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Conserved domains on  [gi|32140182|ref|NP_859016|]
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keratin-associated protein 10-10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 135-251 1.45e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.01  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182   135 TCCTSSPCQQACCVPVCSKSVCYVPVCSGASTS---CCQQSSCQPAC---CTASCCRPSSSVSLLCHPVCKSTCCVPVPS 208
Cdd:pfam01500  13 TCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCqptTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 32140182   209 CGASASS---CQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC 251
Cdd:pfam01500  93 SGAVSSRtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCC 138
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 135-251 1.45e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.01  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182   135 TCCTSSPCQQACCVPVCSKSVCYVPVCSGASTS---CCQQSSCQPAC---CTASCCRPSSSVSLLCHPVCKSTCCVPVPS 208
Cdd:pfam01500  13 TCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCqptTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 32140182   209 CGASASS---CQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC 251
Cdd:pfam01500  93 SGAVSSRtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCC 138
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 135-251 1.45e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.01  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182   135 TCCTSSPCQQACCVPVCSKSVCYVPVCSGASTS---CCQQSSCQPAC---CTASCCRPSSSVSLLCHPVCKSTCCVPVPS 208
Cdd:pfam01500  13 TCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCqptTFQSSCCRPTCqpcCQTSCCQPTCCQTSSCQTGCGGIGYGQEGS 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 32140182   209 CGASASS---CQPSCCRTASCVSLLCRPVCSRPACYSLCSGQKSSC 251
Cdd:pfam01500  93 SGAVSSRtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCC 138
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 114-245 3.15e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 40.16  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182   114 CFVPTCSESSPS---CCQQSSCQPTCCTSSPCQQACCVPVCSKSVCYVPVCSGA-STSCCQQSSCQPACCTASCC----- 184
Cdd:pfam01500   9 CGFPTCSTGGTCgsgCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCcQTSCCQPTCCQTSSCQTGCGgigyg 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32140182   185 -RPSSSVSLLCHPVCKSTCCVPVPSCGASA--SSCQPSCCRTASCVSLLCRPV-----CSRPACYSLCS 245
Cdd:pfam01500  89 qEGSSGAVSSRTRWCRPDCRVEGTCLPPCCvvSCTPPTCCQLHHAQASCCRPSycgqsCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
168-206 9.91e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.21  E-value: 9.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 32140182   168 CCQQSSCQPACCTASCCRPSSSVSLLCHPV-CKSTCCVPV 206
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCCRSS 40
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
165-206 1.12e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.82  E-value: 1.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 32140182   165 STSCCQQSSCQPACCTASCCRPSSSVSLLCHPVC-KSTCCVPV 206
Cdd:pfam13885   3 QPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 151-228 2.42e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.46  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182   151 CSKSVCYVPVCSGAST---SCCQQSSCQPACCTASCCRPSSSVSLlchpVCKSTCCVPVPSCGASASSCQPSCCRTASCV 227
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTcgsGCCQPCCCQSSCCRPSCCQTSCCQPT----TFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQ 79


                  .
gi 32140182   228 S 228
Cdd:pfam01500  80 T 80
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
198-241 8.70e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 33.51  E-value: 8.70e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 32140182   198 CKSTCCVPVPScgaSASSCQPSCCRTASCVSLLCRPVCSRPACY 241
Cdd:pfam13885   2 CQPSCCQPSCC---QPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 74-244 9.08e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.92  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182    74 CYQQSSCQPDCCTSSPCQQACCVPVCCVPVCCVPVCNKPVCFVPTCSesspsccqqsscqpTCCTSSPCQQACCVPVCSK 153
Cdd:pfam01500  14 CSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ--------------PCCQTSCCQPTCCQTSSCQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32140182   154 SVCyvpvcsgASTSCCQQSSCQPACCTASCCRPSSSVSLLCHPVCKSTCCVPVPSCgaSASSCQPSCCRTASCVSLLCRP 233
Cdd:pfam01500  80 TGC-------GGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCC--QLHHAQASCCRPSYCGQSCCRP 150

                         170
                  ....*....|.
gi 32140182   234 VCSRPACYSLC 244
Cdd:pfam01500 151 ACCCQCSEPTC 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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