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Conserved domains on  [gi|190014629|ref|NP_780495|]
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taperin [Mus musculus]

Protein Classification

Phostensin_N and Phostensin domain-containing protein( domain architecture ID 10621602)

Phostensin_N and Phostensin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Phostensin pfam13914
Phostensin PP1-binding and SH3-binding region; Phostensin has been identified as a PP1 ...
 506-645 2.38e-61

Phostensin PP1-binding and SH3-binding region; Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.


:

Pssm-ID: 464038 [Multi-domain]  Cd Length: 138  Bit Score: 202.48  E-value: 2.38e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  506 FQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQephlSQTNGQ--SQQGAEEQDAESLSGPHT 583
Cdd:pfam13914   1 PSTAKLPSSNIGSPLQYFPHPGGPSHSSELQHRGGNTFTVVPRRKPGGLQ----SQANSEppSQPTAEEEEAPSLVGPDA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190014629  584 TLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLA 645
Cdd:pfam13914  77 TLGGTLKKRYPTVHEIEVIGGYLALDKSCLVKAGSSRKKMKISFNEKSLETTFEYPSESSLL 138
Phostensin_N pfam13916
PP1-regulatory protein, Phostensin N-terminal; Phostensin has been identified as a PP1 ...
 8-89 2.03e-37

PP1-regulatory protein, Phostensin N-terminal; Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.


:

Pssm-ID: 464039  Cd Length: 84  Bit Score: 134.58  E-value: 2.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629    8 DPGPRTVMPAWKREILERRRAKLAALSGGQGSGAA-PDGPNERLVLAESLGPLSQNPFMRLESERRR-GTRPAQQLLELY 85
Cdd:pfam13916   1 GPGPRTAMPAWKREILERRRAKLAALGGGAGPGAAePAGPDERLVLAESLGPLHENPFMRLESERRRqGQAPAQQLLEDY 80


                  ....
gi 190014629   86 CRVP 89
Cdd:pfam13916  81 RRVP 84
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 109-321 1.16e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  109 PPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRL 188
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  189 SQ-PAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHP--------RGLPRSAVNRSLSNGPM 259
Cdd:PHA03247 2821 AAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPaaparppvRRLARPAVSRSTESFAL 2900

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190014629  260 TQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATP 321
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
Phostensin pfam13914
Phostensin PP1-binding and SH3-binding region; Phostensin has been identified as a PP1 ...
 506-645 2.38e-61

Phostensin PP1-binding and SH3-binding region; Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.


Pssm-ID: 464038 [Multi-domain]  Cd Length: 138  Bit Score: 202.48  E-value: 2.38e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  506 FQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQephlSQTNGQ--SQQGAEEQDAESLSGPHT 583
Cdd:pfam13914   1 PSTAKLPSSNIGSPLQYFPHPGGPSHSSELQHRGGNTFTVVPRRKPGGLQ----SQANSEppSQPTAEEEEAPSLVGPDA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190014629  584 TLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLA 645
Cdd:pfam13914  77 TLGGTLKKRYPTVHEIEVIGGYLALDKSCLVKAGSSRKKMKISFNEKSLETTFEYPSESSLL 138
Phostensin_N pfam13916
PP1-regulatory protein, Phostensin N-terminal; Phostensin has been identified as a PP1 ...
 8-89 2.03e-37

PP1-regulatory protein, Phostensin N-terminal; Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.


Pssm-ID: 464039  Cd Length: 84  Bit Score: 134.58  E-value: 2.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629    8 DPGPRTVMPAWKREILERRRAKLAALSGGQGSGAA-PDGPNERLVLAESLGPLSQNPFMRLESERRR-GTRPAQQLLELY 85
Cdd:pfam13916   1 GPGPRTAMPAWKREILERRRAKLAALGGGAGPGAAePAGPDERLVLAESLGPLHENPFMRLESERRRqGQAPAQQLLEDY 80


                  ....
gi 190014629   86 CRVP 89
Cdd:pfam13916  81 RRVP 84
PHA03247 PHA03247
large tegument protein UL36; Provisional
 109-321 1.16e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  109 PPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRL 188
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  189 SQ-PAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHP--------RGLPRSAVNRSLSNGPM 259
Cdd:PHA03247 2821 AAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPaaparppvRRLARPAVSRSTESFAL 2900

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190014629  260 TQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATP 321
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
Phostensin pfam13914
Phostensin PP1-binding and SH3-binding region; Phostensin has been identified as a PP1 ...
 506-645 2.38e-61

Phostensin PP1-binding and SH3-binding region; Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.


Pssm-ID: 464038 [Multi-domain]  Cd Length: 138  Bit Score: 202.48  E-value: 2.38e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  506 FQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQephlSQTNGQ--SQQGAEEQDAESLSGPHT 583
Cdd:pfam13914   1 PSTAKLPSSNIGSPLQYFPHPGGPSHSSELQHRGGNTFTVVPRRKPGGLQ----SQANSEppSQPTAEEEEAPSLVGPDA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190014629  584 TLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLA 645
Cdd:pfam13914  77 TLGGTLKKRYPTVHEIEVIGGYLALDKSCLVKAGSSRKKMKISFNEKSLETTFEYPSESSLL 138
Phostensin_N pfam13916
PP1-regulatory protein, Phostensin N-terminal; Phostensin has been identified as a PP1 ...
 8-89 2.03e-37

PP1-regulatory protein, Phostensin N-terminal; Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerization rates of actin filament pointed ends.


Pssm-ID: 464039  Cd Length: 84  Bit Score: 134.58  E-value: 2.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629    8 DPGPRTVMPAWKREILERRRAKLAALSGGQGSGAA-PDGPNERLVLAESLGPLSQNPFMRLESERRR-GTRPAQQLLELY 85
Cdd:pfam13916   1 GPGPRTAMPAWKREILERRRAKLAALGGGAGPGAAePAGPDERLVLAESLGPLHENPFMRLESERRRqGQAPAQQLLEDY 80


                  ....
gi 190014629   86 CRVP 89
Cdd:pfam13916  81 RRVP 84
PHA03247 PHA03247
large tegument protein UL36; Provisional
 109-321 1.16e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  109 PPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRL 188
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  189 SQ-PAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHP--------RGLPRSAVNRSLSNGPM 259
Cdd:PHA03247 2821 AAsPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPaaparppvRRLARPAVSRSTESFAL 2900

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190014629  260 TQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATP 321
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PHA03247 PHA03247
large tegument protein UL36; Provisional
 103-460 1.64e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  103 ESAPGFPPAVPPAAGIRaaevvvyEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRtPTNRSLAP 182
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPR-------DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD-PPPPPPTP 2708

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  183 ASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHP---DGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPM 259
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAV 2788

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  260 TQESPTGPAnglSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEI 339
Cdd:PHA03247 2789 ASLSESRES---LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  340 RPSSKPDMETIPIGDLQARALANLRVN-SRNSFVLIPKRKAPGNYPLAGRQ-----FEEPKGEVGWASQSQGL-GSQLVS 412
Cdd:PHA03247 2866 PPSRSPAAKPAAPARPPVRRLARPAVSrSTESFALPPDQPERPPQPQAPPPpqpqpQPPPPPQPQPPPPPPPRpQPPLAP 2945

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 190014629  413 TVDGAPALEKSPLAAEMQW-AVRKGACPRPAISDTDKCVRWQRPASPPP 460
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFRVPQPAPSREAPASSTP 2994
PHA03247 PHA03247
large tegument protein UL36; Provisional
 104-322 7.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  104 SAPGFPPAVPPAAGIRAA---------------EVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASA 168
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPaanepdphppptvppPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL 2695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  169 SAATRtPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGArrsdflqktgsnsftvhpRGLPRS 248
Cdd:PHA03247 2696 TSLAD-PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT------------------PGGPAR 2756

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 190014629  249 AVNRSLSNGPMTQESPTGPAnglsgSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPS 322
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPA-----AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825
PHA03247 PHA03247
large tegument protein UL36; Provisional
 41-349 4.50e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629   41 AAPDGPNERLVLAESLGPLSQN-PFMRLESERRRGTRPA-QQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGI 118
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPApPAAPAAGPPRRLTRPAvASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL 2828

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  119 RAAEVVVYEAPQPgrVSRLLEKFDSPAAPCRRGSPERFRPAlPQLPVASASAATRTPTNRSLAPA-SPVRLSQPAPPISP 197
Cdd:PHA03247 2829 PPPTSAQPTAPPP--PPGPPPPSLPLGGSVAPGGDVRRRPP-SRSPAAKPAAPARPPVRRLARPAvSRSTESFALPPDQP 2905

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  198 VPVAQRAGQrsaccEPAHPDGTAGPGARRsdflqktgsnsfTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPV 277
Cdd:PHA03247 2906 ERPPQPQAP-----PPPQPQPQPPPPPQP------------QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  278 PGKW----------KPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQ--WVSSATSANDSFEIRPSSKP 345
Cdd:PHA03247 2969 PGRVavprfrvpqpAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlWPPDDTEDSDADSLFDSDSE 3048


                  ....
gi 190014629  346 DMET 349
Cdd:PHA03247 3049 RSDL 3052
PHA03247 PHA03247
large tegument protein UL36; Provisional
 105-519 4.58e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  105 APGFPPAVPPAAGIRAAEVVVYeAPQPgrvsrllekfDSPAAPCRRGSPErfrpALPQlpvasaSAATRTPTNRSLAPAS 184
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRP-APRP----------SEPAVTSRARRPD----APPQ------SARPRAPVDDRGDPRG 2610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  185 PVRlSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESP 264
Cdd:PHA03247 2611 PAP-PSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  265 --TGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPsqrqwvssATSANDSFEIRPS 342
Cdd:PHA03247 2690 ptVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP--------ATPGGPARPARPP 2761

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  343 S-----KPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAgrqFEEPKGEVGWASQSQGLGSQLVSTVDGA 417
Cdd:PHA03247 2762 TtagppAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  418 PALEKSPLAAEMQ---WAVRKGAcprpaisdtdkcVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVT 494
Cdd:PHA03247 2839 PPPPPGPPPPSLPlggSVAPGGD------------VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPE 2906

                         410       420
                  ....*....|....*....|....*
gi 190014629  495 FIDEVDSEEEAFQEAKLPSSAVGVP 519
Cdd:PHA03247 2907 RPPQPQAPPPPQPQPQPPPPPQPQP 2931
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 103-359 1.03e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.93  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  103 ESAPGFPPAVPPAAgiraaevvvyeaPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAP 182
Cdd:PHA03307  112 SSPDPPPPTPPPAS------------PPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  183 ASPVRlSQPAPPISPVPVAQRAGQRSACCEP------AHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSN 256
Cdd:PHA03307  180 EETAR-APSSPPAEPPPSTPPAAASPRPPRRsspisaSASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLP 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  257 GPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSvgppafpapspASATPSQRQWVSSATSANDS 336
Cdd:PHA03307  259 RPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGP-----------APSSPRASSSSSSSRESSSS 327

                         250       260
                  ....*....|....*....|...
gi 190014629  337 FEIRPSSKPDMETIPIGDLQARA 359
Cdd:PHA03307  328 STSSSSESSRGAAVSPGPSPSRS 350
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
105-307 5.98e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 5.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 105 APGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPA- 183
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAp 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 184 SPVRLSQPAPPI-SPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQE 262
Cdd:PRK12323 455 AAAPAAAARPAAaGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADP 534

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 190014629 263 SPTGPAnglsgspPVPGKWKPKVESKEPSLHPPPSPGTPSATSVG 307
Cdd:PRK12323 535 DDAFET-------LAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
104-279 1.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 104 SAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFdsPAAPCRRGSPERFRPALPQLPVASASAATRTPTnrslAPA 183
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL--AAARQASARGPGGAPAPAPAPAAAPAAAARPAA----AGP 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 184 SPVRLSQPAPPISPVPVAQRAGQRSACCE-PAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQE 262
Cdd:PRK12323 470 RPVAAAAAAAPARAAPAAAPAPADDDPPPwEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP 549

                        170
                 ....*....|....*..
gi 190014629 263 SPTGPANGLSGSPPVPG 279
Cdd:PRK12323 550 APRAAAATEPVVAPRPP 566
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 109-502 3.31e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 109 PPAVPPAAGIRAAEVVVYEAPQPGRVSRllekfdsPAAPCRRGSPERFRPALPQLPVASASAATRTPTNrslAPASPVRL 188
Cdd:PRK07764 407 AAAPAPAAAAPAAAAAPAPAAAPQPAPA-------PAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP---APAAAPEP 476

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 189 SQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRS--DFLQKTGSNSFTV---------------------HPRGL 245
Cdd:PRK07764 477 TAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERwpEILAAVPKRSRKTwaillpeatvlgvrgdtlvlgFSTGG 556

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 246 PRSAVNRSLSNGPMTQ--------------ESPTGPANGLSGSPPVPGKWKPKVESKEPSlhPPPSPGTPSATSVGPPAF 311
Cdd:PRK07764 557 LARRFASPGNAEVLVTalaeelggdwqveaVVGPAPGAAGGEGPPAPASSGPPEEAARPA--APAAPAAPAAPAPAGAAA 634

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 312 PAPSPASATPSQRQwvSSATSANDSFEIRPSSKPDMETIPIGDLQARAlanlRVNSRNSFVLIPKRKAPGNYPLAGRQFE 391
Cdd:PRK07764 635 APAEASAAPAPGVA--APEHHPKHVAVPDASDGGDGWPAKAGGAAPAA----PPPAPAPAAPAAPAGAAPAQPAPAPAAT 708

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 392 EPKGEV-----GWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGAcPRPAISDTDKCVRWQRPASPPPFLPATA 466
Cdd:PRK07764 709 PPAGQAddpaaQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPP-PPPAPAPAAAPAAAPPPSPPSEEEEMAE 787

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 190014629 467 EAEPAEGLGVPGLAKN-GQEPVRPGLPVTFIDEVDSE 502
Cdd:PRK07764 788 DDAPSMDDEDRRDAEEvAMELLEEELGAKKIEEFAAD 824
PHA03247 PHA03247
large tegument protein UL36; Provisional
 110-493 3.38e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  110 PAVPPAAGIRAAEVVVYEAPQPGRVSRL------LEKFDSPAApcrrGSPERFRPALPQLPVASASAATRTPTNRSLAPA 183
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGEPVHPRMltwirgLEELASDDA----GDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPA 2581

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  184 SPVRLSQP-APPISPVPVAQRAGQ----RSACCEPAHPDGTA---GPGARRSDFLQKTGSNSFTVHPRGLPR--SAVNR- 252
Cdd:PHA03247 2582 VTSRARRPdAPPQSARPRAPVDDRgdprGPAPPSPLPPDTHApdpPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRv 2661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  253 SLSNGPMTQESPTGPANGLSGspPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATS 332
Cdd:PHA03247 2662 SRPRRARRLGRAAQASSPPQR--PRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  333 AndsfeirPSSKPDMETIPIGDlqaralanlRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVS 412
Cdd:PHA03247 2740 A-------PPAVPAGPATPGGP---------ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629  413 TVDgAPALEKSPLAAEMQWAVRKGACPRPAISdtdkcvrwqRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLP 492
Cdd:PHA03247 2804 PAD-PPAAVLAPAAALPPAASPAGPLPPPTSA---------QPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA 2873


                  .
gi 190014629  493 V 493
Cdd:PHA03247 2874 K 2874
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
104-281 4.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 104 SAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPErfrPALPQLPVASASAATRTPTNRSLAPA 183
Cdd:PRK12323 401 APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA---PAPAAAPAAAARPAAAGPRPVAAAAA 477

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 184 SPVRLSQPAPPISPVPVA---------QRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSl 254
Cdd:PRK12323 478 AAPARAAPAAAPAPADDDpppweelppEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAA- 556

                        170       180
                 ....*....|....*....|....*...
gi 190014629 255 sngPMTQESPTGPANGLSGSPPV-PGKW 281
Cdd:PRK12323 557 ---TEPVVAPRPPRASASGLPDMfDGDW 581
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 103-229 5.47e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 103 ESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLlekfDSPAAPCRRGSPErfrPALPQLPVASASAATRTPTNRSLAP 182
Cdd:PRK14951 377 EKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAA----SAPAAPPAAAPPA---PVAAPAAAAPAAAPAAAPAAVALAP 449

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 190014629 183 ASPVRlSQPAPPISPVPVAQRAGQRSACCEPA-HPDGTAGPGARRSDF 229
Cdd:PRK14951 450 APPAQ-AAPETVAIPVRVAPEPAVASAAPAPAaAPAAARLTPTEEGDV 496
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 142-298 8.79e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 39.46  E-value: 8.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 142 DSPAAPCRRGSPE----R---FRPALPQL-----PVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSa 209
Cdd:PRK07994 338 DLPLAPDRRMGVEmtllRmlaFHPAAPLPepevpPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLP- 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190014629 210 ccEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLP-RSAVNRSLSNGPMTQESPTGPANglsgSPPVPGKWKPKVESK 288
Cdd:PRK07994 417 --ETTSQLLAARQQLQRAQGATKAKKSEPAAASRARPvNSALERLASVRPAPSALEKAPAK----KEAYRWKATNPVEVK 490

                        170
                 ....*....|
gi 190014629 289 EPSLHPPPSP 298
Cdd:PRK07994 491 KEPVATPKAL 500
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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