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Conserved domains on  [gi|2028477657|ref|NP_803880|]
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sulfotransferase 1A1 isoform c [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
24-186 1.66e-67

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 206.81  E-value: 1.66e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657  24 VVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREI 103
Cdd:pfam00685  95 IIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEI 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657 104 QKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEfmdhsISPFMRKGMAGDWKTTFTVAQNERFDADYAEKM 183
Cdd:pfam00685 175 KKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTPEQAEKFDEIYQEKM 249


                  ...
gi 2028477657 184 AGC 186
Cdd:pfam00685 250 KGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
24-186 1.66e-67

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 206.81  E-value: 1.66e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657  24 VVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREI 103
Cdd:pfam00685  95 IIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEI 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657 104 QKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEfmdhsISPFMRKGMAGDWKTTFTVAQNERFDADYAEKM 183
Cdd:pfam00685 175 KKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTPEQAEKFDEIYQEKM 249


                  ...
gi 2028477657 184 AGC 186
Cdd:pfam00685 250 KGT 252
PLN02164 PLN02164
sulfotransferase
 24-188 1.83e-13

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 67.64  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657  24 VVYVARNAKDVAVSYYHFYHMAKVH--PEPGTWDSFlEKFMVGEVSYGSWYQHVQEWWELSRTHP--VLYLFYEDMKENP 99
Cdd:PLN02164  168 MVYIWRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQENPdrILFLKYETMRADP 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657 100 KREIQKILEFVGRSLPEE-----TVDFVVQHTSFkEMKKNPMTNYTTVPQEFMD--HSISPFMRKGMAGDWKTTFTVAQN 172
Cdd:PLN02164  247 LPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFRKGKVGDWQNYLTPEMA 325

                         170
                  ....*....|....*.
gi 2028477657 173 ERFDADYAEKMAGCSL 188
Cdd:PLN02164  326 ARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
24-186 1.66e-67

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 206.81  E-value: 1.66e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657  24 VVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREI 103
Cdd:pfam00685  95 IIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILFLRYEDLKKDPRGEI 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657 104 QKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEfmdhsISPFMRKGMAGDWKTTFTVAQNERFDADYAEKM 183
Cdd:pfam00685 175 KKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTPEQAEKFDEIYQEKM 249


                  ...
gi 2028477657 184 AGC 186
Cdd:pfam00685 250 KGT 252
PLN02164 PLN02164
sulfotransferase
 24-188 1.83e-13

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 67.64  E-value: 1.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657  24 VVYVARNAKDVAVSYYHFYHMAKVH--PEPGTWDSFlEKFMVGEVSYGSWYQHVQEWWELSRTHP--VLYLFYEDMKENP 99
Cdd:PLN02164  168 MVYIWRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQENPdrILFLKYETMRADP 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657 100 KREIQKILEFVGRSLPEE-----TVDFVVQHTSFkEMKKNPMTNYTTVPQEFMD--HSISPFMRKGMAGDWKTTFTVAQN 172
Cdd:PLN02164  247 LPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFRKGKVGDWQNYLTPEMA 325

                         170
                  ....*....|....*.
gi 2028477657 173 ERFDADYAEKMAGCSL 188
Cdd:PLN02164  326 ARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
23-116 1.17e-05

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 43.82  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2028477657  23 MVVYVARNAKDVAVSyyHFYHMAKVHPEPgtWDSFLEKFMVGEVSYgsWYQHVQEWWELSRTHP---VLYLFYEDMKENP 99
Cdd:pfam13469  83 KFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrFLDVRYEDLVADP 156

                          90
                  ....*....|....*..
gi 2028477657 100 KREIQKILEFVGRSLPE 116
Cdd:pfam13469 157 EGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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