NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|28144897|ref|NP_777283|]
View 

adenylate kinase isoenzyme 5 isoform 1 [Homo sapiens]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 17786576)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 374-561 5.43e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 364.52  E-value: 5.43e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   374 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 453
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   454 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 533
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 28144897   534 TKTQLHKINAEGTPEDVFLQLCTAIDSI 561
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 134-307 3.04e-53

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 3.04e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 134 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 213
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTEL--GKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 214 GIVIDGFPRDVAQALSFEDQIC---TPDLVVFLACANQRLKERLLKR-------------------AEQQGRPDDNVKAT 271
Cdd:cd01428  79 GFILDGFPRTVDQAEALDELLDegiKPDKVIELDVPDEVLIERILGRricpvsgrvyhlgkddvtgEPLSQRSDDNEETI 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 28144897 272 QRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 307
Cdd:cd01428 159 KKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
DD_AK5 cd22978
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar ...
 3-46 1.39e-20

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar proteins; AK5 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 5, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It is active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. It also displays broad nucleoside diphosphate kinase activity. AK5 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


:

Pssm-ID: 438547  Cd Length: 44  Bit Score: 84.89  E-value: 1.39e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 28144897   3 TNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVK 46
Cdd:cd22978   1 SEDAKDYLSRKEIPQLFESLMTGLMYNRPDDPIEFLEDCLEKIR 44
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 374-561 5.43e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 364.52  E-value: 5.43e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   374 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 453
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   454 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 533
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 28144897   534 TKTQLHKINAEGTPEDVFLQLCTAIDSI 561
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 378-550 1.57e-60

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 198.61  E-value: 1.57e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRG 457
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 458 FLIDGYPREVKQGEEFGRRI---GDPQLVICMDCSADTMTNRLLQRSRSSLP-------------------VDDTTKTIA 515
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICPVSgrvyhlgkddvtgeplsqrSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 28144897 516 KRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 550
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 134-307 3.04e-53

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 3.04e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 134 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 213
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTEL--GKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 214 GIVIDGFPRDVAQALSFEDQIC---TPDLVVFLACANQRLKERLLKR-------------------AEQQGRPDDNVKAT 271
Cdd:cd01428  79 GFILDGFPRTVDQAEALDELLDegiKPDKVIELDVPDEVLIERILGRricpvsgrvyhlgkddvtgEPLSQRSDDNEETI 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 28144897 272 QRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 307
Cdd:cd01428 159 KKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 133-316 1.05e-49

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 170.00  E-value: 1.05e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   133 KIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQ-IPD 211
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGK--QLQAIMESGDLVPLDTVLDLLKDAMVAaLGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   212 EEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQE 291
Cdd:TIGR01360  82 SKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYET 161

                         170       180
                  ....*....|....*....|....*
gi 28144897   292 KGLIMTFDADRDEDEVFYDISMAVD 316
Cdd:TIGR01360 162 KGKLRKINAEGTVDDVFLQVCTAID 186
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 377-558 1.46e-48

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 167.61  E-value: 1.46e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 377 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTR 456
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 457 GFLIDGYPREVKQGE-------EFGRRIgdpQLVICMDCSADTMTNRLLQR-----------SRSSLPV----------- 507
Cdd:COG0563  80 GFILDGFPRTVAQAEaldellaELGIKL---DAVIELDVDDEELVERLSGRrvcpncgatyhVKFNPPKvegvcdkcgge 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897 508 -----DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAI 558
Cdd:COG0563 157 lvqraDDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
381-535 3.37e-48

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 165.56  E-value: 3.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   381 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVAsLGDTRGFLI 460
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ-NDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   461 DGYPREVKQGEEFGR---RIGDPQLVICMDCSADTMTNRLLQR---------------------------SRSSLPVDDT 510
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRrihpnsgrsyhlefnppkvpgkddvtgEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 28144897   511 TKTIAKRLEAYYRASIPVIAYYETK 535
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
PLN02200 PLN02200
adenylate kinase family protein
 378-554 5.29e-48

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.99  E-value: 5.29e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTRG 457
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESS--DNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  458 FLIDGYPREVKQGEEFGRRIG-DPQLVICMDCSADTMTNRLLQRSRSSlpVDDTTKTIAKRLEAYYRASIPVIAYYETKT 536
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQGR--VDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
gi 28144897  537 QLHKINAEGTPEDVFLQL 554
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
PLN02200 PLN02200
adenylate kinase family protein
 113-308 1.45e-38

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 141.57  E-value: 1.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  113 SETAELIEEYEVFDPTRPR-PKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGE 191
Cdd:PLN02200  23 SFSTEIITLEERGSSSKEKtPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEH--GAMILNTIKEGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  192 LAPQETTITEIKQKlMQIPDEEGIVIDGFPRDVAQALSFEDQI-CTPDLVVFLACANQRLKERLLKRaeQQGRPDDNVKA 270
Cdd:PLN02200 101 IVPSEVTVKLIQKE-MESSDNNKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNR--NQGRVDDNIDT 177

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 28144897  271 TQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVF 308
Cdd:PLN02200 178 IKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIF 215
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 133-311 1.67e-37

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 137.57  E-value: 1.67e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 133 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLMQIPD 211
Cdd:COG0563   2 RIIL-LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAV---KAGTELGKKAKeYMDAGELVPDEIVIGLVKERLAQPDC 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 212 EEGIVIDGFPRDVAQALSFEDQIC----TPDLVVFLACANQRLKERLLKRA---------------------------EQ 260
Cdd:COG0563  78 ANGFILDGFPRTVAQAEALDELLAelgiKLDAVIELDVDDEELVERLSGRRvcpncgatyhvkfnppkvegvcdkcggEL 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 28144897 261 QGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDI 311
Cdd:COG0563 158 VQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADI 208
ADK pfam00406
Adenylate kinase;
137-292 9.81e-36

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 132.05  E-value: 9.81e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   137 VIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIV 216
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGK--EAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   217 IDGFPRDVAQALSFED---QICTPDLVVFLACANQRLKERLLKRAEQQ---------------------------GRPDD 266
Cdd:pfam00406  79 LDGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHPnsgrsyhlefnppkvpgkddvtgeplvQRSDD 158

                         170       180
                  ....*....|....*....|....*.
gi 28144897   267 NVKATQRRLMNFKQNAAPLVKYFQEK 292
Cdd:pfam00406 159 NEETVKKRLETYHKQTKPLIDYYKKK 184
DD_AK5 cd22978
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar ...
 3-46 1.39e-20

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar proteins; AK5 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 5, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It is active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. It also displays broad nucleoside diphosphate kinase activity. AK5 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438547  Cd Length: 44  Bit Score: 84.89  E-value: 1.39e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 28144897   3 TNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVK 46
Cdd:cd22978   1 SEDAKDYLSRKEIPQLFESLMTGLMYNRPDDPIEFLEDCLEKIR 44
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 133-187 6.25e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 37.47  E-value: 6.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897  133 KIILVIGGPGSGKgTQSL-KIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKII 187
Cdd:NF033453  17 KLILLVGPPGSGK-TALLrELAAKRGAPVINVNLELSRRLLELPEKQRALRAPRLL 71
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 374-561 5.43e-125

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 364.52  E-value: 5.43e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   374 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 453
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   454 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 533
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 28144897   534 TKTQLHKINAEGTPEDVFLQLCTAIDSI 561
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 378-550 1.57e-60

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 198.61  E-value: 1.57e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRG 457
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 458 FLIDGYPREVKQGEEFGRRI---GDPQLVICMDCSADTMTNRLLQRSRSSLP-------------------VDDTTKTIA 515
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICPVSgrvyhlgkddvtgeplsqrSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
gi 28144897 516 KRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 550
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 378-551 1.23e-57

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 190.66  E-value: 1.23e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASE-SERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 456
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIQED-GSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   457 GFLIDGYPREVKQGEEFGRRIG---DPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 533
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDnkvNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170
                  ....*....|....*...
gi 28144897   534 TKTQLHKINAEGTPEDVF 551
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVF 177
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 134-307 3.04e-53

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 3.04e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 134 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 213
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTEL--GKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 214 GIVIDGFPRDVAQALSFEDQIC---TPDLVVFLACANQRLKERLLKR-------------------AEQQGRPDDNVKAT 271
Cdd:cd01428  79 GFILDGFPRTVDQAEALDELLDegiKPDKVIELDVPDEVLIERILGRricpvsgrvyhlgkddvtgEPLSQRSDDNEETI 158

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 28144897 272 QRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 307
Cdd:cd01428 159 KKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 133-316 1.05e-49

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 170.00  E-value: 1.05e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   133 KIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQ-IPD 211
Cdd:TIGR01360   4 KIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGK--QLQAIMESGDLVPLDTVLDLLKDAMVAaLGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   212 EEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQE 291
Cdd:TIGR01360  82 SKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYET 161

                         170       180
                  ....*....|....*....|....*
gi 28144897   292 KGLIMTFDADRDEDEVFYDISMAVD 316
Cdd:TIGR01360 162 KGKLRKINAEGTVDDVFLQVCTAID 186
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 377-558 1.46e-48

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 167.61  E-value: 1.46e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 377 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTR 456
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 457 GFLIDGYPREVKQGE-------EFGRRIgdpQLVICMDCSADTMTNRLLQR-----------SRSSLPV----------- 507
Cdd:COG0563  80 GFILDGFPRTVAQAEaldellaELGIKL---DAVIELDVDDEELVERLSGRrvcpncgatyhVKFNPPKvegvcdkcgge 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897 508 -----DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAI 558
Cdd:COG0563 157 lvqraDDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
381-535 3.37e-48

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 165.56  E-value: 3.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   381 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVAsLGDTRGFLI 460
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ-NDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   461 DGYPREVKQGEEFGR---RIGDPQLVICMDCSADTMTNRLLQR---------------------------SRSSLPVDDT 510
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRrihpnsgrsyhlefnppkvpgkddvtgEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 28144897   511 TKTIAKRLEAYYRASIPVIAYYETK 535
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
PLN02200 PLN02200
adenylate kinase family protein
 378-554 5.29e-48

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.99  E-value: 5.29e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTRG 457
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESS--DNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  458 FLIDGYPREVKQGEEFGRRIG-DPQLVICMDCSADTMTNRLLQRSRSSlpVDDTTKTIAKRLEAYYRASIPVIAYYETKT 536
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVLNRNQGR--VDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
gi 28144897  537 QLHKINAEGTPEDVFLQL 554
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
adk PRK00279
adenylate kinase; Reviewed
 379-561 6.67e-45

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 158.00  E-value: 6.67e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  379 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRGF 458
Cdd:PRK00279   3 LILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  459 LIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQRS--RSSLPV------------------------- 507
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLSGRRicPACGRTyhvkfnppkvegkcdvcgeeliqra 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 28144897  508 DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSI 561
Cdd:PRK00279 162 DDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 377-559 2.21e-42

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 150.85  E-value: 2.21e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   377 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTR 456
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   457 GFLIDGYPREVKQGEEF--------------------------GRRI------------GDPQLVICMDCSADtmtnRLL 498
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALdalleepidavieldvpdeelverlsGRRIcpscgrvyhlkfNPPKVPGCDDCTGE----LLV 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28144897   499 QRSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAID 559
Cdd:TIGR01351 156 QRE------DDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 134-311 9.68e-39

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 140.20  E-value: 9.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   134 IILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwSLIAKIITTGELAPQETTITEIKQKLMQIPDEE 213
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREGSENG-SLIESYIKEGKIVPSEVTVELLKKAIQEDGSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   214 GIVIDGFPRDVAQALSFEDQICT---PDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQ 290
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDNkvnFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 28144897   291 EKGLIMTFDADRDEDEVFYDI 311
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
PLN02200 PLN02200
adenylate kinase family protein
 113-308 1.45e-38

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 141.57  E-value: 1.45e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  113 SETAELIEEYEVFDPTRPR-PKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNrkWSLIAKIITTGE 191
Cdd:PLN02200  23 SFSTEIITLEERGSSSKEKtPFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEH--GAMILNTIKEGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  192 LAPQETTITEIKQKlMQIPDEEGIVIDGFPRDVAQALSFEDQI-CTPDLVVFLACANQRLKERLLKRaeQQGRPDDNVKA 270
Cdd:PLN02200 101 IVPSEVTVKLIQKE-MESSDNNKFLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNR--NQGRVDDNIDT 177

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 28144897  271 TQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVF 308
Cdd:PLN02200 178 IKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIF 215
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 133-311 1.67e-37

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 137.57  E-value: 1.67e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 133 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLMQIPD 211
Cdd:COG0563   2 RIIL-LGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAV---KAGTELGKKAKeYMDAGELVPDEIVIGLVKERLAQPDC 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 212 EEGIVIDGFPRDVAQALSFEDQIC----TPDLVVFLACANQRLKERLLKRA---------------------------EQ 260
Cdd:COG0563  78 ANGFILDGFPRTVAQAEALDELLAelgiKLDAVIELDVDDEELVERLSGRRvcpncgatyhvkfnppkvegvcdkcggEL 157

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 28144897 261 QGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDI 311
Cdd:COG0563 158 VQRADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADI 208
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 135-316 2.69e-36

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 134.28  E-value: 2.69e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDEE- 213
Cdd:TIGR01351   2 LVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGK--KAKEYMEKGELVPDEIVNQLVKERLTQNDDNEn 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   214 GIVIDGFPRDVAQALSFEDQIC-TPDLVVFLACANQRLKERLLKR---------------------------AEQQGRPD 265
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEePIDAVIELDVPDEELVERLSGRricpscgrvyhlkfnppkvpgcddctgELLVQRED 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28144897   266 DNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVD 316
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK pfam00406
Adenylate kinase;
137-292 9.81e-36

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 132.05  E-value: 9.81e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   137 VIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIV 216
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGK--EAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   217 IDGFPRDVAQALSFED---QICTPDLVVFLACANQRLKERLLKRAEQQ---------------------------GRPDD 266
Cdd:pfam00406  79 LDGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTGRRIHPnsgrsyhlefnppkvpgkddvtgeplvQRSDD 158

                         170       180
                  ....*....|....*....|....*.
gi 28144897   267 NVKATQRRLMNFKQNAAPLVKYFQEK 292
Cdd:pfam00406 159 NEETVKKRLETYHKQTKPLIDYYKKK 184
adk PRK00279
adenylate kinase; Reviewed
 133-318 9.41e-35

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 130.27  E-value: 9.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  133 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIPDE 212
Cdd:PRK00279   2 RLIL-LGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGK--EAKSYMDAGELVPDEIVIGLVKERLAQPDCK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  213 EGIVIDGFPRDVAQALSFEDQIC----TPDLVVFLACANQRLKERLLKRA---------------------------EQQ 261
Cdd:PRK00279  79 NGFLLDGFPRTIPQAEALDEMLKelgiKLDAVIEIDVPDEELVERLSGRRicpacgrtyhvkfnppkvegkcdvcgeELI 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 28144897  262 GRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNK 318
Cdd:PRK00279 159 QRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
PRK14527 PRK14527
adenylate kinase; Provisional
 377-551 4.98e-34

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 127.60  E-value: 4.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  377 KIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAmVASLGDTR 456
Cdd:PRK14527   7 KVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEPVR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  457 gFLIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYY 532
Cdd:PRK14527  86 -VIFDGFPRTLAQAEALDRLLEELGArllaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVDYY 164

                        170
                 ....*....|....*....
gi 28144897  533 ETKTQLHKINAEGTPEDVF 551
Cdd:PRK14527 165 EARGHLKRVDGLGTPDEVY 183
PRK14531 PRK14531
adenylate kinase; Provisional
 375-559 7.86e-33

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 124.15  E-value: 7.86e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  375 KCKIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGD 454
Cdd:PRK14531   2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  455 trGFLIDGYPREVKQGEEFGRRIGD---P-QLVICMDCSADTMTNRLLQRSRSslpvDDTTKTIAKRLEAYYRASIPVIA 530
Cdd:PRK14531  81 --GWLLDGFPRTVAQAEALEPLLEElkqPiEAVVLLELDDAVLIERLLARGRA----DDNEAVIRNRLEVYREKTAPLID 154

                        170       180
                 ....*....|....*....|....*....
gi 28144897  531 YYETKTQLHKINAEGTPEDVFLQLCTAID 559
Cdd:PRK14531 155 HYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14532 PRK14532
adenylate kinase; Provisional
 379-560 2.39e-31

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 119.93  E-value: 2.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  379 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGdTRGF 458
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  459 LIDGYPREVKQGEEF-------GRRIgdpQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAY 531
Cdd:PRK14532  82 IFDGFPRTVAQAEALdkmlasrGQKI---DVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPY 158

                        170       180
                 ....*....|....*....|....*....
gi 28144897  532 YETKTQLHKINAEGTPEDVflqlCTAIDS 560
Cdd:PRK14532 159 YAGQGKLTEVDGMGSIEAV----AASIDA 183
adk PRK02496
adenylate kinase; Provisional
 377-558 4.14e-31

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 119.08  E-value: 4.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  377 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTR 456
Cdd:PRK02496   3 RLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQP--DAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  457 -GFLIDGYPREVKQG---EEFGRRIGDP-QLVICMDCSADTMTNRLLQRSRSslpvDDTTKTIAKRLEAYYRASIPVIAY 531
Cdd:PRK02496  80 nGWILDGFPRKVTQAaflDELLQEIGQSgERVVNLDVPDDVVVERLLARGRK----DDTEEVIRRRLEVYREQTAPLIDY 155

                        170       180
                 ....*....|....*....|....*..
gi 28144897  532 YETKTQLHKINAEGTPEDVFLQLCTAI 558
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAVTTELKAAL 182
AAA_17 pfam13207
AAA domain;
383-514 1.21e-30

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 116.18  E-value: 1.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   383 GGPGSGKGTQCEKLVEKYGFTHLSTGELLREElASESERSKlIRDIMERGDLVPSGIVLELLKEAMvASLGDTRGFLIDG 462
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREE-AKERGLVE-DRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 28144897   463 YPREVKQGEEFGR------RIGDPQLVICMDCSADTMTNRLLQRsRSSLPVDDTTKTI 514
Cdd:pfam13207  79 HPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEI 135
PRK14532 PRK14532
adenylate kinase; Provisional
 135-315 1.27e-30

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 118.00  E-value: 1.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSS-NRKwslIAKIITTGELAPQETTITEIKQKLMQIPDEE 213
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSElGQR---VKGIMDRGELVSDEIVIALIEERLPEAEAAG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  214 GIVIDGFPRDVAQALSFEDQICTP----DLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYF 289
Cdd:PRK14532  80 GAIFDGFPRTVAQAEALDKMLASRgqkiDVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPYY 159

                        170       180
                 ....*....|....*....|....*.
gi 28144897  290 QEKGLIMTFDADRDEDEVFYDISMAV 315
Cdd:PRK14532 160 AGQGKLTEVDGMGSIEAVAASIDAAL 185
PRK14530 PRK14530
adenylate kinase; Provisional
 379-560 8.85e-30

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 116.43  E-value: 8.85e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  379 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLReelaseSERSKLIRDI----------MERGDLVPSGIVLELLKEAm 448
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALR------ANKQMDISDMdteydtpgeyMDAGELVPDAVVNEIVEEA- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  449 vasLGDTRGFLIDGYPREVKQGEEFGR----------RIGDPQLV-------ICMDCSA---------------DTMTNR 496
Cdd:PRK14530  79 ---LSDADGFVLDGYPRNLEQAEYLESitdldvvlylDVSEEELVdrltgrrVCPDCGAnyhvefnqpeeegvcDECGGE 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28144897  497 LLQRSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDS 560
Cdd:PRK14530 156 LIQRD------DDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
PRK14527 PRK14527
adenylate kinase; Provisional
 128-315 3.26e-28

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 111.42  E-value: 3.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  128 TRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKL 206
Cdd:PRK14527   2 TQTKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHV---ARGTELGQRAKpIMEAGDLVPDELILALIRDEL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  207 MQIPDEEgIVIDGFPRDVAQA----LSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNA 282
Cdd:PRK14527  79 AGMEPVR-VIFDGFPRTLAQAealdRLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQT 157

                        170       180       190
                 ....*....|....*....|....*....|...
gi 28144897  283 APLVKYFQEKGLIMTFDADRDEDEVFYDISMAV 315
Cdd:PRK14527 158 QPLVDYYEARGHLKRVDGLGTPDEVYARILKAL 190
adk PRK02496
adenylate kinase; Provisional
 135-307 3.17e-27

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 108.30  E-value: 3.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAKI-ITTGELAPQETTITEIKQKLMQIPDEE 213
Cdd:PRK02496   4 LIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAI---KEQTPLGIKAQGyMDKGELVPDQLVLDLVQERLQQPDAAN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  214 GIVIDGFPRDVAQAlSFEDQICTP-----DLVVFLACANQRLKERLLKRaeqqGRPDDNVKATQRRLMNFKQNAAPLVKY 288
Cdd:PRK02496  81 GWILDGFPRKVTQA-AFLDELLQEigqsgERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDY 155

                        170
                 ....*....|....*....
gi 28144897  289 FQEKGLIMTFDADRDEDEV 307
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAV 174
PRK14528 PRK14528
adenylate kinase; Provisional
 377-550 4.06e-26

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 105.48  E-value: 4.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  377 KIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 456
Cdd:PRK14528   2 KNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREA-DCKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  457 GFLIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYY 532
Cdd:PRK14528  81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                        170
                 ....*....|....*...
gi 28144897  533 ETKTQLHKINAEGTPEDV 550
Cdd:PRK14528 161 AAQKKLSQVNGVGSLEEV 178
AAA_17 pfam13207
AAA domain;
139-268 4.34e-26

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 103.47  E-value: 4.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   139 GGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstsSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVID 218
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREEA----KERGLVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVD 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897   219 GFPRDVAQALSFED------QICTPDLVVFLACANQRLKERLLKRAEqQGRPDDNV 268
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT-RGRDDDSE 132
PRK14530 PRK14530
adenylate kinase; Provisional
 135-319 1.18e-24

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 102.17  E-value: 1.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLR--KKIHSTSSNRKWSLIAKIITTGELAPQEtTITEIKQKlmQIPDE 212
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRanKQMDISDMDTEYDTPGEYMDAGELVPDA-VVNEIVEE--ALSDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  213 EGIVIDGFPRDVAQALSFEDqICTPDLVVFLACANQRLKERLLKR----------------AEQQG-----------RPD 265
Cdd:PRK14530  83 DGFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqPEEEGvcdecggeliqRDD 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 28144897  266 DNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKL 319
Cdd:PRK14530 162 DTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDDAT 215
PRK14531 PRK14531
adenylate kinase; Provisional
 135-300 9.28e-24

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 98.34  E-value: 9.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSliAKIITTGELAPQETTITEIKQKlMQIPDEEG 214
Cdd:PRK14531   5 LLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEA--EAVMNRGELVSDALVLAIVESQ-LKALNSGG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  215 IVIDGFPRDVAQALSFE---DQICTP-DLVVFLACANQRLKERLLKRaeqqGRPDDNVKATQRRLMNFKQNAAPLVKYFQ 290
Cdd:PRK14531  82 WLLDGFPRTVAQAEALEpllEELKQPiEAVVLLELDDAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPLIDHYR 157

                        170
                 ....*....|
gi 28144897  291 EKGLIMTFDA 300
Cdd:PRK14531 158 QRGLLQSVEA 167
PLN02842 PLN02842
nucleotide kinase
 381-561 9.63e-24

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 104.56  E-value: 9.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  381 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLI 460
Cdd:PLN02842   2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  461 DGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQR-----------------------SRSSLPVDDTTKTIAKR 517
Cdd:PLN02842  82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppeseeikARLITRPDDTEEKVKAR 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 28144897  518 LEAYYRASIPVIAYYETKtqLHKINAEGTPEDVFLQLCTAIDSI 561
Cdd:PLN02842 162 LQIYKKNAEAILSTYSDI--MVKIDGNRPKEVVFEEISSLLSQI 203
PRK13808 PRK13808
adenylate kinase; Provisional
 379-550 2.12e-23

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 101.50  E-value: 2.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  379 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTRGF 458
Cdd:PRK13808   3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQP-DAANGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  459 LIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQR-----SRSSLP-VDDTTKTIAKRLEAYYRASIPV 528
Cdd:PRK13808  82 ILDGFPRTVPQAEALDALLKDKQLkldaVVELRVNEGALLARVETRvaemrARGEEVrADDTPEVLAKRLASYRAQTEPL 161

                        170       180
                 ....*....|....*....|..
gi 28144897  529 IAYYETKTQLHKINAEGTPEDV 550
Cdd:PRK13808 162 VHYYSEKRKLLTVDGMMTIDEV 183
PRK13808 PRK13808
adenylate kinase; Provisional
 133-311 8.40e-23

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 99.58  E-value: 8.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  133 KIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLMQIPD 211
Cdd:PRK13808   2 RLIL-LGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAV---AAGTPVGLKAKdIMASGGLVPDEVVVGIISDRIEQPDA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  212 EEGIVIDGFPRDVAQALSFE----DQICTPDLVVFLACANQRLKERLLKR-AEQQG-----RPDDNVKATQRRLMNFKQN 281
Cdd:PRK13808  78 ANGFILDGFPRTVPQAEALDallkDKQLKLDAVVELRVNEGALLARVETRvAEMRArgeevRADDTPEVLAKRLASYRAQ 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 28144897  282 AAPLVKYFQEKGLIMTFDADRDEDEVFYDI 311
Cdd:PRK13808 158 TEPLVHYYSEKRKLLTVDGMMTIDEVTREI 187
PLN02674 PLN02674
adenylate kinase
 377-550 2.98e-22

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 96.11  E-value: 2.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  377 KIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 456
Cdd:PLN02674  32 KRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKP-SCQK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  457 GFLIDGYPREVKQGEEF-------GRRIgDPQLVICMDCS--ADTMTNR-----------------------------LL 498
Cdd:PLN02674 111 GFILDGFPRTVVQAQKLdemlakqGAKI-DKVLNFAIDDAilEERITGRwihpssgrtyhtkfappkvpgvddvtgepLI 189

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 28144897  499 QRSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 550
Cdd:PLN02674 190 QRK------DDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEV 235
PRK14528 PRK14528
adenylate kinase; Provisional
 133-295 3.22e-22

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 94.31  E-value: 3.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  133 KIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSliAKIITTGELAPQETTITEIKQKLMQIPDE 212
Cdd:PRK14528   2 KNIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEA--KRYMDAGDLVPDSVVIGIIKDRIREADCK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  213 EGIVIDGFPRDVAQALSFEDQI----CTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKY 288
Cdd:PRK14528  80 NGFLLDGFPRTVEQADALDALLknegKSIDKAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDF 159


                 ....*..
gi 28144897  289 FQEKGLI 295
Cdd:PRK14528 160 YAAQKKL 166
PLN02459 PLN02459
probable adenylate kinase
 382-548 1.18e-20

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 91.83  E-value: 1.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  382 IGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGD-TRGFLI 460
Cdd:PLN02459  35 LGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgESGFIL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  461 DGYPREVKQGEEF------------------------GRRI----GDPQLVICMDCSADTMTNRLLQRSRSSLP------ 506
Cdd:PLN02459 115 DGFPRTVRQAEILegvtdidlvvnlklreevlvekclGRRIcsecGKNFNVADIDLKGEDGRPGIVMPPLLPPPecaskl 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 28144897  507 ---VDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKIN-AEGTPE 548
Cdd:PLN02459 195 itrADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFElPGGIPE 240
DD_AK5 cd22978
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar ...
 3-46 1.39e-20

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 5 (AK5) and similar proteins; AK5 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 5, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It is active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. It also displays broad nucleoside diphosphate kinase activity. AK5 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438547  Cd Length: 44  Bit Score: 84.89  E-value: 1.39e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 28144897   3 TNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVK 46
Cdd:cd22978   1 SEDAKDYLSRKEIPQLFESLMTGLMYNRPDDPIEFLEDCLEKIR 44
PLN02842 PLN02842
nucleotide kinase
 136-312 3.36e-20

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 93.77  E-value: 3.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  136 LVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSliAKIITTGELAPQETTITEIKQKLmQIPD--EE 213
Cdd:PLN02842   1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRA--KEFMNSGRLVPDEIVIAMVTGRL-SREDakEK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  214 GIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKR-----------------------AEQQGRPDDNVKA 270
Cdd:PLN02842  78 GWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppeseeikARLITRPDDTEEK 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 28144897  271 TQRRLMNFKQNAAPLVKYFQEkgLIMTFDADRDEDEVFYDIS 312
Cdd:PLN02842 158 VKARLQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEIS 197
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 370-533 1.29e-19

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 87.93  E-value: 1.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  370 MEDLRKCKIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMV 449
Cdd:PTZ00088   1 MKLKGPLKIVLF-GAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  450 ASLGDT-RGFLIDGYPREVKQGEEFGrRIGDPQLV------------------ICMDCSADTMTNRLLQRSRSSLPV--- 507
Cdd:PTZ00088  80 KVTDDCfKGFILDGFPRNLKQCKELG-KITNIDLFvniylprnilikkllgrrICNTCNRNFNIAHIRSDPYDMPPIlpp 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 28144897  508 ----------------DDTTKTIAKRLEAYYRASIPVIAYYE 533
Cdd:PTZ00088 159 adcegckgnpklqkrsDDTEEIVAHRLNTYESTNSPIIQFFK 200
PRK14526 PRK14526
adenylate kinase; Provisional
 377-550 3.85e-18

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 83.36  E-value: 3.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  377 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLkEAMVASLGDTR 456
Cdd:PRK14526   2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIV-EDKINTIKNND 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  457 GFLIDGYPREVKQGEEFGRRIGDPQLV-----------------ICMDCS---------------ADTMTNRLLQRSrss 504
Cdd:PRK14526  80 NFILDGFPRNINQAKALDKFLPNIKIInflideellikrlsgrrICKSCNnifniytlptkekgiCDVCKGDLYQRK--- 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 28144897  505 lpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 550
Cdd:PRK14526 157 ---DDKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 131-293 1.13e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 73.68  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  131 RPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKwsLIAKIITTGELAPQETTITEIKQKLMQIP 210
Cdd:PTZ00088   5 GPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGK--EIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  211 DE--EGIVIDGFPRDVAQALSFEdQICTPDLVVFLACANQRLKERLLKR------------------------------- 257
Cdd:PTZ00088  83 DDcfKGFILDGFPRNLKQCKELG-KITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppadc 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 28144897  258 ------AEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKG 293
Cdd:PTZ00088 162 egckgnPKLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNEN 203
PRK14526 PRK14526
adenylate kinase; Provisional
 135-307 5.79e-14

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 71.04  E-value: 5.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWslIAKIITTGELAPQETTITEIKQKLMQIPDEEG 214
Cdd:PRK14526   3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKE--IKQIVENGQLVPDSITIKIVEDKINTIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  215 IVIDGFPRDVAQALSFEDQICTPDLVVFL---ACANQRLKERLLKRA------------EQQG-----------RPDDNV 268
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLideELLIKRLSGRRICKScnnifniytlptKEKGicdvckgdlyqRKDDKE 160

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 28144897  269 KATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEV 307
Cdd:PRK14526 161 ESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PRK14529 PRK14529
adenylate kinase; Provisional
 379-471 8.64e-14

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 70.90  E-value: 8.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  379 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGI----VLELLKEAmvaslgD 454
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDItipmILETLKQD------G 76

                         90
                 ....*....|....*..
gi 28144897  455 TRGFLIDGYPREVKQGE 471
Cdd:PRK14529  77 KNGWLLDGFPRNKVQAE 93
PLN02674 PLN02674
adenylate kinase
 128-315 9.44e-14

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 71.07  E-value: 9.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  128 TRPRPKIILvIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKL 206
Cdd:PLN02674  28 SKPDKRLIL-IGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAV---AAKTPLGIKAKeAMDKGELVSDDLVVGIIDEAM 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  207 MQIPDEEGIVIDGFPRDVAQALSFED----QICTPDLVVFLACANQRLKERLLKR----------------------AEQ 260
Cdd:PLN02674 104 KKPSCQKGFILDGFPRTVVQAQKLDEmlakQGAKIDKVLNFAIDDAILEERITGRwihpssgrtyhtkfappkvpgvDDV 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  261 QGRP-----DDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAV 315
Cdd:PLN02674 184 TGEPliqrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKAL 243
PLN02459 PLN02459
probable adenylate kinase
 108-299 5.98e-13

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 69.11  E-value: 5.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  108 SDTDLSETAELIEEYEV-FDPTRPRPKII--LVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSnrKWSLIA 184
Cdd:PLN02459   2 SERDAKSTSALADDLASaCDRSLAKGRNVnwVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGP--LGAQLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  185 KIITTGELAPQETTITEIKQKLMQIPD--EEGIVIDGFPRDVAQALSFEDqICTPDLVVFLACANQRLKERLLKR----- 257
Cdd:PLN02459  80 EIVNQGKLVPDEIIFSLLSKRLEAGEEegESGFILDGFPRTVRQAEILEG-VTDIDLVVNLKLREEVLVEKCLGRricse 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28144897  258 ------------AEQQGRP---------------------DDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFD 299
Cdd:PLN02459 159 cgknfnvadidlKGEDGRPgivmppllpppecasklitraDDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFE 233
DD_TEX55-like cd22961
dimerization/docking (D/D) domain found in the testis-specific expressed protein 55 (TEX55) ...
 5-44 5.60e-12

dimerization/docking (D/D) domain found in the testis-specific expressed protein 55 (TEX55)-like family; The TEX55-like family includes TEX55, F-box/LRR-repeat protein 13 (FBXL13), adenylate kinase isoenzymes AK5 and AK8, as well as uncharacterized EF-hand calcium-binding domain-containing protein 10 (EFCAB10), and protein VEST-1. TEX55, also called testis-specific conserved cAMP-dependent type II PK-anchoring protein (TSCPA), is a putative A-kinase anchoring protein (AKAP) that is dispensable for male fertility. FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6 (DRC6), is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It may also function as a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. AK5 and AK8 act as nucleoside monophosphate (NMP) kinases that catalyze the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Members of this family contain a conserved helical bundle domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438530  Cd Length: 43  Bit Score: 60.51  E-value: 5.60e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 28144897   5 DAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQK 44
Cdd:cd22961   3 DAEEYLEKHKIPELFESLLTALLIEKPEDPIEFLIDKLQQ 42
PRK14529 PRK14529
adenylate kinase; Provisional
 135-257 4.57e-10

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 59.73  E-value: 4.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  135 ILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIhstSSNRKWSLIAK-IITTGELAPQETTITEIKQKLmQIPDEE 213
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHI---GGGTELGKKAKeYIDRGDLVPDDITIPMILETL-KQDGKN 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 28144897  214 GIVIDGFPRDVAQALSFEDQICTP----DLVVFLACANQRLKERLLKR 257
Cdd:PRK14529  79 GWLLDGFPRNKVQAEKLWEALQKEgmklDYVIEILLPREVAKNRIMGR 126
DD_FBXL13 cd22977
dimerization/docking (D/D) domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar ...
 7-45 3.02e-07

dimerization/docking (D/D) domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6 (DRC6), is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It may also function as a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438546  Cd Length: 43  Bit Score: 46.78  E-value: 3.02e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 28144897   7 KEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKV 45
Cdd:cd22977   5 RKYLRKHKLPDVYEALLTGLAVMCPEDPLRFIEEKLKEL 43
DD_EFCAB10 cd22976
dimerization/docking (D/D) domain found in EF-hand calcium-binding domain-containing protein ...
 5-47 1.09e-06

dimerization/docking (D/D) domain found in EF-hand calcium-binding domain-containing protein 10 (EFCAB10) and similar proteins; The subfamily includes uncharacterized EF-hand calcium-binding domain-containing protein 10 (EFCAB10), which contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438545  Cd Length: 47  Bit Score: 45.56  E-value: 1.09e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 28144897   5 DAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKE 47
Cdd:cd22976   3 EAEEYLEKHKIPELFENLTSLLLYHRPEDPKAFLIEQLEKLKE 45
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 378-442 1.23e-06

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 48.25  E-value: 1.23e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28144897 378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREE---LASESERSKLIRDIM---ERGDLVPSGIVLE 442
Cdd:cd02020   1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEvgkLASEVAAIPEVRKALderQRELAKKPGIVLE 71
DD_AK8 cd22979
dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar ...
 8-44 6.24e-06

dimerization/docking (D/D) domain found in adenylate kinase isoenzyme 8 (AK8) and similar proteins; AK8 (EC 2.7.4.3/EC 2.7.4.6), also called ATP-AMP transphosphorylase 8, acts as a nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. It has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. It also displays broad nucleoside diphosphate kinase activity. AK8 contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438548  Cd Length: 45  Bit Score: 43.22  E-value: 6.24e-06
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 28144897   8 EYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQK 44
Cdd:cd22979   8 AYAEKHRIFELFQDLLKQLLIHKPEDPLQFLIDYLQK 44
DD_TbAK-like cd22981
dimerization/docking (D/D) domain found in Trypanosoma brucei adenylate kinase (AK) and ...
 5-44 1.40e-05

dimerization/docking (D/D) domain found in Trypanosoma brucei adenylate kinase (AK) and similar proteins; AK (EC 2.7.4.3), also called ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, or adenylate monophosphate kinase, catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Members of this subfamily contain an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438550  Cd Length: 44  Bit Score: 42.40  E-value: 1.40e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 28144897   5 DAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQK 44
Cdd:cd22981   4 DAQKYLKEKNIPQLFEFLLRHLLLDKPENPLEYLHDLLER 43
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 135-166 2.07e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 44.78  E-value: 2.07e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 28144897 135 ILVIGGP-GSGKGTQSLKIAERYGFQYISVGEL 166
Cdd:cd02020   1 IIAIDGPaGSGKSTVAKLLAKKLGLPYLDTGGI 33
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
378-521 2.08e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 44.90  E-value: 2.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLST----GELLREELASE---SERSKLIRDIMERgdlvpsgIVLELLKEamva 450
Cdd:COG0645   1 LILVCGLPGSGKSTLARALAERLGAVRLRSdvvrKRLFGAGLAPLersPEATARTYARLLA-------LARELLAA---- 69

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897 451 slgdtrGF--LIDG---YPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAY 521
Cdd:COG0645  70 ------GRsvILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE 139
PRK04182 PRK04182
cytidylate kinase; Provisional
 378-418 3.08e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 44.80  E-value: 3.08e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 28144897  378 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLReELASE 418
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR-ELAKE 41
PRK04182 PRK04182
cytidylate kinase; Provisional
 135-169 3.51e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 44.80  E-value: 3.51e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 28144897  135 ILVIGG-PGSGKGTQSLKIAERYGFQYISVGELLRK 169
Cdd:PRK04182   2 IITISGpPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
132-266 4.32e-05

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 44.55  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  132 PKIILVIGGPGSGKGTQSlKIAERYGFQYISVGELLRKK-----IHSTSSNrkwslIAKIITT-----GELAPQETTITE 201
Cdd:PRK01184   1 MKIIGVVGMPGSGKGEFS-KIAREMGIPVVVMGDVIREEvkkrgLEPTDEN-----IGKVAIDlrkelGMDAVAKRTVPK 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897  202 IKQKLMQIpdeegIVIDGFpRDVAQALSFEDQI-CTPDLVVFLACANQRLkERLLKRaeqqGRPDD 266
Cdd:PRK01184  75 IREKGDEV-----VVIDGV-RGDAEVEYFRKEFpEDFILIAIHAPPEVRF-ERLKKR----GRSDD 129
DD_CrRSP_unchar cd22964
dimerization/docking (D/D) domain of an uncharacterized subunit found in Chlamydomonas ...
 4-47 5.25e-05

dimerization/docking (D/D) domain of an uncharacterized subunit found in Chlamydomonas reinhardtii radial spoke 1; Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. This subfamily includes an uncharacterized protein found in Chlamydomonas reinhardtii radial spoke 1. It contains a conserved domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438533  Cd Length: 46  Bit Score: 40.68  E-value: 5.25e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 28144897   4 NDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKE 47
Cdd:cd22964   3 EEKKEYLQQKVINPILEQLVTDLLQEKPEDPVPFMIQWLRKKRS 46
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 129-279 1.02e-04

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 43.78  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 129 RPRPKIILVIGGPGSGKGTQSLKIAERYGFQYI----SVGELLRK--------KIHsTSSNRKW-SLIAKIITTGELAPQ 195
Cdd:COG2074   3 MKRPRIILIGGASGVGKSTIAAELARRLGIPRVistdSIREVMRPiiskelvpTLH-TSSYEAYkSLSEEEIIAGFLDQA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 196 ETTITEIKQklMQ---IPDEEGIVIDG---FPRDVAQALSFEDQICtpdLVVFLACANQRLKERLLKRAEQQGRpddnvK 269
Cdd:COG2074  82 EAVSPGIEA--VIeraLKEGESLVIEGvhlVPGFLAELKFNGGNVV---MLVLLVSDEELHRERFYSRARYTHA-----N 151

                       170
                ....*....|.
gi 28144897 270 ATQRRLM-NFK 279
Cdd:COG2074 152 RPGERYLdHFE 162
AAA_18 pfam13238
AAA domain;
135-272 2.02e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 41.26  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897   135 ILVIGGPGSGKGTQSLKIAERYGFqYISVGELLRKKIHSTSSNRKWSLiAKIITTGELApqettitEIKQKLMQIPDEEG 214
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETRE-SKRLDEDKLD-------RLLDLLEENAALEE 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28144897   215 ---IVIDGFPrdvAQALSFEDqicTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQ 272
Cdd:pfam13238  72 ggnLIIDGHL---AELEPERA---KDLVGIVLRASPEELLERLEKRGYEEAKIKENEEAEI 126
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 378-428 3.23e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 39.24  E-value: 3.23e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 28144897 378 IIFIIGGPGSGKGTQCEKLVEKYG---FTHLSTGELLREELASESERSKLIRDI 428
Cdd:cd02019   1 IIAITGGSGSGKSTVAKKLAEQLGgrsVVVLDEIVILEGLYASYKSRDARIRDL 54
PRK03839 PRK03839
putative kinase; Provisional
 134-356 4.24e-04

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 41.63  E-value: 4.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  134 IILVIGGPGSGKGTQSLKIAERYGFQYISVGEL-LRKKIHSTSSNrkwsliakiittgELapqETTITEIKQKLMQIPDE 212
Cdd:PRK03839   2 IIAITGTPGVGKTTVSKLLAEKLGYEYVDLTEFaLKKGIGEEKDD-------------EM---EIDFDKLAYFIEEEFKE 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897  213 EGIVIDGFprdvaqaLSfedQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKAtqrRLMNfkqnaAPLVKYFQEK 292
Cdd:PRK03839  66 KNVVLDGH-------LS---HLLPVDYVIVLRAHPKIIKERLKERGYSKKKILENVEA---ELVD-----VCLCEALEEK 127

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28144897  293 GLIMTFD-ADRDEDEVFYDISMAVDNKlfpnKEAAAGssdldpsmILDTGEIIDTGSDYEDQGDD 356
Cdd:PRK03839 128 EKVIEVDtTGKTPEEVVEEILELIKSG----KKRKVG--------IVDWSEVYDEIFPYLRLGID 180
DD_VEST1 cd22980
dimerization/docking (D/D) domain found in protein VEST-1 and similar proteins; VEST-1 (also ...
 9-47 9.36e-04

dimerization/docking (D/D) domain found in protein VEST-1 and similar proteins; VEST-1 (also called protein C8orf34) is an uncharacterized protein which contains an N-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438549  Cd Length: 45  Bit Score: 37.23  E-value: 9.36e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 28144897   9 YLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKE 47
Cdd:cd22980   7 YLEKHKIGALFEDLMAKLIRDTPDEPIPYLIKVLQKKAG 45
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 133-187 6.25e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 37.47  E-value: 6.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 28144897  133 KIILVIGGPGSGKgTQSL-KIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKII 187
Cdd:NF033453  17 KLILLVGPPGSGK-TALLrELAAKRGAPVINVNLELSRRLLELPEKQRALRAPRLL 71
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
134-219 6.77e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 37.88  E-value: 6.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28144897 134 IILVIGG-PGSGKGTQSLKIAERYGFQYISvGELLRKkihsTSSNRKWSLI--------AKIITTGELAPQETTITEIKQ 204
Cdd:COG1102   1 MVITISRePGSGGTTIAKRLAEKLGLPLYD-GEILRE----AAKERGLSEEefekldekAPSLLYRDTAEEDEIDRALDK 75

                        90
                ....*....|....*
gi 28144897 205 KLMQIPDEEGIVIDG 219
Cdd:COG1102  76 VIRELARKGNCVIVG 90
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 377-444 8.30e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 38.02  E-value: 8.30e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28144897 377 KIIFIIGGPGSGKGTQCEKLVE---KYGFTHLSTGELlreelaSESERSKLIRDIMERGDLVPSGIVLELL 444
Cdd:cd01672   1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELL 65
DD_TEX55 cd22975
dimerization/docking (D/D) domain found in testis-specific expressed protein 55 (TEX55) and ...
 6-47 8.81e-03

dimerization/docking (D/D) domain found in testis-specific expressed protein 55 (TEX55) and similar proteins; TEX55, also called testis-specific conserved cAMP-dependent type II PK-anchoring protein (TSCPA), is a putative A-kinase anchoring protein (AKAP) that is dispensable for male fertility. It contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domains of regulatory subunit of cAMP-dependent protein kinase (PKA) and protein DPY-30/SDC1.


Pssm-ID: 438544  Cd Length: 50  Bit Score: 34.46  E-value: 8.81e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 28144897   6 AKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKE 47
Cdd:cd22975   7 AVKYLEKHNILQLFQELTAGLVYERPDDPIQFMIDEIEKIIK 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH