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Conserved domains on  [gi|194394139|ref|NP_848588|]
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palmitoleoyl-protein carboxylesterase NOTUM precursor [Homo sapiens]

Protein Classification

pectinacetylesterase family protein( domain architecture ID 10505531)

pectinacetylesterase (PAE) family protein such as Arabidopsis thaliana pectin acetylesterase, which hydrolyzes acetyl esters in homogalacturonan regions of pectin, and human palmitoleoyl-protein carboxylesterase NOTUM, which acts as a key negative regulator of the Wnt signaling pathway

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PAE pfam03283
Pectinacetylesterase;
81-417 7.03e-122

Pectinacetylesterase;


:

Pssm-ID: 460874  Cd Length: 345  Bit Score: 360.38  E-value: 7.03e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139   81 SAQQLNEDLRLHLLLNTSV---TCNDGSPAGYYLKE--SRGSRRWLLFLEGGWYCFNRENCDSRYDTmrRLMSSRDWPRT 155
Cdd:pfam03283   1 SLQAEGLDVPLTLVKNAVAkgaVCLDGSPPGYHFDRgfGSGANNWLIHLEGGGWCNNLESCLSRKKT--RLGSSKYMEKQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  156 RTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKN-EYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAG 234
Cdd:pfam03283  79 ISFSGILSNNQSENPDFYNWNRVKIRYCDGASFTGDVEPVDPAtNLYFRGQRIWQAIIEDLLAKGMKNAKNALLSGCSAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  235 GTGVLLNVDRVAEQLEklgyPAIQVRGLADSGWFLDNKQYRHTDCVDTI--TCAPTEAIRRGIrywngvvPERCRRQFQe 312
Cdd:pfam03283 159 GLAAILHCDYFRDLLP----ANAKVKCLSDAGFFLDAKDISGTRHIRSFysGVVTLQGSAKNL-------PESCTSRLN- 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  313 geEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTV-----DNVHLTGQPVQEGLRLYIQNLGRELRHTLKDV-----PASF 382
Cdd:pfam03283 227 --PWKCFFPQYVIPYIKTPLFILNSAYDSWQIQNilgswCNCKLDIQNCSPSQLQFLQGFRSEFLNALKGFgnspnNGMF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 194394139  383 APACLSHE-IIIRSHWT---DVQVKGTSLPRALHCW--DRS 417
Cdd:pfam03283 305 INSCFAHCqSESQDTWFaddSPRISNKTIAKAVGDWyfDRS 345
 
Name Accession Description Interval E-value
PAE pfam03283
Pectinacetylesterase;
81-417 7.03e-122

Pectinacetylesterase;


Pssm-ID: 460874  Cd Length: 345  Bit Score: 360.38  E-value: 7.03e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139   81 SAQQLNEDLRLHLLLNTSV---TCNDGSPAGYYLKE--SRGSRRWLLFLEGGWYCFNRENCDSRYDTmrRLMSSRDWPRT 155
Cdd:pfam03283   1 SLQAEGLDVPLTLVKNAVAkgaVCLDGSPPGYHFDRgfGSGANNWLIHLEGGGWCNNLESCLSRKKT--RLGSSKYMEKQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  156 RTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKN-EYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAG 234
Cdd:pfam03283  79 ISFSGILSNNQSENPDFYNWNRVKIRYCDGASFTGDVEPVDPAtNLYFRGQRIWQAIIEDLLAKGMKNAKNALLSGCSAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  235 GTGVLLNVDRVAEQLEklgyPAIQVRGLADSGWFLDNKQYRHTDCVDTI--TCAPTEAIRRGIrywngvvPERCRRQFQe 312
Cdd:pfam03283 159 GLAAILHCDYFRDLLP----ANAKVKCLSDAGFFLDAKDISGTRHIRSFysGVVTLQGSAKNL-------PESCTSRLN- 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  313 geEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTV-----DNVHLTGQPVQEGLRLYIQNLGRELRHTLKDV-----PASF 382
Cdd:pfam03283 227 --PWKCFFPQYVIPYIKTPLFILNSAYDSWQIQNilgswCNCKLDIQNCSPSQLQFLQGFRSEFLNALKGFgnspnNGMF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 194394139  383 APACLSHE-IIIRSHWT---DVQVKGTSLPRALHCW--DRS 417
Cdd:pfam03283 305 INSCFAHCqSESQDTWFaddSPRISNKTIAKAVGDWyfDRS 345
 
Name Accession Description Interval E-value
PAE pfam03283
Pectinacetylesterase;
81-417 7.03e-122

Pectinacetylesterase;


Pssm-ID: 460874  Cd Length: 345  Bit Score: 360.38  E-value: 7.03e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139   81 SAQQLNEDLRLHLLLNTSV---TCNDGSPAGYYLKE--SRGSRRWLLFLEGGWYCFNRENCDSRYDTmrRLMSSRDWPRT 155
Cdd:pfam03283   1 SLQAEGLDVPLTLVKNAVAkgaVCLDGSPPGYHFDRgfGSGANNWLIHLEGGGWCNNLESCLSRKKT--RLGSSKYMEKQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  156 RTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKN-EYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAG 234
Cdd:pfam03283  79 ISFSGILSNNQSENPDFYNWNRVKIRYCDGASFTGDVEPVDPAtNLYFRGQRIWQAIIEDLLAKGMKNAKNALLSGCSAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  235 GTGVLLNVDRVAEQLEklgyPAIQVRGLADSGWFLDNKQYRHTDCVDTI--TCAPTEAIRRGIrywngvvPERCRRQFQe 312
Cdd:pfam03283 159 GLAAILHCDYFRDLLP----ANAKVKCLSDAGFFLDAKDISGTRHIRSFysGVVTLQGSAKNL-------PESCTSRLN- 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194394139  313 geEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTV-----DNVHLTGQPVQEGLRLYIQNLGRELRHTLKDV-----PASF 382
Cdd:pfam03283 227 --PWKCFFPQYVIPYIKTPLFILNSAYDSWQIQNilgswCNCKLDIQNCSPSQLQFLQGFRSEFLNALKGFgnspnNGMF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 194394139  383 APACLSHE-IIIRSHWT---DVQVKGTSLPRALHCW--DRS 417
Cdd:pfam03283 305 INSCFAHCqSESQDTWFaddSPRISNKTIAKAVGDWyfDRS 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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