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Conserved domains on  [gi|194097407|ref|NP_848653|]
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zinc finger protein 680 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 1.08e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.85  E-value: 1.08e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194097407    13 LTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFLGIAVSKPHLITCLEQGKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-513 4.60e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 152 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 228
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 229 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 300
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 301 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 365
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 366 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 430
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 431 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 501
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                        410
                 ....*....|..
gi 194097407 502 SSHLTRHKKIHT 513
Cdd:COG5048  431 HYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 1.08e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.85  E-value: 1.08e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194097407    13 LTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFLGIAVSKPHLITCLEQGKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 6.68e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 6.68e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194097407   12 PLTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.30e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 2.30e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 194097407  13 LTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-513 4.60e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 152 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 228
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 229 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 300
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 301 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 365
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 366 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 430
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 431 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 501
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                        410
                 ....*....|..
gi 194097407 502 SSHLTRHKKIHT 513
Cdd:COG5048  431 HYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-416 3.06e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.06e-05
                          10        20
                  ....*....|....*....|....*
gi 194097407  392 NLTEHMRIHTGEKPYKCEECGKAFN 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 1.08e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.85  E-value: 1.08e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194097407    13 LTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFLGIAVSKPHLITCLEQGKEPWN 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 6.68e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 6.68e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194097407   12 PLTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFLG 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 2.30e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 2.30e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 194097407  13 LTFRDVAIEFSLEEWQCLDTAQRNLYRKVMFENYRNLVFL 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-513 4.60e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 152 KIFQCDKYVKVFHKFSNSNSHKKRNTGKKVFKC--KECGKSFCMLSHLTQHIRIHTRENSYKCE-ECGKVLNWFSELIKH 228
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 229 KGIHMGEKPYKCEECGKAFNQSSTLIK--HKKIHIEEKPFK-----CEECGKAFSLFSILSKHKIIHTGDKPYKCDECH- 300
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnssSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 301 KAFNWFATLTNHKRIHTGEKPFKCEECGKDfNQFSNLTKHKKIHTGEKPYKCE---------------ECGKAFNQFANL 365
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLE-NSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 366 TRHKKIHTGE-------KSYKCEECGKAFIQSSNLTEHMR--IHTGE--KPYKCEE--CGKAFNGCSSLTRHKRIHT--R 430
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTsiS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 431 ENTYKCEECGKGFTLFST-----LTNHKVIHTGEKSYKCD--ECGNVFNWPATLANHKRIHAREKPY--KCEECGKAFNR 501
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                        410
                 ....*....|..
gi 194097407 502 SSHLTRHKKIHT 513
Cdd:COG5048  431 HYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-342 7.64e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 7.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 174 KRNTGKKVFKCKECGKSFCMLSHLTQHIR--IHTRENSYKCEE----CGKVLNWFSELIKHKGIHMGEKPYKC--EECGK 245
Cdd:COG5048  282 SEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEklLNSSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 246 AFNQSST-----LIKHKKIHIEEKPFKCE--ECGKAFSLFSILSKHKIIHTGDKPY--KCDECHKAFNWFATLTNHKRIH 316
Cdd:COG5048  362 KFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441

                        170       180
                 ....*....|....*....|....*.
gi 194097407 317 TGEKPFKCEECGKdFNQFSNLTKHKK 342
Cdd:COG5048  442 TNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
236-519 2.85e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 236 KPYKCEECGKAFNQSSTLIKHKKIHIEEKPFKC--EECGKAFSLFSILSKHKIIHTGDKPYKC-DECHKAFNWFATLTNH 312
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 313 KRIHTGEKPFKCEECGKDFNQFSNLTK--HKKIHTGEKPYK---------------------CEECGKAFNQFANLTRHK 369
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 370 KIHTGEKSYKCEECGKAFIQSSNLTEHMRIHTgEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFSTL 449
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 450 TNHKVIHTGE-------KSYKCDECGNVFNWPATLANHKR--IHARE--KPYKCEE--CGKAFNRSSHLTRHKKIHTGEK 516
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350


                 ...
gi 194097407 517 LYK 519
Cdd:COG5048  351 PAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-510 3.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 348 KPYKCEECGKAFNQFANLTRHK--KIHTGE--KSYKCEE--CGKAFIQSSNLTEHMRIHTGEKPYKCEEC------GKAF 415
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 416 NGCSSLTRHKRIHTRENTYKC---EECGKGFTLFSTLTNHKVIHTGEKS--YKCDECGNVFNWPATLANHKRIHAREKPY 490
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 194097407 491 KCEECGKaFNRSSHLTRHKK 510
Cdd:COG5048  448 LCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-416 3.06e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.06e-05
                          10        20
                  ....*....|....*....|....*
gi 194097407  392 NLTEHMRIHTGEKPYKCEECGKAFN 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-361 7.54e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.54e-05
                          10        20
                  ....*....|....*....|....*.
gi 194097407  336 NLTKHKKIHTGEKPYKCEECGKAFNQ 361
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-389 1.93e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.93e-04
                          10        20
                  ....*....|....*....|....*.
gi 194097407  364 NLTRHKKIHTGEKSYKCEECGKAFIQ 389
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 3.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*
gi 194097407  309 LTNHKRIHTGEKPFKCEECGKDFNQ 333
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-526 4.05e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 291 DKPYKCDECHKAFNWFATLTNHKRIHTGEKPFKCEECGKDFNQF--SNLTKHKKIHTGEKPYKCEECGKAFNQFA-NLTR 367
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKAsSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 368 HKKIHTGEKSYKCEECGKAFIQSSNLTEHMRIHTGEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFS 447
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097407 448 TLTN----------------------HKVIHTGEKSYKCDECGNVF-----------NWPATLANHKRIHARE------- 487
Cdd:COG5048  191 NVSTsipsssensplsssysipssssDQNLENSSSSLPLTTNSQLSpksllsqspssLSSSDSSSSASESPRSslptass 270

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194097407 488 -----------------KPYKCEECGKAFNRSSHLTRHK--KIHTGEKLyKPEKCDNN 526
Cdd:COG5048  271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESL-KPFSCPYS 327
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-304 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....
gi 194097407  281 LSKHKIIHTGDKPYKCDECHKAFN 304
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 378-400 1.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|...
gi 194097407  378 YKCEECGKAFIQSSNLTEHMRIH 400
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 233-303 1.73e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194097407 233 MGEKPYKCE--ECGKAFNQSSTLIKHKKiHIEEKPFKCEECGKafslfsilSKHKIIHTGDKPYKCDECHKAF 303
Cdd:COG5189  345 KDGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-249 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....*.
gi 194097407  224 ELIKHKGIHMGEKPYKCEECGKAFNQ 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 490-512 2.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|...
gi 194097407  490 YKCEECGKAFNRSSHLTRHKKIH 512
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 182-204 5.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.47e-03
                          10        20
                  ....*....|....*....|...
gi 194097407  182 FKCKECGKSFCMLSHLTQHIRIH 204
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-501 5.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.60e-03
                          10        20
                  ....*....|....*....|....*
gi 194097407  477 LANHKRIHAREKPYKCEECGKAFNR 501
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-276 8.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.72e-03
                          10        20
                  ....*....|....*....|....
gi 194097407  253 LIKHKKIHIEEKPFKCEECGKAFS 276
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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