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Conserved domains on  [gi|31652255|ref|NP_783862|]
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lysozyme g-like protein 2 precursor [Homo sapiens]

Protein Classification

lysozyme family protein; lytic transglycosylase domain-containing protein( domain architecture ID 10099091)

lysozyme family protein; lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 47-210 6.43e-84

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


:

Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 246.36  E-value: 6.43e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255  47 KTSGATCDANSVMN---CGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVL-QDGWDHRGLK 122
Cdd:cd01021   1 ETTGASAATAKQDGllyGGVAASEKMAETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALdKNGWGDHGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255 123 FGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFKSGIEAIATPSDID-----NDFV 197
Cdd:cd01021  81 FGLMQVDKRYHPPKGAWDSEEHIEQATGILIDFIKTVQRKHPSWSPEQQLKGGIAAYNAGVGNVQSYAGMDigttgNDYS 160

                       170
                ....*....|...
gi 31652255 198 NDIIARAKFYKRQ 210
Cdd:cd01021 161 NDVIARAQWYKNN 173
 
Name Accession Description Interval E-value
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 47-210 6.43e-84

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 246.36  E-value: 6.43e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255  47 KTSGATCDANSVMN---CGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVL-QDGWDHRGLK 122
Cdd:cd01021   1 ETTGASAATAKQDGllyGGVAASEKMAETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALdKNGWGDHGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255 123 FGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFKSGIEAIATPSDID-----NDFV 197
Cdd:cd01021  81 FGLMQVDKRYHPPKGAWDSEEHIEQATGILIDFIKTVQRKHPSWSPEQQLKGGIAAYNAGVGNVQSYAGMDigttgNDYS 160

                       170
                ....*....|...
gi 31652255 198 NDIIARAKFYKRQ 210
Cdd:cd01021 161 NDVIARAQWYKNN 173
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 70-128 1.74e-03

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 38.44  E-value: 1.74e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31652255  70 AEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISREShggsvlqdGWD-----HRGLKfGLMQL 128
Cdd:COG0741  93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQES--------AFNpnavsPAGAR-GLMQL 147
 
Name Accession Description Interval E-value
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 47-210 6.43e-84

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 246.36  E-value: 6.43e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255  47 KTSGATCDANSVMN---CGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVL-QDGWDHRGLK 122
Cdd:cd01021   1 ETTGASAATAKQDGllyGGVAASEKMAETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALdKNGWGDHGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255 123 FGLMQLDKQTYHPVGAWDSKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFKSGIEAIATPSDID-----NDFV 197
Cdd:cd01021  81 FGLMQVDKRYHPPKGAWDSEEHIEQATGILIDFIKTVQRKHPSWSPEQQLKGGIAAYNAGVGNVQSYAGMDigttgNDYS 160

                       170
                ....*....|...
gi 31652255 198 NDIIARAKFYKRQ 210
Cdd:cd01021 161 NDVIARAQWYKNN 173
lyz_G-like_1 cd16888
lysozyme G-like protein 1; Eukaryotic goose-type or G-type lysozymes (goose egg-white lysozyme; ...
 61-212 1.35e-47

lysozyme G-like protein 1; Eukaryotic goose-type or G-type lysozymes (goose egg-white lysozyme; GEWL) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozyme G-like proteins, and this family corresponds to human and mouse lysozyme G-like protein 1. In humans and some other species, the canonical catalytic glutamate residue is absent, suggesting a loss of muramidase activity.


Pssm-ID: 381609  Cd Length: 160  Bit Score: 153.53  E-value: 1.35e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31652255  61 CGIRGSEMFAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHGGSVLQDGWDhRGLKFGLMQlDKQTYHPVgAWD 140
Cdd:cd16888  12 CGVRASERLAEIDMPYLLRYQPMMRTVGQKYCMDPAVIAGVLSRESPGGNYLVDLGN-VGDGLGMVQ-DTGFYAPT-SWI 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31652255 141 SKEHLSQATGILTERIKAIQKKFPTWSVAQHLKGGLSAFKSGIEAIATPSDIDNDFVNDIIARAKFYKRQSF 212
Cdd:cd16888  89 SESQVSQKTEVLTSRIKEIQRRFPTWTPDQCLRGGLCAYSGGPGYVRSNQDLSCDFCNDVLARAKYFKRHGF 160
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 70-128 1.74e-03

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 38.44  E-value: 1.74e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31652255  70 AEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISREShggsvlqdGWD-----HRGLKfGLMQL 128
Cdd:COG0741  93 AALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQES--------AFNpnavsPAGAR-GLMQL 147
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 69-132 3.32e-03

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 37.73  E-value: 3.32e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31652255  69 FAEMDLRAIKPYQTLIKEVGQRHCVDPAVIAAIISRESHggsvlqdgWD-----HRGLKfGLMQLDKQT 132
Cdd:COG4623 253 FLRRIEGRLPPYDPLFEKYAEEYGLDWRLLAALAYQESH--------WNprarsPTGAR-GLMQLMPAT 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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