NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|222418631|ref|NP_861441|]
View 

proton-coupled amino acid transporter 2 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
52-463 3.40e-65

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 216.02  E-value: 3.40e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631   52 KGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAqRFCKRLNKPFMDYGDTVMHgl 131
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCS-KEVPVTGKRNKSYGDLGYR-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  132 eanpnawlqNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSttnncysnetvilTPTMDSRLYMLSFLPF 211
Cdd:pfam01490  78 ---------LLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFGLI 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRL-PLVASW-----KTYPLFFGTAIFSFESIGVVLPL 285
Cdd:pfam01490 136 FIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPI 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  286 ENKMKNARHFPA---ILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPN-CWLYQSVKLLYIAGILCTYALQFYVP 361
Cdd:pfam01490 216 QNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPI 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  362 AEII--------IPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEV----T 429
Cdd:pfam01490 296 RQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLklkkT 375
                         410       420       430
                  ....*....|....*....|....*....|....
gi 222418631  430 TFYSEGMSPLTIFKDALISILGFVGFVVGTYQAL 463
Cdd:pfam01490 376 KKKSQEKLWKPDILDVICIVIGLLLMAYGVAGLI 409
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
52-463 3.40e-65

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 216.02  E-value: 3.40e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631   52 KGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAqRFCKRLNKPFMDYGDTVMHgl 131
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCS-KEVPVTGKRNKSYGDLGYR-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  132 eanpnawlqNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSttnncysnetvilTPTMDSRLYMLSFLPF 211
Cdd:pfam01490  78 ---------LLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFGLI 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRL-PLVASW-----KTYPLFFGTAIFSFESIGVVLPL 285
Cdd:pfam01490 136 FIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPI 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  286 ENKMKNARHFPA---ILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPN-CWLYQSVKLLYIAGILCTYALQFYVP 361
Cdd:pfam01490 216 QNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPI 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  362 AEII--------IPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEV----T 429
Cdd:pfam01490 296 RQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLklkkT 375
                         410       420       430
                  ....*....|....*....|....*....|....
gi 222418631  430 TFYSEGMSPLTIFKDALISILGFVGFVVGTYQAL 463
Cdd:pfam01490 376 KKKSQEKLWKPDILDVICIVIGLLLMAYGVAGLI 409
PTZ00206 PTZ00206
amino acid transporter; Provisional
68-459 7.08e-05

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 45.24  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  68 MGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRfckrlnkpfmdygdTVMHGLEANPNAWLqnhAHWGR 147
Cdd:PTZ00206  74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADK--------------TNIRTYEGVARVLL---GPWGS 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 148 HIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMdsrlyMLSFLPFLVLLVLIRNLRILTIF 227
Cdd:PTZ00206 137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLM-----WLCFMLPLVIPRHIDSLRYVSTI 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 228 SMLANISMLVSLVII---------IQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKN--ARHFP 296
Cdd:PTZ00206 212 AVSFMVYLVIVIVVHscmnglpenIKNVSVGKDDNAEIILFNSGNRAIEGLGVFIFAYVFQITAYEVYMDMTNrsVGKFV 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 297 AILSLGMSIVTSLYIGMAALGYLRFGDDIKASISL-----NLPNCW---------LYQSVKLLyiaGILCTYALQfyvpa 362
Cdd:PTZ00206 292 LASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLmydpvNEPAIMvgfvgvlvkLFVSYALL---GMACRNALY----- 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 363 eIIIPFAISRVSTrWALPLDLsIRLVMVCLTCllAILIPRLDLVISLVGSVSGTALALIIPPLLEVTT--FYSEGMSPLT 440
Cdd:PTZ00206 364 -DVIGWDARKVAF-WKHCIAV-VTLSVVMLLC--GLFIPKINTVLGFAGSISGGLLGFILPALLFMYSggFTWQKVGPFY 438
                        410
                 ....*....|....*....
gi 222418631 441 IFKDALISILGFVGFVVGT 459
Cdd:PTZ00206 439 YISTYVVLITGVIAIVFGT 457
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
52-463 3.40e-65

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 216.02  E-value: 3.40e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631   52 KGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAqRFCKRLNKPFMDYGDTVMHgl 131
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCS-KEVPVTGKRNKSYGDLGYR-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  132 eanpnawlqNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSttnncysnetvilTPTMDSRLYMLSFLPF 211
Cdd:pfam01490  78 ---------LLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFGLI 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRL-PLVASW-----KTYPLFFGTAIFSFESIGVVLPL 285
Cdd:pfam01490 136 FIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPI 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  286 ENKMKNARHFPA---ILSLGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPN-CWLYQSVKLLYIAGILCTYALQFYVP 361
Cdd:pfam01490 216 QNEMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPI 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  362 AEII--------IPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEV----T 429
Cdd:pfam01490 296 RQIVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLklkkT 375
                         410       420       430
                  ....*....|....*....|....*....|....
gi 222418631  430 TFYSEGMSPLTIFKDALISILGFVGFVVGTYQAL 463
Cdd:pfam01490 376 KKKSQEKLWKPDILDVICIVIGLLLMAYGVAGLI 409
PTZ00206 PTZ00206
amino acid transporter; Provisional
68-459 7.08e-05

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 45.24  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631  68 MGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRfckrlnkpfmdygdTVMHGLEANPNAWLqnhAHWGR 147
Cdd:PTZ00206  74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADK--------------TNIRTYEGVARVLL---GPWGS 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 148 HIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSTTNNCYSNETVILTPTMdsrlyMLSFLPFLVLLVLIRNLRILTIF 227
Cdd:PTZ00206 137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLM-----WLCFMLPLVIPRHIDSLRYVSTI 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 228 SMLANISMLVSLVII---------IQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKN--ARHFP 296
Cdd:PTZ00206 212 AVSFMVYLVIVIVVHscmnglpenIKNVSVGKDDNAEIILFNSGNRAIEGLGVFIFAYVFQITAYEVYMDMTNrsVGKFV 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 297 AILSLGMSIVTSLYIGMAALGYLRFGDDIKASISL-----NLPNCW---------LYQSVKLLyiaGILCTYALQfyvpa 362
Cdd:PTZ00206 292 LASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLLmydpvNEPAIMvgfvgvlvkLFVSYALL---GMACRNALY----- 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222418631 363 eIIIPFAISRVSTrWALPLDLsIRLVMVCLTCllAILIPRLDLVISLVGSVSGTALALIIPPLLEVTT--FYSEGMSPLT 440
Cdd:PTZ00206 364 -DVIGWDARKVAF-WKHCIAV-VTLSVVMLLC--GLFIPKINTVLGFAGSISGGLLGFILPALLFMYSggFTWQKVGPFY 438
                        410
                 ....*....|....*....
gi 222418631 441 IFKDALISILGFVGFVVGT 459
Cdd:PTZ00206 439 YISTYVVLITGVIAIVFGT 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH