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Conserved domains on  [gi|116256460|ref|NP_775951|]
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zinc finger protein 775 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-524 3.03e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 275 PGEPRQFICNECGKSFTWWSSLNIHQRIHTGERPYACPECGR--RFSQKPNLTRHLRNHTGERPHPCPHCGRGFRQK--- 349
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 350 -----------------QHLLKH-----------LRTHLPGAQAAPCPScgKSCRSRAALRAHQRAHAVAEPAVPAGEPG 401
Cdd:COG5048  108 sslsssssnsndnnllsSHSLPPssrdpqlpdllSISNLRNNPLPGNNS--SSVNTPQSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 402 DQPQAEAIPGLAA----RPRSSQRSPGA-----------------------RDTLWGRGQAGLAGPGEPRQ----FICNE 450
Cdd:COG5048  186 LLISSNVSTSIPSssenSPLSSSYSIPSsssdqnlensssslplttnsqlsPKSLLSQSPSSLSSSDSSSSasesPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 451 CGKSFSWWSALTIHQRIHTGER-PYPCPECGRRFSQKPNLTRHRR--NHTGE--RPYLCPA--CGRGFSQKQHLLKHQRV 523
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 .
gi 116256460 524 H 524
Cdd:COG5048  346 H 346
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-220 7.38e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 133 KPYLCGKCGKSFSQKPNLARHQR--HHTGE--RPFCCPE--CARRFSQKQHLLKHQKTHSRPATHSCPECERCFRHQVGL 206
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90
                 ....*....|....
gi 116256460 207 RIHQRAHARDRQGS 220
Cdd:COG5048  368 NNEPPQSLQQYKDL 381
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-524 3.03e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 275 PGEPRQFICNECGKSFTWWSSLNIHQRIHTGERPYACPECGR--RFSQKPNLTRHLRNHTGERPHPCPHCGRGFRQK--- 349
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 350 -----------------QHLLKH-----------LRTHLPGAQAAPCPScgKSCRSRAALRAHQRAHAVAEPAVPAGEPG 401
Cdd:COG5048  108 sslsssssnsndnnllsSHSLPPssrdpqlpdllSISNLRNNPLPGNNS--SSVNTPQSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 402 DQPQAEAIPGLAA----RPRSSQRSPGA-----------------------RDTLWGRGQAGLAGPGEPRQ----FICNE 450
Cdd:COG5048  186 LLISSNVSTSIPSssenSPLSSSYSIPSsssdqnlensssslplttnsqlsPKSLLSQSPSSLSSSDSSSSasesPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 451 CGKSFSWWSALTIHQRIHTGER-PYPCPECGRRFSQKPNLTRHRR--NHTGE--RPYLCPA--CGRGFSQKQHLLKHQRV 523
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 .
gi 116256460 524 H 524
Cdd:COG5048  346 H 346
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-220 7.38e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 133 KPYLCGKCGKSFSQKPNLARHQR--HHTGE--RPFCCPE--CARRFSQKQHLLKHQKTHSRPATHSCPECERCFRHQVGL 206
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90
                 ....*....|....
gi 116256460 207 RIHQRAHARDRQGS 220
Cdd:COG5048  368 NNEPPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 4.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 116256460  323 NLTRHLRNHTGERPHPCPHCGRGFRQ 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
121-146 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 116256460  121 SLKIHQRTHTGEKPYLCGKCGKSFSQ 146
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 308-356 1.56e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 1.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 116256460 308 PYACPECGRRFSQKPNLTRHLRnhTGERPHPCPHCGRGFRQKQHLLKHL 356
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-524 3.03e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 275 PGEPRQFICNECGKSFTWWSSLNIHQRIHTGERPYACPECGR--RFSQKPNLTRHLRNHTGERPHPCPHCGRGFRQK--- 349
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKass 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 350 -----------------QHLLKH-----------LRTHLPGAQAAPCPScgKSCRSRAALRAHQRAHAVAEPAVPAGEPG 401
Cdd:COG5048  108 sslsssssnsndnnllsSHSLPPssrdpqlpdllSISNLRNNPLPGNNS--SSVNTPQSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 402 DQPQAEAIPGLAA----RPRSSQRSPGA-----------------------RDTLWGRGQAGLAGPGEPRQ----FICNE 450
Cdd:COG5048  186 LLISSNVSTSIPSssenSPLSSSYSIPSsssdqnlensssslplttnsqlsPKSLLSQSPSSLSSSDSSSSasesPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 451 CGKSFSWWSALTIHQRIHTGER-PYPCPECGRRFSQKPNLTRHRR--NHTGE--RPYLCPA--CGRGFSQKQHLLKHQRV 523
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 .
gi 116256460 524 H 524
Cdd:COG5048  346 H 346
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-220 7.38e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 133 KPYLCGKCGKSFSQKPNLARHQR--HHTGE--RPFCCPE--CARRFSQKQHLLKHQKTHSRPATHSCPECERCFRHQVGL 206
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                         90
                 ....*....|....
gi 116256460 207 RIHQRAHARDRQGS 220
Cdd:COG5048  368 NNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-361 8.48e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 8.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 280 QFICNECGKSFTWWSSLNIHQR--IHTGE--RPYACPE--CGRRFSQKPNLTRHLRNHTGERPHPCP------------- 340
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfsplln 368

                         90       100
                 ....*....|....*....|.
gi 116256460 341 HCGRGFRQKQHLLKHLRTHLP 361
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSET 389
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 4.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 116256460  323 NLTRHLRNHTGERPHPCPHCGRGFRQ 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 8.67e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.67e-05
                          10        20
                  ....*....|....*....|....*.
gi 116256460  295 SLNIHQRIHTGERPYACPECGRRFSQ 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 9.29e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 9.29e-05
                          10        20
                  ....*....|....*....|....*.
gi 116256460  460 ALTIHQRIHTGERPYPCPECGRRFSQ 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
121-146 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 116256460  121 SLKIHQRTHTGEKPYLCGKCGKSFSQ 146
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
149-174 1.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....*.
gi 116256460  149 NLARHQRHHTGERPFCCPECARRFSQ 174
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 474-496 6.40e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.40e-04
                          10        20
                  ....*....|....*....|...
gi 116256460  474 YPCPECGRRFSQKPNLTRHRRNH 496
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-359 7.06e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 7.06e-04
                          10        20
                  ....*....|....*....|...
gi 116256460  337 HPCPHCGRGFRQKQHLLKHLRTH 359
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 309-331 8.02e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 8.02e-04
                          10        20
                  ....*....|....*....|...
gi 116256460  309 YACPECGRRFSQKPNLTRHLRNH 331
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-188 8.11e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116256460 107 FVCLDCGKRFSWWSSLKIHQRT--HTGE--KPYLCGK--CGKSFSQKPNLARHQRHHTGERPFCCP--ECARRFSQKQHL 178
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNN 369

                         90
                 ....*....|
gi 116256460 179 LKHQKTHSRP 188
Cdd:COG5048  370 EPPQSLQQYK 379
PHA00733 PHA00733
hypothetical protein
 308-356 1.56e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 38.70  E-value: 1.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 116256460 308 PYACPECGRRFSQKPNLTRHLRnhTGERPHPCPHCGRGFRQKQHLLKHL 356
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHV 119
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 135-157 3.29e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|...
gi 116256460  135 YLCGKCGKSFSQKPNLARHQRHH 157
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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