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Conserved domains on  [gi|112420992|ref|NP_775960|]
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protein crumbs homolog 2 precursor [Homo sapiens]

Protein Classification

EGF_CA and LamG domain-containing protein( domain architecture ID 10810331)

EGF_CA and LamG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 465-588 2.36e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   465 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 543
Cdd:pfam02210    1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 112420992   544 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 588
Cdd:pfam02210   78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 653-773 1.06e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  653 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 722
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112420992  723 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 773
Cdd:cd00110    85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 321-356 6.18e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 6.18e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  321 VDECASR-PCLNGGHCQDLPNGFQCHCPDGYAGPTCE 356
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 147-182 2.10e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 2.10e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  147 VDECASA-PCLHGGSCLDGVGSFRCVCAPGYGGTRCQ 182
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 108-144 2.56e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 2.56e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 112420992  108 DIDECASR-PCHHGATCRNLADRYECHCPLGYAGVTCE 144
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 184-221 1.60e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 112420992  184 DLDECQSQ-PCAHGGTCHDLVNGFRCDCAgTGYEGTHCE 221
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 900-1024 6.06e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member pfam00054:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 6.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   900 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 976
Cdd:pfam00054    1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112420992   977 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 1024
Cdd:pfam00054   71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 358-393 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  358 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 393
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 811-841 2.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.46e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 841
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 226-259 1.50e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 112420992  226 ECASA-PCEHNASCLEGLGSFRCLCWPGYSGELCE 259
Cdd:cd00054     4 ECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1060-1090 2.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992  1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 1090
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-640 9.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|....*...
gi 112420992  613 PCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 465-588 2.36e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   465 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 543
Cdd:pfam02210    1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 112420992   544 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 588
Cdd:pfam02210   78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 653-773 1.06e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  653 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 722
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112420992  723 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 773
Cdd:cd00110    85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
461-588 6.66e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 6.66e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992    461 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATlWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhE 538
Cdd:smart00282    2 ISFSFRTTSPNGLLlyAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--D 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 112420992    539 GCPARLCVASGPVALASTasATPL-----PAGISSAQLGDAT-FAGCLQDVRVDGH 588
Cdd:smart00282   79 GGNRVSGESPGGLTILNL--DGPLylgglPEDLKLPPLPVTPgFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
671-774 2.01e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.96  E-value: 2.01e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992    671 TVSFLLRTRESAGLLlqFANDSAAG---LTVFLSEGRIRAEV-PGSPAVVL--------PGRWD---------------D 723
Cdd:smart00282    1 SISFSFRTTSPNGLL--LYAGSKGGgdyLALELRDGRLVLRYdLGSGPARLtsdptplnDGQWHrvaverngrsvtlsvD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 112420992    724 GLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 774
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGlpEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 676-774 5.10e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 55.50  E-value: 5.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   676 LRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV--PGSPAVVLP-------GRW----------------DDGLRHLVM 730
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlGSGPESLLSsgknlndGQWhsvrverngntltlsvDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 112420992   731 LSFGPDQLqDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 774
Cdd:pfam02210   81 PPGESLLL-NLNGPLYLGGlpPLLLLPALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 321-356 6.18e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 6.18e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  321 VDECASR-PCLNGGHCQDLPNGFQCHCPDGYAGPTCE 356
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 147-182 2.10e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 2.10e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  147 VDECASA-PCLHGGSCLDGVGSFRCVCAPGYGGTRCQ 182
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 108-144 2.56e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 2.56e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 112420992  108 DIDECASR-PCHHGATCRNLADRYECHCPLGYAGVTCE 144
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
320-356 4.58e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.58e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    320 EVDECASR-PCLNGGHCQDLPNGFQCHCPDGY-AGPTCE 356
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
146-182 8.32e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 8.32e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    146 EVDECASA-PCLHGGSCLDGVGSFRCVCAPGY-GGTRCQ 182
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
108-144 1.45e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.45e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    108 DIDECASR-PCHHGATCRNLADRYECHCPLGY-AGVTCE 144
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 184-221 1.60e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 112420992  184 DLDECQSQ-PCAHGGTCHDLVNGFRCDCAgTGYEGTHCE 221
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
900-1024 6.06e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 6.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   900 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 976
Cdd:pfam00054    1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112420992   977 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 1024
Cdd:pfam00054   71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF_CA smart00179
Calcium-binding EGF-like domain;
184-221 7.40e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 7.40e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    184 DLDECQS-QPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE 221
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 358-393 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  358 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 393
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 461-586 1.88e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.95  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  461 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLaLNDGHWHQVEVVLHLATLELRLwhE 538
Cdd:cd00110    24 ISFSFRTTSPNGLLlyAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTP-LNDGQWHSVSVERNGRSVTLSV--D 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 112420992  539 GCP-ARLCVASGPVALASTasaTPL-----PAGISSAQLGDAT-FAGCLQDVRVD 586
Cdd:cd00110   100 GERvVESGSPGGSALLNLD---GPLylgglPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 872-1017 2.67e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.57  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  872 ATFREGPPAAFSGHNASSGRLlgGLSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGlpGAVLPiPGP 949
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAG-SQNGGDFLALelEDGRLVLRYDLGSG--SLVLS-SKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112420992  950 RVADGAWHRVRLAMERPAATtsrwlLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRV 1017
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVT-----LSVDGERVVESGSPGGSALLNLDGPlylGGLpedlkspGLPVSPGFVGCIRDL 148
LamG smart00282
Laminin G domain;
896-1021 2.74e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 2.74e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992    896 LSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPGPRVADGAWHRVRLAMERPAATtsrw 973
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAG-SKGGGDYLALelRDGRLVLRYDLGSGP--ARLTSDPTPLNDGQWHRVAVERNGRSVT---- 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 112420992    974 lLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRVALGG 1021
Cdd:smart00282   75 -LSVDGGNRVSGESPGGLTILNLDGPlylGGLpedlklpPLPVTPGFRGCIRNLKVNG 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
358-393 6.99e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.99e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 112420992    358 DVDECLS-DPCLHGGTCSDTVAGYICRCPETW-GGRDC 393
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 324-354 9.68e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 9.68e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   324 CASRPCLNGGHCQDLPNGFQCHCPDGYAGPT 354
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 811-841 2.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.46e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 841
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-842 3.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.62e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 112420992  812 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 842
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 112-140 7.03e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 7.03e-05
                           10        20
                   ....*....|....*....|....*....
gi 112420992   112 CASRPCHHGATCRNLADRYECHCPLGYAG 140
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 226-259 1.50e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 112420992  226 ECASA-PCEHNASCLEGLGSFRCLCWPGYSGELCE 259
Cdd:cd00054     4 ECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 150-180 2.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.70e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   150 CASAPCLHGGSCLDGVGSFRCVCAPGYGGTR 180
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
226-259 1.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.44e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 112420992    226 ECASA-PCEHNASCLEGLGSFRCLCWPGYS-GELCE 259
Cdd:smart00179    4 ECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 362-392 1.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   362 CLSDPCLHGGTCSDTVAGYICRCPETWGGRD 392
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1060-1090 2.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992  1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 1090
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1062-1092 4.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.48e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 112420992 1062 PSPCLHDGACRDLFDAFACACGPGWEGPRCE 1092
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 227-256 8.85e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.85e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 112420992   227 CASAPCEHNASCLEGLGSFRCLCWPGYSGE 256
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
812-842 9.82e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.82e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 112420992    812 SPDPCFNGGTCLVTWNDFHCTCPANFT-GPTC 842
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-640 9.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|....*...
gi 112420992  613 PCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 465-588 2.36e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   465 FRTTLPAGTL-ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhEGCPAR 543
Cdd:pfam02210    1 FRTRQPNGLLlYAGGGGSDFLALELVNGRLVLRY-DLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV--DGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 112420992   544 LCVASGPVALAST-------ASATPLPAGISSAQLGdatFAGCLQDVRVDGH 588
Cdd:pfam02210   78 SSLPPGESLLLNLngplylgGLPPLLLLPALPVRAG---FVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 653-773 1.06e-10

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 61.28  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  653 GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAG-LTVFLSEGRIRAEV-PGSPAVVLP-------GRWD- 722
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDfLALELEDGRLVLRYdLGSGSLVLSsktplndGQWHs 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 112420992  723 --------------DGLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLD 773
Cdd:cd00110    85 vsverngrsvtlsvDGERVVESGSPGGSALLNLDGPLYLGGlpEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
461-588 6.66e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 6.66e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992    461 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATlWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLwhE 538
Cdd:smart00282    2 ISFSFRTTSPNGLLlyAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV--D 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 112420992    539 GCPARLCVASGPVALASTasATPL-----PAGISSAQLGDAT-FAGCLQDVRVDGH 588
Cdd:smart00282   79 GGNRVSGESPGGLTILNL--DGPLylgglPEDLKLPPLPVTPgFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
671-774 2.01e-09

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 56.96  E-value: 2.01e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992    671 TVSFLLRTRESAGLLlqFANDSAAG---LTVFLSEGRIRAEV-PGSPAVVL--------PGRWD---------------D 723
Cdd:smart00282    1 SISFSFRTTSPNGLL--LYAGSKGGgdyLALELRDGRLVLRYdLGSGPARLtsdptplnDGQWHrvaverngrsvtlsvD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 112420992    724 GLRHLVMLSFGPDQLQDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 774
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGlpEDLKLPPLPVTPGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 676-774 5.10e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 55.50  E-value: 5.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   676 LRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEV--PGSPAVVLP-------GRW----------------DDGLRHLVM 730
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYdlGSGPESLLSsgknlndGQWhsvrverngntltlsvDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 112420992   731 LSFGPDQLqDLGQHVHVGG--RLLAADSQPWGGPFRGCLQDLRLDG 774
Cdd:pfam02210   81 PPGESLLL-NLNGPLYLGGlpPLLLLPALPVRAGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 321-356 6.18e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 6.18e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  321 VDECASR-PCLNGGHCQDLPNGFQCHCPDGYAGPTCE 356
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 147-182 2.10e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 2.10e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  147 VDECASA-PCLHGGSCLDGVGSFRCVCAPGYGGTRCQ 182
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 108-144 2.56e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 2.56e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 112420992  108 DIDECASR-PCHHGATCRNLADRYECHCPLGYAGVTCE 144
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
320-356 4.58e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 4.58e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    320 EVDECASR-PCLNGGHCQDLPNGFQCHCPDGY-AGPTCE 356
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
146-182 8.32e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.55  E-value: 8.32e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    146 EVDECASA-PCLHGGSCLDGVGSFRCVCAPGY-GGTRCQ 182
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
108-144 1.45e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.45e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    108 DIDECASR-PCHHGATCRNLADRYECHCPLGY-AGVTCE 144
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 184-221 1.60e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 112420992  184 DLDECQSQ-PCAHGGTCHDLVNGFRCDCAgTGYEGTHCE 221
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
900-1024 6.06e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 50.01  E-value: 6.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   900 FRTRDSEAWLLrAAAGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPgPRVADGAWHRVRLAMERpaattsRWL-LW 976
Cdd:pfam00054    1 FRTTEPSGLLL-YNGTQTERDFLALelRDGRLEVSYDLGSGA--AVVRSG-DKLNDGKWHSVELERNG------RSGtLS 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112420992   977 LDGAATPVA-----------LR-----GLASDLGFLQGPGAVRIllaeNFTGCLGRVALGGLPL 1024
Cdd:pfam00054   71 VDGEARPTGesplgattdldVDgplyvGGLPSLGVKKRRLAISP----SFDGCIRDVIVNGKPL 130
EGF_CA smart00179
Calcium-binding EGF-like domain;
184-221 7.40e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 7.40e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 112420992    184 DLDECQS-QPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE 221
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 358-393 1.10e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 112420992  358 DVDECLS-DPCLHGGTCSDTVAGYICRCPETWGGRDC 393
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 461-586 1.88e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.95  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  461 LALRFRTTLPAGTL--ATRNDTKESLELALVAATLQATLwSYSTTVLVLRLPDLaLNDGHWHQVEVVLHLATLELRLwhE 538
Cdd:cd00110    24 ISFSFRTTSPNGLLlyAGSQNGGDFLALELEDGRLVLRY-DLGSGSLVLSSKTP-LNDGQWHSVSVERNGRSVTLSV--D 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 112420992  539 GCP-ARLCVASGPVALASTasaTPL-----PAGISSAQLGDAT-FAGCLQDVRVD 586
Cdd:cd00110   100 GERvVESGSPGGSALLNLD---GPLylgglPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 872-1017 2.67e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 48.57  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992  872 ATFREGPPAAFSGHNASSGRLlgGLSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGlpGAVLPiPGP 949
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRL--SISFSFRTTSPNGLLLYAG-SQNGGDFLALelEDGRLVLRYDLGSG--SLVLS-SKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112420992  950 RVADGAWHRVRLAMERPAATtsrwlLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRV 1017
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVT-----LSVDGERVVESGSPGGSALLNLDGPlylGGLpedlkspGLPVSPGFVGCIRDL 148
LamG smart00282
Laminin G domain;
896-1021 2.74e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 2.74e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992    896 LSLAFRTRDSEAWLLRAAaGALEGVWLAV--RNGSLAGGVRGGHGLpgAVLPIPGPRVADGAWHRVRLAMERPAATtsrw 973
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAG-SKGGGDYLALelRDGRLVLRYDLGSGP--ARLTSDPTPLNDGQWHRVAVERNGRSVT---- 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 112420992    974 lLWLDGAATPVALRGLASDLGFLQGP---GAV-------RILLAENFTGCLGRVALGG 1021
Cdd:smart00282   75 -LSVDGGNRVSGESPGGLTILNLDGPlylGGLpedlklpPLPVTPGFRGCIRNLKVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
465-591 4.64e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 4.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   465 FRTTLPAGTLAT--RNDTKESLELALVAATLQaTLWSYSTTVLVLRLPDLaLNDGHWHQVEVVL--HLATLELRlwheGC 540
Cdd:pfam00054    1 FRTTEPSGLLLYngTQTERDFLALELRDGRLE-VSYDLGSGAAVVRSGDK-LNDGKWHSVELERngRSGTLSVD----GE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112420992   541 pARLCVAS--GP-----------VALASTASATPLPAGISSAqlgdatFAGCLQDVRVDGHLLL 591
Cdd:pfam00054   75 -ARPTGESplGAttdldvdgplyVGGLPSLGVKKRRLAISPS------FDGCIRDVIVNGKPLD 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
358-393 6.99e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.99e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 112420992    358 DVDECLS-DPCLHGGTCSDTVAGYICRCPETW-GGRDC 393
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 324-354 9.68e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 9.68e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   324 CASRPCLNGGHCQDLPNGFQCHCPDGYAGPT 354
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 900-1021 1.54e-05

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 45.87  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112420992   900 FRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVlpIPGPRVADGAWHRVRLAMERPAATtsrwlLWLDG 979
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL--SSGKNLNDGQWHSVRVERNGNTLT-----LSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 112420992   980 AATPVALRGLASDLGFLQGP---GAVRILLA-------ENFTGCLGRVALGG 1021
Cdd:pfam02210   74 QTVVSSLPPGESLLLNLNGPlylGGLPPLLLlpalpvrAGFVGCIRDVRVNG 125
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 811-841 2.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.46e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPT 841
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-842 3.62e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.62e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 112420992  812 SPDPCFNGGTCLVTWNDFHCTCPANFTGPTC 842
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 112-140 7.03e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 7.03e-05
                           10        20
                   ....*....|....*....|....*....
gi 112420992   112 CASRPCHHGATCRNLADRYECHCPLGYAG 140
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 226-259 1.50e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 112420992  226 ECASA-PCEHNASCLEGLGSFRCLCWPGYSGELCE 259
Cdd:cd00054     4 ECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 150-180 2.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.70e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   150 CASAPCLHGGSCLDGVGSFRCVCAPGYGGTR 180
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 323-356 3.67e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 3.67e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 112420992  323 ECA-SRPCLNGGHCQDLPNGFQCHCPDGYAGP-TCE 356
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
226-259 1.44e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.44e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 112420992    226 ECASA-PCEHNASCLEGLGSFRCLCWPGYS-GELCE 259
Cdd:smart00179    4 ECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 149-182 1.57e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 1.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 112420992  149 ECA-SAPCLHGGSCLDGVGSFRCVCAPGY-GGTRCQ 182
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYtGDRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 362-392 1.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992   362 CLSDPCLHGGTCSDTVAGYICRCPETWGGRD 392
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 329-350 2.12e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 2.12e-03
                           10        20
                   ....*....|....*....|..
gi 112420992   329 CLNGGHCQDLPNGFQCHCPDGY 350
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1060-1090 2.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 112420992  1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPR 1090
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 111-144 3.07e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 3.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 112420992  111 ECA-SRPCHHGATCRNLADRYECHCPLGYAGV-TCE 144
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1062-1092 4.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 4.48e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 112420992 1062 PSPCLHDGACRDLFDAFACACGPGWEGPRCE 1092
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 155-176 4.93e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 4.93e-03
                           10        20
                   ....*....|....*....|..
gi 112420992   155 CLHGGSCLDGVGSFRCVCAPGY 176
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 227-256 8.85e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.85e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 112420992   227 CASAPCEHNASCLEGLGSFRCLCWPGYSGE 256
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
812-842 9.82e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 9.82e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 112420992    812 SPDPCFNGGTCLVTWNDFHCTCPANFT-GPTC 842
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-640 9.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|....*...
gi 112420992  613 PCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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