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Conserved domains on  [gi|194018469|ref|NP_848639|]
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zinc finger protein 546 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
60-120 3.47e-34

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.63  E-value: 3.47e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194018469    60 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWI 120
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-823 5.16e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 5.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 383 KPYKCNECGKAFSHGSYLVQHQKIHTGEKPYEC--KECGKSFSFHAELARHRRIHTGEKPYECRecgKAFRLQTELTRH- 459
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 460 ---HRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRL 536
Cdd:COG5048  109 slsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 537 QGELTRHHRIHtcekpYECKECGKAFIHSNQfISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGK 616
Cdd:COG5048  189 SSNVSTSIPSS-----SENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 617 AFRFQTELTQHHRIHTGE-------KPYKCTECGKAFIRSTHLTQH--HRIHTGE--KPYECTE--CGKTFSRHYHLTQH 683
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 684 HRGHTGEKPYIC-------------NECGNAFICSYRLTLHQRIHTGELPyeckECGKTFSRRYHLTQHFRLHTGEKPYS 750
Cdd:COG5048  343 ILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194018469 751 CKecgnafrlqaeltrhhivhtgekpykCKECGKAFSVNSELTRHHRIHTGEKPYQCkECGKAFIRSDQLTLH 823
Cdd:COG5048  419 CK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-375 1.80e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 215 KSYECKECRKAFRQQSYLIQHLR--IHTGE--RPYKCME--CGKAFCRVGDLRVHHTIHAGERPYECKEC-------GKA 281
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 282 FRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRD--LRVHQTIHAGERPYECK--ECGKAFRLHYQLTEHQRIHTGERPY 357
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 194018469 358 ECKVCGKtFRVQRHISQH 375
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
60-120 3.47e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.63  E-value: 3.47e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194018469    60 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWI 120
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 59-100 1.86e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194018469   59 SLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLG 100
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 60-99 2.97e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.97e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 194018469  60 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSL 99
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-823 5.16e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 5.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 383 KPYKCNECGKAFSHGSYLVQHQKIHTGEKPYEC--KECGKSFSFHAELARHRRIHTGEKPYECRecgKAFRLQTELTRH- 459
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 460 ---HRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRL 536
Cdd:COG5048  109 slsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 537 QGELTRHHRIHtcekpYECKECGKAFIHSNQfISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGK 616
Cdd:COG5048  189 SSNVSTSIPSS-----SENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 617 AFRFQTELTQHHRIHTGE-------KPYKCTECGKAFIRSTHLTQH--HRIHTGE--KPYECTE--CGKTFSRHYHLTQH 683
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 684 HRGHTGEKPYIC-------------NECGNAFICSYRLTLHQRIHTGELPyeckECGKTFSRRYHLTQHFRLHTGEKPYS 750
Cdd:COG5048  343 ILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194018469 751 CKecgnafrlqaeltrhhivhtgekpykCKECGKAFSVNSELTRHHRIHTGEKPYQCkECGKAFIRSDQLTLH 823
Cdd:COG5048  419 CK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-375 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 215 KSYECKECRKAFRQQSYLIQHLR--IHTGE--RPYKCME--CGKAFCRVGDLRVHHTIHAGERPYECKEC-------GKA 281
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 282 FRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRD--LRVHQTIHAGERPYECK--ECGKAFRLHYQLTEHQRIHTGERPY 357
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 194018469 358 ECKVCGKtFRVQRHISQH 375
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-480 8.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.30e-04
                          10        20
                  ....*....|....*....|....*.
gi 194018469  455 ELTRHHRTHTGEKPYECKECGKAFIC 480
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-254 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....
gi 194018469  231 YLIQHLRIHTGERPYKCMECGKAF 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
60-120 3.47e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.63  E-value: 3.47e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194018469    60 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWI 120
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 59-100 1.86e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194018469   59 SLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLG 100
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 60-99 2.97e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.97e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 194018469  60 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSL 99
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-823 5.16e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 5.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 383 KPYKCNECGKAFSHGSYLVQHQKIHTGEKPYEC--KECGKSFSFHAELARHRRIHTGEKPYECRecgKAFRLQTELTRH- 459
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 460 ---HRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRL 536
Cdd:COG5048  109 slsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 537 QGELTRHHRIHtcekpYECKECGKAFIHSNQfISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGK 616
Cdd:COG5048  189 SSNVSTSIPSS-----SENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 617 AFRFQTELTQHHRIHTGE-------KPYKCTECGKAFIRSTHLTQH--HRIHTGE--KPYECTE--CGKTFSRHYHLTQH 683
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 684 HRGHTGEKPYIC-------------NECGNAFICSYRLTLHQRIHTGELPyeckECGKTFSRRYHLTQHFRLHTGEKPYS 750
Cdd:COG5048  343 ILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194018469 751 CKecgnafrlqaeltrhhivhtgekpykCKECGKAFSVNSELTRHHRIHTGEKPYQCkECGKAFIRSDQLTLH 823
Cdd:COG5048  419 CK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-657 6.59e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 6.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 271 RPYECKECGKAFRLHYHLTEHQRIHSGVKPYEC--KECGKAFSRVRDLRVHQTIH---------AGERPYECK------- 332
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHhnnpsdlnsKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 333 ECGKAFRLHYQLTEH---QRIHTGERP-------YECKVCGKTFRVQRHISQHQKIHTGVKPYkcNECGKAFSHGSYLVQ 402
Cdd:COG5048  112 SSSSNSNDNNLLSSHslpPSSRDPQLPdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 403 HQKIHTGEKPYECKECGKSFSFHAELARHRRIHTgEKPYECRECGKAFRLQ-------TELTRHHRTHTGEKPYECKecG 475
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspsSLSSSDSSSSASESPRSSL--P 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 476 KAFICGYQLTLHL-RTHTGEI-PYECKECGKTFSSRYHLTQHYR--IHTGE--KPYICNE--CGKAFRLQGELTRHHRIH 547
Cdd:COG5048  267 TASSQSSSPNESDsSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 548 TCEKPYECK--ECGKAFIHSN-----QFISHQRIHTSESTYIC--KECGKIFSRRYNLTQHFKIHTGEKP--YICNECGK 616
Cdd:COG5048  347 TSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 194018469 617 AFRFQTELTQHHRIHTgEKPYKCTECGKAFIRSTHLTQHHR 657
Cdd:COG5048  427 SFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-830 1.02e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 496 PYECKECGKTFSSRYHLTQHYRIHTGEKPYICN--ECGKAFRLQGELTRHHRIHTCEKPYECKecgKAFIHSNQFISHQ- 572
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSSs 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 573 -RIHTSESTYICKECGKI--FSRRYNLTQHFKIHT---GEKPYICNecGKAFRFQTELTQHHRIHTGEKPYKCTECGKAF 646
Cdd:COG5048  110 lSSSSSNSNDNNLLSSHSlpPSSRDPQLPDLLSISnlrNNPLPGNN--SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 647 IrsthltqHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYICNECGNAFICSYRLTLHQRIHTGELPYECKEC 726
Cdd:COG5048  188 I-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 727 GKTF--SRRYHLTQHFRLHTGE-----KPYSCKECGNAFRLQAELTRH--HIVHTGE--KPYKCKE--CGKAFSVNSELT 793
Cdd:COG5048  261 PRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 194018469 794 RHHRIHTGEKPYQCKEC------GKAFIRSDQLTLHQRNHISE 830
Cdd:COG5048  341 RHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKN 383
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
439-835 3.63e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 439 KPYECRECGKAFRLQTELTRHHRTHTGEKPYEC--KECGKAFICGYQLTLHLRTHTGEIPYEC-KECGKTFSSRYHLTQH 515
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 516 YRIHTGEKPYICNECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSNQFISHqrIHTSESTYICKECGKIFSRRYN 595
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSL--HPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 596 LTqhfkIHTGEKPYICNECGKAFRFQTELTQHHRIHTGEKPYKCTECGKAFirstHLTQHHRIHTGEKPYECTECGKTFS 675
Cdd:COG5048  190 SN----VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLS----PKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 676 RHYHLTQHHRGHTG-----------EKPYICNECGNAFICSYRLTLHQR--IHTGE--LPYECKE--CGKTFSRRYHLTQ 738
Cdd:COG5048  262 RSSLPTASSQSSSPnesdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 739 HFRLHTGEKPYSCKEC-------GNAFRLQAELTRHHIvhtGEKPYKCKECGKAFSVNSELTRH----HRI-HTGEKPYQ 806
Cdd:COG5048  342 HILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYK---DLKNDKKSETLSNSCIRNFKRDSnlslHIItHLSFRPYN 418

                        410       420       430
                 ....*....|....*....|....*....|.
gi 194018469 807 CK--ECGKAFIRSDQLTLHQRNHISEEVLCI 835
Cdd:COG5048  419 CKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
569-829 1.53e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 569 ISHQRIHTSES----TYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQT--ELTQHHRIHTGEKPYKC--- 639
Cdd:COG5048   18 STPKSTLKSLSnaprPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNsks 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 640 -------------TECGKAFIRSTHLTQHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYIC--------NEC 698
Cdd:COG5048   98 lplsnskasssslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 699 GNAFICSyRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHFRLHTGEKPYSC--------------------------- 751
Cdd:COG5048  178 KDPSSNL-SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlspksllsqspsslsssdssss 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 752 -KECGNAFRLQAELTRHHIVHTGE-------KPYKCKECGKAFSVNSELTRH--HRIHTGE--KPYQCKE--CGKAFIRS 817
Cdd:COG5048  257 aSESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                        330
                 ....*....|..
gi 194018469 818 DQLTLHQRNHIS 829
Cdd:COG5048  337 DALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-375 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 215 KSYECKECRKAFRQQSYLIQHLR--IHTGE--RPYKCME--CGKAFCRVGDLRVHHTIHAGERPYECKEC-------GKA 281
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018469 282 FRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRD--LRVHQTIHAGERPYECK--ECGKAFRLHYQLTEHQRIHTGERPY 357
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 194018469 358 ECKVCGKtFRVQRHISQH 375
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-480 8.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.30e-04
                          10        20
                  ....*....|....*....|....*.
gi 194018469  455 ELTRHHRTHTGEKPYECKECGKAFIC 480
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
791-816 9.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.25e-04
                          10        20
                  ....*....|....*....|....*.
gi 194018469  791 ELTRHHRIHTGEKPYQCKECGKAFIR 816
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-450 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....
gi 194018469  427 ELARHRRIHTGEKPYECRECGKAF 450
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-423 1.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|....*
gi 194018469  399 YLVQHQKIHTGEKPYECKECGKSFS 423
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
651-676 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....*.
gi 194018469  651 HLTQHHRIHTGEKPYECTECGKTFSR 676
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
623-648 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 194018469  623 ELTQHHRIHTGEKPYKCTECGKAFIR 648
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-254 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....
gi 194018469  231 YLIQHLRIHTGERPYKCMECGKAF 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 3.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 194018469  287 HLTEHQRIHSGVKPYECKECGKAFSR 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 6.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 194018469  371 HISQHQKIHTGVKPYKCNECGKAFSH 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
763-787 7.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|....*
gi 194018469  763 ELTRHHIVHTGEKPYKCKECGKAFS 787
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-366 8.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|...
gi 194018469  344 LTEHQRIHTGERPYECKVCGKTF 366
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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