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Conserved domains on  [gi|159110932|ref|NP_808877|]
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urea transporter 2 isoform 2 [Rattus norvegicus]

Protein Classification

urea transporter( domain architecture ID 10505473)

urea transporter is an integral membrane protein that facilitates the rapid and passive diffusion of urea down its concentration gradient

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
127-411 2.58e-124

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


:

Pssm-ID: 460863  Cd Length: 292  Bit Score: 363.02  E-value: 2.58e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  127 LDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFse 206
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVF-- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  207 kLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEiE 286
Cdd:pfam03253  79 -LEPSPLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  287 MPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIG 366
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 159110932  367 GMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFC 411
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFV 281
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
127-411 2.58e-124

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 363.02  E-value: 2.58e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  127 LDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFse 206
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVF-- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  207 kLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEiE 286
Cdd:pfam03253  79 -LEPSPLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  287 MPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIG 366
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 159110932  367 GMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFC 411
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFV 281
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
123-411 4.97e-74

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 234.76  E-value: 4.97e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 123 VLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVA 202
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 203 VFsekLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITW 282
Cdd:COG4413   83 FF---FGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 283 SEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSC 362
Cdd:COG4413  160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 159110932 363 VAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFC 411
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFV 288
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
125-410 1.78e-44

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 157.10  E-value: 1.78e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  125 QFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVF 204
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  205 sekLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSE 284
Cdd:TIGR03441  82 ---LAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPVAFGGP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  285 IEMPlLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVA 364
Cdd:TIGR03441 159 AREN-FFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 159110932  365 IGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAF 410
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPF 283
 
Name Accession Description Interval E-value
UT pfam03253
Urea transporter; Members of this family transport urea across membranes. The family includes ...
127-411 2.58e-124

Urea transporter; Members of this family transport urea across membranes. The family includes a bacterial homolog Swiss:Q9S408.


Pssm-ID: 460863  Cd Length: 292  Bit Score: 363.02  E-value: 2.58e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  127 LDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVFse 206
Cdd:pfam03253   1 IDAILRGIGQVMFQNNPLSGLLILAGLFFGSPWLGLLGLLGTLVSTLTALLLGQDRAEIRAGLYGYNGVLVGLALGVF-- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  207 kLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEiE 286
Cdd:pfam03253  79 -LEPSPLLLLLVVLGAALSTLVTAALARILSPWKLPVLTLPFVLVTWLLLLATGSFNPLLPSSLAAPALPLPNVTASD-D 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  287 MPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIG 366
Cdd:pfam03253 157 LPDLLLGLFKGVGQVFFQDNVVTGLLILLALLISSRIAALLALLGSLLGLLAALLLGAPHSDIYSGLYGFNAVLTAIALG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 159110932  367 GMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFC 411
Cdd:pfam03253 237 GVFLVPSWRSALLAVLGAVLTVFLQAALSTLLAPLGLPVLTWPFV 281
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
123-411 4.97e-74

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 234.76  E-value: 4.97e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 123 VLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVA 202
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 203 VFsekLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITW 282
Cdd:COG4413   83 FF---FGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTWLLLLAAYKFGGLPVSPLLPPALPAPASAT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 283 SEIEMPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSC 362
Cdd:COG4413  160 NGLTLPDLVEALFKGVGQVFFQDSWVAGLLILAGLAIASRIAALLALIGSVLGLLVALLLGAPPASIALGLYGFNAVLTA 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 159110932 363 VAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFC 411
Cdd:COG4413  240 IALGGVFLKPSPRSFLYALLGAILTVFLQAALTVLFAPLGLPVLTAPFV 288
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
125-410 1.78e-44

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 157.10  E-value: 1.78e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  125 QFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGMLVGLLVAVF 204
Cdd:TIGR03441   2 KLIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALPLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  205 sekLDYYWWLLFPVTFASMACPVISSALSTVFAKWDLPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSE 284
Cdd:TIGR03441  82 ---LAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTWIFLLASYAFKGLHTDAPVLPHDIEPVAFGGP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  285 IEMPlLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVA 364
Cdd:TIGR03441 159 AREN-FFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLTAIA 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 159110932  365 IGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAF 410
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTVFVQGALDTLLTPLGLPTLTFPF 283
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
121-257 6.47e-14

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 71.97  E-value: 6.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  121 PLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQDRSAIASGLHGYNGML--VG 198
Cdd:TIGR03441 158 PARENFFVAFFKGFSQVFLLDSAIAGVLILIGILIASRKAAIMALIGALISILAAILLGADLDSINQGLFGFNPVLtaIA 237
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 159110932  199 LLVAVFSEKLDYYWWLLFPVTFASmacpVISSALSTVFAKWDLPVFTLPFNIALTLYLA 257
Cdd:TIGR03441 238 LGVVFLRPSIRSAAYAVLGVVLTV----FVQGALDTLLTPLGLPTLTFPFVLVTWLFLF 292
Utp COG4413
Urea transporter [Amino acid transport and metabolism];
287-415 9.23e-14

Urea transporter [Amino acid transport and metabolism];


Pssm-ID: 443533  Cd Length: 302  Bit Score: 71.82  E-value: 9.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932 287 MPLLLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIG 366
Cdd:COG4413    3 LLDFIRALLRGIGQVFFQNNALTGLLILAAIALASPRLGLGALLGVLIATLTARLLGFDRAEIRAGLYGFNGALVGLALG 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 159110932 367 gMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTL 415
Cdd:COG4413   83 -FFFGPSPASWVLLVLGAALSALVTAALSRLLIPWGLPALTLPFVLVTW 130
urea_trans_yut TIGR03441
urea transporter, Yersinia type; Members of this protein family are bacterial urea ...
290-415 1.26e-10

urea transporter, Yersinia type; Members of this protein family are bacterial urea transporters, found not only is species that contain urease, but adjacent to the urease operon. It was characterized in Yersinia pseudotuberculosis. Members are homologous to eukaryotic members of solute carrier family 14, a family that includes urea transporters, and to bacterial proteins in species with no detectable urea degradation system. [Transport and binding proteins, Other]


Pssm-ID: 163267  Cd Length: 292  Bit Score: 61.95  E-value: 1.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110932  290 LLQTIPVGVGQVYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVLSCVAIGgMF 369
Cdd:TIGR03441   3 LIDVLLRGISQVVFQNNPLTGLFFLIALFIGNWAVGIGALIGVLVATLTARLLNYDKKSIRSGLYGFNGVLVGIALP-LF 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 159110932  370 YVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTL 415
Cdd:TIGR03441  82 LAPSPQLWAIIVIGSILSTVVMAAVSEILKPWKVPALTMPFVLTTW 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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