTADSLGNTLLH-------------LLVMENE----FKAEYEELSCQMYnfalslLDK 242
|
250 260 270
....*....|....*....|....*....|....*
gi 157743284 252 --DAVAIELVnaganvnqPNDKGFTPLHVAAVSTN 284
Cdd:TIGR00870 243 lrDSKELEVI--------LNHQGLTPLKLAAKEGR 269
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
209-345 |
8.99e-13 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 72.35 E-value: 8.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 209 LLHTAAASGQIEVVKYLLRM-GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGAN-VNQPND----KGFTPLHVAAVS 282
Cdd:cd22192 20 PLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTsdlyQGETALHIAVVN 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 283 TNGALcLELLVNNGADVN-------YQSKEGKS-------PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHV 345
Cdd:cd22192 100 QNLNL-VRELIARGADVVspratgtFFRPGPKNliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHI 175
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
533-789 |
9.18e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 71.62 E-value: 9.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNclEDVESTIPVSPLHLAAYNGHC-----EALKTLAET 607
Cdd:PHA03100 18 IKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGAD--INSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 608 LVNLDVRDHKGRTALFLA--TERGSTECVEVLTAHGASALIKeRKRKWTPLHAAAASGHTDS--LHLLIDSGerADItDV 683
Cdd:PHA03100 96 GANVNAPDNNGITPLLYAisKKSNSYSIVEYLLDNGANVNIK-NSDGENLLHLYLESNKIDLkiLKLLIDKG--VDI-NA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 684 MDAygqtplmlaimnghvdcVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 763
Cdd:PHA03100 172 KNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
|
250 260
....*....|....*....|....*.
gi 157743284 764 CGHTAVLRTLLQAALSTDPLDAGVDY 789
Cdd:PHA03100 235 NNNKEIFKLLLNNGPSIKTIIETLLY 260
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
441-761 |
9.34e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 72.40 E-value: 9.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 441 LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRraephtpsshdaeedep 520
Cdd:PHA02876 163 MLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID----------------- 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 521 lkesrrkeaffCLEFLLDNGADPSLRDRQGYTAVhyaaaygNRQNLE--LLLE---MSFNCLEDVESTipvsPLHLAAYN 595
Cdd:PHA02876 226 -----------TIKAIIDNRSNINKNDLSLLKAI-------RNEDLEtsLLLYdagFSVNSIDDCKNT----PLHHASQA 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 596 GHCEAL-KTLAETLVNLDVRDHKGRTALFLATERG-STECVEVLTAHGASALIKERKRKwTPLHAAAA-SGHTDSLHLLI 672
Cdd:PHA02876 284 PSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYI-TPLHQASTlDRNKDIVITLL 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 673 DSGERadiTDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRgAVTGCEDCLA--ALLDHDAFVLCR 750
Cdd:PHA02876 363 ELGAN---VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHF-ALCGTNPYMSvkTLIDRGANVNSK 438
|
330
....*....|.
gi 157743284 751 DFKGRTPIHLA 761
Cdd:PHA02876 439 NKDLSTPLHYA 449
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
9-168 |
1.01e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 71.56 E-value: 1.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 9 QPPLVQAIFSRDVEEVRSLLSQKENIN-VLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNE 87
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 88 KVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR-SALHHAVHSGHLETVNLLLNKGASL 166
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADC 228
|
..
gi 157743284 167 NV 168
Cdd:PHA02875 229 NI 230
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
343-453 |
1.34e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 343 LHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSgqlysivsslsnehvlsagFDINTPDNl 422
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-------------------ADVNLKDN- 60
|
90 100 110
....*....|....*....|....*....|.
gi 157743284 423 GRTCLHAAASGGNVECLNLLLSSGADLRRRD 453
Cdd:pfam12796 61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
233-477 |
1.40e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 71.45 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 233 DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN---------------------------- 284
Cdd:PHA02878 31 TSASLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNklgmkemirsinkcsvfytlvaikdafn 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 285 -----------------------------------GALCLELLVNNGADVNYQSKE-GKSPLHMAAIHGRFTRSQILIQN 328
Cdd:PHA02878 111 nrnveifkiiltnrykniqtidlvyidkkskddiiEAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 329 GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVlfgfsdccrkllSSGQLYSIVSSLsneh 408
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV------------GYCKDYDILKLL---- 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743284 409 vLSAGFDINTPDN-LGRTCLHAAASGGNVecLNLLLSSGADLRRRDKFGRTPLHYAAANGS-YQCAVTLVT 477
Cdd:PHA02878 255 -LEHGVDVNAKSYiLGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPLSSAVKQYLcINIGRILIS 322
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
310-395 |
1.49e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAdtARRGIHDMFPLHLAVLFGFSDCCR 389
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVK 78
|
....*.
gi 157743284 390 KLLSSG 395
Cdd:pfam12796 79 LLLEKG 84
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
536-761 |
1.49e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 71.15 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVsplHLAAYNGHCEALKTLAETLVNLDVR 614
Cdd:PHA02874 110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVnIEDDNGCYPI---HIAIKHNFFDIIKLLLEKGAYANVK 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 615 DHKGRTALFLATERGSTECVEVLTAHGASALIKeRKRKWTPLHAAAasghtdslhllidsgeraditdvmdAYGQTPLML 694
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNGFTPLHNAI-------------------------IHNRSAIEL 240
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 695 AIMNghvdcvhlllekgSTADAADLRGRTALHRGAVTGCE-DCLAALLDHDAFVLCRDFKGRTPIHLA 761
Cdd:PHA02874 241 LINN-------------ASINDQDIDGSTPLHHAINPPCDiDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
276-364 |
1.76e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 276 LHVAAVStNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGsEIDCADKfGNTPLHVAARYGHELLI 355
Cdd:pfam12796 1 LHLAAKN-GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDN-GRTALHYAARSGHLEIV 77
|
....*....
gi 157743284 356 STLMTNGAD 364
Cdd:pfam12796 78 KLLLEKGAD 86
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
555-647 |
2.20e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.98 E-value: 2.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 555 HYAAAYGNRQNLELLLEMSFNCleDVESTIPVSPLHLAAYNGHCEALKTLAETlVNLDVRDHkGRTALFLATERGSTECV 634
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADA--NLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIV 77
|
90
....*....|...
gi 157743284 635 EVLTAHGASALIK 647
Cdd:pfam12796 78 KLLLEKGADINVK 90
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
265-571 |
2.28e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 70.46 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 265 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA-IHGRFTR----SQILIQNGSEIDCADKFG 339
Cdd:PHA03100 27 LNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnIKYNLTDvkeiVKLLLEYGANVNAPDNNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 340 NTPLHVAA--RYGHELLISTLMTNGADT---ARRGIHdmfPLHLAVlfgfSDCCRKLlssgqlySIVSSLsnehvLSAGF 414
Cdd:PHA03100 107 ITPLLYAIskKSNSYSIVEYLLDNGANVnikNSDGEN---LLHLYL----ESNKIDL-------KILKLL-----IDKGV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 415 DINTPDNLgrtclhaaasggnveclNLLLSSGADlrrrdkfgrtplhyaaangsyqcavtlvtagagVNEADCKGCSPLH 494
Cdd:PHA03100 168 DINAKNRV-----------------NYLLSYGVP---------------------------------INIKDVYGFTPLH 197
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 495 YAAasdtyrraephtpsSHDAEEdeplkesrrkeaFFclEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLE 571
Cdd:PHA03100 198 YAV--------------YNNNPE------------FV--KYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
459-761 |
3.79e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 3.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 459 PLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAsdtyrraEPHTPSshdaeedepLKESRRKEaffcleflld 538
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICK-------EPNKLG---------MKEMIRSI---------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 539 ngadpsLRDRQGYTAVHYAAAYGNRqNLELLLEMSFNCLeDVESTIPVSPLHLAAYNGHCEA--LKTLAETLVNLDVRD- 615
Cdd:PHA02878 94 ------NKCSVFYTLVAIKDAFNNR-NVEIFKIILTNRY-KNIQTIDLVYIDKKSKDDIIEAeiTKLLLSYGADINMKDr 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 616 HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKwTPLHAAAASGHTDSLHLLIDSGERadiTDVMDAYGQTPLMLA 695
Cdd:PHA02878 166 HKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNN-SPLHHAVKHYNKPIVHILLENGAS---TDARDKCGNTPLHIS 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 696 ImnGHV---DCVHLLLEKGSTADA-ADLRGRTALHRGAVTgcEDCLAALLDHDAFVLCRDFKGRTPIHLA 761
Cdd:PHA02878 242 V--GYCkdyDILKLLLEHGVDVNAkSYILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSA 307
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
342-592 |
4.28e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 4.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 342 PLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV----LFGFSDCCRKLLS---SGQLYSIVSSLSNEHV----- 409
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnKLGMKEMIRSINKcsvFYTLVAIKDAFNNRNVeifki 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 410 -LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDK-FGRTPLHYAAANGSYQCAVTLVTAGAGVNEADC 487
Cdd:PHA02878 120 iLTNRYKNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 488 KGCSPLHYAaasdtyrraephtpsshdaeedepLKESRRKeaffCLEFLLDNGADPSLRDRQGYTAVHYAAAY-GNRQNL 566
Cdd:PHA02878 200 TNNSPLHHA------------------------VKHYNKP----IVHILLENGASTDARDKCGNTPLHISVGYcKDYDIL 251
|
250 260
....*....|....*....|....*..
gi 157743284 567 ELLLEMSFNCleDVESTI-PVSPLHLA 592
Cdd:PHA02878 252 KLLLEHGVDV--NAKSYIlGLTALHSS 276
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
81-236 |
6.69e-12 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 69.90 E-value: 6.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 160
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 161 NKGASLNvcDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN 236
Cdd:PLN03192 612 HFASISD--PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAN 685
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
795-888 |
8.36e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 62.44 E-value: 8.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 795 MHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNsrdaKGRTPLHAAAFADNVSG 873
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLEnGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 157743284 874 LRMLLQHQAEVNATD 888
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
246-490 |
1.36e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 67.71 E-value: 1.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAaVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325
Cdd:PHA02875 9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLA-MKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 326 IQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGfsdccrkllssgqlysivssl 404
Cdd:PHA02875 88 LDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG--------------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 405 snehvlsagfDINTpdnlgrtclhaaasggnvecLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
Cdd:PHA02875 147 ----------DIKG--------------------IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196
|
....*.
gi 157743284 485 ADCKGC 490
Cdd:PHA02875 197 FGKNGC 202
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
670-919 |
1.61e-11 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 68.74 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 670 LLIDSGERaDITDVMDAygqtPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLC 749
Cdd:PLN03192 512 LLGDNGGE-HDDPNMAS----NLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHI 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 750 RDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGvdysgyspmhwasytghedclELLLEhspfsylegnpftplhc 829
Cdd:PLN03192 587 RDANGNTALWNAISAKHHKIFRILYHFASISDPHAAG---------------------DLLCT----------------- 628
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 830 avinnqdsttemllgalgakivnsrdakgrtplhaAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
Cdd:PLN03192 629 -----------------------------------AAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRL 673
|
250
....*....|
gi 157743284 910 LLYRGkADLT 919
Cdd:PLN03192 674 LIMNG-ADVD 682
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
532-615 |
2.52e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 60.90 E-value: 2.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 532 CLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTipvsPLHLAAYNGHCEALKTLAETLVNL 611
Cdd:pfam12796 12 LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRT----ALHYAARSGHLEIVKLLLEKGADI 87
|
....
gi 157743284 612 DVRD 615
Cdd:pfam12796 88 NVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
20-168 |
3.71e-11 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 66.59 E-value: 3.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 20 DVEEVRSLLSQKENINVLDQERRTPLHA-AAYVGDVP-ILQLLLMSGANVNAKDTLWLTPLHRAAASRNEK--VLGLLLA 95
Cdd:PHA03095 166 NVELLRLLIDAGADVYAVDDRFRSLLHHhLQSFKPRArIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLI 245
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157743284 96 HSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV 168
Cdd:PHA03095 246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAET 318
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
113-276 |
5.35e-11 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 66.82 E-value: 5.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 113 VAAANRATKCAEALAPLLSSL-------NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELlkakldpDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH 603
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 186 LEVLKLL--VARGADlgckDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGA 263
Cdd:PLN03192 604 HKIFRILyhFASISD----PHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
|
170
....*....|....
gi 157743284 264 NVNQPN-DKGFTPL 276
Cdd:PLN03192 680 DVDKANtDDDFSPT 693
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
423-476 |
5.69e-11 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 58.83 E-value: 5.69e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 423 GRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
274-461 |
1.03e-10 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 65.80 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 274 TPLHVAAvSTNGALCLE-LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSE-----IDCADKFGNTPLHVAA 347
Cdd:cd22192 19 SPLLLAA-KENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 348 RYGHELLISTLMTNGADTA---------RRGIHDMFplhlavLFGfsdccrkllssgqlysivsslsnEHVLSagFdint 418
Cdd:cd22192 98 VNQNLNLVRELIARGADVVspratgtffRPGPKNLI------YYG-----------------------EHPLS--F---- 142
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 157743284 419 pdnlgrtclhaAASGGNVECLNLLLSSGADLRRRDKFGRTPLH 461
Cdd:cd22192 143 -----------AACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
257-460 |
1.09e-10 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 65.08 E-value: 1.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 257 ELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLVNNGADVNYQSKEGKSPLHMAAIHGR--FTRSQILIQNGSEID- 333
Cdd:PHA02946 57 ELLHRGYSPNETDDDGNYPLHIASKINNNRI-VAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINn 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 334 CADKFGNTPLhVAARYGHELLISTLMTNGadtarrgihdmFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLsnehvLSAG 413
Cdd:PHA02946 136 SVDEEGCGPL-LACTDPSERVFKKIMSIG-----------FEARIVDKFGKNHIHRHLMSDNPKASTISWM-----MKLG 198
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 157743284 414 FDINTPDNLGRTCLHAAASG--GNVECLNLLLSSgADLRRRDKFGRTPL 460
Cdd:PHA02946 199 ISPSKPDHDGNTPLHIVCSKtvKNVDIINLLLPS-TDVNKQNKFGDSPL 246
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
140-193 |
1.86e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 57.28 E-value: 1.86e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
659-934 |
3.35e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 63.47 E-value: 3.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 659 AAASGHTDSLHLLIDSGERADITdVMDAYgqTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLA 738
Cdd:PHA02875 9 AILFGELDIARRLLDIGINPNFE-IYDGI--SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 739 ALLDHDAF---VLCRDfkGRTPIHLASACGHTAVLRTLLqaALSTDPLDAGVDYsgYSPMHWASYTGHEDCLELLLEHSP 815
Cdd:PHA02875 86 ELLDLGKFaddVFYKD--GMTPLHLATILKKLDIMKLLI--ARGADPDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 816 FSYLEgnpftplhcavinnqdsttemllgalgakivnsrDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Cdd:PHA02875 160 CLDIE----------------------------------DCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 157743284 896 M-TAAENGQTAAVEFLLYRGkAD---LTVLDENKNTALHLACS 934
Cdd:PHA02875 206 LcYAIENNKIDIVRLFIKRG-ADcniMFMIEGEECTILDMICN 247
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
851-1011 |
6.66e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 62.67 E-value: 6.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 851 VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALH 930
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG-AYANVKDNNGESPLH 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 931 LACSKGHEKCALMILAETQDlgLINATNSALqMPLHIAARNGLASVvqALLSHGATVLAVDEEGHTP---ALACAPNKDV 1007
Cdd:PHA02874 196 NAAEYGDYACIKLLIDHGNH--IMNKCKNGF-TPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPlhhAINPPCDIDI 270
|
....
gi 157743284 1008 ADCL 1011
Cdd:PHA02874 271 IDIL 274
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
173-226 |
8.21e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 55.36 E-value: 8.21e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 173 ERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
51-346 |
1.05e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 62.16 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 51 VGDVPILQL--LLMSGANVN---AKDTLWLTPLHRAAASRneKVLGLLLAHSADVNARDKLWQTPLhvaaanratkCAea 125
Cdd:PHA02798 12 FSDNVKLSTvkLLIKSCNPNeivNEYSIFQKYLQRDSPST--DIVKLFINLGANVNGLDNEYSTPL----------CT-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 126 lapLLSslNVADrsgrsalhhavHSGHLETVNLLLNKGASLNVCDKKERQPLHWA---AFLGHLEVLKLLVARGADLGCK 202
Cdd:PHA02798 78 ---ILS--NIKD-----------YKHMLDIVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILLFMIENGADTTLL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 203 DRKGYGLLHTAAASG---QIEVVKYLLRMGAEIDE-PNAFGNTALHiaCYLGQDAVAIE------LVNAGANVNQPND-- 270
Cdd:PHA02798 142 DKDGFTMLQVYLQSNhhiDIEIIKLLLEKGVDINThNNKEKYDTLH--CYFKYNIDRIDadilklFVDNGFIINKENKsh 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157743284 271 -KGFTPLHVAAVSTNGALCLELL--VNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346
Cdd:PHA02798 220 kKKFMEYLNSLLYDNKRFKKNILdfIFSYIDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGNTCLFTA 298
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
132-312 |
1.33e-09 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 61.61 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH--LEVLKLLVARGADLGCK-DRKGYG 208
Cdd:PHA02946 64 SPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINNSvDEEGCG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 209 LLhTAAASGQIEVVKYLLRMGAEIDEPNAFGNTalHIACYLGQD---AVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTN 284
Cdd:PHA02946 144 PL-LACTDPSERVFKKIMSIGFEARIVDKFGKN--HIHRHLMSDnpkASTISwMMKLGISPSKPDHDGNTPLHIVCSKTV 220
|
170 180
....*....|....*....|....*...
gi 157743284 285 GALCLELLVNNGADVNYQSKEGKSPLHM 312
Cdd:PHA02946 221 KNVDIINLLLPSTDVNKQNKFGDSPLTL 248
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
653-708 |
2.53e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 53.82 E-value: 2.53e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 653 WTPLHAAAASGHTDSLHLLIDSGerADItDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKG--ADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
858-1020 |
4.21e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 60.00 E-value: 4.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 858 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH 937
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 938 EKCALMILAETQDLGLINATNSAlqmPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILST 1017
Cdd:PHA02875 115 LDIMKLLIARGADPDIPNTDKFS---PLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
|
...
gi 157743284 1018 MKP 1020
Cdd:PHA02875 192 ANI 194
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
339-576 |
6.75e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 59.23 E-value: 6.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 339 GNTPLHVAARYGHELLISTLMTNGA--DTARRGIHDmfPLHLAVLFGFSDCCRKLLSSGqlysivsSLSNEHVLSAGfdi 416
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGDVKAVEELLDLG-------KFADDVFYKDG--- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 417 NTPdnlgrtcLHAAASGGNVECLNLLLSSGAD--LRRRDKFgrTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494
Cdd:PHA02875 103 MTP-------LHLATILKKLDIMKLLIARGADpdIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 495 YAAAsdtyrraephtpsshdaeedeplkesrRKEAFFClEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL-ELLLEMS 573
Cdd:PHA02875 174 IAMA---------------------------KGDIAIC-KMLLDSGANIDYFGKNGCVAALCYAIENNKIDIvRLFIKRG 225
|
...
gi 157743284 574 FNC 576
Cdd:PHA02875 226 ADC 228
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
429-570 |
7.75e-09 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 59.88 E-value: 7.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 429 AAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPL--------------- 493
Cdd:PLN03192 531 TVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifril 610
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 494 -HYAAASDtyrraePHTPSshdaeedEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 570
Cdd:PLN03192 611 yHFASISD------PHAAG-------DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
578-719 |
8.15e-09 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 59.88 E-value: 8.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 578 EDVESTIPVSPLHLAAyNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE--------- 648
Cdd:PLN03192 519 EHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDangntalwn 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 649 ------RKRKWTPLHAAAASGHTDSLHLLIDSGERADIT------------DVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Cdd:PLN03192 598 aisakhHKIFRILYHFASISDPHAAGDLLCTAAKRNDLTamkellkqglnvDSEDHQGATALQVAMAEDHVDMVRLLIMN 677
|
....*....
gi 157743284 711 GSTADAADL 719
Cdd:PLN03192 678 GADVDKANT 686
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
858-911 |
8.27e-09 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 52.66 E-value: 8.27e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 858 GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
722-914 |
1.86e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.08 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 722 RTALHRGAVTGCEDCLAALLD---HDAFVLcrdFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDysgySPMHWA 798
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDigiNPNFEI---YDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIE----SELHDA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 799 SYTGHEDCLELLLEHSPFS----YLEGNpfTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKgrTPLHAAAFADNVSGL 874
Cdd:PHA02875 76 VEEGDVKAVEELLDLGKFAddvfYKDGM--TPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGI 151
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 157743284 875 RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
49-276 |
2.00e-08 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 58.14 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 49 AYVG----DVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKcae 124
Cdd:PHA02946 43 AYCGikglDERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEV--- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 125 alapllsslnvadrsgrsalhhavhsghLETVNLLLNKGASL-NVCDKKERQPLhWAAFLGHLEVLKLLVARGADLGCKD 203
Cdd:PHA02946 120 ----------------------------IERINLLVQYGAKInNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVD 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 204 RKGYGLLHTAAASG--QIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAV-AIELVNAGANVNQPNDKGFTPL 276
Cdd:PHA02946 171 KFGKNHIHRHLMSDnpKASTISWMMKLGISPSKPDHDGNTPLHIVCSKTVKNVdIINLLLPSTDVNKQNKFGDSPL 246
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
766-992 |
2.70e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 57.37 E-value: 2.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS--PFSYLEGNpFTPLH-----CAVINNQDST 838
Cdd:PHA03100 10 SRIIKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGadINSSTKNN-STPLHylsniKYNLTDVKEI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 839 TEMLLgALGAkIVNSRDAKGRTPLHAAAFA--DNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ--TAAVEFLLYRG 914
Cdd:PHA03100 89 VKLLL-EYGA-NVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 915 ---------------KADLTVLDENKNTALHLACSKGHEKCALMILaetqDLGL-INATNSALQMPLHIAARNGLASVVQ 978
Cdd:PHA03100 167 vdinaknrvnyllsyGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL----DLGAnPNLVNKYGDTPLHIAILNNNKEIFK 242
|
250
....*....|....
gi 157743284 979 ALLSHGATVLAVDE 992
Cdd:PHA03100 243 LLLNNGPSIKTIIE 256
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
201-347 |
4.47e-08 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 57.40 E-value: 4.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 201 CKDRKGYGLLHTAAASGQ-IEVVKYLLRMGAEIDEpnafGNTALHIACYLGQDAV----AIELVNAGANVNQP--ND--- 270
Cdd:TIGR00870 47 CPDRLGRSALFVAAIENEnLELTELLLNLSCRGAV----GDTLLHAISLEYVDAVeailLHLLAAFRKSGPLElaNDqyt 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 271 ----KGFTPLHVAAVsTNGALCLELLVNNGADVNYQSK--------------EGKSPLHMAAIHGRFTRSQILIQNGSEI 332
Cdd:TIGR00870 123 seftPGITALHLAAH-RQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSPSIVALLSEDPADI 201
|
170
....*....|....*
gi 157743284 333 DCADKFGNTPLHVAA 347
Cdd:TIGR00870 202 LTADSLGNTLLHLLV 216
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
41-94 |
6.73e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.97 E-value: 6.73e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 41 RRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLL 94
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
337-494 |
7.00e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 56.56 E-value: 7.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 337 KFGNTPLHVAARYGHELLISTLMT-NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSgqlysiVSSLSNEHVLSAGFd 415
Cdd:cd22192 15 RISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA------APELVNEPMTSDLY- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 416 intpdnLGRTCLHAAASGGNVECLNLLLSSGADL----------RRRDK----FGRTPLHYAAANGSYQCAVTLVTAGAG 481
Cdd:cd22192 88 ------QGETALHIAVVNQNLNLVRELIARGADVvspratgtffRPGPKnliyYGEHPLSFAACVGNEEIVRLLIEHGAD 161
|
170
....*....|...
gi 157743284 482 VNEADCKGCSPLH 494
Cdd:cd22192 162 IRAQDSLGNTVLH 174
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
842-997 |
8.60e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.04 E-value: 8.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 842 LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVL 921
Cdd:PHA02878 152 LLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDAR 230
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 922 DENKNTALHLACSKGHEKCALMILAETQdlGLINATNSALQM-PLHIAARNglASVVQALLSHGATVLAVDEEGHTP 997
Cdd:PHA02878 231 DKCGNTPLHISVGYCKDYDILKLLLEHG--VDVNAKSYILGLtALHSSIKS--ERKLKLLLEYGADINSLNSYKLTP 303
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
27-166 |
1.04e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.03 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 27 LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL--LAHSADVNARD 104
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAAG 623
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 105 KLWQTplhvaAANRATkcAEALAPLLS-SLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASL 166
Cdd:PLN03192 624 DLLCT-----AAKRND--LTAMKELLKqGLNVdsEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
153-448 |
1.34e-07 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 55.61 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 153 LETVNLLLNKGASLNVCDKKERQPL-----HWAAFLGHLEVLKLLVARGADLGCKDRKG----YGLLHTAAASgQIEVVK 223
Cdd:PHA02798 51 TDIVKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGetplYCLLSNGYIN-NLEILL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 224 YLLRMGAEIDEPNAFGNTALHI----ACYLGQDAVAIeLVNAGANVNQPNDK-GFTPLHV---AAVSTNGALCLELLVNN 295
Cdd:PHA02798 130 FMIENGADTTLLDKDGFTMLQVylqsNHHIDIEIIKL-LLEKGVDINTHNNKeKYDTLHCyfkYNIDRIDADILKLFVDN 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 296 GADVNYQSKegksplhmaaihgrFTRSQILiqngseidcadkfgntplhvaaryghELLISTLMTNgadtaRRGIHDMFP 375
Cdd:PHA02798 209 GFIINKENK--------------SHKKKFM--------------------------EYLNSLLYDN-----KRFKKNILD 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 376 LhlavLFGFSDCCRK-LLSSGQLYSIVSSLSN---EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 448
Cdd:PHA02798 244 F----IFSYIDINQVdELGFNPLYYSVSHNNRkifEYLLQLGGDINIITELGNTCLFTAFENESKFIFNSILNKKPN 316
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
55-237 |
1.35e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.67 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 55 PILQLLLMSGANVNAKDTLWLTPLHRAAASRNEkvLGLLLAHSADVNARDKLWQTPLHVAAANratkcaEALAP-LLSSL 133
Cdd:PTZ00322 11 SAFAAQLFFGTEGSRKRRAKPISFERMAAIQEE--IARIDTHLEALEATENKDATPDHNLTTE------EVIDPvVAHML 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 134 NVAdrsgrsaLHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 213
Cdd:PTZ00322 83 TVE-------LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
|
170 180
....*....|....*....|....
gi 157743284 214 AASGQIEVVKYLLRMGAEIDEPNA 237
Cdd:PTZ00322 156 EENGFREVVQLLSRHSQCHFELGA 179
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
74-126 |
1.39e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.20 E-value: 1.39e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 157743284 74 WLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
825-997 |
1.48e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 54.97 E-value: 1.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 825 TPLHCAVINNQDSTTEMLLgALGAKiVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 904
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLF-EYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 905 AAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMILAETqdlglINATNSALQMPLHIAARNGLA-SVVQALLSH 983
Cdd:PHA02874 204 ACIKLLIDHG-NHIMNKCKNGFTPLHNAIIHNRSAIELLINNAS-----INDQDIDGSTPLHHAINPPCDiDIIDILLYH 277
|
170
....*....|....
gi 157743284 984 GATVLAVDEEGHTP 997
Cdd:PHA02874 278 KADISIKDNKGENP 291
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
428-531 |
1.49e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 55.67 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 428 HAAASGGNVEcLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE- 506
Cdd:PTZ00322 88 QLAASGDAVG-ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQl 166
|
90 100
....*....|....*....|....*..
gi 157743284 507 --PHTPSSHDAEEDEPLKESRRKEAFF 531
Cdd:PTZ00322 167 lsRHSQCHFELGANAKPDSFTGKPPSL 193
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
869-1015 |
1.65e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 55.64 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 869 DNVSGLRMLLQHQAEVNA--------------TDHTGRTALMTAAENGQTAAVEFLLyRGKADLTVLDENKNTALHLACS 934
Cdd:PLN03192 489 DNVVILKNFLQHHKELHDlnvgdllgdnggehDDPNMASNLLTVASTGNAALLEELL-KAKLDPDIGDSKGRTPLHIAAS 567
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 935 KGHEKCALMILAETQDLGLINAT-NSAL---------------------QMP------LHIAARNGLASVVQALLSHGAT 986
Cdd:PLN03192 568 KGYEDCVLVLLKHACNVHIRDANgNTALwnaisakhhkifrilyhfasiSDPhaagdlLCTAAKRNDLTAMKELLKQGLN 647
|
170 180
....*....|....*....|....*....
gi 157743284 987 VLAVDEEGHTpALACAPNKDVADCLALIL 1015
Cdd:PLN03192 648 VDSEDHQGAT-ALQVAMAEDHVDMVRLLI 675
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
218-471 |
1.95e-07 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 55.30 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 218 QIEVVKYLLRMG-AEID-EPNAFGNTALHiaCYLGQDAVAIE----LVNAGANVNQPNDKGFTPLHVAAVSTN-GALCLE 290
Cdd:PHA02716 154 DLDLIKYMVDVGiVNLNyVCKKTGYGILH--AYLGNMYVDIDilewLCNNGVNVNLQNNHLITPLHTYLITGNvCASVIK 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 291 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDcADKFGNTP--LHV---AARYGHELLISTLMTNGA-- 363
Cdd:PHA02716 232 KIIELGGDMDMKCVNGMSPIMTYIINIDNINPEITNIYIESLD-GNKVKNIPmiLHSyitLARNIDISVVYSFLQPGVkl 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 364 ---DTARRGIhdmfpLHLAVLfgfsdccRKLLSSgqlySIVSSLsNEHvlsaGFDINTPDNLGRTCLHAAAS-------- 432
Cdd:PHA02716 311 hykDSAGRTC-----LHQYIL-------RHNIST----DIIKLL-HEY----GNDLNEPDNIGNTVLHTYLSmlsvvnil 369
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 157743284 433 ------GGNVECLNLLLSSGADLRRRDKFGRTPLhyaaanGSYQC 471
Cdd:PHA02716 370 dpetdnDIRLDVIQCLISLGADITAVNCLGYTPL------TSYIC 408
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
587-760 |
2.53e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 54.63 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 587 SPLHLAAYNGHCEALKTLAETlvnldvrdhkGRTALFlatERGstecvevltAHGASALikerkrkwtplHAAAASGHTD 666
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKC----------PSCDLF---QRG---------ALGETAL-----------HVAALYDNLE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 667 SLHLLIDSGERAdITDVM--DAY-GQTPLMLAIMNGHVDCVHLLLEKGstADAADLR----------------GRTALHR 727
Cdd:cd22192 66 AAVVLMEAAPEL-VNEPMtsDLYqGETALHIAVVNQNLNLVRELIARG--ADVVSPRatgtffrpgpknliyyGEHPLSF 142
|
170 180 190
....*....|....*....|....*....|...
gi 157743284 728 GAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760
Cdd:cd22192 143 AACVGNEEIVRLLIEHGADIRAQDSLGNTVLHI 175
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
723-814 |
3.20e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.52 E-value: 3.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 723 TALHRGAVTGCEdcLAA---------LLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQaaLSTDPldAGVDYSGYS 793
Cdd:PTZ00322 77 VVAHMLTVELCQ--LAAsgdavgariLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLE--FGADP--TLLDKDGKT 150
|
90 100
....*....|....*....|.
gi 157743284 794 PMHWASYTGHEDCLELLLEHS 814
Cdd:PTZ00322 151 PLELAEENGFREVVQLLSRHS 171
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
309-499 |
3.40e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 54.12 E-value: 3.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY----GHELLISTLMTNGADTARRGIHDMFPLHLAVLF-- 382
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpnklGMKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFki 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 383 -------GFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD-NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDK 454
Cdd:PHA02878 120 iltnrykNIQTIDLVYIDKKSKDDIIEAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 157743284 455 FGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS 499
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGY 244
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
658-790 |
3.48e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 54.49 E-value: 3.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 658 AAAASGHTDSLHLLIDSGERADITDvmdAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL------------ 725
Cdd:PLN03192 531 TVASTGNAALLEELLKAKLDPDIGD---SKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkif 607
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 726 ------------HRGAVTGCE-------DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAG 786
Cdd:PLN03192 608 rilyhfasisdpHAAGDLLCTaakrndlTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
....
gi 157743284 787 VDYS 790
Cdd:PLN03192 688 DDFS 691
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
721-774 |
3.53e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.04 E-value: 3.53e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 721 GRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL 774
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
682-879 |
3.61e-07 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 54.32 E-value: 3.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 682 DVMDAYGQTPLM-LAIMNGHVDCVHLLLEKGSTADAadlrGRTALH---RGAVTGCEDCLAALLDHD----------AFV 747
Cdd:TIGR00870 46 NCPDRLGRSALFvAAIENENLELTELLLNLSCRGAV----GDTLLHaisLEYVDAVEAILLHLLAAFrksgplelanDQY 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 748 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTdPLDAGVD-----------YSGYSPMHWASYTGHEDCLELLLEHsPF 816
Cdd:TIGR00870 122 TSEFTPGITALHLAAHRQNYEIVKLLLERGASV-PARACGDffvksqgvdsfYHGESPLNAAACLGSPSIVALLSED-PA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 817 SYLE----GNpfTPLHCAVINNQDST--TEM------LLGALGAKIVNSRDA------KGRTPLHAAAFADNVSGLRMLL 878
Cdd:TIGR00870 200 DILTadslGN--TLLHLLVMENEFKAeyEELscqmynFALSLLDKLRDSKELevilnhQGLTPLKLAAKEGRIVLFRLKL 277
|
.
gi 157743284 879 Q 879
Cdd:TIGR00870 278 A 278
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
660-743 |
4.24e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 54.13 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 660 AASGHTDSLHLLIDSGerADiTDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 739
Cdd:PTZ00322 90 AASGDAVGARILLTGG--AD-PNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166
|
....
gi 157743284 740 LLDH 743
Cdd:PTZ00322 167 LSRH 170
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
87-284 |
4.36e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 54.12 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 87 EKVLGLL----LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS--------------GRSALHHAV 148
Cdd:cd21882 2 EELLGLLeclrWYLTDSAYQRGATGKTCLHKAALNLNDGVNEAIMLLLEAAPDSGNPkelvnapctdefyqGQTALHIAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 149 HSGHLETVNLLLNKGASLNV--CDKKERQPLHWAAFLGHLEvlkllvargadlgckdrkgyglLHTAAASGQIEVVKYLL 226
Cdd:cd21882 82 ENRNLNLVRLLVENGADVSAraTGRFFRKSPGNLFYFGELP----------------------LSLAACTNQEEIVRLLL 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 227 RMGAEIDEPNA---FGNTALHIACYLGQDAVAI---------ELVNAGANVNQ-------PNDKGFTPLHVAAVSTN 284
Cdd:cd21882 140 ENGAQPAALEAqdsLGNTVLHALVLQADNTPENsafvcqmynLLLSYGAHLDPtqqleeiPNHQGLTPLKLAAVEGK 216
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
206-259 |
5.33e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 5.33e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
308-358 |
5.38e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 5.38e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 157743284 308 SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
587-637 |
5.65e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 5.65e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 157743284 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL 637
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
615-774 |
6.26e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 53.61 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 615 DHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPlhaaaasghtdslhllidsgeradiTDVMDAY--GQTPL 692
Cdd:cd22194 138 AYEGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGVFFNP-------------------------KYKHEGFyfGETPL 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 693 MLAIMNGHVDCVHLLLEKGSTADAA-DLRGRTALHrGAVTGCEDclaaLLDHDAFVL-----------------CRDFKG 754
Cdd:cd22194 193 ALAACTNQPEIVQLLMEKESTDITSqDSRGNTVLH-ALVTVAED----SKTQNDFVKrmydmillksenknletIRNNEG 267
|
170 180
....*....|....*....|
gi 157743284 755 RTPIHLASACGHTAVLRTLL 774
Cdd:cd22194 268 LTPLQLAAKMGKAEILKYIL 287
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
180-343 |
7.87e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 53.33 E-value: 7.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVaIELV 259
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKI-FRIL 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 260 NAGANVNQPNDKGftPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA---D 336
Cdd:PLN03192 611 YHFASISDPHAAG--DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdD 688
|
....*..
gi 157743284 337 KFGNTPL 343
Cdd:PLN03192 689 DFSPTEL 695
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
840-997 |
8.25e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.14 E-value: 8.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 840 EMLLGalGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE----------- 908
Cdd:PHA02876 162 EMLLE--GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKaiidnrsnink 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 909 -----------------FLLYRGKADLTVLDENKNTALHLAC-SKGHEKCALMILAETQDlglINATNSALQMPLHIAAR 970
Cdd:PHA02876 240 ndlsllkairnedletsLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGAD---VNAKNIKGETPLYLMAK 316
|
170 180
....*....|....*....|....*...
gi 157743284 971 NGLASV-VQALLSHGATVLAVDEEGHTP 997
Cdd:PHA02876 317 NGYDTEnIRTLIMLGADVNAADRLYITP 344
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
227-359 |
9.95e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 52.98 E-value: 9.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 227 RMGAeIDEPNAFGNTALHiACYLGQDAVAielvnaGANVNQPNDKGFTP--LHVAAV------STNGALCLELLVNNGAD 298
Cdd:PTZ00322 36 RMAA-IQEEIARIDTHLE-ALEATENKDA------TPDHNLTTEEVIDPvvAHMLTVelcqlaASGDAVGARILLTGGAD 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743284 299 VNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
Cdd:PTZ00322 108 PNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
415-463 |
1.25e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 46.57 E-value: 1.25e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 157743284 415 DINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
845-911 |
1.62e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 52.21 E-value: 1.62e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157743284 845 ALGAKIV-------NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
Cdd:PTZ00322 95 AVGARILltggadpNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
325-486 |
1.74e-06 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 52.18 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 325 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSsgqlysiVSSL 404
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYH-------FASI 616
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 405 SNEHvlsAGFDIntpdnlgrtcLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
Cdd:PLN03192 617 SDPH---AAGDL----------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
|
..
gi 157743284 485 AD 486
Cdd:PLN03192 684 AN 685
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
783-1016 |
1.76e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 51.53 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 783 LDAGVD-----YSGYSPMHWASYTGHEDCLELLLEHSPF-SYLEGNPFTPLHCAVINNQDSTTEMLLgALGAKIVNSRDA 856
Cdd:PHA02875 22 LDIGINpnfeiYDGISPIKLAMKFRDSEAIKLLMKHGAIpDVKYPDIESELHDAVEEGDVKAVEELL-DLGKFADDVFYK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 857 KGRTPLHAAAFADNVSGLRMLLQHQAE--VNATDHTgrTALMTAAENGQTAAVEFLLYrgkadltvldenkntalHLACS 934
Cdd:PHA02875 101 DGMTPLHLATILKKLDIMKLLIARGADpdIPNTDKF--SPLHLAVMMGDIKGIELLID-----------------HKACL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 935 KGHEKCALMilaetqdlglinatnsalqmPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
Cdd:PHA02875 162 DIEDCCGCT--------------------PLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLF 221
|
..
gi 157743284 1015 LS 1016
Cdd:PHA02875 222 IK 223
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
430-604 |
2.22e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 51.55 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 430 AASGGNVECLN-LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG-VNEADC----KGCSPLHYAAASDTY- 502
Cdd:cd22192 24 AAKENDVQAIKkLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTsdlyQGETALHIAVVNQNLn 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 503 -------RRAEPHTPsshdaeedeplkesRRKEAFF-------------------C------LEFLLDNGADPSLRDRQG 550
Cdd:cd22192 104 lvreliaRGADVVSP--------------RATGTFFrpgpknliyygehplsfaaCvgneeiVRLLIEHGADIRAQDSLG 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157743284 551 YTAVHYAAAYGNR----QNLELLLEMSFN----CLEDVESTIPVSPLHLAAYNGHCEALKTL 604
Cdd:cd22192 170 NTVLHILVLQPNKtfacQMYDLILSYDKEddlqPLDLVPNNQGLTPFKLAAKEGNIVMFQHL 231
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
423-692 |
2.44e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 51.42 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 423 GRTCLHAAA---SGGNVECLNLLLSSGADLRRRDKF-----------GRTPLHYAAANGSYQCAVTLVTAGAGVNeadck 488
Cdd:cd21882 26 GKTCLHKAAlnlNDGVNEAIMLLLEAAPDSGNPKELvnapctdefyqGQTALHIAIENRNLNLVRLLVENGADVS----- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 489 gcsplhyAAASDTYRRAEPHtPSSHDAEEDEPLKESRRKEAFfcLEFLLDNGADP---SLRDRQGYTAVHyaaaygnrqn 565
Cdd:cd21882 101 -------ARATGRFFRKSPG-NLFYFGELPLSLAACTNQEEI--VRLLLENGAQPaalEAQDSLGNTVLH---------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 566 leLLLEMSFNCLEDVESTIPVSPLhLAAYNGHCEALKTLAEtlvnldVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Cdd:cd21882 161 --ALVLQADNTPENSAFVCQMYNL-LLSYGAHLDPTQQLEE------IPNHQGLTPLKLAAVEGKIVMFQHILQREFSGP 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 157743284 646 IKERKRK---WT--PLHAAA-------ASGHTDSLHLLIDSGERADITDVMDaygQTPL 692
Cdd:cd21882 232 YQPLSRKfteWTygPVTSSLydlseidSWEKNSVLELIAFSKKREARHQMLV---QEPL 287
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
608-814 |
2.67e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 51.33 E-value: 2.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 608 LVNLDVRD--HKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPlhaaaASGHTDSLhllidsgeraditdvmd 685
Cdd:cd22193 64 FINAEYTDeyYEGQTALHIAIERRQGDIVALLVENGADVHAHAKGRFFQP-----KYQGEGFY----------------- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 686 aYGQTPLMLAIMNGHVDCVHLLLE---KGSTADAADLRGRTALHrGAVTGCEDclaaLLDHDAFV-------------LC 749
Cdd:cd22193 122 -FGELPLSLAACTNQPDIVQYLLEnehQPADIEAQDSRGNTVLH-ALVTVADN----TKENTKFVtrmydmilirgakLC 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 750 --------RDFKGRTPIHLASACGHTAVLRTLLQAALSTDP---LDAGVDYSGYSPMHWASY-------TGHEDCLELLL 811
Cdd:cd22193 196 ptveleeiRNNDGLTPLQLAAKMGKIEILKYILQREIKEPElrhLSRKFTDWAYGPVSSSLYdlsnvdtCEKNSVLEIIV 275
|
...
gi 157743284 812 EHS 814
Cdd:cd22193 276 YNS 278
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
123-227 |
3.18e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 50.04 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 123 AEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKerQPLHWAAFLGHLEVLKLLVARGADLG 200
Cdd:PHA02791 11 SKQLKSFLSSKDAfkADVHGHSALYYAIADNNVRLVCTLLNAGALKNLLENE--FPLHQAATLEDTKIVKILLFSGMDDS 88
|
90 100
....*....|....*....|....*..
gi 157743284 201 CKDRKGYGLLHTAAASGQIEVVKYLLR 227
Cdd:PHA02791 89 QFDDKGNTALYYAVDSGNMQTVKLFVK 115
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
520-697 |
3.47e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 50.76 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 520 PLKESRRKEAFFCLEFLLDNG--ADPSLRdRQGYTAVHYAAAYGNRQNLELLLEMSFNclEDVESTIPVSPLHLAAYNGH 597
Cdd:PHA02875 71 ELHDAVEEGDVKAVEELLDLGkfADDVFY-KDGMTPLHLATILKKLDIMKLLIARGAD--PDIPNTDKFSPLHLAVMMGD 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677
Cdd:PHA02875 148 IKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGAD 227
|
170 180
....*....|....*....|.
gi 157743284 678 ADI-TDVMDAYGQTPLMLAIM 697
Cdd:PHA02875 228 CNImFMIEGEECTILDMICNM 248
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
863-983 |
4.40e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 50.67 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 863 HAAAFADNVsGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTalhlacskghekcal 942
Cdd:PTZ00322 88 QLAASGDAV-GARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG-ADPTLLDKDGKT--------------- 150
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 157743284 943 milaetqdlglinatnsalqmPLHIAARNGLASVVQALLSH 983
Cdd:PTZ00322 151 ---------------------PLELAEENGFREVVQLLSRH 170
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
582-898 |
4.97e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 50.26 E-value: 4.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 582 STIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAtergsteCVEVlTAHGASALIKER-KRK-WTPLHAA 659
Cdd:PHA02878 34 SLIPFIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHII-------CKEP-NKLGMKEMIRSInKCSvFYTLVAI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 660 AASGHTDSLH----LLIDSGERadITDVMDAYGQTPLMLAIMNGHVdcVHLLLEKGSTADAADL-RGRTALHRGAVTGCE 734
Cdd:PHA02878 106 KDAFNNRNVEifkiILTNRYKN--IQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRhKGNTALHYATENKDQ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAgvdySGYSPMHWA-SYTGHEDCLELLLEH 813
Cdd:PHA02878 182 RLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDK----CGNTPLHISvGYCKDYDILKLLLEH 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 814 SpfsylegnpftplhcAVINNQDSTtemllgalgakivnsrdaKGRTPLHAAAFADNVsgLRMLLQHQAEVNATDHTGRT 893
Cdd:PHA02878 258 G---------------VDVNAKSYI------------------LGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLT 302
|
....*
gi 157743284 894 ALMTA 898
Cdd:PHA02878 303 PLSSA 307
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
45-243 |
6.86e-06 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 50.30 E-value: 6.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 45 LHAaaYVG----DVPILQLLLMSGANVNAKDTLWLTPLHRAAASRN--EKVLGLLLAHSADVNARDKLWQTPLHVAAANr 118
Cdd:PHA02716 181 LHA--YLGnmyvDIDILEWLCNNGVNVNLQNNHLITPLHTYLITGNvcASVIKKIIELGGDMDMKCVNGMSPIMTYIIN- 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 119 atkcAEALAPLLSSLNVADRSGRSA------LHHAVHSGH---LETVNLLLNKGASLNVCDKKERQPLHwAAFLGH---L 186
Cdd:PHA02716 258 ----IDNINPEITNIYIESLDGNKVknipmiLHSYITLARnidISVVYSFLQPGVKLHYKDSAGRTCLH-QYILRHnisT 332
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157743284 187 EVLKLLVARGADLGCKDRKGYGLLHTAAA--------------SGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
Cdd:PHA02716 333 DIIKLLHEYGNDLNEPDNIGNTVLHTYLSmlsvvnildpetdnDIRLDVIQCLISLGADITAVNCLGYTPL 403
|
|
| PHA02989 |
PHA02989 |
ankyrin repeat protein; Provisional |
57-317 |
7.77e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222954 [Multi-domain] Cd Length: 494 Bit Score: 49.74 E-value: 7.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 57 LQLLLMSGANVNAK---DTLWLTPLHRAAASrnEKVLGLLLAHSADVNARDkLWQTPLHVAAANR--ATKCAEALAPLL- 130
Cdd:PHA02989 19 LEFLLRTGFDVNEEyrgNSILLLYLKRKDVK--IKIVKLLIDNGADVNYKG-YIETPLCAVLRNReiTSNKIKKIVKLLl 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 131 ---SSLNVADRSGRSALHHAVHSGHLETVN---LLLNKGASLN-VCDKKERQPLH--WAAFLGHLEVLKLLVARGADLgC 201
Cdd:PHA02989 96 kfgADINLKTFNGVSPIVCFIYNSNINNCDmlrFLLSKGINVNdVKNSRGYNLLHmyLESFSVKKDVIKILLSFGVNL-F 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 202 KDRKGYGL------LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTAL------HIACYlGQDAVAIELVNAGANVNQPN 269
Cdd:PHA02989 175 EKTSLYGLtpmniyLRNDIDVISIKVIKYLIKKGVNIETNNNGSESVLesfldnNKILS-KKEFKVLNFILKYIKINKKD 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 157743284 270 DKGFTPLHVAAVSTNGALCLELLvNNGADVNYQSKEGKSPLHMAAIHG 317
Cdd:PHA02989 254 KKGFNPLLISAKVDNYEAFNYLL-KLGDDIYNVSKDGDTVLTYAIKHG 300
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
109-160 |
1.05e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.80 E-value: 1.05e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 157743284 109 TPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLL 160
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
216-360 |
1.17e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 47.51 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 216 SGQIEVVKYLLRMgaeIDEPNAFGNTALHiACyLGQDAVAIE----LVNAGANVN-QPNDKGFTPLHvAAVSTNGAL--- 287
Cdd:PHA02859 31 KDDIEGVKKWIKF---VNDCNDLYETPIF-SC-LEKDKVNVEilkfLIENGADVNfKTRDNNLSALH-HYLSFNKNVepe 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 288 CLELLVNNGADVNYQSKEGKSPLH--MAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360
Cdd:PHA02859 105 ILKILIDSGSSITEEDEDGKNLLHmyMCNFNVRINVIKLLIDSGVSFLNKDFDNNNILYSYILFHSDKKIFDFLT 179
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
533-643 |
1.18e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 49.48 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTI----PVSPLH----------------- 590
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVhIRDANGNTalwnAISAKHhkifrilyhfasisdph 620
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 591 -------LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAS 643
Cdd:PLN03192 621 aagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
547-775 |
1.19e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 49.31 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 547 DRQGYTAVHYAAAYGNRQNLELLLEmSFNCLEDVESTIpvspLHLAA--YNGHCEAL---------KTLAETLVNLDVRD 615
Cdd:TIGR00870 49 DRLGRSALFVAAIENENLELTELLL-NLSCRGAVGDTL----LHAISleYVDAVEAIllhllaafrKSGPLELANDQYTS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 616 --HKGRTALFLATERGSTECVEVLTAHGASalikerkrkwtpLHAAA------ASGHTDSLHllidsgeraditdvmdaY 687
Cdd:TIGR00870 124 efTPGITALHLAAHRQNYEIVKLLLERGAS------------VPARAcgdffvKSQGVDSFY-----------------H 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 688 GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALH------------RGAVTGCEDCLAALLDHdafvlCRD---- 751
Cdd:TIGR00870 175 GESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHllvmenefkaeyEELSCQMYNFALSLLDK-----LRDskel 249
|
250 260
....*....|....*....|....*....
gi 157743284 752 -----FKGRTPIHLASACGHTAVLRTLLQ 775
Cdd:TIGR00870 250 evilnHQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
274-326 |
1.24e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.42 E-value: 1.24e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 157743284 274 TPLHVAAVSTNGAlCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILI 326
Cdd:pfam13637 3 TALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
258-313 |
1.28e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 1.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 258 LVNAG-ANVNQPNDKGFTPLHVAAvSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 313
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAA-KYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
291-346 |
1.31e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 1.31e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 291 LLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
191-246 |
1.33e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.49 E-value: 1.33e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
230-350 |
1.46e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 48.99 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 230 AEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN--------QPNDK--GF----TPLHVAAVsTNGALCLELLVNN 295
Cdd:cd22194 132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNahakgvffNPKYKheGFyfgeTPLALAAC-TNQPEIVQLLMEK 210
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 296 GAD-VNYQSKEGKSPLHMAAIHGRFTRSQI--LIQNGSEI--DCADKF--------GNTPLHVAARYG 350
Cdd:cd22194 211 ESTdITSQDSRGNTVLHALVTVAEDSKTQNdfVKRMYDMIllKSENKNletirnneGLTPLQLAAKMG 278
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
10-61 |
2.47e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.65 E-value: 2.47e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 157743284 10 PPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLL 61
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
409-467 |
2.55e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 48.36 E-value: 2.55e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 157743284 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANG 467
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
891-945 |
3.13e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.26 E-value: 3.13e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 891 GRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEKCALMIL 945
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
237-345 |
3.17e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 47.95 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 237 AFGNTALHIAC-YL--GQDAVAIELVNAGANVNQPND-----------KGFTPLHVAAVSTNgALCLELLVNNGADVNYQ 302
Cdd:cd21882 24 ATGKTCLHKAAlNLndGVNEAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENRN-LNLVRLLVENGADVSAR 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 157743284 303 SKE-------------GKSPLHMAAIHGRFTRSQILIQNGSEI---DCADKFGNTPLHV 345
Cdd:cd21882 103 ATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPaalEAQDSLGNTVLHA 161
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
690-741 |
3.29e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.26 E-value: 3.29e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 157743284 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
517-570 |
3.32e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.26 E-value: 3.32e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 517 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL 570
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
609-775 |
3.53e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 47.77 E-value: 3.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 609 VNLDVRDHKGRTALFLATERGST-ECVEVLTAHGASALIKErkrkwTPLHAAAASGHTD----SLHLLIDSGERADITDV 683
Cdd:TIGR00870 43 LNINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVGD-----TLLHAISLEYVDAveaiLLHLLAAFRKSGPLELA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 684 MDAY------GQTPLMLAIMNGHVDCVHLLLEKGSTADAAdlrgrtalhrgavTGCEDCLAAlLDHDAFvlcrdFKGRTP 757
Cdd:TIGR00870 118 NDQYtseftpGITALHLAAHRQNYEIVKLLLERGASVPAR-------------ACGDFFVKS-QGVDSF-----YHGESP 178
|
170
....*....|....*...
gi 157743284 758 IHLASACGHTAVLRTLLQ 775
Cdd:TIGR00870 179 LNAAACLGSPSIVALLSE 196
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
153-275 |
3.88e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 45.97 E-value: 3.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 153 LETVNLLLNKGASLNVCDKKER-QPLHWaaFLGH-----LEVLKLLVARGADLGCKDRKGYGLLHT--AAASGQIEVVKY 224
Cdd:PHA02859 66 VEILKFLIENGADVNFKTRDNNlSALHH--YLSFnknvePEILKILIDSGSSITEEDEDGKNLLHMymCNFNVRINVIKL 143
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 157743284 225 LLRMGAEIDEPNAFGNTALH-IACYLGQDAVAIELVNAGANVNQPNDKGFTP 275
Cdd:PHA02859 144 LIDSGVSFLNKDFDNNNILYsYILFHSDKKIFDFLTSLGIDINETNKSGYNC 195
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
43-115 |
4.15e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 47.77 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 43 TPLHAAAYVGDVPILQLLLMSGANVNAK------------DTLWLT--PLHRAAASRNEKVLGLLLAHSADVNARDKLWQ 108
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPARacgdffvksqgvDSFYHGesPLNAAACLGSPSIVALLSEDPADILTADSLGN 209
|
....*..
gi 157743284 109 TPLHVAA 115
Cdd:TIGR00870 210 TLLHLLV 216
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
13-178 |
4.35e-05 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 47.36 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 13 VQAIFSRDVEEvrsLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKV--L 90
Cdd:PHA02946 47 IKGLDERFVEE---LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIerI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 91 GLLLAHSADV-NARDKLWQTPLhVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGH--LETVNLLLNKGASLN 167
Cdd:PHA02946 124 NLLVQYGAKInNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNpkASTISWMMKLGISPS 202
|
170
....*....|.
gi 157743284 168 VCDKKERQPLH 178
Cdd:PHA02946 203 KPDHDGNTPLH 213
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
32-81 |
4.42e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.95 E-value: 4.42e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 157743284 32 ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81
Cdd:pfam13857 7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
791-843 |
4.46e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.88 E-value: 4.46e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 791 GYSPMHWASYTGHEDCLELLLEHS-PFSYLEGNPFTPLHCAVINNQDSTTEMLL 843
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGaDINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
52-126 |
4.51e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.59 E-value: 4.51e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 52 GDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Cdd:PTZ00322 93 GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
754-811 |
4.78e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.88 E-value: 4.78e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 754 GRTPIHLASACGHTAVLRTLLQAALSTDPldagVDYSGYSPMHWASYTGHEDCLELLL 811
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINA----VDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
12-97 |
4.83e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.59 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLG 91
Cdd:PTZ00322 86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
|
....*.
gi 157743284 92 LLLAHS 97
Cdd:PTZ00322 166 LLSRHS 171
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
566-814 |
4.94e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 47.18 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 566 LELLLEMSFNCLEDVESTIPV---SPLHLAAYNGHCEALKTLA------------ETLVNLDVRD--HKGRTALFLATER 628
Cdd:cd21882 4 LLGLLECLRWYLTDSAYQRGAtgkTCLHKAALNLNDGVNEAIMllleaapdsgnpKELVNAPCTDefYQGQTALHIAIEN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 629 GSTECVEVLTAHGASAlikerkrkwtplhAAAASGH--TDSLHLLIdsgeraditdvmdAYGQTPLMLAIMNGHVDCVHL 706
Cdd:cd21882 84 RNLNLVRLLVENGADV-------------SARATGRffRKSPGNLF-------------YFGELPLSLAACTNQEEIVRL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 707 LLEKG---STADAADLRGRTALH------------RGAVTGCEDCLAAL---LDH-DAFVLCRDFKGRTPIHLASACGHT 767
Cdd:cd21882 138 LLENGaqpAALEAQDSLGNTVLHalvlqadntpenSAFVCQMYNLLLSYgahLDPtQQLEEIPNHQGLTPLKLAAVEGKI 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 768 AVLRTLLQAALST--DPLDAGVDYSGYSPMHWASY-------TGHEDCLELLLEHS 814
Cdd:cd21882 218 VMFQHILQREFSGpyQPLSRKFTEWTYGPVTSSLYdlseidsWEKNSVLELIAFSK 273
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
330-594 |
5.69e-05 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 47.38 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 330 SEIDCADKFGNTPLHVAARYG-HELLISTLMTNGA-----DTArrgihdmfpLHLAVLfGFSDCCRKLLSSgQLYSIVSS 403
Cdd:TIGR00870 43 LNINCPDRLGRSALFVAAIENeNLELTELLLNLSCrgavgDTL---------LHAISL-EYVDAVEAILLH-LLAAFRKS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 404 LSNEHVLSAGFDINTPDnlgRTCLHAAASGGNVECLNLLLSSGADLRRRDK--------------FGRTPLHYAAANGSY 469
Cdd:TIGR00870 112 GPLELANDQYTSEFTPG---ITALHLAAHRQNYEIVKLLLERGASVPARACgdffvksqgvdsfyHGESPLNAAACLGSP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 470 QCAVTLVTAGAGVNEADCKGCSPLHyAAASDTYRRAEPHTPSSHdaeedeplkesrrkeaffCLEFLLDNGA--DPSL-- 545
Cdd:TIGR00870 189 SIVALLSEDPADILTADSLGNTLLH-LLVMENEFKAEYEELSCQ------------------MYNFALSLLDklRDSKel 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 157743284 546 ---RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVEStiPVSPLHLAAY 594
Cdd:TIGR00870 250 eviLNHQGLTPLKLAAKEGRIVLFRLKLAIKYKQKKFVAW--PNGQQLLSLY 299
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
92-147 |
6.23e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.56 E-value: 6.23e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 92 LLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA 147
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
140-168 |
6.25e-05 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 41.03 E-value: 6.25e-05
10 20
....*....|....*....|....*....
gi 157743284 140 GRSALHHAVHSGHLETVNLLLNKGASLNV 168
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
822-1007 |
7.40e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 46.58 E-value: 7.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 822 NPFTPLHCAVINNQDSTTEMLLgALGAKIVNSRDaKGRTPLHAAAFA-----DNVSGLRMLLQHQAEVNATDHTGRTALM 896
Cdd:PHA03100 34 KPVLPLYLAKEARNIDVVKILL-DNGADINSSTK-NNSTPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 897 TAAEN--GQTAAVEFLLYRGkADLTVLDENKNTALHLACSKGHEK---CALMIlaetqDLGL-INATNSalqmplhiaar 970
Cdd:PHA03100 112 YAISKksNSYSIVEYLLDNG-ANVNIKNSDGENLLHLYLESNKIDlkiLKLLI-----DKGVdINAKNR----------- 174
|
170 180 190
....*....|....*....|....*....|....*....
gi 157743284 971 nglasvVQALLSHGATVLAVDEEGHTPAL-AC-APNKDV 1007
Cdd:PHA03100 175 ------VNYLLSYGVPINIKDVYGFTPLHyAVyNNNPEF 207
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
271-304 |
8.50e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 40.74 E-value: 8.50e-05
10 20 30
....*....|....*....|....*....|....
gi 157743284 271 KGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
Cdd:pfam00023 1 DGNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
339-392 |
8.87e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.11 E-value: 8.87e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 339 GNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLL 392
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
375-443 |
9.69e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.11 E-value: 9.69e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157743284 375 PLHLAVLFGFSDCCRKLLSSGqlysivsslsnehvlsagFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Cdd:pfam13637 4 ALHAAAASGHLELLRLLLEKG------------------ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
407-493 |
9.95e-05 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 46.20 E-value: 9.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS--YQCAVTLVTAGAGVNE 484
Cdd:PHA02946 56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINN 135
|
90
....*....|
gi 157743284 485 A-DCKGCSPL 493
Cdd:PHA02946 136 SvDEEGCGPL 145
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
354-575 |
1.14e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 45.75 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 354 LISTLMTNGADTARR----GIHDMF-------PLHLAVLFGFSDCCRKLLSSGQLYsivsslsnehvlsagfDINTPDNl 422
Cdd:PHA02875 6 LCDAILFGELDIARRlldiGINPNFeiydgisPIKLAMKFRDSEAIKLLMKHGAIP----------------DVKYPDI- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 423 gRTCLHAAASGGNVECLNLLLSSGA---DLRRRDkfGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAAS 499
Cdd:PHA02875 69 -ESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMM 145
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 500 DTYRRaephtpsshdaeedeplkesrrkeaffcLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFN 575
Cdd:PHA02875 146 GDIKG----------------------------IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
271-344 |
1.32e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 45.95 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 271 KGFTPLHVAAVSTNGALcLELLVNNGADVN-------YQSKEGKS-------PLHMAAIHGRFTRSQILIQN---GSEID 333
Cdd:cd22196 93 KGQTALHIAIERRNMHL-VELLVQNGADVHarasgefFKKKKGGPgfyfgelPLSLAACTNQLDIVKFLLENphsPADIS 171
|
90
....*....|.
gi 157743284 334 CADKFGNTPLH 344
Cdd:cd22196 172 ARDSMGNTVLH 182
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
447-496 |
1.41e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.79 E-value: 1.41e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 157743284 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
Cdd:pfam13857 7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
214-314 |
1.60e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.66 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 214 AASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALcLELLV 293
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV-VQLLS 168
|
90 100 110
....*....|....*....|....*....|....
gi 157743284 294 -------NNGADVNYQSKEGK------SPLHMAA 314
Cdd:PTZ00322 169 rhsqchfELGANAKPDSFTGKppsledSPISSHH 202
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
687-716 |
1.75e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 1.75e-04
10 20 30
....*....|....*....|....*....|
gi 157743284 687 YGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
311-399 |
1.77e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.66 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 311 HMAAiHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRK 390
Cdd:PTZ00322 88 QLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166
|
....*....
gi 157743284 391 LLSSGQLYS 399
Cdd:PTZ00322 167 LSRHSQCHF 175
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
140-171 |
2.02e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.58 E-value: 2.02e-04
10 20 30
....*....|....*....|....*....|...
gi 157743284 140 GRSALHHAV-HSGHLETVNLLLNKGASLNVCDK 171
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
852-1017 |
2.03e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 45.04 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 852 NSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL--MTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929
Cdd:PHA02946 66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKINNSVDEEGCGPL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 930 hLACSKGHEKCALMILAETQDLGLINATNSAlQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVA 1008
Cdd:PHA02946 146 -LACTDPSERVFKKIMSIGFEARIVDKFGKN-HIHRHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLhIVCSKTVKNV 223
|
....*....
gi 157743284 1009 DCLALILST 1017
Cdd:PHA02946 224 DIINLLLPS 232
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
190-246 |
2.40e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.27 E-value: 2.40e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 190 KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Cdd:PTZ00322 99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
877-932 |
2.62e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.02 E-value: 2.62e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 157743284 877 LLQH-QAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLA 932
Cdd:pfam13857 1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
926-981 |
2.64e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.95 E-value: 2.64e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 926 NTALHLACSKGHEKCALMILAETQDlglINATNSALQMPLHIAARNGLASVVQALL 981
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
43-162 |
2.88e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 45.00 E-value: 2.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 43 TPLHAAAYVGDVPILQLLLMSGANVN---AKDTLWLT-----------PLHRAAASRNEKVLGLLLAHSADVNARDKLWQ 108
Cdd:cd22192 91 TALHIAVVNQNLNLVRELIARGADVVsprATGTFFRPgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157743284 109 TPLHVAAANRATKCAEALAPLLSSLNVADRS----------GRSALHHAVHSGHLETVNLLLNK 162
Cdd:cd22192 171 TVLHILVLQPNKTFACQMYDLILSYDKEDDLqpldlvpnnqGLTPFKLAAKEGNIVMFQHLVQK 234
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
42-71 |
3.23e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 38.81 E-value: 3.23e-04
10 20 30
....*....|....*....|....*....|.
gi 157743284 42 RTPLHAAAY-VGDVPILQLLLMSGANVNAKD 71
Cdd:pfam00023 3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
158-213 |
3.81e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.25 E-value: 3.81e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 157743284 158 LLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 213
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
12-167 |
3.94e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 43.49 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 12 LVQAIFSRDVEEVRSLLSQKENINVLDQErrTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLG 91
Cdd:PHA02791 34 LYYAIADNNVRLVCTLLNAGALKNLLENE--FPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDSGNMQTVK 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 92 LLLAHSADVNARDKL-WQTPL-HVAAANRATKCAEALAPLLSSLNVADRsgRSALHHAVHSGHLETVNLLLNKGASLN 167
Cdd:PHA02791 112 LFVKKNWRLMFYGKTgWKTSFyHAVMLNDVSIVSYFLSEIPSTFDLAIL--LSCIHITIKNGHVDMMILLLDYMTSTN 187
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
156-358 |
4.27e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 44.27 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 156 VNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ--IEVVKYLLRMGAEID 233
Cdd:PHA02946 55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKIN 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 234 EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN-GALCLELLVNNGADVNYQSKEGKSPLHM 312
Cdd:PHA02946 135 NSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNpKASTISWMMKLGISPSKPDHDGNTPLHI 214
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 157743284 313 AAIHGRFTRSQI-LIQNGSEIDCADKFGNTPLhvaaryghELLISTL 358
Cdd:PHA02946 215 VCSKTVKNVDIInLLLPSTDVNKQNKFGDSPL--------TLLIKTL 253
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
423-449 |
4.58e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.34 E-value: 4.58e-04
10 20
....*....|....*....|....*..
gi 157743284 423 GRTCLHAAASGGNVECLNLLLSSGADL 449
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
860-1031 |
5.23e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.85 E-value: 5.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 860 TPLHAAAFADNVSGL-RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL---------------LYRGKadltvlde 923
Cdd:cd22192 19 SPLLLAAKENDVQAIkKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLmeaapelvnepmtsdLYQGE-------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 924 nknTALHLACSKGHEKCALMILAETQDLGLINATNSAL-----------QMPLHIAARNGLASVVQALLSHGATVLAVDE 992
Cdd:cd22192 91 ---TALHIAVVNQNLNLVRELIARGADVVSPRATGTFFrpgpknliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 157743284 993 EGHTP--ALACAPNKDVAdCLA--LILSTMKP--------FPPKDAVSPFS 1031
Cdd:cd22192 168 LGNTVlhILVLQPNKTFA-CQMydLILSYDKEddlqpldlVPNNQGLTPFK 217
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
618-672 |
5.26e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 38.79 E-value: 5.26e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 618 GRTALFLATERGSTECVEVLTAHGASALIKERkRKWTPLHAAAASGHTDSLHLLI 672
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02989 |
PHA02989 |
ankyrin repeat protein; Provisional |
219-496 |
6.95e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222954 [Multi-domain] Cd Length: 494 Bit Score: 43.58 E-value: 6.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 219 IEVVKYLLRMGAEIDEPNAfGNTALHIacYLGQDAVAIE----LVNAGANVNQpndKGF--TPLhvAAVSTNGALC---- 288
Cdd:PHA02989 16 KNALEFLLRTGFDVNEEYR-GNSILLL--YLKRKDVKIKivklLIDNGADVNY---KGYieTPL--CAVLRNREITsnki 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 289 ---LELLVNNGADVNYQSKEGKSPLhMAAIHGrftrsqiliqngSEIDCADkfgntplhvaaryghelLISTLMTNGADT 365
Cdd:PHA02989 88 kkiVKLLLKFGADINLKTFNGVSPI-VCFIYN------------SNINNCD-----------------MLRFLLSKGINV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 366 ARRGIHDMFPLHLAVLFGFS---DCCRKLLSSG-------QLY-------------SIVSSLSNEHVLSAGFDINTPDNL 422
Cdd:PHA02989 138 NDVKNSRGYNLLHMYLESFSvkkDVIKILLSFGvnlfektSLYgltpmniylrndiDVISIKVIKYLIKKGVNIETNNNG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 423 GRTCL------HAAASGGNVECLNLLLSSgADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
Cdd:PHA02989 218 SESVLesfldnNKILSKKEFKVLNFILKY-IKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYA 296
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
423-454 |
7.99e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 38.04 E-value: 7.99e-04
10 20 30
....*....|....*....|....*....|...
gi 157743284 423 GRTCLHAAA-SGGNVECLNLLLSSGADLRRRDK 454
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
950-997 |
8.62e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 8.62e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 157743284 950 DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTA 52
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
825-878 |
1.10e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 38.02 E-value: 1.10e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 825 TPLHCAVINNQDSTTEMLLgALGAKIvNSRDAKGRTPLHAAAFADNVSGLRMLL 878
Cdd:pfam13637 3 TALHAAAASGHLELLRLLL-EKGADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
687-716 |
1.11e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 37.24 E-value: 1.11e-03
10 20 30
....*....|....*....|....*....|
gi 157743284 687 YGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
271-344 |
1.72e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 42.48 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 271 KGFTPLHVAAVSTNGAlCLELLVNNGADVNYQSKE--------------GKSPLHMAAIHGRFTRSQILIQNG---SEID 333
Cdd:cd22193 75 EGQTALHIAIERRQGD-IVALLVENGADVHAHAKGrffqpkyqgegfyfGELPLSLAACTNQPDIVQYLLENEhqpADIE 153
|
90
....*....|.
gi 157743284 334 CADKFGNTPLH 344
Cdd:cd22193 154 AQDSRGNTVLH 164
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
140-168 |
1.95e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.85 E-value: 1.95e-03
10 20
....*....|....*....|....*....
gi 157743284 140 GRSALHHAVHSGHLETVNLLLNKGASLNV 168
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
687-718 |
2.01e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 36.88 E-value: 2.01e-03
10 20 30
....*....|....*....|....*....|...
gi 157743284 687 YGQTPLMLAI-MNGHVDCVHLLLEKGSTADAAD 718
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
239-293 |
2.11e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 2.11e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 239 GNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAlCLELLV 293
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVE-VLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
962-1029 |
2.11e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 42.19 E-value: 2.11e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743284 962 QMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPaLACAPNKDVADCLALILSTMKPFPPKDAVSP 1029
Cdd:PTZ00322 116 RTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTP-LELAEENGFREVVQLLSRHSQCHFELGANAK 182
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
456-506 |
2.17e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 2.17e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 157743284 456 GRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
803-932 |
2.21e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 41.99 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 803 HEDCLELLLEHSPFSYLEGnpfTPLHCAVINNQDSTTEMLL-------GALGAKIVNSRDA----KGRTPLHAAAFADNV 871
Cdd:TIGR00870 65 NLELTELLLNLSCRGAVGD---TLLHAISLEYVDAVEAILLhllaafrKSGPLELANDQYTseftPGITALHLAAHRQNY 141
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 872 SGLRMLLQHQAEVNA---------TDHT-----GRTALMTAAENGQTAAVEFLLYRGkADLTVLDENKNTALHLA 932
Cdd:TIGR00870 142 EIVKLLLERGASVPAracgdffvkSQGVdsfyhGESPLNAAACLGSPSIVALLSEDP-ADILTADSLGNTLLHLL 215
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
910-968 |
2.26e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.33 E-value: 2.26e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 157743284 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDlglINATNSALQMPLHIA 968
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVD---LNLKDEEGLTALDLA 56
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
205-234 |
2.32e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 2.32e-03
10 20 30
....*....|....*....|....*....|
gi 157743284 205 KGYGLLHTAAASGQIEVVKYLLRMGAEIDE 234
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
550-604 |
3.56e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.48 E-value: 3.56e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPvsPLHLAAYNGHCEALKTL 604
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGET--ALHFAASNGNVEVLKLL 53
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
456-484 |
3.83e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 3.83e-03
10 20
....*....|....*....|....*....
gi 157743284 456 GRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
857-889 |
3.86e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 36.11 E-value: 3.86e-03
10 20 30
....*....|....*....|....*....|....
gi 157743284 857 KGRTPLHAAA-FADNVSGLRMLLQHQAEVNATDH 889
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02884 |
PHA02884 |
ankyrin repeat protein; Provisional |
209-313 |
4.04e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165212 [Multi-domain] Cd Length: 300 Bit Score: 40.74 E-value: 4.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 209 LLHTAAASGQIEVVKYLLRMGAEIDEP-----NAFGNTALHIACYLGQDAvAIELVNAGANVNQ-PNDKGFTPLHVAAVS 282
Cdd:PHA02884 36 ILYSSIKFHYTDIIDAILKLGADPEAPfplseNSKTNPLIYAIDCDNDDA-AKLLIRYGADVNRyAEEAKITPLYISVLH 114
|
90 100 110
....*....|....*....|....*....|.
gi 157743284 283 TNGAlCLELLVNNGADVNYQSKEGKSPLHMA 313
Cdd:PHA02884 115 GCLK-CLEILLSYGADINIQTNDMVTPIELA 144
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
609-726 |
4.38e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 40.94 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 609 VNLDVRD--HKGRTALFLATERGSTECVEVLTAHGASalikerkrkwtpLHAAAasghtdslhllidSGERADITDVMDA 686
Cdd:cd22196 83 VNAAYTDsyYKGQTALHIAIERRNMHLVELLVQNGAD------------VHARA-------------SGEFFKKKKGGPG 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 157743284 687 --YGQTPLMLAIMNGHVDCVHLLLE---KGSTADAADLRGRTALH 726
Cdd:cd22196 138 fyFGELPLSLAACTNQLDIVKFLLEnphSPADISARDSMGNTVLH 182
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
558-640 |
4.55e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.04 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 558 AAYGNRQNLELLLE--MSFNCLEDVESTipvsPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVE 635
Cdd:PTZ00322 90 AASGDAVGARILLTggADPNCRDYDGRT----PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
|
....*
gi 157743284 636 VLTAH 640
Cdd:PTZ00322 166 LLSRH 170
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
654-708 |
4.55e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.04 E-value: 4.55e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157743284 654 TPLHAAAASGHTDSLHLLIDSGerADITdVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFG--ADPT-LLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
791-815 |
4.95e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.64 E-value: 4.95e-03
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
132-180 |
5.18e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.17 E-value: 5.18e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 157743284 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
42-69 |
5.25e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.64 E-value: 5.25e-03
10 20
....*....|....*....|....*...
gi 157743284 42 RTPLHAAAYVGDVPILQLLLMSGANVNA 69
Cdd:smart00248 3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
176-204 |
5.49e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.34 E-value: 5.49e-03
10 20 30
....*....|....*....|....*....|
gi 157743284 176 PLHWAA-FLGHLEVLKLLVARGADLGCKDR 204
Cdd:pfam00023 5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
76-105 |
6.43e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.34 E-value: 6.43e-03
10 20 30
....*....|....*....|....*....|.
gi 157743284 76 TPLHRAAASR-NEKVLGLLLAHSADVNARDK 105
Cdd:pfam00023 4 TPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02859 |
PHA02859 |
ankyrin repeat protein; Provisional |
11-171 |
6.71e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165195 [Multi-domain] Cd Length: 209 Bit Score: 39.03 E-value: 6.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQerrTPLHAA---AYVgDVPILQLLLMSGANVNAKDTLW-LTPLHRAAA--- 83
Cdd:PHA02859 24 PLFYYVEKDDIEGVKKWIKFVNDCNDLYE---TPIFSClekDKV-NVEILKFLIENGADVNFKTRDNnLSALHHYLSfnk 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743284 84 SRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK--CAEALAPLLSSLNVADRSGRSALHHAV--HSGHlETVNLL 159
Cdd:PHA02859 100 NVEPEILKILIDSGSSITEEDEDGKNLLHMYMCNFNVRinVIKLLIDSGVSFLNKDFDNNNILYSYIlfHSDK-KIFDFL 178
|
170
....*....|..
gi 157743284 160 LNKGASLNVCDK 171
Cdd:PHA02859 179 TSLGIDINETNK 190
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
235-279 |
7.17e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 35.79 E-value: 7.17e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 157743284 235 PNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVA 279
Cdd:pfam13857 12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
239-270 |
8.07e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 34.96 E-value: 8.07e-03
10 20 30
....*....|....*....|....*....|...
gi 157743284 239 GNTALHIACY-LGQDAVAIELVNAGANVNQPND 270
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
339-364 |
9.11e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 34.87 E-value: 9.11e-03
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
965-1018 |
9.30e-03 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 36.63 E-value: 9.30e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 965 LHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACApNKDVADCLALILSTM 1018
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA-KNGHLEIVKLLLEHA 53
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
423-472 |
9.86e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 37.93 E-value: 9.86e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 157743284 423 GRTCLHAAASGGNV---ECLNLLLSSGADLRRRD-KFGRTPLHYAAANGSYQCA 472
Cdd:PHA02736 55 GKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKErVFGNTPLHIAVYTQNYELA 108
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
857-886 |
9.95e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 34.49 E-value: 9.95e-03
10 20 30
....*....|....*....|....*....|
gi 157743284 857 KGRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
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