NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|28373109|ref|NP_777615|]
View 

sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform b [Homo sapiens]

Protein Classification

calcium-transporting ATPase( domain architecture ID 11550595)

calcium-transporting ATPase such as sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle, which re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1955.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083    1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083   81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083  160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083  240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083  320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083  399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083  479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083  555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083  635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083  715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083  795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083  875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                        970       980
                 ....*....|....*....|....*
gi 28373109  965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083  955 AEWIAVIKISLPVILLDELLKFIAR 979
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1955.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083    1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083   81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083  160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083  240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083  320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083  399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083  479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083  555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083  635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083  715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083  795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083  875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                        970       980
                 ....*....|....*....|....*
gi 28373109  965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083  955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1466.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     53 VLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRS 132
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    133 DRKGVqrIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116   81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    213 NITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
Cdd:TIGR01116  157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaea 372
Cdd:TIGR01116  237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAL--- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    373 DAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM 452
Cdd:TIGR01116  314 DPSSSSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    453 NVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRphptgqGSKMFVKGAPESVIERCSSVRVG- 531
Cdd:TIGR01116  394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPST------GNKLFVKGAPEGVLERCTHILNGd 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    532 SRTAPLTPTSREQILAKIRDWGSGsDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACI 611
Cdd:TIGR01116  468 GRAVPLTDKMKNTILSVIKEMGTT-KALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    612 TRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENL 691
Cdd:TIGR01116  547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    692 QSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGE 771
Cdd:TIGR01116  627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    772 VVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAA 851
Cdd:TIGR01116  707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATVGG 786
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    852 ATWWfvydaegphinfYQLRNFLKCSEDN----PLFAGIDCEVFESRFP-TTMALSVLVTIEMCNALNSVSENQSLLRMP 926
Cdd:TIGR01116  787 FVWW------------YLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPaRTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373109    927 PWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01116  855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-989 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 953.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    1 MEAAHLLPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfee 80
Cdd:COG0474    5 LKDWHALSAEEVLAELGTSEEG-LSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   81 GEetttaFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474   79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGK--WVEIPAEELVPGDIVLLEAGDRVP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  161 ADLRLIEIKSttLRVDQSILTGESVSVTKHTEAIPDPRAVnQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA 240
Cdd:COG0474  152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  241 AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLR----------GAVyyfkiavalavaaiPEG 310
Cdd:COG0474  229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftiSGTTYT 390
Cdd:COG0474  289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYT----------------GGGTYE 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  391 PEGEVRqgdqpvrcgqfDGLVELATICALCNDSALDYNEAkgvyekVGEATETALTCLVEKMNVFDTDLQalsrveraga 470
Cdd:COG0474  353 VTGEFD-----------PALEELLRAAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEELR---------- 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  471 cntvikQLMRKEFTLEFSRDRKSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:COG0474  406 ------KEYPRVDEIPFDSERKRMSTVH-----EDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:COG0474  475 ELAA--QGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  631 TAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:COG0474  546 TARAIARQLGLGDDGD----RVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  711 LKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789
Cdd:COG0474  622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaATWWFVydaegphinfyq 869
Cdd:COG0474  702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTL--LTFALA------------ 767
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  870 lrnflkcsednpLFAGIDCEVFesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILL 949
Cdd:COG0474  768 ------------LARGASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|
gi 28373109  950 VPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:COG0474  831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRR 870
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
7-863 1.65e-97

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.95  E-value: 1.65e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     7 LPAADVLRHFSvTAEGGLSPAQVTGARERYGPNELPSEEG----KSLWELVLEQFeDLLVRILllaALVSFVLawfeegE 82
Cdd:PRK10517   52 MPEEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPF-NILLTIL---GAISYAT------E 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    83 ETTTAfvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSD----RKGVQRIRARDIVPGDIVEVAVGDK 158
Cdd:PRK10517  121 DLFAA----GVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDM 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   159 VPADLRLIEIKSttLRVDQSILTGESVSVtkhtEAIPDPRAVNQ----DKKNMLFSGTNITSGKAVGVAVATGLHTELGK 234
Cdd:PRK10517  197 IPADLRILQARD--LFVAQASLTGESLPV----EKFATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQ 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   235 IRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGL 311
Cdd:PRK10517  271 LAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN---------GytkGDWWEAALF----ALSVAVGLTPEML 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   312 PAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcRMFVVAEADagscllheftISGTTytp 391
Cdd:PRK10517  338 PMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTD----------ISGKT--- 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   392 egevrqgdqpvrcgqfdglvelaticalcNDSALDYNEAKGVYEkvgeateTALTCLVekmnvfdtDLQALSRVERAGAC 471
Cdd:PRK10517  400 -----------------------------SERVLHSAWLNSHYQ-------TGLKNLL--------DTAVLEGVDEESAR 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   472 NtvIKQLMRKEFTLEFSRDRKSMSVYC-TPTRPHptgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:PRK10517  436 S--LASRWQKIDEIPFDFERRRMSVVVaENTEHH------QLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTD 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:PRK10517  508 TLNR--QGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSEL 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   631 TAVAICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:PRK10517  579 VAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPA 652
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   711 LKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFL-TAILG-LPeaLI 788
Cdd:PRK10517  653 LRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVaSAFLPfLP--ML 730
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373109   789 PVQLLWVNLVTDgLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRylAIGVYVGLATVAAAtwWFVYDAEGP 863
Cdd:PRK10517  731 PLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFG--PISSIFDILTFCLM--WWVFHANTP 800
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 8.84e-47

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.44  E-value: 8.84e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    121 EYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEiksTTLRVDQSILTGESVSVTKHteaipdprav 200
Cdd:pfam00122    1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    201 nqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfa 280
Cdd:pfam00122   66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 28373109    281 dpahggSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARK 329
Cdd:pfam00122  139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 3.35e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 76.85  E-value: 3.35e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373109       5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
Cdd:smart00831    5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1955.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083    1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083   81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083  160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083  240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083  320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083  399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083  479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083  555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083  635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083  715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083  795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083  875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                        970       980
                 ....*....|....*....|....*
gi 28373109  965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083  955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1466.93  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     53 VLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRS 132
Cdd:TIGR01116    1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    133 DRKGVqrIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116   81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    213 NITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
Cdd:TIGR01116  157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaea 372
Cdd:TIGR01116  237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAL--- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    373 DAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM 452
Cdd:TIGR01116  314 DPSSSSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    453 NVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRphptgqGSKMFVKGAPESVIERCSSVRVG- 531
Cdd:TIGR01116  394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPST------GNKLFVKGAPEGVLERCTHILNGd 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    532 SRTAPLTPTSREQILAKIRDWGSGsDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACI 611
Cdd:TIGR01116  468 GRAVPLTDKMKNTILSVIKEMGTT-KALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    612 TRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENL 691
Cdd:TIGR01116  547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    692 QSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGE 771
Cdd:TIGR01116  627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    772 VVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAA 851
Cdd:TIGR01116  707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATVGG 786
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    852 ATWWfvydaegphinfYQLRNFLKCSEDN----PLFAGIDCEVFESRFP-TTMALSVLVTIEMCNALNSVSENQSLLRMP 926
Cdd:TIGR01116  787 FVWW------------YLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPaRTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373109    927 PWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01116  855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-989 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 953.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    1 MEAAHLLPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfee 80
Cdd:COG0474    5 LKDWHALSAEEVLAELGTSEEG-LSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   81 GEetttaFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474   79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGK--WVEIPAEELVPGDIVLLEAGDRVP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  161 ADLRLIEIKSttLRVDQSILTGESVSVTKHTEAIPDPRAVnQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA 240
Cdd:COG0474  152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  241 AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLR----------GAVyyfkiavalavaaiPEG 310
Cdd:COG0474  229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftiSGTTYT 390
Cdd:COG0474  289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYT----------------GGGTYE 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  391 PEGEVRqgdqpvrcgqfDGLVELATICALCNDSALDYNEAkgvyekVGEATETALTCLVEKMNVFDTDLQalsrveraga 470
Cdd:COG0474  353 VTGEFD-----------PALEELLRAAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEELR---------- 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  471 cntvikQLMRKEFTLEFSRDRKSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:COG0474  406 ------KEYPRVDEIPFDSERKRMSTVH-----EDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:COG0474  475 ELAA--QGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  631 TAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:COG0474  546 TARAIARQLGLGDDGD----RVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  711 LKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789
Cdd:COG0474  622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaATWWFVydaegphinfyq 869
Cdd:COG0474  702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTL--LTFALA------------ 767
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  870 lrnflkcsednpLFAGIDCEVFesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILL 949
Cdd:COG0474  768 ------------LARGASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|
gi 28373109  950 VPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:COG0474  831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRR 870
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
23-822 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 755.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfeeGEEtttafVEPLVIMLILVANA 102
Cdd:cd02089    1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL-----GEY-----VDAIVIIAIVILNA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  103 IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:cd02089   71 VLGFVQEYKAEKALAALKKMSAPTAKVLRDGKK--QEIPARELVPGDIVLLEAGDYVPADGRLIE--SASLRVEESSLTG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  183 ESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:cd02089  147 ESEPVEKDADTLLEEDVPLGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAI 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  263 AISVICVAVWVINIGHFADPAhgGSWLRG---AVyyfkiavalavAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSV 339
Cdd:cd02089  227 AALIICALVFALGLLRGEDLL--DMLLTAvslAV-----------AAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAV 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  340 ETLGCTSVICSDKTGTLTTNQMSVCRMFVVaeadagscllheftisgttytpegevrqgdqpvrcgqfdglvelatical 419
Cdd:cd02089  294 ETLGSVSVICSDKTGTLTQNKMTVEKIYTI-------------------------------------------------- 323
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  420 cndsaldyneakgvyekvGEATETALTCLVEKMNVFDTDLQALSRveragacntvikqlmrKEFTLEFSRDRKSMSVYct 499
Cdd:cd02089  324 ------------------GDPTETALIRAARKAGLDKEELEKKYP----------------RIAEIPFDSERKLMTTV-- 367
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  500 ptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSgsDTLRCLALATR--DAPPRKEDME 577
Cdd:cd02089  368 ----HKDAGKYIVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSE--EALRVLAVAYKplDEDPTESSED 441
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  578 LddcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDtedvAGKAYTGRE 657
Cdd:cd02089  442 L---------ENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILED----GDKALTGEE 508
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  658 FDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLS 736
Cdd:cd02089  509 LDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGiTGTDVAKEAADMILT 588
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  737 DDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDI 816
Cdd:cd02089  589 DDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDI 668

                 ....*.
gi 28373109  817 MEKLPR 822
Cdd:cd02089  669 MDRKPR 674
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
23-985 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 744.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfeeGEETTTAfveplVIMLILVANA 102
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFL-----GHWVDAI-----VIFGVVLINA 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  103 IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLRVDQSILTG 182
Cdd:cd02080   71 IIGYIQEGKAEKALAAIKNMLSPEATVLRDGKK--LTIDAEELVPGDIVLLEAGDKVPADLRLIEARN--LQIDESALTG 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  183 ESVSVTKHTEAIPdPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:cd02080  147 ESVPVEKQEGPLE-EDTPLGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLI 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  263 AISVICVAVWVInighfadpahgGSWLRG--AVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVE 340
Cdd:cd02080  226 VILVLAALTFVF-----------GLLRGDysLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVE 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  341 TLGCTSVICSDKTGTLTTNQMSVCRMFvvaeadagscllheftisgttytpegevrqgdqpvrcgqfdglvelaticALC 420
Cdd:cd02080  295 TLGSVTVICSDKTGTLTRNEMTVQAIV--------------------------------------------------TLC 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  421 NDSALDYNEakGVYEKVGEATETALTCLVEKMNVFDTDLqaLSRVERAGacntvikqlmrkefTLEFSRDRKSMSvyctp 500
Cdd:cd02080  325 NDAQLHQED--GHWKITGDPTEGALLVLAAKAGLDPDRL--ASSYPRVD--------------KIPFDSAYRYMA----- 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  501 TRpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLtptSREQILAKIRDWGSgsDTLRCLALATRDAPPRKEDMELDD 580
Cdd:cd02080  382 TL-HRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPL---DRAYWEAEAEDLAK--QGLRVLAFAYREVDSEVEEIDHAD 455
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  581 CskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDtedvaGKAYTGREFDD 660
Cdd:cd02080  456 L------EGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDG-----KKVLTGAELDA 524
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  661 LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDN 739
Cdd:cd02080  525 LDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGiKGTEVAKEAADMVLADDN 604
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  740 FASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEK 819
Cdd:cd02080  605 FATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMKR 684
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  820 LPRSPREALISGWLFFRYlaigVYVGLATVAAATWWFVYDaegphinfyqlrnflkcsednpLFAGIDCEvfESRfptTM 899
Cdd:cd02080  685 PPRDPSEPLLSRELIWRI----LLVSLLMLGGAFGLFLWA----------------------LDRGYSLE--TAR---TM 733
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  900 ALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVIL 979
Cdd:cd02080  734 AVNTIVVAQIFYLFNCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFI 813

                 ....*.
gi 28373109  980 LDEALK 985
Cdd:cd02080  814 VVELEK 819
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
33-985 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 572.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   33 RERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfveplviMLILVANAIVgvwQERNA 112
Cdd:cd02085    2 RKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVA-------ILIVVTVAFV---QEYRS 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  113 ESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTE 192
Cdd:cd02085   72 EKSLEALNKLVPPECHCLRDGK--LEHFLARELVPGDLVCLSIGDRIPADLRLFE--ATDLSIDESSLTGETEPCSKTTE 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  193 AIPDPRAVN-QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLShAISVICVAV 271
Cdd:cd02085  148 VIPKASNGDlTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLS-LYSFIIIGV 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  272 WVInIGHFadpaHGGSWLRgavyYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSD 351
Cdd:cd02085  227 IML-IGWL----QGKNLLE----MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSD 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  352 KTGTLTTNQMSVCRMFvvaeadagscllheftisgttytpegevrqgdqpvrCGqfdglvelaticALCNDSALDYNEAk 431
Cdd:cd02085  298 KTGTLTKNEMTVTKIV------------------------------------TG------------CVCNNAVIRNNTL- 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  432 gvyekVGEATETALTCLVEKMNVFDTDlqalsrveragacNTVIkqlmRKEFtLEFSRDRKSMSVYCtptRPHPTGQGSK 511
Cdd:cd02085  329 -----MGQPTEGALIALAMKMGLSDIR-------------ETYI----RKQE-IPFSSEQKWMAVKC---IPKYNSDNEE 382
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  512 M-FVKGAPESVIERCSSVRVGSRTA-PLTPTSREQILAKIRDwgSGSDTLRCLALAtrdappRKEDMElddcskfvqyet 589
Cdd:cd02085  383 IyFMKGALEQVLDYCTTYNSSDGSAlPLTQQQRSEINEEEKE--MGSKGLRVLALA------SGPELG------------ 442
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQA 669
Cdd:cd02085  443 DLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSL----QALSGEEVDQMSDSQLASV 518
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  670 CRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVE 748
Cdd:cd02085  519 VRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGrTGTDVCKEAADMILVDDDFSTILAAIE 598
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  749 EGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREAL 828
Cdd:cd02085  599 EGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPI 678
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  829 ISGWLFFRYLaigvyVGLATVAAATWWfvydaegphINFYQLRNFLKCSEDnplfagidcevfesrfpTTMALSVLVTIE 908
Cdd:cd02085  679 LTRSLILNVL-----LSAAIIVSGTLW---------VFWKEMSDDNVTPRD-----------------TTMTFTCFVFFD 727
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28373109  909 MCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALK 985
Cdd:cd02085  728 MFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
7-989 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 565.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109      7 LPAADVLRHFSVTAEGGLSPAQ-VTGARERYGPNELPSEEGKSLWELVLEQF-EDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:TIGR01522    7 LSVEETCSKLQTDLQNGLNSSQeASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNIDDAVSI 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     85 TTAfveplviMLILVAnaiVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:TIGR01522   87 TLA-------ILIVVT---VGFVQEYRSEKSLEALNKLVPPECHLIREGKL--EHVLASTLVPGDLVCLSVGDRVPADLR 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    165 LIEikSTTLRVDQSILTGESVSVTKHTEAIPDPRAVN-QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVE 243
Cdd:TIGR01522  155 IVE--AVDLSIDESNLTGETTPVSKVTAPIPAATNGDlAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    244 PERTPLQRKLDEFGRQLShAISVICVAVWVInIGHFadpaHGGSWLRgavyYFKIAVALAVAAIPEGLPAVITTCLALGT 323
Cdd:TIGR01522  233 KPKTPLQKSMDLLGKQLS-LVSFGVIGVICL-VGWF----QGKDWLE----MFTISVSLAVAAIPEGLPIIVTVTLALGV 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    324 RRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaeaDAGSCLLheftiSGTTYTPEGEVRQGDQPVR 403
Cdd:TIGR01522  303 LRMSKKRAIVRKLPSVETLGSVNVICSDKTGTLTKNHMTVTKIWTS---DGLHTML-----NAVSLNQFGEVIVDGDVLH 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    404 CGQFDGLVELATICALCNDSALDyNEAKGVyekVGEATETALTCLVEKMNVFDTDlQALSRVERagacntvikqlmrkef 483
Cdd:TIGR01522  375 GFYTVAVSRILEAGNLCNNAKFR-NEADTL---LGNPTDVALIELLMKFGLDDLR-ETYIRVAE---------------- 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    484 tLEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERCSS-VRVGSRTAPLTPTSREQILAKIRDWGSgsDTLRCL 562
Cdd:TIGR01522  434 -VPFSSERKWMAVKCV----HRQDRSEMCFMKGAYEQVLKYCTYyQKKDGKTLTLTQQQRDVIQEEAAEMAS--AGLRVI 506
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    563 ALAtrdapprkedmelddcSKFVQYEtdLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:TIGR01522  507 AFA----------------SGPEKGQ--LTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAVSIARRLGMP 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    643 GDTedvaGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG- 721
Cdd:TIGR01522  569 SKT----SQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIGVAMGq 644
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDG 801
Cdd:TIGR01522  645 TGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWINILMDG 724
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    802 LPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaatwwFVYdaegphinFYQLRNFLKCSEDnp 881
Cdd:TIGR01522  725 PPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTL------FVF--------VREMQDGVITARD-- 788
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    882 lfagidcevfesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTP 961
Cdd:TIGR01522  789 ---------------TTMTFTCFVFFDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEA 853
                          970       980
                   ....*....|....*....|....*...
gi 28373109    962 LSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01522  854 LSIKDLLFLLLITSSVCIVDEIRKKVER 881
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
33-830 5.99e-167

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 507.90  E-value: 5.99e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   33 RERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEE--GEETTTAFVEPLVIMLILVANAIVGVWQER 110
Cdd:cd02081    5 REVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPfgEGEGKTGWIEGVAILVAVILVVLVTAGNDY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  111 NAESAIEAL-KEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTK 189
Cdd:cd02081   85 QKEKQFRKLnSKKEDQKVTVIRDGE--VIQISVFDIVVGDIVQLKYGDLIPADGLLIE--GNDLKIDESSLTGESDPIKK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  190 HTEaipdpravNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICV 269
Cdd:cd02081  161 TPD--------NQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIVAA 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  270 AVWVINIGHFA-DPAHGGSWLRGAVY------YFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:cd02081  233 LTFIVLIIRFIiDGFVNDGKSFSAEDlqefvnFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETM 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  343 GCTSVICSDKTGTLTTNQMSVCRMFVvaeadaGSCllheftisgttytpegevrqgdqpvrcgqfdglvelaticalcnd 422
Cdd:cd02081  313 GNATAICSDKTGTLTQNRMTVVQGYI------GNK--------------------------------------------- 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  423 saldyneakgvyekvgeaTETALTCLVEKmnvfdtdLQALSRVERAGACNTVIKQlmrkeFTleFSRDRKSMSVYCtptr 502
Cdd:cd02081  342 ------------------TECALLGFVLE-------LGGDYRYREKRPEEKVLKV-----YP--FNSARKRMSTVV---- 385
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  503 PHPTGqGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQIL-AKIRDWGSgsDTLRCLALATRDAPPRKEDMELDDC 581
Cdd:cd02081  386 RLKDG-GYRLYVKGASEIVLKKCSYILNSDGEVVFLTSEKKEEIkRVIEPMAS--DSLRTIGLAYRDFSPDEEPTAERDW 462
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  582 SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFgdTEDVAGKAYTGREFDDL 661
Cdd:cd02081  463 DDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGIL--TEGEDGLVLEGKEFREL 540
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  662 SPEQQRQACRTA--------RCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAE 732
Cdd:cd02081  541 IDEEVGEVCQEKfdkiwpklRVLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGiAGTEVAKEASD 620
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  733 MVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPP 812
Cdd:cd02081  621 IILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPP 700
                        810
                 ....*....|....*...
gi 28373109  813 DLDIMEKLPRSPREALIS 830
Cdd:cd02081  701 TEDLLKRKPYGRDKPLIS 718
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
23-989 5.53e-166

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 512.00  E-value: 5.53e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSF-VLAWFEEGeetttafveplVIMLILVAN 101
Cdd:cd02086    1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFaVKDWIEGG-----------VIAAVIALN 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  102 AIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLRVDQSILT 181
Cdd:cd02086   70 VIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSGK--TETISSKDVVPGDIVLLKVGDTVPADLRLIETKN--FETDEALLT 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  182 GESVSVTKHTEAI--PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKI----RSQMAAVEPER--------- 246
Cdd:cd02086  146 GESLPVIKDAELVfgKEEDVSVGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIakalRGKGGLISRDRvkswlygtl 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  247 ----------------TPLQRKLDEFGRQLsHAISVIC-VAVWVINIGHFADpahggswlRGAVYyfkiAVALAVAAIPE 309
Cdd:cd02086  226 ivtwdavgrflgtnvgTPLQRKLSKLAYLL-FFIAVILaIIVFAVNKFDVDN--------EVIIY----AIALAISMIPE 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  310 GLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftisgtty 389
Cdd:cd02086  293 SLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVV-------------------------- 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  390 tpegevRQGDQPvrcgqfdglvelatiCALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMnvfdtDLQALSRVERAG 469
Cdd:cd02086  347 ------RQVWIP---------------AALCNIATVFKDEETDCWKAHGDPTEIALQVFATKF-----DMGKNALTKGGS 400
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  470 ACNTVIKqlmrkEFTleFSRDRKSMSVYCTPTRphptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKI 549
Cdd:cd02086  401 AQFQHVA-----EFP--FDSTVKRMSVVYYNNQ----AGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDEFRKTIIKNV 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  550 RDWGSgsDTLRCLALATRDAPPR-KEDMELDDC-SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGD 627
Cdd:cd02086  470 ESLAS--QGLRVLAFASRSFTKAqFNDDQLKNItLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGD 547
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  628 NKGTAVAICRRLGIF------GDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMT 701
Cdd:cd02086  548 HPGTAKAIAREVGILppnsyhYSQEIMDSMVMTASQFDGLSDEEVDALPVLPLVIARCSPQTKVRMIEALHRRKKFCAMT 627
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  702 GDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVvcIFLTAI 780
Cdd:cd02086  628 GDGVNDSPSLKMADVGIAMGlNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQV--ILLLIG 705
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  781 LGLPEA-------LIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAat 853
Cdd:cd02086  706 LAFKDEdglsvfpLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTFMGVLCLAS-- 783
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  854 wwFVYDAEGphINFYQLrnflkcsednplfaGIDCE---------VFESRFPTTMALSVLVTIemcNALNSVSENQSLLR 924
Cdd:cd02086  784 --FTLVIYG--IGNGDL--------------GSDCNesynsscedVFRARAAVFATLTWCALI---LAWEVVDMRRSFFN 842
                        970       980       990      1000      1010      1020      1030
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28373109  925 MPP-------------WMNPWLLVAVAMSMALHFLIL-LVPPLPLIFQVTPLsGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02086  843 MHPdtdspvksffktlWKNKFLFWSVVLGFVSVFPTLyIPVINDDVFKHTGI-GWEWGLVIACTVAFFAGVELWKAGKR 920
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
93-807 7.30e-163

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 491.06  E-value: 7.30e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     93 VIMLILVANAIVGVWQERNAESAIEALKEYEpEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIeikSTT 172
Cdd:TIGR01494    1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSL-VNTATVLVLRNGWKEISSKDLVPGDVVLVKSGDTVPADGVLL---SGS 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    173 LRVDQSILTGESVSVTKHTEaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRK 252
Cdd:TIGR01494   77 AFVDESSLTGESLPVLKTAL----------PDGDAVFAGTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSK 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    253 LDEFGRQL-SHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAValavaaiPEGLPAVITTCLALGTRRMARKNA 331
Cdd:TIGR01494  147 ADKFENFIfILFLLLLALAVFLLLPIGGWDGNSIYKAILRALAVLVIAI-------PCALPLAVSVALAVGDARMAKKGI 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftisgttytpegevrqgdqpvrcgqfDGLV 411
Cdd:TIGR01494  220 LVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVII---------------------------------------IGGV 260
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    412 ELATIcalcndsaLDYNEAKGVYEKVGEATETALTCLVEKMNVFDtdlqalsrveragacntVIKQLMRKEFTLEFSRDR 491
Cdd:TIGR01494  261 EEASL--------ALALLAASLEYLSGHPLERAIVKSAEGVIKSD-----------------EINVEYKILDVFPFSSVL 315
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    492 KSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltptsrEQILAKIRDWGSgsDTLRCLALATRDAPP 571
Cdd:TIGR01494  316 KRMGVIV-----EGANGSDLLFVKGAPEFVLERCNNE--------------NDYDEKVDEYAR--QGLRVLAFASKKLPD 374
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    572 rkedmelddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFgdtedvagk 651
Cdd:TIGR01494  375 ------------------DLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID--------- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    652 aytgrefddlspeqqrqacrtarCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGtAVAKSAA 731
Cdd:TIGR01494  428 -----------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSG-DVAKAAA 483
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28373109    732 EMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAIlglpealipvqllwVNLVTDGLPATAL 807
Cdd:TIGR01494  484 DIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIV--------------IILLPPLLAALAL 545
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
35-807 1.35e-138

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 431.07  E-value: 1.35e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   35 RYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVlawfeegeetTTAFVEPLVIMLILVANAIVGVWQERNAES 114
Cdd:cd07539   14 LPARNLALETATRSGILAVAAQLELPPVALLGLAAGASAS----------TGGGVDAVLIVGVLTVNAVIGGVQRLRAER 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  115 AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTEAI 194
Cdd:cd07539   84 ALAALLAQQQQPARVVRAPAGRTQTVPAESLVPGDVIELRAGEVVPADARLLE--ADDLEVDESALTGESLPVDKQVAPT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  195 PdpRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPErTPLQRKLDEFGRQLSHAISVICVAVWvi 274
Cdd:cd07539  162 P--GAPLADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAPVETA-TGVQAQLRELTSQLLPLSLGGGAAVT-- 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  275 nighfadpahGGSWLRGA--VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDK 352
Cdd:cd07539  237 ----------GLGLLRGAplRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDK 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  353 TGTLTTNQMSVcrmfvvaeadagscllheftisGTTYTPEGEVrqgdqPVRCGQfdglvelaticalcndsaldyNEAKG 432
Cdd:cd07539  307 TGTLTENRLRV----------------------VQVRPPLAEL-----PFESSR---------------------GYAAA 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  433 VYEKVGEATETAltclvekmnvfdtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphptgqgskm 512
Cdd:cd07539  339 IGRTGGGIPLLA-------------------------------------------------------------------- 350
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  513 fVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDwgSGSDTLRCLALATRDAPPRKEDMeLDDCskfvqyETDLT 592
Cdd:cd07539  351 -VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNEL--LAGQGLRVLAVAYRTLDAGTTHA-VEAV------VDDLE 420
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  593 FVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVagkayTGREFDDLSPEQQRQACRT 672
Cdd:cd07539  421 LLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLPRDAEVV-----TGAELDALDEEALTGLVAD 495
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  673 ARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGR 751
Cdd:cd07539  496 IDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGArGSDAAREAADLVLTDDDLETLLDAVVEGR 575
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373109  752 AIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATAL 807
Cdd:cd07539  576 TMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALAL 631
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
23-861 6.27e-134

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 427.15  E-value: 6.27e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETttafvEP--------LVI 94
Cdd:cd02608    1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEE-----EPsndnlylgIVL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   95 MLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLR 174
Cdd:cd02608   76 AAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEK--MQINAEELVVGDLVEVKGGDRIPADIRIISAHG--CK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  175 VDQSILTGESVSVTKHTEAIPDpravNQ-DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKL 253
Cdd:cd02608  152 VDNSSLTGESEPQTRSPEFTHE----NPlETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREI 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  254 DEFgrqlSHAISVicVAVWvINIGHFA-DPAHGGSWLRGAVYYFkiavALAVAAIPEGLPAVITTCLALGTRRMARKNAI 332
Cdd:cd02608  228 EHF----IHIITG--VAVF-LGVSFFIlSLILGYTWLEAVIFLI----GIIVANVPEGLLATVTVCLTLTAKRMARKNCL 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  333 VRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEADAGScllhefTISGTTYTPEGevrqgdqpvrcgqfDG 409
Cdd:cd02608  297 VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqIHEADTTE------DQSGASFDKSS--------------AT 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  410 LVELATICALCNDSALDYNEAKGVYEK---VGEATETALTCLVEkMNVFDTDLqalsrveragacntvIKQLMRKEFTLE 486
Cdd:cd02608  357 WLALSRIAGLCNRAEFKAGQENVPILKrdvNGDASESALLKCIE-LSCGSVME---------------MRERNPKVAEIP 420
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  487 F-SRDRKSMSVYctpTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDtlRCLALA 565
Cdd:cd02608  421 FnSTNKYQLSIH---ENEDPGDPRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGGLGE--RVLGFC 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  566 trdapprkeDMEL--DDCSKFVQYETD--------LTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:cd02608  496 ---------HLYLpdDKFPEGFKFDTDevnfptenLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI 566
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  636 CRRLGIFgdtedvagkaytgrefddlspeqqrqacrtarCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
Cdd:cd02608  567 AKGVGII--------------------------------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 614
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  716 IGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLW 794
Cdd:cd02608  615 IGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILC 694
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373109  795 VNLVTDGLPATALGFNPPDLDIMEKLPRSPR------EALISgwlfFRYLAIGVyvgLATVAAATWWFVYDAE 861
Cdd:cd02608  695 IDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS----MAYGQIGM---IQALAGFFTYFVIMAE 760
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
5-861 1.51e-133

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 428.83  E-value: 1.51e-133
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109      5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:TIGR01106   18 HKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQASTEE 97
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     85 TTAFVE---PLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPA 161
Cdd:TIGR01106   98 EPQNDNlylGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEK--MSINAEQVVVGDLVEVKGGDRIPA 175
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    162 DLRLIEIKSttLRVDQSILTGESVsvtkhteaiPDPRAVN------QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKI 235
Cdd:TIGR01106  176 DLRIISAQG--CKVDNSSLTGESE---------PQTRSPEfthenpLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRI 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    236 RSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLRGAVYYFkiavALAVAAIPEGLPAVI 315
Cdd:TIGR01106  245 ASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSL------ILGYTWLEAVIFLI----GIIVANVPEGLLATV 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    316 TTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEADAGScllhefTISGTTYtpe 392
Cdd:TIGR01106  315 TVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqIHEADTTE------DQSGVSF--- 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    393 gevrqgDQPVRcgqfdGLVELATICALCNDSALDYN-EAKGVYEK--VGEATETALTCLVEKmnvfdtdlqalsrverag 469
Cdd:TIGR01106  386 ------DKSSA-----TWLALSRIAGLCNRAVFKAGqENVPILKRavAGDASESALLKCIEL------------------ 436
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    470 ACNTVIKqlMRKEFT----LEF-SRDRKSMSVYctpTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQ 544
Cdd:TIGR01106  437 CLGSVME--MRERNPkvveIPFnSTNKYQLSIH---ENEDPRDPRHLLVMKGAPERILERCSSILIHGKEQPLDEELKEA 511
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    545 I-LAKIRDWGSGSDTLR-CLALATRDAPPRKEDMELDDcskfVQYETD-LTFVGCVGMLDPPRPEVAACITRCYQAGIRV 621
Cdd:TIGR01106  512 FqNAYLELGGLGERVLGfCHLYLPDEQFPEGFQFDTDD----VNFPTDnLCFVGLISMIDPPRAAVPDAVGKCRSAGIKV 587
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    622 VMITGDNKGTAVAICRRLGIFGD----TEDVA--------------GKA--YTGREFDDLSPEQQRQACR--TARCFARV 679
Cdd:TIGR01106  588 IMVTGDHPITAKAIAKGVGIISEgnetVEDIAarlnipvsqvnprdAKAcvVHGSDLKDMTSEQLDEILKyhTEIVFART 667
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    680 EPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMK 758
Cdd:TIGR01106  668 SPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLK 747
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    759 QFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPR------EALISgw 832
Cdd:TIGR01106  748 KSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS-- 825
                          890       900
                   ....*....|....*....|....*....
gi 28373109    833 lfFRYLAIGVyvgLATVAAATWWFVYDAE 861
Cdd:TIGR01106  826 --MAYGQIGM---IQALGGFFTYFVILAE 849
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
23-842 5.01e-133

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 416.84  E-value: 5.01e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGeetttafveplVIMLILVANA 102
Cdd:cd07538    1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREG-----------LILLIFVVVI 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  103 IV-GVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILT 181
Cdd:cd07538   70 IAiEVVQEWRTERALEALKNLSSPRATVIRDGRE--RRIPSRELVPGDLLILGEGERIPADGRLLE--NDDLGVDESTLT 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  182 GESVSVTKhTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS 261
Cdd:cd07538  146 GESVPVWK-RIDGKAMSAPGGWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  262 HAISVIC---VAVWVINIGHFADPAHGGSWLRGAVyyfkiavalavaaIPEGLPAVITTCLALGTRRMARKNAIVRSLPS 338
Cdd:cd07538  225 LAALVFCaliVAVYGVTRGDWIQAILAGITLAMAM-------------IPEEFPVILTVFMAMGAWRLAKKNVLVRRAAA 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  339 VETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscLLHEFTisgttYTPEgevrqgdqpvrcgqfdglvelatica 418
Cdd:cd07538  292 VETLGSITVLCVDKTGTLTKNQMEVVELTS---------LVREYP-----LRPE-------------------------- 331
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  419 lcndsaldyneaKGVYEKVGEATETALTCLvekmnvfdtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyc 498
Cdd:cd07538  332 ------------LRMMGQVWKRPEGAFAAA-------------------------------------------------- 349
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  499 tptrphptgqgskmfvKGAPESVIERCSsvrvgsrtapLTPTSREQILAKIRDWGSgsDTLRCLALATRDAPPRKEDMEL 578
Cdd:cd07538  350 ----------------KGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAG--EGLRVLAVAACRIDESFLPDDL 401
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  579 DDCSkfvqyetdLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdteDVAGKAYTGREF 658
Cdd:cd07538  402 EDAV--------FIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-----DNTDNVITGQEL 468
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  659 DDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSD 737
Cdd:cd07538  469 DAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKrGTDVAREASDIVLLD 548
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  738 DNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDglPATALGF--NPPDLD 815
Cdd:cd07538  549 DNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIID--PTCSIVFeaEPAERD 626
                        810       820
                 ....*....|....*....|....*..
gi 28373109  816 IMEKLPRSPREALISGWLFFRYLAIGV 842
Cdd:cd07538  627 IMRRPPRPPDEPLFGPRLVIKAILQGA 653
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
24-980 6.11e-132

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 423.42  E-value: 6.11e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     24 LSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWF-----EEGEETTTAFVEPLVIML-I 97
Cdd:TIGR01517   62 LSSSTLERREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYvpsvgEDKADTETGWIEGVAILVsV 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     98 LVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLrlIEIKSTTLRVDQ 177
Cdd:TIGR01517  142 ILVVLVTAVNDYKKELQFRQLNREKSAQKIAVIRGGQ--EQQISIHDIVVGDIVSLSTGDVVPADG--VFISGLSLEIDE 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    178 SILTGESvsvtkhteaipDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFG 257
Cdd:TIGR01517  218 SSITGES-----------DPIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAGEEETPLQEKLSELA 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    258 RQLSHA---ISVICVAV----WVINI----GHFADPAHGGSWLrgaVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
Cdd:TIGR01517  287 GLIGKFgmgSAVLLFLVlslrYVFRIirgdGRFEDTEEDAQTF---LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKM 363
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFvvaeadagscllheftISGTTYTPEGEVRQGDQP--VRc 404
Cdd:TIGR01517  364 MKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY----------------IGEQRFNVRDEIVLRNLPaaVR- 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    405 gqfDGLVElatiCALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERagacntVIKqlmrkefT 484
Cdd:TIGR01517  427 ---NILVE----GISLNSSSEEVVDRGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEK------VVK-------I 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    485 LEFSRDRKSMSVYCTptrpHPTGQgSKMFVKGAPESVIERCSSVRVGSRTA-PLTPTSREQILAKIRdwGSGSDTLRCLA 563
Cdd:TIGR01517  487 YPFNSERKFMSVVVK----HSGGK-YREFRKGASEIVLKPCRKRLDSNGEAtPISEDDKDRCADVIE--PLASDALRTIC 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    564 LATRDAPPRKEDmelddcskFVQY-ETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:TIGR01517  560 LAYRDFAPEEFP--------RKDYpNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGIL 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    643 GDTedvaGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG- 721
Cdd:TIGR01517  632 TFG----GLAMEGKEFRSLVYEEMDPILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGi 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA--LIPVQLLWVNLVT 799
Cdd:TIGR01517  708 SGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISSSHTspLTAVQLLWVNLIM 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    800 DGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAaatwwfvydaegphINFYQLRNFLKCSED 879
Cdd:TIGR01517  788 DTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFI--------------LLFAGGSIFDVSGPD 853
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    880 N-PLFAGIDCEvfesrfptTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVaMSMALHFLILLVPPLPLIFQ 958
Cdd:TIGR01517  854 EiTSHQQGELN--------TIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTI-MGFTFGFQVIIVEFGGSFFS 924
                          970       980
                   ....*....|....*....|....*
gi 28373109    959 VTPLSGRQW---VVVLQISLPVILL 980
Cdd:TIGR01517  925 TVSLSIEQWigcVLLGMLSLIFGVL 949
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
10-854 3.35e-131

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 424.04  E-value: 3.35e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     10 ADVLRHFSVTA-EGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFvlawfeegeeTTTAF 88
Cdd:TIGR01523   12 ADEAAEFIGTSiPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISF----------AMHDW 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     89 VEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEI 168
Cdd:TIGR01523   82 IEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKS--DAIDSHDLVPGDICLLKTGDTIPADLRLIET 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    169 KSttLRVDQSILTGESVSVTKHTEAI--PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIR---------- 236
Cdd:TIGR01523  160 KN--FDTDEALLTGESLPVIKDAHATfgKEEDTPIGDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAaglqgdgglf 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    237 SQMAAVEPER-------------------------TPLQRKLDEFgrqlshAISVICVAVWVINIGHFADPAHGGSwlRG 291
Cdd:TIGR01523  238 QRPEKDDPNKrrklnkwilkvtkkvtgaflglnvgTPLHRKLSKL------AVILFCIAIIFAIIVMAAHKFDVDK--EV 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    292 AVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV--- 368
Cdd:TIGR01523  310 AIY----AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIprf 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    369 ----VAEAD-------AGSCLLHEFTISGTTYTPEG----------EVRQGDQP--VRCGQFDGLVElatICALCNDSAL 425
Cdd:TIGR01523  386 gtisIDNSDdafnpneGNVSGIPRFSPYEYSHNEAAdqdilkefkdELKEIDLPedIDMDLFIKLLE---TAALANIATV 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    426 DYNEAKGVYEKVGEATETALTCLVEKMNVFDTDL-------QALSRVERAGACNTVIKQLMRKEFTLEFSRDR--KSMSV 496
Cdd:TIGR01523  463 FKDDATDCWKAHGDPTEIAIHVFAKKFDLPHNALtgeedllKSNENDQSSLSQHNEKPGSAQFEFIAEFPFDSeiKRMAS 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    497 YCTPTRphptGQGSKMFVKGAPESVIERCSSV--RVGSRTAPLTPTSREQILAKIrdWGSGSDTLRCLALATR--DAPPR 572
Cdd:TIGR01523  543 IYEDNH----GETYNIYAKGAFERIIECCSSSngKDGVKISPLEDCDRELIIANM--ESLAAEGLRVLAFASKsfDKADN 616
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    573 KEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDT------E 646
Cdd:TIGR01523  617 NDDQLKNETLNRATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIPPNfihdrdE 696
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    647 DVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 725
Cdd:TIGR01523  697 IMDSMVMTGSQFDALSDEEVDDLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGiNGSD 776
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    726 VAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIfltaILGL-----------PeaLIPVQLLW 794
Cdd:TIGR01523  777 VAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILL----IIGLafrdengksvfP--LSPVEILW 850
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    795 VNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLatVAAATW 854
Cdd:TIGR01523  851 CIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFFLGG--SCLASF 908
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
23-800 1.94e-116

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 376.59  E-value: 1.94e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTtaFVEPLVIMLILVANA 102
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD--LVGALIILLMVLISG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  103 IVGVWQERNAESAIEALKEYEPEMGKVIRsDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:cd02077   79 LLDFIQEIRSLKAAEKLKKMVKNTATVIR-DGSKYMEIPIDELVPGDIVYLSAGDMIPADVRIIQ--SKDLFVSQSSLTG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  183 ESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPErTPLQRKLDEFGRQLSH 262
Cdd:cd02077  156 ESEPVEKHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSITEKRPE-TSFDKGINKVSKLLIR 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  263 AISVICVAVWVINIghfadpAHGGSWLRGAVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:cd02077  235 FMLVMVPVVFLING------LTKGDWLEALLF----ALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNF 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  343 GCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISgttYTPEGevrqgdqpvrcgqFDGLVELATICALCND 422
Cdd:cd02077  305 GAMDILCTDKTGTLTQDKIVLERHLDVNGKESERVLRLAYLNS---YFQTG-------------LKNLLDKAIIDHAEEA 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  423 SaldYNEAKGVYEKVGEatetaltclvekmnvfdtdlqalsrveragacntvikqlmrkeftLEFSRDRKSMSVYCTPTR 502
Cdd:cd02077  369 N---ANGLIQDYTKIDE---------------------------------------------IPFDFERRRMSVVVKDND 400
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  503 phptgQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDwgSGSDTLRCLALATRDAPPRKEDMELDDcs 582
Cdd:cd02077  401 -----GKHLLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVEE--LNREGLRVLAIAYKKLPAPEGEYSVKD-- 471
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  583 kfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgDTEDVagkaYTGREFDDLS 662
Cdd:cd02077  472 -----EKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINRV----LTGSEIEALS 540
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  663 PEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFAS 742
Cdd:cd02077  541 DEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEAADIILLEKDLMV 620
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373109  743 IVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILgLP-EALIPVQLLWVNLVTD 800
Cdd:cd02077  621 LEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASAF-LPfLPMLPIQLLLQNLLYD 678
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
23-793 4.03e-107

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 352.30  E-value: 4.03e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEgKSLWELVLEQFEDLLVRILLLAALVSFVLA-WfeegeetttafVEPLVIMLILVAN 101
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNELPEKK-ENPILKFLSFFWGPIPWMLEAAAILAAALGdW-----------VDFAIILLLLLIN 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  102 AIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILT 181
Cdd:cd02076   69 AGIGFIEERQAGNAVAALKKSLAPKARVLRDGQ--WQEIDAKELVPGDIVSLKIGDIVPADARLLTGD--ALQVDQSALT 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  182 GESVSVTKHTEAipdpravnqdkknMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPeRTPLQRKLDEFGRQLS 261
Cdd:cd02076  145 GESLPVTKHPGD-------------EAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEE-QGHLQKVLNKIGNFLI 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  262 HAISVICVAVWVINIGHFADPAHGgswLRGAVYYFkiavalaVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVET 341
Cdd:cd02076  211 LLALILVLIIVIVALYRHDPFLEI---LQFVLVLL-------IASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEE 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  342 LGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHeftisgttytpegevrqgdqpvrcgqfdglvelatiCALCN 421
Cdd:cd02076  281 LAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKDELLLL------------------------------------AALAS 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  422 DsaldyneakgvyEKVGEATETALtclvekmnvfdtdLQALSRVERAGACntvIKQLMRKEFTLEfsrDRKSMSVYCTPT 501
Cdd:cd02076  325 D------------TENPDAIDTAI-------------LNALDDYKPDLAG---YKQLKFTPFDPV---DKRTEATVEDPD 373
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  502 rphptgqGSKMFV-KGAPESVIERCSsvrvgsrtapLTPTSREQILAKIRDWGS-GsdtLRCLALAtrdappRKEDMELD 579
Cdd:cd02076  374 -------GERFKVtKGAPQVILELVG----------NDEAIRQAVEEKIDELASrG---YRSLGVA------RKEDGGRW 427
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  580 DcskfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfGDTEDVAGKAYTGREFD 659
Cdd:cd02076  428 E------------LLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGM-GTNILSAERLKLGGGGG 494
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  660 DLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDN 739
Cdd:cd02076  495 GMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATDAARAAADIVLTAPG 574
                        730       740       750       760       770
                 ....*....|....*....|....*....|....*....|....*....|....
gi 28373109  740 FASIVAAVEEGRAIYSNMKQFIRYLISSNVgEVVCIFLTAILGLPEALIPVQLL 793
Cdd:cd02076  575 LSVIIDAIKTSRQIFQRMKSYVIYRIAETL-RILVFFTLGILILNFYPLPLIMI 627
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
23-874 2.40e-105

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 346.62  E-value: 2.40e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     23 GLSPAQVTGARERYGPNELPsEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGeetttafvepLVIMLILVANA 102
Cdd:TIGR01647    1 GLTSAEAKKRLAKYGPNELP-EKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVDF----------VIILGLLLLNA 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    103 IVGVWQERNAESAIEALKEYEPEMGKVIRsDRKGVQrIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:TIGR01647   70 TIGFIEENKAGNAVEALKQSLAPKARVLR-DGKWQE-IPASELVPGDVVRLKIGDIVPADCRLFE--GDYIQVDQAALTG 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    183 ESVSVTKHTEAIPdpravnqdkknmlFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:TIGR01647  146 ESLPVTKKTGDIA-------------YSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIV 212
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    263 AISVICVAVWVINIGHFadpahGGSWLRGAVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:TIGR01647  213 LIGVLVLIELVVLFFGR-----GESFREGLQF----ALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEEL 283
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    343 GCTSVICSDKTGTLTTNQMSvcrmfvvaeadagsclLHEFTISGTTYTPEgevrqgdqpvrcgqfDGLVELATICALCND 422
Cdd:TIGR01647  284 AGMDILCSDKTGTLTLNKLS----------------IDEILPFFNGFDKD---------------DVLLYAALASREEDQ 332
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    423 SALDyneaKGVYEKVGEATETALTCLVEKMNVFDtdlqalsrveragacnTVIKqlmRKEFTLEFSRDRKSMSVyctptr 502
Cdd:TIGR01647  333 DAID----TAVLGSAKDLKEARDGYKVLEFVPFD----------------PVDK---RTEATVEDPETGKRFKV------ 383
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    503 phptgqgskmfVKGAPESVIERCSSVRvgsrtapltpTSREQILAKIRDWGSGSdtLRCLALATRDAPPRKEdmelddcs 582
Cdd:TIGR01647  384 -----------TKGAPQVILDLCDNKK----------EIEEKVEEKVDELASRG--YRALGVARTDEEGRWH-------- 432
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    583 kfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD--TEDVAGKAYTGrefdD 660
Cdd:TIGR01647  433 ----------FLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiyTADVLLKGDNR----D 498
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    661 LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNF 740
Cdd:TIGR01647  499 DLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAVAGATDAARSAADIVLTEPGL 578
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    741 ASIVAAVEEGRAIYSNMKQFIRYLISSNVgEVVCIFLTAILGLPEALIPVQLLWVNLVTDGlPATALGFN---PPDLDIM 817
Cdd:TIGR01647  579 SVIVDAILESRKIFQRMKSYVIYRIAETI-RIVFFFGLLILILNFYFPPIMVVIIAILNDG-TIMTIAYDnvkPSKLPQR 656
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 28373109    818 EKLPRSPREALISGWlffrYLAIGVYVGLATVAAATWWfvYDAEGPHINFYQLRNFL 874
Cdd:TIGR01647  657 WNLREVFTMSTVLGI----YLVISTFLLLAIALDTTFF--IDKFGLQLLHGNLQSFI 707
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
483-807 1.06e-103

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 327.49  E-value: 1.06e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  483 FTLEFSRDRKSMSVYCTPTRPHptgqgsKMFVKGAPESVIERCSSvrvgsrtaPLTPTSREQILAKIRDWGSgsDTLRCL 562
Cdd:cd01431   23 EEIPFNSTRKRMSVVVRLPGRY------RAIVKGAPETILSRCSH--------ALTEEDRNKIEKAQEESAR--EGLRVL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  563 ALATRdapprkedmELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:cd01431   87 ALAYR---------EFDPETSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGID 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  643 GDTEDVagkaYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd01431  158 TKASGV----ILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGS 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  723 -GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDG 801
Cdd:cd01431  234 tGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDL 313

                 ....*.
gi 28373109  802 LPATAL 807
Cdd:cd01431  314 IPALAL 319
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
7-863 1.65e-97

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.95  E-value: 1.65e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     7 LPAADVLRHFSvTAEGGLSPAQVTGARERYGPNELPSEEG----KSLWELVLEQFeDLLVRILllaALVSFVLawfeegE 82
Cdd:PRK10517   52 MPEEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPF-NILLTIL---GAISYAT------E 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    83 ETTTAfvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSD----RKGVQRIRARDIVPGDIVEVAVGDK 158
Cdd:PRK10517  121 DLFAA----GVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDM 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   159 VPADLRLIEIKSttLRVDQSILTGESVSVtkhtEAIPDPRAVNQ----DKKNMLFSGTNITSGKAVGVAVATGLHTELGK 234
Cdd:PRK10517  197 IPADLRILQARD--LFVAQASLTGESLPV----EKFATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQ 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   235 IRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGL 311
Cdd:PRK10517  271 LAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN---------GytkGDWWEAALF----ALSVAVGLTPEML 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   312 PAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcRMFVVAEADagscllheftISGTTytp 391
Cdd:PRK10517  338 PMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTD----------ISGKT--- 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   392 egevrqgdqpvrcgqfdglvelaticalcNDSALDYNEAKGVYEkvgeateTALTCLVekmnvfdtDLQALSRVERAGAC 471
Cdd:PRK10517  400 -----------------------------SERVLHSAWLNSHYQ-------TGLKNLL--------DTAVLEGVDEESAR 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   472 NtvIKQLMRKEFTLEFSRDRKSMSVYC-TPTRPHptgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:PRK10517  436 S--LASRWQKIDEIPFDFERRRMSVVVaENTEHH------QLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTD 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:PRK10517  508 TLNR--QGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSEL 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   631 TAVAICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:PRK10517  579 VAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPA 652
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   711 LKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFL-TAILG-LPeaLI 788
Cdd:PRK10517  653 LRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVaSAFLPfLP--ML 730
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373109   789 PVQLLWVNLVTDgLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRylAIGVYVGLATVAAAtwWFVYDAEGP 863
Cdd:PRK10517  731 PLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFG--PISSIFDILTFCLM--WWVFHANTP 800
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
1-863 2.18e-91

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 311.42  E-value: 2.18e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109      1 MEAAHLlPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVlawfee 80
Cdd:TIGR01524   13 LKESQM-GKETLLRKLGVHETG-LTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYL------ 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     81 geetTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIR---SDRKGVQRIRARD-IVPGDIVEVAVG 156
Cdd:TIGR01524   85 ----TDDLEATVIIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLRvinENGNGSMDEVPIDaLVPGDLIELAAG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    157 DKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTEaIPDPRAVNQ-DKKNMLFSGTNITSGKAVGVAVATGLHTELGKI 235
Cdd:TIGR01524  161 DIIPADARVIS--ARDLFINQSALTGESLPVEKFVE-DKRARDPEIlERENLCFMGTNVLSGHAQAVVLATGSSTWFGSL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    236 rSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINiGHFAdpahgGSWLRGAVYyfkiAVALAVAAIPEGLPAVI 315
Cdd:TIGR01524  238 -AIAATERRGQTAFDKGVKSVSKLLIRFMLVMVPVVLMIN-GLMK-----GDWLEAFLF----ALAVAVGLTPEMLPMIV 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    316 TTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmfvvaeadagscLLHEFTISGTTytpegev 395
Cdd:TIGR01524  307 SSNLAKGAINMSKKKVIVKELSAIQNFGAMDILCTDKTGTLTQDKIE---------------LEKHIDSSGET------- 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    396 rqgdqpvrcgqfdglVELATICALCNDSaldyneakgvyekvgeaTETALTclvekmNVFDTDLqaLSRVERAGACNTVI 475
Cdd:TIGR01524  365 ---------------SERVLKMAWLNSY-----------------FQTGWK------NVLDHAV--LAKLDESAARQTAS 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    476 KQLMRKEFTLEFSRDRKSMSVyctPTRPHPTgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSG 555
Cdd:TIGR01524  405 RWKKVDEIPFDFDRRRLSVVV---ENRAEVT----RLICKGAVEEMLTVCTHKRFGGAVVTLSESEKSELQDMTAEMNRQ 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    556 SdtLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:TIGR01524  478 G--IRVIAVATKTLKVGEADFTKTD-------EEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTARI 548
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    636 CRRLGIfgDTEDVagkaYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
Cdd:TIGR01524  549 CQEVGI--DANDF----LLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKAD 622
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTA--ILGLPeaLIPVQLL 793
Cdd:TIGR01524  623 VGISVDTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASafIPFLP--MLSLHLL 700
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373109    794 WVNLVTDgLPATALGFNPPDLDIMEKlprsPREALISGWLFFrYLAIGVYVGLATVAA-ATWWFVYDAEGP 863
Cdd:TIGR01524  701 IQNLLYD-FSQLTLPWDKMDREFLKK----PHQWEQKGMGRF-MLCIGPVSSIFDIATfLLMWFVFSANTV 765
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
23-813 2.83e-80

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 275.70  E-value: 2.83e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   23 GLSPAQVTGARERYGPNELPSEEGKSLWELVleqFEDLLVRI----LLLAALVSFVLAWfeegeetttafvEPLVIMLIL 98
Cdd:cd02609    1 GLTTKEVEERQAEGKVNDQVEPVSRSVWQIV---RENVFTLFnlinFVIAVLLILVGSY------------SNLAFLGVI 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   99 VANAIVGVWQERNAESAIEALKEYEPEMGKVIRsDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQS 178
Cdd:cd02609   66 IVNTVIGIVQEIRAKRQLDKLSILNAPKVTVIR-DGQ-EVKIPPEELVLDDILILKPGEQIPADGEVVE--GGGLEVDES 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  179 ILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGR 258
Cdd:cd02609  142 LLTGESDLIPK-------------KAGDKLLSGSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILK 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  259 QLSHAISVICVAVWVINIGhfadpAHGGSWLRGAVyyfkIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPS 338
Cdd:cd02609  209 FTSFIIIPLGLLLFVEALF-----RRGGGWRQAVV----STVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYS 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  339 VETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfdglvelatica 418
Cdd:cd02609  280 IETLARVDVLCLDKTGTITEGKMKVERVEPLDEANE-------------------------------------------- 315
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  419 lcndsaldyneakgvyekvgEATETALTCLVEKMNVFDTDLQALsrverAGACNTVIKQLMRKEftLEFSRDRKSMSVyc 498
Cdd:cd02609  316 --------------------AEAAAALAAFVAASEDNNATMQAI-----RAAFFGNNRFEVTSI--IPFSSARKWSAV-- 366
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  499 tptrphpTGQGSKMFVKGAPESVIercssvrvgsRTAPltptsrEQILAKIRDwgSGSDTLRCLALATRDAPPRKEdmel 578
Cdd:cd02609  367 -------EFRDGGTWVLGAPEVLL----------GDLP------SEVLSRVNE--LAAQGYRVLLLARSAGALTHE---- 417
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  579 ddcskfvQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGRef 658
Cdd:cd02609  418 -------QLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGLEGAESYIDASTLTTD-- 488
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  659 ddlspEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDD 738
Cdd:cd02609  489 -----EELAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASGSDATRQVAQVVLLDS 563
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373109  739 NFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPD 813
Cdd:cd02609  564 DFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNK 638
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
19-800 2.17e-78

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 275.75  E-value: 2.17e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    19 TAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL-AWF--EEGEETTTAFVEPLVIM 95
Cdd:PRK15122   41 THRQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTdYWLplRRGEETDLTGVIIILTM 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    96 LILvaNAIVGVWQERNAESAIEALKEYEPEMGKVIR---SDRKGVQR-IRARDIVPGDIVEVAVGDKVPADLRLIEikST 171
Cdd:PRK15122  121 VLL--SGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghAGAEPVRReIPMRELVPGDIVHLSAGDMIPADVRLIE--SR 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   172 TLRVDQSILTGESVSVTK-------HTEAIPDPRAVNQ---DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAA 241
Cdd:PRK15122  197 DLFISQAVLTGEALPVEKydtlgavAGKSADALADDEGsllDLPNICFMGTNVVSGTATAVVVATGSRTYFGSLAKSIVG 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   242 VEPErTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGLPAVITTC 318
Cdd:PRK15122  277 TRAQ-TAFDRGVNSVSWLLIRFMLVMVPVVLLIN---------GftkGDWLEALLF----ALAVAVGLTPEMLPMIVSSN 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   319 LALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMsvcrmfvvaeadagsCLLHEFTISGttytpegevrQG 398
Cdd:PRK15122  343 LAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRI---------------ILEHHLDVSG----------RK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   399 DQPVrcgqfdglVELATicalcndsaLDYNEAKGVyekvgeatetaltclvekMNVFDtdlQA-LSRVERAGAcnTVIKQ 477
Cdd:PRK15122  398 DERV--------LQLAW---------LNSFHQSGM------------------KNLMD---QAvVAFAEGNPE--IVKPA 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   478 LMRK--EFTLEFSRDRKSMSVyctptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWgsG 555
Cdd:PRK15122  438 GYRKvdELPFDFVRRRLSVVV-------EDAQGQHLLICKGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAY--N 508
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   556 SDTLRCLALATRDAPPRKEDMEL--DDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV 633
Cdd:PRK15122  509 ADGFRVLLVATREIPGGESRAQYstAD-------ERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTA 581
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   634 AICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKK 713
Cdd:PRK15122  582 KICREVGL------EPGEPLLGTEIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRD 655
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   714 AEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMkqfIRYL---ISSNVGEVVCIfLTAILGLP-EALIP 789
Cdd:PRK15122  656 ADVGISVDSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNI---IKYLnmtASSNFGNVFSV-LVASAFIPfLPMLA 731
                         810
                  ....*....|.
gi 28373109   790 VQLLWVNLVTD 800
Cdd:PRK15122  732 IHLLLQNLMYD 742
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
59-759 1.85e-57

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 211.93  E-value: 1.85e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   59 DLLVrilLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVAnaiVGVWQE----RNAESAIEALKEYEPEMGKVIRSDR 134
Cdd:COG2217  149 DVLV---ALGTLAAFLYSLYATLFGAGHVYFEAAAMIIFLLL---LGRYLEarakGRARAAIRALLSLQPKTARVLRDGE 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  135 kgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEAIpdpravnqdkknmLFSGTNI 214
Cdd:COG2217  223 --EVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS---VDESMLTGESLPVEKTPGDE-------------VFAGTIN 284
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  215 TSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQL---SHAISVICVAVWVINIGHFADpahggsWLRG 291
Cdd:COG2217  285 LDGSLRVRVTKVGSDTTLARIIRLVEEAQSSKAPIQRLADRIARYFvpaVLAIAALTFLVWLLFGGDFST------ALYR 358
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  292 AVyyfkiavalavaaipeglpAV-ITTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTN 359
Cdd:COG2217  359 AV-------------------AVlVIACpcaLGLatptaimvGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEG 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  360 QMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfDGLVELATicalcndSALDYNE---AKGVYEK 436
Cdd:COG2217  420 KPEVTDVVPLDGLDE---------------------------------DELLALAA-------ALEQGSEhplARAIVAA 459
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  437 VGEATETALTClvekmnvfdTDLQALsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGSKMFVKG 516
Cdd:COG2217  460 AKERGLELPEV---------EDFEAI-------------------------------------------PGKGVEATVDG 487
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  517 ApesviercsSVRVGSRT--APLTPTSREQILAKIRDWGSGSDTLRCLALATRdapprkedmelddcskfvqyetdltFV 594
Cdd:COG2217  488 K---------RVLVGSPRllEEEGIDLPEALEERAEELEAEGKTVVYVAVDGR-------------------------LL 533
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  595 GCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrefddlspeqqrqacrtAR 674
Cdd:COG2217  534 GLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI-------------------------------DE 582
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  675 CFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIY 754
Cdd:COG2217  583 VRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMGSGTDVAIEAADIVLMRDDLRGVPDAIRLSRATM 662

                 ....*
gi 28373109  755 SNMKQ 759
Cdd:COG2217  663 RIIRQ 667
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
59-788 9.12e-56

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 203.25  E-value: 9.12e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     59 DLLVrilLLAALVSFVLAWFEEGeetttafvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgVQ 138
Cdd:TIGR01525    2 DTLM---ALAAIAAYAMGLVLEG----------ALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQGDGS-EE 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    139 RIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTeaipdpravnQDKknmLFSGTNITSGK 218
Cdd:TIGR01525   68 EVPVEELQVGDIVIVRPGERIPVDGVVISGESE---VDESALTGESMPVEKKE----------GDE---VFAGTINGDGS 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    219 AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVInighfadPAHGGSWLRGAVYYFki 298
Cdd:TIGR01525  132 LTIRVTKLGEDSTLAQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVV-------WLALGALWREALYRA-- 202
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    299 aVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRmFVVAEADAGSCL 378
Cdd:TIGR01525  203 -LTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVD-IEPLDDASEEEL 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    379 LHeftisgttytpegevrqgdqpvrcgqfdglvelatiCALCNDSALDYNEAKGVYEKVGEATETALTclvekmnvfdTD 458
Cdd:TIGR01525  281 LA------------------------------------LAAALEQSSSHPLARAIVRYAKERGLELPP----------ED 314
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    459 LQALSrveragacntvikqlmrkeftlefsrdrksmsvyctptrphptGQGSKMFVKGAPESVIERCSSvrVGSRTAPLT 538
Cdd:TIGR01525  315 VEEVP-------------------------------------------GKGVEATVDGGREVRIGNPRF--LGNRELAIE 349
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    539 PTSREQILakIRDWGSGSDTLRCLALatrdapprkedmelddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAG 618
Cdd:TIGR01525  350 PISASPDL--LNEGESQGKTVVFVAV-------------------------DGELLGVIALRDQLRPEAKEAIAALKRAG 402
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    619 -IRVVMITGDNKGTAVAICRRLGIfgdTEDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEI 697
Cdd:TIGR01525  403 gIKLVMLTGDNRSAAEAVAAELGI---DDEV---------------------------HAELLPEDKLAIVKKLQEEGGP 452
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    698 TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVcIFL 777
Cdd:TIGR01525  453 VAMVGDGINDAPALAAADVGIAMGSGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIP-LAA 531
                          730
                   ....*....|.
gi 28373109    778 TAILGLPEALI 788
Cdd:TIGR01525  532 GGLLPLWLAVL 542
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
59-788 2.91e-48

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 182.41  E-value: 2.91e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   59 DLLVrilLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEmgKVIRSDRKGVQ 138
Cdd:cd02079   62 DVLV---SLAAIGAFVASLLTPLLGGIGYFEEAAMLLFLFLLGRYLEERARSRARSALKALLSLAPE--TATVLEDGSTE 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  139 RIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEAipdprAVnqdkknmlFSGTNITSGK 218
Cdd:cd02079  137 EVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS---VDESSLTGESLPVEKGAGD-----TV--------FAGTINLNGP 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  219 AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHggsWLRGAVyyfki 298
Cdd:cd02079  201 LTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSL---ALYRAL----- 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  299 avalavaaipeglpAV-ITTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRM 366
Cdd:cd02079  273 --------------AVlVVACpcaLGLatptaivaGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEI 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  367 FVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfdglvelaticalcndsaldyneakgvyekvgeatetalt 446
Cdd:cd02079  339 EPLEGFSE------------------------------------------------------------------------ 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  447 clvekmnvfDTDLQALSRVERAgacntvikqlmrkeftlefsrdrksmsvyctptRPHPTGQGskmFVKGAPESVIErcs 526
Cdd:cd02079  347 ---------DELLALAAALEQH---------------------------------SEHPLARA---IVEAAEEKGLP--- 378
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  527 svrvgsrtaPLTPTSREQILAK-IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSK--FVQYETDLTFVGCVGMLDPP 603
Cdd:cd02079  379 ---------PLEVEDVEEIPGKgISGEVDGREVLIGSLSFAEEEGLVEAADALSDAGKtsAVYVGRDGKLVGLFALEDQL 449
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAH 683
Cdd:cd02079  450 RPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI-------------------------------DEVHAGLLPED 498
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  684 KSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRY 763
Cdd:cd02079  499 KLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAW 578
                        730       740
                 ....*....|....*....|....*
gi 28373109  764 LISSNvgeVVCIFLtAILGLPEALI 788
Cdd:cd02079  579 ALGYN---AIALPL-AALGLLTPWI 599
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
23-857 1.86e-47

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 184.49  E-value: 1.86e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     23 GLSPAQVTGARERYGPNEL----PSEEgKSLWELVLEQFEDLLVRILLLAALVSFVlawfeegeetttafVEPLVIMLIL 98
Cdd:TIGR01657  139 GLTTGDIAQRKAKYGKNEIeipvPSFL-ELLKEEVLHPFYVFQVFSVILWLLDEYY--------------YYSLCIVFMS 203
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     99 VANAIVGVWQERNAESAIEALKeYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAV--GDKVPADLRLIeikSTTLRVD 176
Cdd:TIGR01657  204 STSISLSVYQIRKQMQRLRDMV-HKPQSVIVIRNGKW--VTIASDELVPGDIVSIPRpeEKTMPCDSVLL---SGSCIVN 277
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    177 QSILTGESVSVTKhtEAIPDPRAVNQD-------KKNMLFSGTNI-------TSGKAVGVAVATGLHTELGKIRSQMaaV 242
Cdd:TIGR01657  278 ESMLTGESVPVLK--FPIPDNGDDDEDlflyetsKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQLVRSI--L 353
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    243 EPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHfadpahggswLRGAVYYFKIAVALA--VAAIPEGLPAVITTCLA 320
Cdd:TIGR01657  354 YPKPRVFKFYKDSFKFILFLAVLALIGFIYTIIELI----------KDGRPLGKIILRSLDiiTIVVPPALPAELSIGIN 423
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    321 LGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrMFVVAEADAGSCLLHEFTISGTTytpegevrqgdq 400
Cdd:TIGR01657  424 NSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDL--RGVQGLSGNQEFLKIVTEDSSLK------------ 489
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    401 pvrcgqfdgLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQlmr 480
Cdd:TIGR01657  490 ---------PSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEEDDESAEPTSILAVVRTDDPPQELSIIRR--- 557
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    481 keftLEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERCSSVRVgsrtapltPTSREQILAKIRDWGSgsdtlR 560
Cdd:TIGR01657  558 ----FQFSSALQRMSVIVS----TNDERSPDAFVKGAPETIQSLCSPETV--------PSDYQEVLKSYTREGY-----R 616
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    561 CLALATRDAPPRKEDmELDDCSKfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG 640
Cdd:TIGR01657  617 VLALAYKELPKLTLQ-KAQDLSR-DAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECG 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    641 I-----------FGDTEDVAGK--------------------------------------AYTGREFDDL---SPEQQRQ 668
Cdd:TIGR01657  695 IvnpsntlilaeAEPPESGKPNqikfevidsipfastqveipyplgqdsvedllasryhlAMSGKAFAVLqahSPELLLR 774
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAksAAEMVLSDDNFASIVAAVE 748
Cdd:TIGR01657  775 LLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASV--AAPFTSKLASISCVPNVIR 852
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    749 EGRA-------IYSNMKQ---------FIRYLISSNVGEvvcifltailglpealipVQLLWVNLVTDGLPATALGFNPP 812
Cdd:TIGR01657  853 EGRCalvtsfqMFKYMALysliqfysvSILYLIGSNLGD------------------GQFLTIDLLLIFPVALLMSRNKP 914
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28373109    813 dldiMEKLPRS-PREALISGWLFFR-----YLAIGVYVGLATVAAATWWFV 857
Cdd:TIGR01657  915 ----LKKLSKErPPSNLFSVYILTSvliqfVLHILSQVYLVFELHAQPWYK 961
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 8.84e-47

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.44  E-value: 8.84e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    121 EYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEiksTTLRVDQSILTGESVSVTKHteaipdprav 200
Cdd:pfam00122    1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    201 nqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfa 280
Cdd:pfam00122   66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 28373109    281 dpahggSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARK 329
Cdd:pfam00122  139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
66-759 1.75e-45

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 173.23  E-value: 1.75e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     66 LLAALVSFVLAWFEEGEETTTAFVEPLVIMLILvanaIVGVWQERNAES----AIEALKEYEPEMGKVIRSDrKGVQRIR 141
Cdd:TIGR01511   32 YGYSLVALLANQVLTGLHVHTFFDASAMLITFI----LLGRWLEMLAKGrasdALSKLAKLQPSTATLLTKD-GSIEEVP 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    142 ARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTeaipdpravnQDKknmLFSGTNITSGKAVG 221
Cdd:TIGR01511  107 VALLQPGDIVKVLPGEKIPVDGTVIEGESE---VDESLVTGESLPVPKKV----------GDP---VIAGTVNGTGSLVV 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    222 VAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS---HAISVICVAVWVinighFAdpahggswLRGAVYYFki 298
Cdd:TIGR01511  171 RATATGEDTTLAQIVRLVRQAQQSKAPIQRLADKVAGYFVpvvIAIALITFVIWL-----FA--------LEFAVTVL-- 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    299 avalaVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscl 378
Cdd:TIGR01511  236 -----IIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTV--------------- 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    379 lheftisgTTYTPEGEVRQGDQpvrcgqfdglveLATICALCNDSalDYNEAKGVYEKVGEATETALTClvekmnvfdTD 458
Cdd:TIGR01511  296 --------TDVHVFGDRDRTEL------------LALAAALEAGS--EHPLAKAIVSYAKEKGITLVTV---------SD 344
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    459 LQALsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGSKMFVKGApesviercsSVRVGSrtaplt 538
Cdd:TIGR01511  345 FKAI-------------------------------------------PGIGVEGTVEGT---------KIQLGN------ 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    539 ptsreqilakiRDWgsgsdtlrCLALATRDAPPRKEDMElddcSKFVQYETDLTFVGCVGmlDPPRPEVAACITRCYQAG 618
Cdd:TIGR01511  367 -----------EKL--------LGENAIKIDGKAGQGST----VVLVAVNGELAGVFALE--DQLRPEAKEVIQALKRRG 421
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    619 IRVVMITGDNKGTAVAICRRLGIfgdteDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEIT 698
Cdd:TIGR01511  422 IEPVMLTGDNRKTAKAVAKELGI-----DV---------------------------RAEVLPDDKAALIKKLQEKGPVV 469
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373109    699 AMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:TIGR01511  470 AMVGDGINDAPALAQADVGIAIGAGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQ 530
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
784-987 3.86e-45

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 160.48  E-value: 3.86e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    784 PEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGP 863
Cdd:pfam00689    1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    864 HINFYqlrnflkcsednplfagidcevfesrfptTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMAL 943
Cdd:pfam00689   81 SQNAQ-----------------------------TMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLL 131
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 28373109    944 HFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYL 987
Cdd:pfam00689  132 QLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
33-770 7.37e-45

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 174.36  E-value: 7.37e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   33 RERYGPNELPSEEgKSLWEL----VLEQFedllvrilLLAALVSfVLAWFEEGeetttaFVE-PLVIMLILVANAIVGVW 107
Cdd:cd07542    7 RLIYGPNEIDVPL-KSILKLlfkeVLNPF--------YVFQLFS-VILWSSDD------YYYyAACIVIISVISIFLSLY 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  108 QERNAESAIEALKEYePEMGKVIRsdRKGVQRIRARDIVPGDIVEVAVGDKV-PADLRLIeikSTTLRVDQSILTGESVS 186
Cdd:cd07542   71 ETRKQSKRLREMVHF-TCPVRVIR--DGEWQTISSSELVPGDILVIPDNGTLlPCDAILL---SGSCIVNESMLTGESVP 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  187 VTK-----HTEAIPDPRAVNQD-KKNMLFSGTNI------TSGKAVGVAVATGLHTELGK-IRSQMAavePERTPLQRKL 253
Cdd:cd07542  145 VTKtplpdESNDSLWSIYSIEDhSKHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILY---PKPVDFKFYR 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  254 DefgrqlshAISVICVAVWVINIGHFADpahggswlrgAVYYFKIAVALAVA----------AIPEGLPAVITTCLALGT 323
Cdd:cd07542  222 D--------SMKFILFLAIIALIGFIYT----------LIILILNGESLGEIiiraldiitiVVPPALPAALTVGIIYAQ 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  324 RRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagSCLLhefTISGTtytpegevRQGDQPVr 403
Cdd:cd07542  284 SRLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDL------------WGVR---PVSGN--------NFGDLEV- 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  404 cgqfdglvelaTICALCNDSALDYneakgvyekvGEATETALTC----LVEkmNVFDTDLQALSRVERAGACNTVIKQLm 479
Cdd:cd07542  340 -----------FSLDLDLDSSLPN----------GPLLRAMATChsltLID--GELVGDPLDLKMFEFTGWSLEILRQF- 395
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  480 rkeftlEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERC--SSVrvgsrtapltPTSREQILAKIRDWGsgsd 557
Cdd:cd07542  396 ------PFSSALQRMSVIVK----TPGDDSMMAFTKGAPEMIASLCkpETV----------PSNFQEVLNEYTKQG---- 451
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  558 tLRCLALATRDAPprKEDMELDDCSKfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICR 637
Cdd:cd07542  452 -FRVIALAYKALE--SKTWLLQKLSR-EEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVAR 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  638 RLGIFGDTEdvagKAYTGR---EFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKA 714
Cdd:cd07542  528 ECGMISPSK----KVILIEavkPEDDDSASLTWTLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAA 603
                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373109  715 EIGIAMGSgtAVAKSAAEMVLSDDNFASIVAAVEEGRA-------------IYSnMKQFIR----YLISSNVG 770
Cdd:cd07542  604 DVGISLSE--AEASVAAPFTSKVPDISCVPTVIKEGRAalvtsfscfkymaLYS-LIQFISvlilYSINSNLG 673
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
58-788 1.60e-44

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 170.20  E-value: 1.60e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     58 EDLLVRILLLAALvsFVLAWFEEgeetttafvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrkGV 137
Cdd:TIGR01512    1 VDLLMALAALGAV--AIGEYLEG-----------ALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGD--SL 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    138 QRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEaipdpravnqDKknmLFSGTNITSG 217
Cdd:TIGR01512   66 EEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS---VDESALTGESVPVEKAPG----------DE---VFAGAINLDG 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    218 KAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadPAHGGSWLRGAVYYFk 297
Cdd:TIGR01512  130 VLTIEVTKLPADSTIAKIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVP------PLLGAGPFLEWIYRA- 202
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    298 iaVALAVAAIPEGLpaVITTCLAL--GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRmFVVAEADAG 375
Cdd:TIGR01512  203 --LVLLVVASPCAL--VISAPAAYlsAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD-VHPADGHSE 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    376 SCLLHEFTISGTTYTpegevrqgdQPVrcgqfdglvelaticalcNDSALDYNEAKGVYEKVGEATEtaltclvekmnvf 455
Cdd:TIGR01512  278 SEVLRLAAAAEQGST---------HPL------------------ARAIVDYARARELAPPVEDVEE------------- 317
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    456 dtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphPTGQGSKMFVKGApesviercsSVRVGSRTA 535
Cdd:TIGR01512  318 -------------------------------------------------VPGEGVRAVVDGG---------EVRIGNPRS 339
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    536 pltptSREQILAKIRDWGSGSDTlrcLALATRDApprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCY 615
Cdd:TIGR01512  340 -----LSEAVGASIAVPESAGKT---IVLVARDG----------------------TLLGYIALSDELRPDAAEAIAELK 389
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    616 QAGI-RVVMITGDNKGTAVAICRRLGIfgdTEDVAgkaytgrefdDLSPEQqrqacrtarcfarvepahKSRIVENLQSF 694
Cdd:TIGR01512  390 ALGIkRLVMLTGDRRAVAEAVARELGI---DEVHA----------ELLPED------------------KLEIVKELREK 438
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    695 NEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGeVV 773
Cdd:TIGR01512  439 AGPVAMVGDGINDAPALAAADVGIAMGaSGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILV-LI 517
                          730
                   ....*....|....*
gi 28373109    774 CIFLTAILGLPEALI 788
Cdd:TIGR01512  518 LLALFGVLPLWLAVL 532
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
92-759 1.15e-41

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 163.03  E-value: 1.15e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   92 LVIMLILVanaivGVWQE----RNAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIE 167
Cdd:cd02094  107 VIITFILL-----GKYLEarakGKTSEAIKKLLGLQPKTARVIRDG--KEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVE 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  168 IKSTtlrVDQSILTGESVSVTKHTEaipdpravnqDKknmLFSGTNITSGKAVGVAVATGLHTELGKIrsqMAAVEpE-- 245
Cdd:cd02094  180 GESS---VDESMLTGESLPVEKKPG----------DK---VIGGTINGNGSLLVRATRVGADTTLAQI---IRLVE-Eaq 239
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  246 --RTPLQRKLDefgrQLS-------HAISVICVAVWVInIGHFADPAHGgswLRGAVyyfkiavalavaaipeglpAV-I 315
Cdd:cd02094  240 gsKAPIQRLAD----RVSgvfvpvvIAIAILTFLVWLL-LGPEPALTFA---LVAAV-------------------AVlV 292
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  316 TTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGscllhefti 384
Cdd:cd02094  293 IACpcaLGLatptaimvGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED--------- 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  385 sgttytpegevrqgdqpvrcgqfdglvELATICAlcndSALDYNE---AKGVYEKVGEATETALTClvekmnvfdTDLQA 461
Cdd:cd02094  364 ---------------------------ELLRLAA----SLEQGSEhplAKAIVAAAKEKGLELPEV---------EDFEA 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  462 LsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGskmfVKGAPESViercsSVRVGSRtapltpts 541
Cdd:cd02094  404 I-------------------------------------------PGKG----VRGTVDGR-----RVLVGNR-------- 423
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  542 reqilAKIRDWG--SGSDTLRCLALATRDAPPrkedmelddcskfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGI 619
Cdd:cd02094  424 -----RLMEENGidLSALEAEALALEEEGKTV-------------VLVAVDGELAGLIAVADPLKPDAAEAIEALKKMGI 485
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  620 RVVMITGDNKGTAVAICRRLGIfgdtEDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITA 699
Cdd:cd02094  486 KVVMLTGDNRRTARAIAKELGI----DEV---------------------------IAEVLPEDKAEKVKKLQAQGKKVA 534
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  700 MTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd02094  535 MVGDGINDAPALAQADVGIAIGSGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIKQ 594
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
92-846 3.58e-38

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 153.90  E-value: 3.58e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   92 LVIMLILVANAIVGVWQERNAESAIEALKeYEPEMGKVIRSDRKgVQRIRARDIVPGDIVEVAV-GDKVPADLRLIEiks 170
Cdd:cd02082   54 ITVVFMTTINSLSCIYIRGVMQKELKDAC-LNNTSVIVQRHGYQ-EITIASNMIVPGDIVLIKRrEVTLPCDCVLLE--- 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  171 TTLRVDQSILTGESVSVTKhtEAIPDP----RAVNQD--KKNMLFSGTNI------TSGKAVGVAVATGLHTELGKIRsq 238
Cdd:cd02082  129 GSCIVTEAMLTGESVPIGK--CQIPTDshddVLFKYEssKSHTLFQGTQVmqiippEDDILKAIVVRTGFGTSKGQLI-- 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  239 maavepeRTPLQRKLDEFGRQLSHAISVICVAVwvinighFADPAHGGSWLRG------AVYYFKIAVALAVAAIPEGLP 312
Cdd:cd02082  205 -------RAILYPKPFNKKFQQQAVKFTLLLAT-------LALIGFLYTLIRLldielpPLFIAFEFLDILTYSVPPGLP 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  313 AVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAdagscllHEFTisgttytpe 392
Cdd:cd02082  271 MLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQN-------QTFD--------- 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  393 gevrqgdqPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTclvekmnvFDTDLQALSRVERAGACN 472
Cdd:cd02082  335 --------PIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMAEASTWD--------LDYDHEAKQHYSKSGTKR 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  473 TVIKQlmrkefTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltPTSREQILAKIRDW 552
Cdd:cd02082  399 FYIIQ------VFQFHSALQRMSVVAKEVDMITKDFKHYAFIKGAPEKIQSLFSHV----------PSDEKAQLSTLINE 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  553 GSgsdtlRCLALATRDAPPRKEDMELDdcSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTA 632
Cdd:cd02082  463 GY-----RVLALGYKELPQSEIDAFLD--LSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTA 535
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  633 VAICRRLGIFGdtedvagKAYTGREFDDLSPEQQRQACRTAR------CFARVEPAHKSRIVENLQSFNEITAMTGDGVN 706
Cdd:cd02082  536 LKVAQELEIIN-------RKNPTIIIHLLIPEIQKDNSTQWIliihtnVFARTAPEQKQTIIRLLKESDYIVCMCGDGAN 608
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  707 DAPALKKAEIGIAMGSGTavAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA 786
Cdd:cd02082  609 DCGALKEADVGISLAEAD--ASFASPFTSKSTSISCVKRVILEGRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYS 686
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28373109  787 LIPVQLLWVNLVTDGLPATALGFNPPdLDIMEKLPR---SPREALISGWLFFRYLA-IGVYVGL 846
Cdd:cd02082  687 SSGQMDWQLLAAGYFLVYLRLGCNTP-LKKLEKDDNlfsIYNVTSVLFGFTLHILSiVGCVESL 749
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
124-720 5.01e-37

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 150.61  E-value: 5.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  124 PEMGKVIRsDRKGVQrIRARDIVPGDIVEV---AVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTKHT-EAIPDPRA 199
Cdd:cd07543   85 PYTIQVYR-DGKWVP-ISSDELLPGDLVSIgrsAEDNLVPCDLLLL---RGSCIVNEAMLTGESVPLMKEPiEDRDPEDV 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  200 V---NQDKKNMLFSGTNI-------------TSGKAVGVAVATGLHTELGK-IRSQMAAVEpERTPLQRKldefgrqlsh 262
Cdd:cd07543  160 LdddGDDKLHVLFGGTKVvqhtppgkgglkpPDGGCLAYVLRTGFETSQGKlLRTILFSTE-RVTANNLE---------- 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  263 aiSVICVAVWVInighFADPAHGGSWLRGA----VYY--FKIAVALAVAAIPEGLPavittclalgtrrMARKNAIVRSL 336
Cdd:cd07543  229 --TFIFILFLLV----FAIAAAAYVWIEGTkdgrSRYklFLECTLILTSVVPPELP-------------MELSLAVNTSL 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  337 PSVETLG--CT-----------SVICSDKTGTLTTNQMSVcrmfvvaeadAGscllheftISGTTYTPEGEVRQGDQPVR 403
Cdd:cd07543  290 IALAKLYifCTepfripfagkvDICCFDKTGTLTSDDLVV----------EG--------VAGLNDGKEVIPVSSIEPVE 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  404 CGQfdglvelatICALCNdSALDYNEAKGVYEKVGEATETALTCLVEKMNVFdtdlqalsrVERAGACNTVikQLMRKef 483
Cdd:cd07543  352 TIL---------VLASCH-SLVKLDDGKLVGDPLEKATLEAVDWTLTKDEKV---------FPRSKKTKGL--KIIQR-- 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  484 tLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltPTSREQILAKIRDWGSgsdtlRCLA 563
Cdd:cd07543  409 -FHFSSALKRMSVVASYKDPGSTDLKYIVAVKGAPETLKSMLSDV----------PADYDEVYKEYTRQGS-----RVLA 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  564 LATRD----APPRKEDMELDDcskfvqYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRL 639
Cdd:cd07543  473 LGYKElghlTKQQARDYKRED------VESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKEL 546
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  640 GIfgdtedvAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIA 719
Cdd:cd07543  547 GI-------VDKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVA 619

                 .
gi 28373109  720 M 720
Cdd:cd07543  620 L 620
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
50-783 4.94e-36

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 145.47  E-value: 4.94e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   50 WELVLEQFEDLL------VRIL-LLAALVSFVLAWFEEGeetttafvePLVIMLILVANAIVGVWQERnAESAIEALKEY 122
Cdd:cd07551   40 YASAKEGIEATLrkktlnVDLLmILAAIGAAAIGYWAEG---------ALLIFIFSLSHALEDYAMGR-SKRAITALMQL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  123 EPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHteaIPDPravnq 202
Cdd:cd07551  110 APETARRIQRD-GEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSSS---IDEASITGESIPVEKT---PGDE----- 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  203 dkknmLFSGTnITSGKAVGVAVaTGLHTE--LGKIRSQMAAVEPERTPLQRKLDEFGRQlsHAISVICVAVWVINIGHFA 280
Cdd:cd07551  178 -----VFAGT-INGSGALTVRV-TKLSSDtvFAKIVQLVEEAQSEKSPTQSFIERFERI--YVKGVLLAVLLLLLLPPFL 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  281 DpahGGSW----LRGAVYyfkiavalAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTL 356
Cdd:cd07551  249 L---GWTWadsfYRAMVF--------LVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  357 TTNQMSVcrmfvvaeadagscllheftisgTTYTPEGEVRQgdqpvrcgqfdglvelaticalcndsaldyneakgvyEK 436
Cdd:cd07551  318 TEGKPRV-----------------------TDVIPAEGVDE-------------------------------------EE 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  437 VgeatetaltclvekmnvfdtdLQALSRVERAGacNTVIKQLMRKEFTLEFSRDRKSMSVyctptrPHPTGQGSKMFVKG 516
Cdd:cd07551  338 L---------------------LQVAAAAESQS--EHPLAQAIVRYAEERGIPRLPAIEV------EAVTGKGVTATVDG 388
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  517 ApesviercsSVRVGSrtapltPTSREQILakirdwgsgsDTLRCLALATRDAPPRKEDMelddcskFVQyeTDLTFVGC 596
Cdd:cd07551  389 Q---------TYRIGK------PGFFGEVG----------IPSEAAALAAELESEGKTVV-------YVA--RDDQVVGL 434
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  597 VGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdTEDVAGkaytgrefddLSPEQqrqacrtarcf 676
Cdd:cd07551  435 IALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI---DEVVAN----------LLPED----------- 490
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  677 arvepahKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRaiysN 756
Cdd:cd07551  491 -------KVAIIRELQQEYGTVAMVGDGINDAPALANADVGIAMGAGTDVALETADVVLMKDDLSKLPYAIRLSR----K 559
                        730       740
                 ....*....|....*....|....*..
gi 28373109  757 MKQFIRYLISSNVGEVVCIFLTAILGL 783
Cdd:cd07551  560 MRRIIKQNLIFALAVIALLIVANLFGL 586
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
92-807 5.98e-33

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 136.00  E-value: 5.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   92 LVIMLILVANAIVGVWQERnAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKST 171
Cdd:cd07546   67 MVLLLFLVGELLEGYAASR-ARSGVKALMALVPETALREENG--ERREVPADSLRPGDVIEVAPGGRLPADGELLSGFAS 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  172 tlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKA-VGVAVATGLHTeLGKIRSQMAAVEPERTPLQ 250
Cdd:cd07546  144 ---FDESALTGESIPVEK-------------AAGDKVFAGSINVDGVLrIRVTSAPGDNA-IDRILHLIEEAEERRAPIE 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  251 RKLDEFGRQLSHAISVICVAVWVInighfadP--AHGGSW----LRGavyyfkiaVALAVAAIPEGL----PAVITTCLA 320
Cdd:cd07546  207 RFIDRFSRWYTPAIMAVALLVIVV-------PplLFGADWqtwiYRG--------LALLLIGCPCALvistPAAITSGLA 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  321 LGTRRmarkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPegevrqgdq 400
Cdd:cd07546  272 AAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTDVVPLTGISEAELLALAAAVEMGSSHP--------- 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  401 pvrcgqfdglveLATicALcndsaldyneakgvyekVGEATETALtclvekmnvfdTDLQALSRVERAgacntvikqlmr 480
Cdd:cd07546  339 ------------LAQ--AI-----------------VARAQAAGL-----------TIPPAEEARALV------------ 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  481 keftlefsrdrksmsvyctptrphptGQGSKMFVKGAPesvIERCSSVRVGSRtapLTPTSREQILAkIRDWGsgsdtlR 560
Cdd:cd07546  365 --------------------------GRGIEGQVDGER---VLIGAPKFAADR---GTLEVQGRIAA-LEQAG------K 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  561 CLALATRDAPPrkedmelddcskfvqyetdltfVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG 640
Cdd:cd07546  406 TVVVVLANGRV----------------------LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELG 463
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  641 IfgdtedvagkaytgrEFDdlspeqqrqacrtarcfARVEPAHKSRIVENLQSfNEITAMTGDGVNDAPALKKAEIGIAM 720
Cdd:cd07546  464 L---------------DFR-----------------AGLLPEDKVKAVRELAQ-HGPVAMVGDGINDAPAMKAASIGIAM 510
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  721 GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISsnvgeVVCIFL-TAILGLPEalipvqlLWVNLVT 799
Cdd:cd07546  511 GSGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALG-----LKAVFLvTTLLGITG-------LWLAVLA 578

                 ....*...
gi 28373109  800 DGlPATAL 807
Cdd:cd07546  579 DT-GATVL 585
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
92-800 2.00e-29

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 124.84  E-value: 2.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   92 LVIMLILVANAIVGVWQERnAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKST 171
Cdd:cd07545   64 MVVFLFAISEALEAYSMDR-ARRSIRSLMDIAPKTALVRRDGQE--REVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  172 tlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGkAVGVAV-ATGLHTELGKIRSQMAAVEPERTPLQ 250
Cdd:cd07545  141 ---VNQAAITGESLPVEK-------------GVGDEVFAGTLNGEG-ALEVRVtKPAEDSTIARIIHLVEEAQAERAPTQ 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  251 RKLDEFGRQLSHAISVICVAVWVINIGHFadpahGGSWLrGAVYyfkIAVALAVAAIPEGLpaVITTCL----ALGTrrM 326
Cdd:cd07545  204 AFVDRFARYYTPVVMAIAALVAIVPPLFF-----GGAWF-TWIY---RGLALLVVACPCAL--VISTPVsivsAIGN--A 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADagscllheftisgttytpEGEVrqgdqpvrcgq 406
Cdd:cd07545  271 ARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLGGQT------------------EKEL----------- 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  407 fdglveLATICALcnDSALDYNEAKGVyekVGEATETALTclvekmnvfdtdlqaLSRVEragacntvikqlmrkEFTle 486
Cdd:cd07545  322 ------LAIAAAL--EYRSEHPLASAI---VKKAEQRGLT---------------LSAVE---------------EFT-- 358
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  487 fsrdrkSMsvyctptrphpTGQGSKMFVKGapesviercSSVRVGSR------TAPLTPTSREQILAkIRDWGSGSdtlr 560
Cdd:cd07545  359 ------AL-----------TGRGVRGVVNG---------TTYYIGSPrlfeelNLSESPALEAKLDA-LQNQGKTV---- 407
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  561 cLALATRDapprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRL 639
Cdd:cd07545  408 -MILGDGE-----------------------RILGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQV 463
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  640 GIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIA 719
Cdd:cd07545  464 GV-------------------------------SDIRAELLPQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIA 512
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  720 MGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQfirylissNVGEVVCIFLTAILglpeALIPVQL-LWVNL 797
Cdd:cd07545  513 MGAaGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQ--------NIAFALGIKLIALL----LVIPGWLtLWMAV 580

                 ...
gi 28373109  798 VTD 800
Cdd:cd07545  581 FAD 583
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
93-759 1.44e-28

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 122.80  E-value: 1.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   93 VIMLIlvanaivGVWQERN----AESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEI 168
Cdd:cd07552  102 VIMLL-------GHWIEMKavmgAGDALKKLAELLPKTAHLVTDG--SIEDVPVSELKVGDVVLVRAGEKIPADGTILEG 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  169 KSttlRVDQSILTGESvsvtkhteaipdpRAVNQDKKNMLFSGTnITSGKAVGVAV-ATGLHTELGKIRSQMAAVEPERT 247
Cdd:cd07552  173 ES---SVNESMVTGES-------------KPVEKKPGDEVIGGS-VNGNGTLEVKVtKTGEDSYLSQVMELVAQAQASKS 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  248 PLQRKLDEFGRQLSHA---ISVICVAVWVInIGHFADPahggswLRGAVYYFkiavalaVAAIPEGLPAVITTCLALGTR 324
Cdd:cd07552  236 RAENLADKVAGWLFYIalgVGIIAFIIWLI-LGDLAFA------LERAVTVL-------VIACPHALGLAIPLVVARSTS 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadagscllheftisgttytpegevrqgdqpvrc 404
Cdd:cd07552  302 IAAKNGLLIRNREALERARDIDVVLFDKTGTLTE---------------------------------------------- 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  405 GQFdGLVELATICALCNDSALDYNEAkgvyekvgeatetaltclvekmnvfdtdLQALSRVERAGACNTVIKQlmrKEFT 484
Cdd:cd07552  336 GKF-GVTDVITFDEYDEDEILSLAAA----------------------------LEAGSEHPLAQAIVSAAKE---KGIR 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  485 LEFSRDRKSMSvyctptrphptGQGSKMFVKGapesviercSSVRVGSR--TAPLTPTSREQILAKIRDWGSgsdTLrcl 562
Cdd:cd07552  384 PVEVENFENIP-----------GVGVEGTVNG---------KRYQVVSPkyLKELGLKYDEELVKRLAQQGN---TV--- 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  563 alatrdapprkedmelddcsKFVQYETDLtfVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIf 642
Cdd:cd07552  438 --------------------SFLIQDGEV--IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGI- 494
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  643 gdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd07552  495 ------------------------------DEYFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIGA 544
                        650       660       670
                 ....*....|....*....|....*....|....*..
gi 28373109  723 GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd07552  545 GTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQ 581
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
84-787 2.70e-28

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 121.23  E-value: 2.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   84 TTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADL 163
Cdd:cd07550   59 LTGDYLAANTIAFLLELGELLEDYTARKSEKALLDLLSPQERTVWVERDGV--EVEVPADEVQPGDTVVVGAGDVIPVDG 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  164 RLIEIKSTtlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVE 243
Cdd:cd07550  137 TVLSGEAL---IDQASLTGESLPVEK-------------REGDLVFASTVVEEGQLVIRAERVGRETRAARIAELIEQSP 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  244 PERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahgGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTClalgt 323
Cdd:cd07550  201 SLKARIQNYAERLADRLVPPTLGLAGLVYALT----------GDISRAAAVLLVDFSCGIRLSTPVAVLSALNHA----- 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  324 rrmARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftisgttytpegevrqgdQPVR 403
Cdd:cd07550  266 ---ARHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEV------------------------------------TAII 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  404 CgqFDGLVELATICALcndsaldyneAKGVYEKVGEATETALtclvekmnvfdtdlqaLSRVERAGacntvIKQLMRKEf 483
Cdd:cd07550  307 T--FDGRLSEEDLLYL----------AASAEEHFPHPVARAI----------------VREAEERG-----IEHPEHEE- 352
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  484 tLEFSrdrksmsvyctptrphpTGQGSKMFVKGAPesviercssVRVGSR------TAPLTPTsreqILAKIRDWGSGSD 557
Cdd:cd07550  353 -VEYI-----------------VGHGIASTVDGKR---------IRVGSRhfmeeeEIILIPE----VDELIEDLHAEGK 401
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  558 TLRCLALATRdapprkedmelddcskfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAG-IRVVMITGDNKGTAVAIC 636
Cdd:cd07550  402 SLLYVAIDGR-------------------------LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA 456
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  637 RRLGIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEI 716
Cdd:cd07550  457 EQLGI-------------------------------DRYHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADV 505
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373109  717 GIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGevvCIFLTAILGLPEAL 787
Cdd:cd07550  506 GISMRGGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTA---VLAGGVFGLLSPIL 573
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
418-528 3.20e-28

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 108.85  E-value: 3.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    418 ALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMnvfdtdlqalsrveraGACNTVIKQLMRKEFTLEFSRDRKSMSVY 497
Cdd:pfam13246    1 ALCNSAAFDENEEKGKWEIVGDPTESALLVFAEKM----------------GIDVEELRKDYPRVAEIPFNSDRKRMSTV 64
                           90       100       110
                   ....*....|....*....|....*....|.
gi 28373109    498 CTPtrphPTGQGSKMFVKGAPESVIERCSSV 528
Cdd:pfam13246   65 HKL----PDDGKYRLFVKGAPEIILDRCTTI 91
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
128-728 1.57e-26

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 117.27  E-value: 1.57e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  128 KVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRL-----------IEIKS----TTLRVDQSILTGESVSVTKHTE 192
Cdd:cd02073   84 PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLlsssepdglcyVETANldgeTNLKIRQALPETALLLSEEDLA 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  193 A----------------------IPDPRAVNQDKKNMLFSGTNI-TSGKAVGVAVATGLHTEL----GKIRSQmaavepe 245
Cdd:cd02073  164 RfsgeieceqpnndlytfngtleLNGGRELPLSPDNLLLRGCTLrNTEWVYGVVVYTGHETKLmlnsGGTPLK------- 236
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  246 RTPLQRKLDE-----FGRQLSHA-ISVICVAVWVINIGHFA---DPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVIT 316
Cdd:cd02073  237 RSSIEKKMNRfiiaiFCILIVMClISAIGKGIWLSKHGRDLwylLPKEERSPALEFFFDFLTFIILYNNLIPISLYVTIE 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  317 TCLALGTRRMA----------RKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFVvaeadagscllhEFTISG 386
Cdd:cd02073  317 VVKFLQSFFINwdldmydeetDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIME----FK------------KCSING 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  387 TTYtpegevrqgdqpvrcgQFdgLVELAticaLCNdsaldyneakgvyekvgeatetalTCLVEKMNVFDTDL-QALSRV 465
Cdd:cd02073  381 VDY----------------GF--FLALA----LCH------------------------TVVPEKDDHPGQLVyQASSPD 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  466 ERA---GACN-----------TVIKQLM--RKEF----TLEFSRDRKSMSVYCTptrpHPTGQgSKMFVKGAPESVIERC 525
Cdd:cd02073  415 EAAlveAARDlgfvflsrtpdTVTINALgeEEEYeilhILEFNSDRKRMSVIVR----DPDGR-ILLYCKGADSVIFERL 489
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  526 SSvrvgsRTAPLtptsREQILAKIRDWGSgsDTLRCLALATRDAPP-------------------RKEdmELDDCSKFVq 586
Cdd:cd02073  490 SP-----SSLEL----VEKTQEHLEDFAS--EGLRTLCLAYREISEeeyeewnekydeastalqnREE--LLDEVAEEI- 555
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  587 yETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAIC------------RRLGIFGDTEDVAGKAYT 654
Cdd:cd02073  556 -EKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGyscrllsedmenLALVIDGKTLTYALDPEL 634
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  655 GREFDDLSpeqqrQACRTARCfARVEPAHKSRIVENLQSF-NEITAMTGDGVNDAPALKKAEIGI----------AMGSG 723
Cdd:cd02073  635 ERLFLELA-----LKCKAVIC-CRVSPLQKALVVKLVKKSkKAVTLAIGDGANDVSMIQEAHVGVgisgqegmqaARASD 708

                 ....*
gi 28373109  724 TAVAK 728
Cdd:cd02073  709 YAIAQ 713
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
92-807 3.84e-25

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 112.39  E-value: 3.84e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    92 LVIMLILVANAIVGvWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIeikST 171
Cdd:PRK11033  211 MVLLLFLIGERLEG-YAASRARRGVSALMALVPETATRLRDGER--EEVAIADLRPGDVIEVAAGGRLPADGKLL---SP 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   172 TLRVDQSILTGESVSVTKHT-EAIPdPRAVNQDKKNMLfsgtNITSGKAvgvavatglHTELGKIRSQMAAVEPERTPLQ 250
Cdd:PRK11033  285 FASFDESALTGESIPVERATgEKVP-AGATSVDRLVTL----EVLSEPG---------ASAIDRILHLIEEAEERRAPIE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPahggsWLrGAVYyfkiavalavaaipEGL---------------PAVI 315
Cdd:PRK11033  351 RFIDRFSRIYTPAIMLVALLVILVPPLLFAAP-----WQ-EWIY--------------RGLtllligcpcalvistPAAI 410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   316 TTCLALGTRRmarkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEadagscllheftisgttytpegev 395
Cdd:PRK11033  411 TSGLAAAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATG------------------------ 462
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   396 rqgdqpvrcgqfdglvelaticalcndsaldyneakgvyekVGEATETALTCLVEkmnVFDTDLQALSRVERAGAcntvi 475
Cdd:PRK11033  463 -----------------------------------------ISESELLALAAAVE---QGSTHPLAQAIVREAQV----- 493
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   476 kqlmrKEFTLEFSRDRKSMSvyctptrphptGQGSKMFVKGapeSVIERCSSvrvgSRTAPLTPtsreQILAKIRDWGSG 555
Cdd:PRK11033  494 -----RGLAIPEAESQRALA-----------GSGIEGQVNG---ERVLICAP----GKLPPLAD----AFAGQINELESA 546
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   556 SDTLrclALATRDApprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:PRK11033  547 GKTV---VLVLRND----------------------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAI 601
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   636 CRRLGIfgdtedvagkaytgrEFDdlspeqqrqacrtarcfARVEPAHKSRIVENLQSfNEITAMTGDGVNDAPALKKAE 715
Cdd:PRK11033  602 AGELGI---------------DFR-----------------AGLLPEDKVKAVTELNQ-HAPLAMVGDGINDAPAMKAAS 648
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNmkqfIRYLISSNVGeVVCIFL-TAILGLPEalipvqlLW 794
Cdd:PRK11033  649 IGIAMGSGTDVALETADAALTHNRLRGLAQMIELSRATHAN----IRQNITIALG-LKAIFLvTTLLGITG-------LW 716
                         730
                  ....*....|...
gi 28373109   795 VNLVTDGlPATAL 807
Cdd:PRK11033  717 LAVLADS-GATAL 728
copA PRK10671
copper-exporting P-type ATPase CopA;
601-759 7.28e-22

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 102.13  E-value: 7.28e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdTEDVAGkaytgrefddlspeqqrqacrtarcfarVE 680
Cdd:PRK10671  649 DPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI---DEVIAG----------------------------VL 697
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28373109   681 PAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:PRK10671  698 PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQ 776
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
117-753 8.01e-22

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 101.57  E-value: 8.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  117 EALKEYEPE-MGKVIRSDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIE-IKSttlrVDQSILTGESVSVTKhtEAI 194
Cdd:cd02078   86 DSLRKTKTEtQAKRLRNDGK-IEKVPATDLKKGDIVLVEAGDIIPADGEVIEgVAS----VDESAITGESAPVIR--ESG 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  195 PDPRAVNqdkknmlfSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVI 274
Cdd:cd02078  159 GDRSSVT--------GGTKVLSDRIKVRITANPGETFLDRMIALVEGASRQKTPNEIALTILLVGLTLIFLIVVATLPPF 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  275 nighfadpahggswlrgAVYYfkiavalavaaipeGLPAVITTCLAL-------------------GTRRMARKNAIVRS 335
Cdd:cd02078  231 -----------------AEYS--------------GAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKS 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  336 LPSVETLGCTSVICSDKTGTLTT-NQMSvcrmfvvaeadagscllheftisgTTYTPEGEVRqgdqpvrcgqfdgLVELA 414
Cdd:cd02078  280 GRAVEAAGDVDTLLLDKTGTITLgNRQA------------------------TEFIPVGGVD-------------EKELA 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  415 TICALCndSALDYN-EAKGVYEkvgeatetaltcLVEKMNVFDTDLQalsrveRAGAcntvikqlmrkEFtLEFSRDRKs 493
Cdd:cd02078  323 DAAQLA--SLADETpEGRSIVI------------LAKQLGGTERDLD------LSGA-----------EF-IPFSAETR- 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  494 MSVYCTPtrphptgqGSKMFVKGAPESVIERCSSvRVGSrtaplTPTSREQILAKIRDWGSGSdtlrcLALATRDapprk 573
Cdd:cd02078  370 MSGVDLP--------DGTEIRKGAVDAIRKYVRS-LGGS-----IPEELEAIVEEISKQGGTP-----LVVAEDD----- 425
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  574 edmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkay 653
Cdd:cd02078  426 ------------------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV------------ 475
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  654 tgrefDDLspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEM 733
Cdd:cd02078  476 -----DDF--------------LAEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAGNM 536
                        650       660
                 ....*....|....*....|
gi 28373109  734 VLSDDNFASIVAAVEEGRAI 753
Cdd:cd02078  537 VDLDSDPTKLIEVVEIGKQL 556
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
110-794 8.99e-21

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 97.78  E-value: 8.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  110 RNAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTK 189
Cdd:cd07544   95 RRASRELTALLDRAPRIAHRLVGG--QLEEVPVEEVTVGDRLLVRPGEVVPVDGEVV---SGTATLDESSLTGESKPVSK 169
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  190 HteaipdpravnqdkknmlfSGTNITSGKAVG------VAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHA 263
Cdd:cd07544  170 R-------------------PGDRVMSGAVNGdsaltmVATKLAADSQYAGIVRLVKEAQANPAPFVRLADRYAVPFTLL 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  264 ISVICVAVWVINighfADPAHGGSWLRGAvyyfkiavalavaaIPegLPAVITTCLAL--GTRRMARKNAIVRSLPSVET 341
Cdd:cd07544  231 ALAIAGVAWAVS----GDPVRFAAVLVVA--------------TP--CPLILAAPVAIvsGMSRSSRRGILVKDGGVLEK 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  342 LGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfDGLVELAticalcn 421
Cdd:cd07544  291 LARAKTVAFDKTGTLTYGQPKVVDVVPAPGVDA---------------------------------DEVLRLA------- 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  422 dSALDYNEAKGVYEKVGEATETALTclvekmnvfdtDLQALSRVERagacntvikqlmrkeftlefsrdrksmsvyctpt 501
Cdd:cd07544  331 -ASVEQYSSHVLARAIVAAAREREL-----------QLSAVTELTE---------------------------------- 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  502 rphPTGQGSKMFVKGApesviercsSVRVGSRTapltptsreqiLAKIRDWGSgsdtlrclalatrdapPRKEDMELDDC 581
Cdd:cd07544  365 ---VPGAGVTGTVDGH---------EVKVGKLK-----------FVLARGAWA----------------PDIRNRPLGGT 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  582 SKFVQyeTDLTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRLGIfgdtEDVAGkaytgrefdD 660
Cdd:cd07544  406 AVYVS--VDGKYAGAITLRDEVRPEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEVGI----DEVRA---------E 470
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  661 LSPEQqrqacrtarcfarvepahKSRIVENLQSfNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKS-AAEMVLSDDN 739
Cdd:cd07544  471 LLPED------------------KLAAVKEAPK-AGPTIMVGDGVNDAPALAAADVGIAMGARGSTAASeAADVVILVDD 531
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28373109  740 FASIVAAVeegrAIYSNMKQFIryLISSNVGEVVCI---------FLTAILG--LPEALIPVQLLW 794
Cdd:cd07544  532 LDRVVDAV----AIARRTRRIA--LQSVLIGMALSIigmliaafgLIPPVAGalLQEVIDVVSILN 591
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
4-71 2.96e-19

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 82.61  E-value: 2.96e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28373109      4 AHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALV 71
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
97-751 1.42e-18

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 91.10  E-value: 1.42e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     97 ILVANAIVGVWQERNAESAiEALKEYEPE-MGKVIRSDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrV 175
Cdd:TIGR01497   77 VLFANFAEAVAEGRGKAQA-DSLKGTKKTtFAKLLRDDGA-IDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGVAS---V 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    176 DQSILTGESVSVTKhtEAIPDPRAVNqdkknmlfSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDE 255
Cdd:TIGR01497  152 DESAITGESAPVIK--ESGGDFASVT--------GGTRILSDWLVVECTANPGETFLDRMIALVEGAQRRKTPNEIALTI 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    256 FGRQLSHAISVICVAVWVinighFAdpAHGGSWLRGAVyyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRS 335
Cdd:TIGR01497  222 LLIALTLVFLLVTATLWP-----FA--AYGGNAISVTV-----LVALLVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATS 289
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    336 LPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadaGSCLLHEFTisgttytpegevrqgdqPVRCGQFDGLVELAT 415
Cdd:TIGR01497  290 GRAVEACGDVDTLLLDKTGTITL----------------GNRLASEFI-----------------PAQGVDEKTLADAAQ 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    416 ICALCNDSAldynEAKGVYEkvgeatetaltcLVEKMNVFDTDLQALSrveragacntvikqlmrKEFtLEFSRDRKsMS 495
Cdd:TIGR01497  337 LASLADDTP----EGKSIVI------------LAKQLGIREDDVQSLH-----------------ATF-VEFTAQTR-MS 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    496 VYCTPtrphptgqGSKMFVKGAPESvIERcssvRVGSRTAPLtPTSREQILAKIRDWGsGSDTLRCLalatrdapprked 575
Cdd:TIGR01497  382 GINLD--------NGRMIRKGAVDA-IKR----HVEANGGHI-PTDLDQAVDQVARQG-GTPLVVCE------------- 433
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    576 melddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytg 655
Cdd:TIGR01497  434 --------------DNRIYGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV-------------- 485
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    656 refDDLspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVL 735
Cdd:TIGR01497  486 ---DDF--------------IAEATPEDKIALIRQEQAEGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAANMVD 548
                          650
                   ....*....|....*.
gi 28373109    736 SDDNFASIVAAVEEGR 751
Cdd:TIGR01497  549 LDSDPTKLIEVVHIGK 564
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
110-759 4.83e-18

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 89.34  E-value: 4.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  110 RNAESAIEALKEYEPEMGKVIRSDrkGVQR-IRARDIVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVT 188
Cdd:cd02092  111 GRARSAAEELAALEARGAQRLQAD--GSREyVPVAEIRPGDRVLVAAGERIPVDGTVV---SGTSELDRSLLTGESAPVT 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  189 KHTEAipdpravnqdkknMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS---HAIS 265
Cdd:cd02092  186 VAPGD-------------LVQAGAMNLSGPLRLRATAAGDDTLLAEIARLMEAAEQGRSRYVRLADRAARLYApvvHLLA 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  266 VICVAVWVInighfadpaHGGSWlRGAVyyfkiavalavaaipegLPAV---ITTC-LALG----------TRRMARKNA 331
Cdd:cd02092  253 LLTFVGWVA---------AGGDW-RHAL-----------------LIAVavlIITCpCALGlavpavqvvaSGRLFRRGV 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftISGTTYTPEgevrqgdqpvrcgqfdglv 411
Cdd:cd02092  306 LVKDGTALERLAEVDTVVFDKTGTLTLGSPRL--------------------VGAHAISAD------------------- 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  412 ELATICALCNDSAldyneakgvyekvgeatetaltclvekmnvfdtdlQALSR--VERAGACNTVIKQLmrKEftlefsr 489
Cdd:cd02092  347 LLALAAALAQASR-----------------------------------HPLSRalAAAAGARPVELDDA--RE------- 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  490 drksmsvycTPtrphptGQGSKMFVKGAPesviercssVRVGSR----TAPLTPTSREQILAKirdwgsGSDTLRCLALA 565
Cdd:cd02092  383 ---------VP------GRGVEGRIDGAR---------VRLGRPawlgASAGVSTASELALSK------GGEEAARFPFE 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  566 trdapprkedmelddcskfvqyetdltfvgcvgmlDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdt 645
Cdd:cd02092  433 -----------------------------------DRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGI---- 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  646 edvagkaytgrefDDLSpeqqrqacrtarcfARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTA 725
Cdd:cd02092  474 -------------EDWR--------------AGLTPAEKVARIEELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASAVD 526
                        650       660       670
                 ....*....|....*....|....*....|....
gi 28373109  726 VAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd02092  527 ASRSAADIVFLGDSLAPVPEAIEIARRARRLIRQ 560
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
67-743 1.61e-17

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 87.57  E-value: 1.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   67 LAALVSFVLAWFEEGEETTTAFVEPL--VIMLILVANAIVGVWQERNAEsaiEALKEYEPEMGKVIRSDRKGVQRIRARD 144
Cdd:cd07553   69 LGIVIGFVVSWYGLIKGDGLVYFDSLsvLVFLMLVGRWLQVVTQERNRN---RLADSRLEAPITEIETGSGSRIKTRADQ 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  145 IVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTKHteaipdpravnqdKKNMLFSGTNITSGKAVGVAV 224
Cdd:cd07553  146 IKSGDVYLVASGQRVPVDGKLL---SEQASIDMSWLTGESLPRIVE-------------RGDKVPAGTSLENQAFEIRVE 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  225 ATGLHTELGKIRSQMAAVEPERTPLqrklDEFGRQLSHAISVICVAVWVinighfadpAHGGSWLR-GAVYYFKIAVALA 303
Cdd:cd07553  210 HSLAESWSGSILQKVEAQEARKTPR----DLLADKIIHYFTVIALLIAV---------AGFGVWLAiDLSIALKVFTSVL 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  304 VAAIP--EGLPAVITTCLALgtRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllhe 381
Cdd:cd07553  277 IVACPcaLALATPFTDEIAL--ARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSF------------------ 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  382 ftisgTTYTPEGEVRQgdqpvrcgqfdGLVELATICALCNdsaldyneakgvyekvgeatetaltclvekmnvfdtdlQA 461
Cdd:cd07553  337 -----VMVNPEGIDRL-----------ALRAISAIEAHSR--------------------------------------HP 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  462 LSRveragacnTVIKQLMRKEFTLEFSRDRKSMsvyctptrphpTGQGSKMFVKGapesviercSSVRVGSrtapltpts 541
Cdd:cd07553  363 ISR--------AIREHLMAKGLIKAGASELVEI-----------VGKGVSGNSSG---------SLWKLGS--------- 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  542 reqilakirdwgsgsdtlrclalatrdapprkedmELDDC---SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAG 618
Cdd:cd07553  406 -----------------------------------APDACgiqESGVVIARDGRQLLDLSFNDLLRPDSNREIEELKKGG 450
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  619 IRVVMITGDNKGTAVAICRRLGIfGDTEDVAGkaytgrefddLSPEQqrqacrtarcfarvepahKSRIVENLQSFNeiT 698
Cdd:cd07553  451 LSIAILSGDNEEKVRLVGDSLGL-DPRQLFGN----------LSPEE------------------KLAWIESHSPEN--T 499
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*
gi 28373109  699 AMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASI 743
Cdd:cd07553  500 LMVGDGANDALALASAFVGIAVAGEVGVSLEAADIYYAGNGIGGI 544
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 3.35e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 76.85  E-value: 3.35e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373109       5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
Cdd:smart00831    5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
92-780 3.64e-17

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 86.68  E-value: 3.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    92 LVIMLILVANAIVGVWQERNAESAIEALKEYEPEM-GKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKS 170
Cdd:PRK14010   70 IILLLTLVFANFSEALAEGRGKAQANALRQTQTEMkARRIKQD-GSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLA 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   171 TtlrVDQSILTGESVSVTKHTEAipdpravnqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Cdd:PRK14010  149 T---VDESAITGESAPVIKESGG----------DFDNVIGGTSVASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNE 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   251 RKLdeFGRQLSHAISVICVAVWVINIGHFadpahggswlrgavYYFKIAVALAVAAIPEGLPAVITTCLAL----GTRRM 326
Cdd:PRK14010  216 IAL--FTLLMTLTIIFLVVILTMYPLAKF--------------LNFNLSIAMLIALAVCLIPTTIGGLLSAigiaGMDRV 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadaGSCLLHEFTisgttytpegevrqgdqPVRCGQ 406
Cdd:PRK14010  280 TQFNILAKSGRSVETCGDVNVLILDKTGTITY----------------GNRMADAFI-----------------PVKSSS 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   407 FDGLVELATICALCNDSALdyneakgvyekvgeatetaltclvekmnvfdtdlqalsrveragacNTVIKQLMRKEFtLE 486
Cdd:PRK14010  327 FERLVKAAYESSIADDTPE----------------------------------------------GRSIVKLAYKQH-ID 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   487 FSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERcssvrvgsrtapltptsreqilakIRDWGSGSdtlrclalat 566
Cdd:PRK14010  360 LPQEVGEYIPFTAETRMSGVKFTTREVYKGAPNSMVKR------------------------VKEAGGHI---------- 405
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   567 rdapPRKEDMELDDCSK-----FVQYETDLtFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI 641
Cdd:PRK14010  406 ----PVDLDALVKGVSKkggtpLVVLEDNE-ILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGV 480
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   642 fgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG 721
Cdd:PRK14010  481 -------------------------------DRFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAMN 529
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373109   722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCI----FLTAI 780
Cdd:PRK14010  530 SGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAIlpamFMAAM 592
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
590-751 1.68e-15

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 81.13  E-value: 1.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  590 DLTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRLGIfgdtedvaGKAYTgrefdDLSPEQQRQ 668
Cdd:cd07548  417 DGKYVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTGDRKSVAEKVAKKLGI--------DEVYA-----ELLPEDKVE 483
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  669 AcrtarcFARVEPAHKSRIvenlqsfneitAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAV 747
Cdd:cd07548  484 K------VEELKAESKGKV-----------AFVGDGINDAPVLARADVGIAMGGlGSDAAIEAADVVLMNDEPSKVAEAI 546

                 ....
gi 28373109  748 EEGR 751
Cdd:cd07548  547 KIAR 550
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
47-718 3.74e-14

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 77.42  E-value: 3.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109     47 KSLWElvleQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfvePLVIMLILVAnaivgvwqernAESAIEALK------ 120
Cdd:TIGR01652   19 KNLFE----QFKRFANLYFLVVALLQQVPILSPTYRGTSIV---PLAFVLIVTA-----------IKEAIEDIRrrrrdk 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    121 EYEPEMGKVIRSDRKGVqRIRARDIVPGDIVEVAVGDKVPADLRL-----------IEIKS----TTLRVDQSI------ 179
Cdd:TIGR01652   81 EVNNRLTEVLEGHGQFV-EIPWKDLRVGDIVKVKKDERIPADLLLlsssepdgvcyVETANldgeTNLKLRQALeetqkm 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    180 --------LTGESVSVTKH--------TEAIPDPRAVNQDKKNMLFSGTNITSGK-AVGVAVATGLHTELGKIRSQmaav 242
Cdd:TIGR01652  160 ldeddiknFSGEIECEQPNaslysfqgNMTINGDRQYPLSPDNILLRGCTLRNTDwVIGVVVYTGHDTKLMRNATQ---- 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    243 eperTPLQRKLDEfgRQLSHAISVICVAVWVINI-----GHFADPAHGGSwlrgaVYYFKIAVALAVAAIPEGLPavITT 317
Cdd:TIGR01652  236 ----APSKRSRLE--KELNFLIIILFCLLFVLCLissvgAGIWNDAHGKD-----LWYIRLDVSERNAAANGFFS--FLT 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    318 CLAL-------------------------GTRRMARKN----AIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFV 368
Cdd:TIGR01652  303 FLILfsslipislyvslelvksvqayfinSDLQMYHEKtdtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIME----FK 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    369 VAeadagscllhefTISGTTYTpEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVY--EKVGEATETALT 446
Cdd:TIGR01652  379 KC------------SIAGVSYG-DGFTEIKDGIRERLGSYVENENSMLVESKGFTFVDPRLVDLLKtnKPNAKRINEFFL 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    447 CL---------VEKMNVFDTDLQALSRVERA-------------GACNTVIKQLMR-----KEF----TLEFSRDRKSMS 495
Cdd:TIGR01652  446 ALalchtvvpeFNDDGPEEITYQAASPDEAAlvkaardvgfvffERTPKSISLLIEmhgetKEYeilnVLEFNSDRKRMS 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    496 VYCTptrpHPTGQgSKMFVKGAPESVIERCSSVRVGSRTApltpTSREqiLAKIrdwgsGSDTLRCLALATRDAPP---- 571
Cdd:TIGR01652  526 VIVR----NPDGR-IKLLCKGADTVIFKRLSSGGNQVNEE----TKEH--LENY-----ASEGLRTLCIAYRELSEeeye 589
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    572 -------------RKEDMELDDCSKFVqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI--- 635
Cdd:TIGR01652  590 ewneeyneastalTDREEKLDVVAESI--EKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIgys 667
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    636 CRRLGI-----------FGDTEDVA-----GKAYTGREFDD-------------------LSPEQQRQ------ACRTAR 674
Cdd:TIGR01652  668 CRLLSRnmeqivitsdsLDATRSVEaaikfGLEGTSEEFNNlgdsgnvalvidgkslgyaLDEELEKEflqlalKCKAVI 747
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 28373109    675 CfARVEPAHKSRIVENLQ-SFNEITAMTGDGVNDAPALKKAEIGI 718
Cdd:TIGR01652  748 C-CRVSPSQKADVVRLVKkSTGKTTLAIGDGANDVSMIQEADVGV 791
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
47-720 1.82e-11

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 68.40  E-value: 1.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   47 KSLWElvleQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfvePLVImlILVANAIVGVWQERNAESAIEALKEYEPem 126
Cdd:cd07536   17 GVLYE----QFKRFLNLYFLVIACLQFVPALKPGYLYTTWA---PLIF--ILAVTMTKEAIDDFRRFQRDKEVNKKQL-- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  127 gKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEI--KSTTLRVDQSILTGES-------VSVTKHTEAI--- 194
Cdd:cd07536   86 -YSKLTGRK--VQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTsePQGSCYVETAQLDGETdlklrvaVSCTQQLPALgdl 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  195 -----------PD-----------------PRAVNQDKKNMLFSGTNI-TSGKAVGVAVATGLHTELGKIRSQmaaVEPE 245
Cdd:cd07536  163 mkisayvecqkPQmdihsfegnftledsdpPIHESLSIENTLLRASTLrNTGWVIGVVVYTGKETKLVMNTSN---AKNK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  246 RTPLQRKLDefgrQLSHAISVICVAVWVINI--GHFADPAHG-GSW----LRGAVYYFKIAVALAVAAIPEGLPAVITTC 318
Cdd:cd07536  240 VGLLDLELN----RLTKALFLALVVLSLVMVtlQGFWGPWYGeKNWyikkMDTTSDNFGRNLLRFLLLFSYIIPISLRVN 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  319 LAL--------------------GTRRMARKNAIVrslpsvETLGCTSVICSDKTGTLTTNQMSVCRMfvvaeadagscl 378
Cdd:cd07536  316 LDMvkavyawfimwdenmyyignDTGTVARTSTIP------EELGQVVYLLTDKTGTLTQNEMIFKRC------------ 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  379 lhefTISGTTYtpegevrqGDQPVRCGqfdglvelaticalcndsaldyneakgvyekvgeatetaltclvekmnvfdtd 458
Cdd:cd07536  378 ----HIGGVSY--------GGQVLSFC----------------------------------------------------- 392
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  459 lqalsrveragacntvIKQLmrkeftLEFSRDRKSMSVYctpTRPHPTGQgSKMFVKGAPESVIERcssVRVGSRTaplt 538
Cdd:cd07536  393 ----------------ILQL------LEFTSDRKRMSVI---VRDESTGE-ITLYMKGADVAISPI---VSKDSYM---- 439
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  539 ptsrEQILAKIRDWGSgsDTLRCLALATRDApprKEDMELDDCSKFVQ------------------YETDLTFVGCVGML 600
Cdd:cd07536  440 ----EQYNDWLEEECG--EGLRTLCVAKKAL---TENEYQEWESRYTEaslslhdrslrvaevvesLERELELLGLTAIE 510
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI-------------------------------CRRLGI-FGDTEDV 648
Cdd:cd07536  511 DRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIakschlvsrtqdihllrqdtsrgeraaitqhAHLELNaFRRKHDV 590
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  649 A----GKA------YTGREFDDLSPEqqrqaCRTARCfARVEPAHKSRIVENLQSFNE-ITAMTGDGVNDAPALKKAEIG 717
Cdd:cd07536  591 AlvidGDSlevalkYYRHEFVELACQ-----CPAVIC-CRVSPTQKARIVTLLKQHTGrRTLAIGDGGNDVSMIQAADCG 664

                 ...
gi 28373109  718 IAM 720
Cdd:cd07536  665 VGI 667
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
601-714 2.68e-11

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 63.76  E-value: 2.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGrefddlspeqqrqacrtarcFARVE 680
Cdd:pfam00702   97 LKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVG--------------------VGKPK 156
                           90       100       110
                   ....*....|....*....|....*....|....
gi 28373109    681 PAHKSRIVENLQSFNEITAMTGDGVNDAPALKKA 714
Cdd:pfam00702  157 PEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAA 190
PLN03190 PLN03190
aminophospholipid translocase; Provisional
334-720 1.93e-08

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 58.76  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   334 RSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFVVAeadagscllhefTISGTTYTPEGEVRQGDQPVRCGQFDGL--- 410
Cdd:PLN03190  442 RALNINEDLGQIKYVFSDKTGTLTENKME----FQCA------------SIWGVDYSDGRTPTQNDHAGYSVEVDGKilr 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   411 ----VELATICALCNDSALDYNEAKGVYE--KVGEATETALTCLVE-----KMNVFD-----TDLQALSR---------V 465
Cdd:PLN03190  506 pkmkVKVDPQLLELSKSGKDTEEAKHVHDffLALAACNTIVPIVVDdtsdpTVKLMDyqgesPDEQALVYaaaaygfmlI 585
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   466 ERAGACNTVIKQLMRKEFTL----EFSRDRKSMSVY--CtptrPHPTgqgSKMFVKGAPES---VIERCSSVRV------ 530
Cdd:PLN03190  586 ERTSGHIVIDIHGERQRFNVlglhEFDSDRKRMSVIlgC----PDKT---VKVFVKGADTSmfsVIDRSLNMNViratea 658
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   531 --------GSRTapLTPTSREQILAKIRDWGSGSDTLRClALATRDAPPRKEDMELddcskfvqyETDLTFVGCVGMLDP 602
Cdd:PLN03190  659 hlhtysslGLRT--LVVGMRELNDSEFEQWHFSFEAAST-ALIGRAALLRKVASNV---------ENNLTILGASAIEDK 726
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   603 PRPEVAACITRCYQAGIRVVMITGDNKGTAVAI-----------------------CRR-----------LGIFGDTEDV 648
Cdd:PLN03190  727 LQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqiiinsnskesCRKsledalvmskkLTTVSGISQN 806
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109   649 AGKAYTGRE---------------FDDLSPEQQRQ---ACRTARCfARVEPAHKSRIVENLQS-FNEITAMTGDGVNDAP 709
Cdd:PLN03190  807 TGGSSAAASdpvaliidgtslvyvLDSELEEQLFQlasKCSVVLC-CRVAPLQKAGIVALVKNrTSDMTLAIGDGANDVS 885
                         490
                  ....*....|.
gi 28373109   710 ALKKAEIGIAM 720
Cdd:PLN03190  886 MIQMADVGVGI 896
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
685-734 3.06e-05

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 46.88  E-value: 3.06e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28373109    685 SRIVENLQ-SFNEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMV 734
Cdd:TIGR00099  194 QSLAEALGiSLEDVIAF-GDGMNDIEMLEAAGYGVAMGNADEELKALADYV 243
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
589-749 6.86e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.74  E-value: 6.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  589 TDL--TFVGCVGMLDPprpEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD--------TEDVAGKAYTGRef 658
Cdd:COG0561    7 LDLdgTLLNDDGEISP---RTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDPlitsngalIYDPDGEVLYER-- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  659 dDLSPEQQRQACRTAR-------CFARVEP---------AHKSRIVENLQ-----SFNEITAMtGDGVNDAPALKKAEIG 717
Cdd:COG0561   82 -PLDPEDVREILELLRehglhlqVVVRSGPgfleilpkgVSKGSALKKLAerlgiPPEEVIAF-GDSGNDLEMLEAAGLG 159
                        170       180       190
                 ....*....|....*....|....*....|..
gi 28373109  718 IAMGSGTAVAKSAAEMVLSDDNFASIVAAVEE 749
Cdd:COG0561  160 VAMGNAPPEVKAAADYVTGSNDEDGVAEALEK 191
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
685-743 1.71e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 44.54  E-value: 1.71e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    685 SRIVENLQ-SFNEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASI 743
Cdd:pfam08282  193 KALAKHLNiSLEEVIAF-GDGENDIEMLEAAGLGVAMGNASPEVKAAADYVTDSNNEDGV 251
COG4087 COG4087
Soluble P-type ATPase [General function prediction only];
619-737 4.57e-04

Soluble P-type ATPase [General function prediction only];


Pssm-ID: 443263 [Multi-domain]  Cd Length: 156  Bit Score: 41.69  E-value: 4.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  619 IRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrEFDDLSPEQQRQAcrtarcfarvepahKSRIVENLQSfnEIT 698
Cdd:COG4087   46 LEIHVLTADTFGTVAKELAGLPV---------------ELHILPSGDQAEE--------------KLEFVEKLGA--ETT 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 28373109  699 AMTGDGVNDAPALKKAEIGIA-MGS-GTAV-AKSAAEMVLSD 737
Cdd:COG4087   95 VAIGNGRNDVLMLKEAALGIAvIGPeGASVkALLAADIVVKS 136
HAD pfam12710
haloacid dehalogenase-like hydrolase;
604-712 5.75e-04

haloacid dehalogenase-like hydrolase;


Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 42.13  E-value: 5.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG---IFGDTEDVAGKAYTGREFDDLSPEQQRQACR--TARCFAR 678
Cdd:pfam12710   86 HPGALELLAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRrlRAWLAAR 165
                           90       100       110
                   ....*....|....*....|....*....|....
gi 28373109    679 VEPAHKSRIVenlqsfneitAMtGDGVNDAPALK 712
Cdd:pfam12710  166 GLGLDLADSV----------AY-GDSPSDLPMLR 188
SerB COG0560
Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is ...
604-719 1.10e-03

Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 440326 [Multi-domain]  Cd Length: 221  Bit Score: 41.75  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109  604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI---FGDTEDVAGKAYTGREFDDLspeqqrqacrtarcfarVE 680
Cdd:COG0560   90 YPGARELIAEHRAAGHKVAIVSGGFTFFVEPIAERLGIdhvIANELEVEDGRLTGEVVGPI-----------------VD 152
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 28373109  681 PAHKSRIVENL-----QSFNEITAMtGDGVNDAPALKKAEIGIA 719
Cdd:COG0560  153 GEGKAEALRELaaelgIDLEQSYAY-GDSANDLPMLEAAGLPVA 195
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
702-760 2.39e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 40.67  E-value: 2.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373109  702 GDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVlSDDNFasivaavEEGraIYSNMKQF 760
Cdd:cd07517  164 GDGLNDIEMLEAVGIGIAMGNAHEELKEIADYV-TKDVD-------EDG--ILKALKHF 212
HAD_Pase cd07514
phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), ...
695-748 6.39e-03

phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), and Pyrococcus horikoshii PH1421, a magnesium-dependent phosphatase; belongs to the haloacid dehalogenase-like superfamily; Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PGPase) catalyzes the magnesium-dependent dephosphorylation of phosphoglycolate. This family also includes Pyrococcus horikoshii OT3 PH1421, a magnesium-dependent phosphatase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319816 [Multi-domain]  Cd Length: 139  Bit Score: 37.95  E-value: 6.39e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 28373109  695 NEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVE 748
Cdd:cd07514   84 EEVLAI-GDSENDIEMFKVAGFKVAVANADEELKEAADYVTDASYGDGVLEAID 136
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
695-749 6.97e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 6.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373109  695 NEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEmVLSDDNFASIVA-AVEE 749
Cdd:cd07516  200 EEVIAF-GDNENDLSMLEYAGLGVAMGNAIDEVKEAAD-YVTLTNNEDGVAkAIEK 253
serB TIGR00338
phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction ...
679-744 9.10e-03

phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate. It catalyzes the last of three steps in the biosynthesis of serine from D-3-phosphoglycerate. Note that this enzyme acts on free phosphoserine, not on phosphoserine residues of phosphoproteins. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273022 [Multi-domain]  Cd Length: 219  Bit Score: 38.88  E-value: 9.10e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373109    679 VEPAHKSRIVENLQSFNEI----TAMTGDGVNDAPALKKAEIGIAMGSGTAVaKSAAEMVLSDDNFASIV 744
Cdd:TIGR00338  148 VDASYKGKTLLILLRKEGIspenTVAVGDGANDLSMIKAAGLGIAFNAKPKL-QQKADICINKKDLTDIL 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH