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Conserved domains on  [gi|302034748|ref|NP_851565|]
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interleukin-21 receptor isoform 2 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 142-247 1.17e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302034748 142 PAPPFNVTVTF--SGQYNISWrsdyeDPAFYMLKGKLQYELQYRNRG-DPWAVSPRRkliSVDSRSVSLLPLefRKDSSY 218
Cdd:cd00063    1 PSPPTNLRVTDvtSTSVTLSW-----TPPEDDGGPITGYVVEYREKGsGDWKEVEVT---PGSETSYTLTGL--KPGTEY 70

                         90       100
                 ....*....|....*....|....*....
gi 302034748 219 ELQVRAgpmpgsSYQGTWSEWSDPVIFQT 247
Cdd:cd00063   71 EFRVRA------VNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 142-247 1.17e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302034748 142 PAPPFNVTVTF--SGQYNISWrsdyeDPAFYMLKGKLQYELQYRNRG-DPWAVSPRRkliSVDSRSVSLLPLefRKDSSY 218
Cdd:cd00063    1 PSPPTNLRVTDvtSTSVTLSW-----TPPEDDGGPITGYVVEYREKGsGDWKEVEVT---PGSETSYTLTGL--KPGTEY 70

                         90       100
                 ....*....|....*....|....*....
gi 302034748 219 ELQVRAgpmpgsSYQGTWSEWSDPVIFQT 247
Cdd:cd00063   71 EFRVRA------VNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 142-247 1.17e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302034748 142 PAPPFNVTVTF--SGQYNISWrsdyeDPAFYMLKGKLQYELQYRNRG-DPWAVSPRRkliSVDSRSVSLLPLefRKDSSY 218
Cdd:cd00063    1 PSPPTNLRVTDvtSTSVTLSW-----TPPEDDGGPITGYVVEYREKGsGDWKEVEVT---PGSETSYTLTGL--KPGTEY 70

                         90       100
                 ....*....|....*....|....*....
gi 302034748 219 ELQVRAgpmpgsSYQGTWSEWSDPVIFQT 247
Cdd:cd00063   71 EFRVRA------VNGGGESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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