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Conserved domains on  [gi|29171738|ref|NP_795714|]
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phospholipid phosphatase 1 isoform 2 [Homo sapiens]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 6.34e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 220.58  E-value: 6.34e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  99 IYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRGNAERVKEGRLSFYSGHSSF 175
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171738 176 SMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVA 244
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 6.34e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 220.58  E-value: 6.34e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  99 IYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRGNAERVKEGRLSFYSGHSSF 175
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171738 176 SMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVA 244
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
107-243 3.09e-29

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 107.43  E-value: 3.09e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738    107 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDpdwskincsdgyieyYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD---------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171738    187 LqarmkgdWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 243
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PLN02250 PLN02250
lipid phosphate phosphatase
 29-240 4.26e-26

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 104.62  E-value: 4.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738   29 LGQIYPFQRgFFCKD--NSINYPYHDSTVTSTVLILVGVGLPISSIIlgetlsVYcnllhsnSFIRNNyIATIYKAIGTF 106
Cdd:PLN02250  39 LNVIEPFHR-FVGKDmlTDLSYPLQDNTIPFWAVPLIAILLPFAVIL------VY-------YFIRRD-VYDLHHAILGL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  107 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKIncSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:PLN02250 104 LFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLY 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171738  187 LQARM-----KGDWARLlrpTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVA 240
Cdd:PLN02250 182 LSGKIrvfdrRGHVAKL---CIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA 237
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 106-247 3.23e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 84.01  E-value: 3.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738   106 FLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSkincsdgyieyyicrgNAERVKEGRLSFYSGHSSFSMYCMLFVAL 185
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29171738   186 YLqarmkGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 247
Cdd:pfam01569  66 LL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 102-247 3.30e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 49.65  E-value: 3.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 102 AIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDwskINCSDGYieyyicrgnaervkegrlSFYSGHSSFSMYCML 181
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171738 182 FVALYLQARmkgdWARLLrptlqfgLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 247
Cdd:COG0671 133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 99-244 6.34e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 220.58  E-value: 6.34e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  99 IYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRGNAERVKEGRLSFYSGHSSF 175
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171738 176 SMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVA 244
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 45-243 1.79e-38

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 133.88  E-value: 1.79e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  45 SINYPYHDS-TVTSTVLILVGVGLPISSIILGetlsvycnllhsnSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYS 123
Cdd:cd03390   2 SISYPFAESeTVPTWLLVIISVGIPLLVIILI-------------SLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNY 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 124 IGRLRPHFLDVCDPDwsKINCSDGYIEYYICR-GNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMK-----GDWAR 197
Cdd:cd03390  69 AGRPRPDFLARCFPD--GGTPSDTLVGIDICCtGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHifdprGSSWR 146

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 29171738 198 LLrptLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 243
Cdd:cd03390 147 LL---LALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLS 189
acidPPc smart00014
Acid phosphatase homologues;
107-243 3.09e-29

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 107.43  E-value: 3.09e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738    107 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDpdwskincsdgyieyYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD---------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171738    187 LqarmkgdWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 243
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PLN02250 PLN02250
lipid phosphate phosphatase
 29-240 4.26e-26

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 104.62  E-value: 4.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738   29 LGQIYPFQRgFFCKD--NSINYPYHDSTVTSTVLILVGVGLPISSIIlgetlsVYcnllhsnSFIRNNyIATIYKAIGTF 106
Cdd:PLN02250  39 LNVIEPFHR-FVGKDmlTDLSYPLQDNTIPFWAVPLIAILLPFAVIL------VY-------YFIRRD-VYDLHHAILGL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  107 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKIncSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:PLN02250 104 LFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLY 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171738  187 LQARM-----KGDWARLlrpTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVA 240
Cdd:PLN02250 182 LSGKIrvfdrRGHVAKL---CIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA 237
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 100-243 1.65e-24

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 95.22  E-value: 1.65e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 100 YKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDwskincsdgyieyyicrGNAERVKEGRLSFYSGHSSFSMYC 179
Cdd:cd01610   2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFAL 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171738 180 MLFVALYLqarmkgdWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 243
Cdd:cd01610  65 ALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
PLN02715 PLN02715
lipid phosphate phosphatase
 29-240 2.32e-22

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 94.35  E-value: 2.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738   29 LGQIYPFQRgFFCKD--NSINYPYHDSTVTSTVLILVGVGLPISSIILgetlsvycnllhsnSFIRNNYIATIYKAIGTF 106
Cdd:PLN02715  64 LNLISPFYR-YVGKDmmTDLKYPFKDNTVPIWSVPVYAVLLPIILFVC--------------FYLKRRCVYDLHHSILGL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  107 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIeyyICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 186
Cdd:PLN02715 129 LFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGV---ICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLY 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 29171738  187 LQARMK-----GDWARLLrpTLQFGLVAVSIyVGLSRVSDYKHHWSDVLTGLIQGALVA 240
Cdd:PLN02715 206 LSGKIKafngeGHVAKLC--LVIFPLLAACL-VGISRVDDYWHHWQDVFAGALIGILVA 261
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 106-247 3.23e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 84.01  E-value: 3.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738   106 FLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSkincsdgyieyyicrgNAERVKEGRLSFYSGHSSFSMYCMLFVAL 185
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29171738   186 YLqarmkGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 247
Cdd:pfam01569  66 LL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 32-236 4.07e-19

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 85.47  E-value: 4.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738   32 IYPFQRgFFCKD--NSINYPYHDSTVtstvlilvgvglPISSIilgetlSVYCNLLHSNSFI----RNNYIATIYKAIGT 105
Cdd:PLN02731  61 IHPFYR-FVGKDmmTDLSYPLKSNTV------------PIWSV------PVYAMLLPLVIFIfiyfRRRDVYDLHHAVLG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  106 FLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCSDGYIeyyICRGNAERVKEGRLSFYSGHSSFSMYCMLFVAL 185
Cdd:PLN02731 122 LLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLGDV---ICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSL 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 29171738  186 YLQARM-----KGDWARLLRPTLQFGLVAVsiyVGLSRVSDYKHHWSDVLTGLIQG 236
Cdd:PLN02731 199 YLSGKIqafdgKGHVAKLCIVILPLLFAAL---VGISRVDDYWHHWQDVFAGGLLG 251
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 51-246 7.42e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 59.93  E-value: 7.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  51 HDSTVTSTVLILVGVGLPISSIILGETLSVYCnllhsnsFIRNNYIATIYkAIGTFLFGAAASQSLtdiaKYSIGRLRPH 130
Cdd:cd03392  24 RTPLLTAFMTAITFLGSPAVLLIIVLLLALLL-------LLKRRRRAALF-LLLALLGGGALNTLL----KLLVQRPRPP 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 131 FLDVCDPdwskincsDGYieyyicrgnaervkegrlSFYSGHSSFSMYCMLFVALYLQARMKGDWARLLrptLQFGLVAV 210
Cdd:cd03392  92 LHLLVPE--------GGY------------------SFPSGHAMGATVLYGFLAYLLARRLPRRRVRIL---LLILAAIL 142

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 29171738 211 SIYVGLSRVSDYKHHWSDVLTGLIQG-ALVAILVAVY 246
Cdd:cd03392 143 ILLVGLSRLYLGVHYPSDVLAGWLLGlAWLALLILLY 179
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 106-247 8.28e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 57.73  E-value: 8.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 106 FLFGAAASQSLTDIAKYSIGRLRPhfldvcdpdwskincsDGYIEYYicrgnaervkegrLSFYSGHSS--FSmycmlfV 183
Cdd:cd03394   8 LAEAAALTAAVTEGLKFAVGRARP----------------DGSNNGY-------------RSFPSGHTAsaFA------A 52

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171738 184 ALYLQARMKGDWArllrptlQFGLVAVSIYVGLSRVSDYKHHWSDVLTgliqGALVAILVAVYV 247
Cdd:cd03394  53 ATFLQYRYGWRWY-------GIPAYALASLVGASRVVANRHWLSDVLA----GAAIGILVGYLV 105
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 102-247 3.30e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 49.65  E-value: 3.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 102 AIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDwskINCSDGYieyyicrgnaervkegrlSFYSGHSSFSMYCML 181
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171738 182 FVALYLQARmkgdWARLLrptlqfgLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 247
Cdd:COG0671 133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 103-247 3.73e-06

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 46.55  E-value: 3.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738 103 IGTFLFGA-AASQSLTDIAKYSIGRLRPHFldvcdpdwskincsdgYIEYYICRGNAERVKEGRLSFYSGHSS--FSMyc 179
Cdd:cd03389  70 AGLFLFATvALSGILVNLLKFIIGRARPKL----------------LFDDGLYGFDPFHADYAFTSFPSGHSAtaGAA-- 131

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29171738 180 mlFVALYLqarmkgdwarlLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 247
Cdd:cd03389 132 --AAALAL-----------LFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 170-242 2.12e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 43.80  E-value: 2.12e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171738 170 SGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAIL 242
Cdd:cd03382  85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 92-243 1.51e-04

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 41.48  E-value: 1.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171738  92 RNNYIATIYKAIGTFLFGAAAsQSLTDIAKYSIGRLRPHF-LDVCDpDWSKINCSDGYieyyicrgnaervkegrlSFYS 170
Cdd:cd03395  49 RKGPIGLLILLLVLLAVGFAD-QLASGFLKPLVARLRPCNaLDGVR-LVVLGDQGGSY------------------SFAS 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171738 171 GHSSFSMYCMLFVALYLqarmkgdWARLLRPTLqfglVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 243
Cdd:cd03395 109 SHAANSFALALFIWLFF-------RRGLFSPVL----LLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLF 170
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 167-243 4.14e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 36.91  E-value: 4.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29171738 167 SFYSGHSSFSMYCMLFVALYLqarmkgDWARLLRPTLqfglVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 243
Cdd:cd03391  92 SFPSGHASRAAFVARFLLNHL------VLAVPLRVLL----VLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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