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Conserved domains on  [gi|304571943|ref|NP_852114|]
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CMRF35-like molecule 2 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-104 2.70e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 2.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  19 KGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQyDTSCESIVETKGeekVERNGRVSIRDHPEALAFTVTMQNLNEDD 98
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKED 77


                 ....*.
gi 304571943  99 AGSYWC 104
Cdd:cd05716   78 AGWYWC 83
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-104 2.70e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 2.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  19 KGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQyDTSCESIVETKGeekVERNGRVSIRDHPEALAFTVTMQNLNEDD 98
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKED 77


                 ....*.
gi 304571943  99 AGSYWC 104
Cdd:cd05716   78 AGWYWC 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 20-106 7.27e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 57.08  E-value: 7.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943   20 GPGSVTGTAGDSLTVWCQY--ESMYKGYNKYWCRGQYDTSCES--IVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLN 95
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFliAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 304571943   96 EDDAGSYWCKI 106
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 21-104 7.62e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 7.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943    21 PGSVTGTAGDSLTVWCQYESmYKGYNKYWCRGqydtscesivetkGEEKVERNGRVSIRDHPeaLAFTVTMQNLNEDDAG 100
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQ-------------GGKLLAESGRFSVSRSG--STSTLTISNVTPEDSG 64


                   ....
gi 304571943   101 SYWC 104
Cdd:smart00410  65 TYTC 68
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 19-104 2.70e-22

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 86.68  E-value: 2.70e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  19 KGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQyDTSCESIVETKGeekVERNGRVSIRDHPEALAFTVTMQNLNEDD 98
Cdd:cd05716    2 VGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEG---VVPGGRISLTDDPDNGVFTVTLNQLRKED 77


                 ....*.
gi 304571943  99 AGSYWC 104
Cdd:cd05716   78 AGWYWC 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 20-106 7.27e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 57.08  E-value: 7.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943   20 GPGSVTGTAGDSLTVWCQY--ESMYKGYNKYWCRGQYDTSCES--IVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLN 95
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFliAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLT 81

                          90
                  ....*....|.
gi 304571943   96 EDDAGSYWCKI 106
Cdd:pfam07686  82 LSDSGTYTCAV 92
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 21-104 7.62e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 7.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943    21 PGSVTGTAGDSLTVWCQYESmYKGYNKYWCRGqydtscesivetkGEEKVERNGRVSIRDHPeaLAFTVTMQNLNEDDAG 100
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASG-SPPPEVTWYKQ-------------GGKLLAESGRFSVSRSG--STSTLTISNVTPEDSG 64


                   ....
gi 304571943   101 SYWC 104
Cdd:smart00410  65 TYTC 68
IgI_3_hemolin-like cd20977
Third immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 25-107 1.57e-04

Third immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The third Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


Pssm-ID: 409569  Cd Length: 93  Bit Score: 39.30  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  25 TGTAGDSLTVWCQYESMYKGYNKYWCRGqydtsceSIVETKGEEKVERNGRVSirdhPEALAFTVTMqnlnEDDAGSYWC 104
Cdd:cd20977   11 MAKAGDVTMIYCMYGSNPTAHPNYFKNG-------KDVNGNPEDRITRHNRTS----GKRLLFKTTL----PEDEGVYTC 75


                 ...
gi 304571943 105 KIQ 107
Cdd:cd20977   76 EVD 78
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 23-104 2.85e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 39.04  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  23 SVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCESIVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSY 102
Cdd:cd07706    8 DVSVQVGEEVTLNCRYETSWTNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQLEDSAKY 87


                 ..
gi 304571943 103 WC 104
Cdd:cd07706   88 FC 89
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 21-104 4.50e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 38.47  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  21 PGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCESIV---ETKGEEKVERNGRVSIRdHPEALAFTVTMQNLNED 97
Cdd:cd00099    5 PRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQGPEFLIylsSSKGKTKGGVPGRFSGS-RDGTSSFSLTISNLQPE 83


                 ....*..
gi 304571943  98 DAGSYWC 104
Cdd:cd00099   84 DSGTYYC 90
Ig_Aggrecan_like cd05878
Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core ...
 20-106 2.12e-03

Immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core protein (CSPG); The members here are composed of the immunoglobulin (Ig)-like domain of the aggrecan-like chondroitin sulfate proteoglycan core proteins (CSPGs). Included in this group are the Ig domains of other CSPGs: versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409462  Cd Length: 125  Bit Score: 36.83  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943  20 GPGSVTGTAGDSLTVWCQYESMYKGYNKY---------WCRGQYDTSCES----IVETKGEEKVERN--GRVSIRDHPEA 84
Cdd:cd05878    3 QSSPVRVLLGTSVTLPCYFIDPPHPVTPStaplaprikWSKVSVDGKKEKevvlLVATEGRVRVNSAyqGRVSLPNYPAI 82

                         90       100
                 ....*....|....*....|...
gi 304571943  85 LA-FTVTMQNLNEDDAGSYWCKI 106
Cdd:cd05878   83 PSdATLEVQSLRASDSGLYRCEV 105
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 19-117 3.82e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.25  E-value: 3.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304571943   19 KGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCR-GQYDTScesivetkGEEKVERNGRVSIrdhpealaFTVTMQNLNED 97
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKeGGTLIE--------SLKVKHDNGRTTQ--------SSLLISNVTKE 64

                          90       100
                  ....*....|....*....|
gi 304571943   98 DAGSYWCKIQTVWVLDSWSR 117
Cdd:pfam00047  65 DAGTYTCVVNNPGGSATLST 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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