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Conserved domains on  [gi|32171205|ref|NP_859074|]
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calcium uptake protein 3, mitochondrial isoform 1 [Homo sapiens]

Protein Classification

EFh_MICU3 and PTZ00183 domain-containing protein( domain architecture ID 13006737)

EFh_MICU3 and PTZ00183 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh_MICU3 cd16175
EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and ...
 236-503 1.11e-57

EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins; MICU3, also termed EF-hand domain-containing family member A2 (EFHA2), is a paralog of MICU1 and notably found in the central nervous system (CNS) and skeletal muscle. At present, the precise molecular function of MICU3 remains unclear. It likely has a role in mitochondrial calcium handling. MICU3 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


:

Pssm-ID: 320083 [Multi-domain]  Cd Length: 128  Bit Score: 188.11  E-value: 1.11e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 236 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRkknekreikgdeekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 315
Cdd:cd16175   1 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFR-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 316 rntsqalfsdlaeradditslvtdtTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 395
Cdd:cd16175  31 -------------------------TLLVHFFGKKGKAELNFEDFYRFMDNLQTEV------------------------ 61

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 396 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 475
Cdd:cd16175  62 -----------------------------------------EDFTIAMRMYTFADRSISQDEFARAVKVCTGLKLSPHLV 100

                       250       260
                ....*....|....*....|....*...
gi 32171205 476 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 503
Cdd:cd16175 101 NTVFKIFDVDGDGQLSYKEFIGIMKDRL 128
PTZ00183 super family cl33171
centrin; Provisional
 238-366 6.59e-06

centrin; Provisional


The actual alignment was detected with superfamily member PTZ00183:

Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 46.22  E-value: 6.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205  238 RIAFNMFDTDGNEMVDKKEFLV-LQEI-FRKKNEkrEIKG-----DEEKRAMLRLQLYgYHSPTNSVLKTDAEELVSRSY 310
Cdd:PTZ00183  20 REAFDLFDTDGSGTIDPKELKVaMRSLgFEPKKE--EIKQmiadvDKDGSGKIDFEEF-LDIMTKKLGERDPREEILKAF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 32171205  311 WDTLRRNTSQALFSDLAERADDITSLVTDTTL--LVHFFGKKGKAELNFEDFYRFMDN 366
Cdd:PTZ00183  97 RLFDDDKTGKISLKNLKRVAKELGETITDEELqeMIDEADRNGDGEISEEEFYRIMKK 154
 
Name Accession Description Interval E-value
EFh_MICU3 cd16175
EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and ...
 236-503 1.11e-57

EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins; MICU3, also termed EF-hand domain-containing family member A2 (EFHA2), is a paralog of MICU1 and notably found in the central nervous system (CNS) and skeletal muscle. At present, the precise molecular function of MICU3 remains unclear. It likely has a role in mitochondrial calcium handling. MICU3 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320083 [Multi-domain]  Cd Length: 128  Bit Score: 188.11  E-value: 1.11e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 236 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRkknekreikgdeekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 315
Cdd:cd16175   1 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFR-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 316 rntsqalfsdlaeradditslvtdtTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 395
Cdd:cd16175  31 -------------------------TLLVHFFGKKGKAELNFEDFYRFMDNLQTEV------------------------ 61

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 396 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 475
Cdd:cd16175  62 -----------------------------------------EDFTIAMRMYTFADRSISQDEFARAVKVCTGLKLSPHLV 100

                       250       260
                ....*....|....*....|....*...
gi 32171205 476 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 503
Cdd:cd16175 101 NTVFKIFDVDGDGQLSYKEFIGIMKDRL 128
PTZ00183 PTZ00183
centrin; Provisional
 238-366 6.59e-06

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 46.22  E-value: 6.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205  238 RIAFNMFDTDGNEMVDKKEFLV-LQEI-FRKKNEkrEIKG-----DEEKRAMLRLQLYgYHSPTNSVLKTDAEELVSRSY 310
Cdd:PTZ00183  20 REAFDLFDTDGSGTIDPKELKVaMRSLgFEPKKE--EIKQmiadvDKDGSGKIDFEEF-LDIMTKKLGERDPREEILKAF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 32171205  311 WDTLRRNTSQALFSDLAERADDITSLVTDTTL--LVHFFGKKGKAELNFEDFYRFMDN 366
Cdd:PTZ00183  97 RLFDDDKTGKISLKNLKRVAKELGETITDEELqeMIDEADRNGDGEISEEEFYRIMKK 154
EF-hand_7 pfam13499
EF-hand domain pair;
450-500 8.86e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 43.40  E-value: 8.86e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 32171205   450 SRSIGQDEFKRAVY-VATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMK 500
Cdd:pfam13499  16 DGYLDVEELKKLLRkLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
421-501 3.11e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 3.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 421 ITFDEFRSFFQFLNNLEDFAIALNMYNFA----SRSIGQDEFKRAVyvaTGLKFSPHLVNTVFKIFDVDKDDQLSYKEFI 496
Cdd:COG5126  50 ISREEFVAGMESLFEATVEPFARAAFDLLdtdgDGKISADEFRRLL---TALGVSEEEADELFARLDTDGDGKISFEEFV 126


                ....*
gi 32171205 497 GIMKD 501
Cdd:COG5126 127 AAVRD 131
 
Name Accession Description Interval E-value
EFh_MICU3 cd16175
EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and ...
 236-503 1.11e-57

EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins; MICU3, also termed EF-hand domain-containing family member A2 (EFHA2), is a paralog of MICU1 and notably found in the central nervous system (CNS) and skeletal muscle. At present, the precise molecular function of MICU3 remains unclear. It likely has a role in mitochondrial calcium handling. MICU3 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320083 [Multi-domain]  Cd Length: 128  Bit Score: 188.11  E-value: 1.11e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 236 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRkknekreikgdeekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 315
Cdd:cd16175   1 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFR-------------------------------------------------- 30

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 316 rntsqalfsdlaeradditslvtdtTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 395
Cdd:cd16175  31 -------------------------TLLVHFFGKKGKAELNFEDFYRFMDNLQTEV------------------------ 61

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 396 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 475
Cdd:cd16175  62 -----------------------------------------EDFTIAMRMYTFADRSISQDEFARAVKVCTGLKLSPHLV 100

                       250       260
                ....*....|....*....|....*...
gi 32171205 476 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 503
Cdd:cd16175 101 NTVFKIFDVDGDGQLSYKEFIGIMKDRL 128
EFh_MICU cd15900
EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, ...
 236-503 5.36e-53

EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins; This family includes mitochondrial calcium uptake protein MICU1 and its two additional paralogs, MICU2 and MICU3. MICU1 localizes to the inner mitochondrial membrane (IMM). It functions as a gatekeeper of the mitochondrial calcium uniporter (MCU) and regulates MCU-mediated mitochondrial Ca2+ uptake, which is essential for maintaining mitochondrial homoeostasis. MICU1 and MICU2 are physically associated within the uniporter complex and are co-expressed across all tissues. They may play non-redundant roles in the regulation of the mitochondrial calcium uniporter. At present, the precise molecular function of MICU2 and MICU3 remain unclear. MICU2 may play possible roles in Ca2+ sensing and regulation of MCU, calcium buffering with a secondary impact on transport or assembly and stabilization of MCU. MICU3 likely has a role in mitochondrial calcium handling. All members in this family contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320080 [Multi-domain]  Cd Length: 152  Bit Score: 176.65  E-value: 5.36e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 236 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEEKRAMLRLQlygyhsptnsvlktdaeelvsrsywdtlr 315
Cdd:cd15900   1 HFEIAFKMFDLDGDGELDKEEFNKVQSIIRSQTSVGQRHRDHTNGESTKLG----------------------------- 51

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 316 rntsqalfsdlaeradditslvTDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 395
Cdd:cd15900  52 ----------------------MNSTLARYFFGKDGKQKLSIEKFLEFQENLQEEI------------------------ 85

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 396 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 475
Cdd:cd15900  86 -----------------------------------------DDVDTALTFYHLAGASIDRKTFKRAAKVVAGVELSDHVV 124

                       250       260
                ....*....|....*....|....*...
gi 32171205 476 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 503
Cdd:cd15900 125 DVVFTIFDEDGDGILSHKEFISVMKDRL 152
EFh_MICU2 cd16174
EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and ...
 236-503 2.28e-38

EF-hand, calcium binding motif, found in calcium uptake protein 2, mitochondrial (MICU2) and similar proteins; MICU2, also termed EF-hand domain-containing family member A1 (EFHA1), is a mitochondrial-localized paralog of MICU1. MICU2 and its paralog, MICU1, are physically associated within the mitochondrial calcium uniporter (MCU) complex and are co-expressed across all tissues. They may operate together with MCU to regulate the channel. At present, the precise molecular function of MICU2 remains unclear. It may play possible roles in Ca2+ sensing and regulation of MCU, calcium buffering with a secondary impact on transport or assembly and stabilization of MCU. MICU2 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320082 [Multi-domain]  Cd Length: 154  Bit Score: 137.69  E-value: 2.28e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 236 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKREIKGDEekramlrlqlygyhsptnsvlktdaeelvsrsywdtlr 315
Cdd:cd16174   1 GFHIAFKMLDTDGNEQVEKREFFKLQKIIGKKDDLMTQGGTE-------------------------------------- 42

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 316 rnTSQALFSDlaerADDItslvtDTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVleieflsysngmntiseedfahil 395
Cdd:cd16174  43 --TYQEASDN----SDEV-----NTTLQVHFFGKDGNEKLQYKEFCRFMENLQTEV------------------------ 87

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 396 lrytnventsvflenvrysipeekgitfdefrsffqflnnlEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLV 475
Cdd:cd16174  88 -----------------------------------------EDFAIAMKMFSEANRPIKLAEFKRAVKVATGQELSDNVL 126

                       250       260
                ....*....|....*....|....*...
gi 32171205 476 NTVFKIFDVDKDDQLSYKEFIGIMKDRL 503
Cdd:cd16174 127 DTVFKIFDLDGDDCLSHGEFLGVLKNRV 154
EFh_MICU1 cd16173
EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and ...
 422-503 2.44e-07

EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins; MICU1, also termed atopy-related autoantigen CALC (ara CALC), or calcium-binding atopy-related autoantigen 1 (CBARA1), or Hom s 4, or EFHA3, localizes to the inner mitochondrial membrane (IMM). It functions as a gatekeeper of the mitochondrial calcium uniporter (MCU) and regulates MCU-mediated mitochondrial Ca2+ uptake, which is essential for maintaining mitochondrial homoeostasis. MICU1 and its paralog, MICU2, are physically associated within the uniporter complex and are co-expressed across all tissues. They may operate together with MCU to regulate the channel. The mutations in MICU1 are associated with neuromuscular abnormalities in children. MICU1 contains an N-terminal mitochondrial targeting sequence (MTS) as well as two evolutionarily conserved canonical Ca2+-binding EF-hands separated by a long stretch of residues predicted to form alpha-helices.


Pssm-ID: 320081 [Multi-domain]  Cd Length: 153  Bit Score: 50.41  E-value: 2.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 422 TFDEFRSFFQflNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKD 501
Cdd:cd16173  74 NFLEFQRKLQ--HDVNDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVAIMKQ 151


                ..
gi 32171205 502 RL 503
Cdd:cd16173 152 RL 153
PTZ00183 PTZ00183
centrin; Provisional
 238-366 6.59e-06

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 46.22  E-value: 6.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205  238 RIAFNMFDTDGNEMVDKKEFLV-LQEI-FRKKNEkrEIKG-----DEEKRAMLRLQLYgYHSPTNSVLKTDAEELVSRSY 310
Cdd:PTZ00183  20 REAFDLFDTDGSGTIDPKELKVaMRSLgFEPKKE--EIKQmiadvDKDGSGKIDFEEF-LDIMTKKLGERDPREEILKAF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 32171205  311 WDTLRRNTSQALFSDLAERADDITSLVTDTTL--LVHFFGKKGKAELNFEDFYRFMDN 366
Cdd:PTZ00183  97 RLFDDDKTGKISLKNLKRVAKELGETITDEELqeMIDEADRNGDGEISEEEFYRIMKK 154
EF-hand_7 pfam13499
EF-hand domain pair;
450-500 8.86e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 43.40  E-value: 8.86e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 32171205   450 SRSIGQDEFKRAVY-VATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMK 500
Cdd:pfam13499  16 DGYLDVEELKKLLRkLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EF-hand_8 pfam13833
EF-hand domain pair;
450-502 6.81e-05

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 40.76  E-value: 6.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 32171205   450 SRSIGQDEFKRAvYVATGLK-FSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDR 502
Cdd:pfam13833   2 KGVITREELKRA-LALLGLKdLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 450-500 1.92e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 39.45  E-value: 1.92e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 32171205 450 SRSIGQDEFKRAVyVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGIMK 500
Cdd:cd00051  14 DGTISADELKAAL-KSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
421-501 3.11e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 40.93  E-value: 3.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 421 ITFDEFRSFFQFLNNLEDFAIALNMYNFA----SRSIGQDEFKRAVyvaTGLKFSPHLVNTVFKIFDVDKDDQLSYKEFI 496
Cdd:COG5126  50 ISREEFVAGMESLFEATVEPFARAAFDLLdtdgDGKISADEFRRLL---TALGVSEEEADELFARLDTDGDGKISFEEFV 126


                ....*
gi 32171205 497 GIMKD 501
Cdd:COG5126 127 AAVRD 131
EFh_PEF_ALG-2_like cd16185
EF-hand, calcium binding motif, found in homologs of mammalian apoptosis-linked gene 2 protein ...
 421-498 3.32e-04

EF-hand, calcium binding motif, found in homologs of mammalian apoptosis-linked gene 2 protein (ALG-2); The family includes some homologs of mammalian apoptosis-linked gene 2 protein (ALG-2) mainly found in lower eukaryotes, such as a parasitic protist Leishmarua major and a cellular slime mold Dictyostelium discoideum. These homologs contains five EF-hand motifs. Due to the presence of unfavorable residues at the Ca2+-coordinating positions, their non-canonical EF4 and EF5 hands may not bind Ca2+. Two Dictyostelium PEF proteins are the prototypes of this family. They may bind to cytoskeletal proteins and/or signal-transducing proteins localized to detergent-resistant membranes named lipid rafts, and occur as monomers or weak homo- or heterodimers like ALG-2. They can serve as a mediator for Ca2+ signaling-related Dictyostehum programmed cell death (PCD).


Pssm-ID: 320060 [Multi-domain]  Cd Length: 163  Bit Score: 41.43  E-value: 3.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171205 421 ITFDEFRSFFQFLNNLEDfaiALNMYNfASRS--IGQDEFKRAVyVATGLKFSPHLVNTVFKIFDVDKDDQLSYKEFIGI 498
Cdd:cd16185  53 IDFEEFAALHQFLSNMQN---GFEQRD-TSRSgrLDANEVHEAL-AASGFQLDPPAFQALFRKFDPDRGGSLGFDDYIEL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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