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Conserved domains on  [gi|32479525|ref|NP_861463|]
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potassium voltage-gated channel subfamily KQT member 1 isoform 2 precursor [Homo sapiens]

Protein Classification

potassium voltage-gated channel subfamily KQT member( domain architecture ID 11998164)

potassium voltage-gated channel subfamily KQT member (KCNQ) similar to human KCNQ1, also known as Kv7.1, which is a voltage-dependent K+ channel that regulates gastric acid secretion, salt and glucose homeostasis, and heart rhythm

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
2-232 7.09e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 122.76  E-value: 7.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525     2 DFLIVLVCLIFSVLSTIE---QYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVglwgrlrfaRKPISIIDLIV 78
Cdd:pfam00520   5 ELFILLLILLNTIFLALEtyfQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYF---------RSPWNILDFVV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525    79 VVASMVVLCVGSKGQVFAtsaIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYI-GFLGLIFSS----YFV 153
Cdd:pfam00520  76 VLPSLISLVLSSVGSLSG---LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLlLLFLFIFAIigyqLFG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525   154 YLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKT-------IASCFSVFAISFFALPAGILGSGFAL 226
Cdd:pfam00520 153 GKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGefwayiyFVSFIILGGFLLLNLFIAVIIDNFQE 232

                  ....*.
gi 32479525   227 KVQQKQ 232
Cdd:pfam00520 233 LTERTE 238
KCNQ_channel super family cl04130
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ...
384-490 5.28e-26

KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels.


The actual alignment was detected with superfamily member pfam03520:

Pssm-ID: 427346  Cd Length: 190  Bit Score: 104.84  E-value: 5.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525   384 RATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSlfISVSEKSKDRGSNTIGA 463
Cdd:pfam03520  72 KTVIRAVRIMKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGP--PPTDKKKREKGPKTPPE 149
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 32479525   464 -----------RLNRVEDKVTQLDQRLALITDMLHQLL 490
Cdd:pfam03520 150 gelvedlsmmgRVVKVEKQVQSIEKKLDFLLDIYSQCL 187
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
2-232 7.09e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 122.76  E-value: 7.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525     2 DFLIVLVCLIFSVLSTIE---QYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVglwgrlrfaRKPISIIDLIV 78
Cdd:pfam00520   5 ELFILLLILLNTIFLALEtyfQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYF---------RSPWNILDFVV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525    79 VVASMVVLCVGSKGQVFAtsaIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYI-GFLGLIFSS----YFV 153
Cdd:pfam00520  76 VLPSLISLVLSSVGSLSG---LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLlLLFLFIFAIigyqLFG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525   154 YLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKT-------IASCFSVFAISFFALPAGILGSGFAL 226
Cdd:pfam00520 153 GKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGefwayiyFVSFIILGGFLLLNLFIAVIIDNFQE 232

                  ....*.
gi 32479525   227 KVQQKQ 232
Cdd:pfam00520 233 LTERTE 238
KCNQ_channel pfam03520
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ...
384-490 5.28e-26

KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels.


Pssm-ID: 427346  Cd Length: 190  Bit Score: 104.84  E-value: 5.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525   384 RATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSlfISVSEKSKDRGSNTIGA 463
Cdd:pfam03520  72 KTVIRAVRIMKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGP--PPTDKKKREKGPKTPPE 149
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 32479525   464 -----------RLNRVEDKVTQLDQRLALITDMLHQLL 490
Cdd:pfam03520 150 gelvedlsmmgRVVKVEKQVQSIEKKLDFLLDIYSQCL 187
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
172-248 1.04e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.78  E-value: 1.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32479525  172 YADALWWGVVTVTTIGYGDKVPQTwvgkTIASCFSVFAISF-FALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLI 248
Cdd:PLN03192 251 YISAIYWSITTMTTVGYGDLHAVN----TIEMIFIIFYMLFnLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFV 324
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
2-232 7.09e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 122.76  E-value: 7.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525     2 DFLIVLVCLIFSVLSTIE---QYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVglwgrlrfaRKPISIIDLIV 78
Cdd:pfam00520   5 ELFILLLILLNTIFLALEtyfQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYF---------RSPWNILDFVV 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525    79 VVASMVVLCVGSKGQVFAtsaIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYI-GFLGLIFSS----YFV 153
Cdd:pfam00520  76 VLPSLISLVLSSVGSLSG---LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLlLLFLFIFAIigyqLFG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525   154 YLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKT-------IASCFSVFAISFFALPAGILGSGFAL 226
Cdd:pfam00520 153 GKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGefwayiyFVSFIILGGFLLLNLFIAVIIDNFQE 232

                  ....*.
gi 32479525   227 KVQQKQ 232
Cdd:pfam00520 233 LTERTE 238
KCNQ_channel pfam03520
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ...
384-490 5.28e-26

KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels.


Pssm-ID: 427346  Cd Length: 190  Bit Score: 104.84  E-value: 5.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32479525   384 RATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSlfISVSEKSKDRGSNTIGA 463
Cdd:pfam03520  72 KTVIRAVRIMKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIVGRGP--PPTDKKKREKGPKTPPE 149
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 32479525   464 -----------RLNRVEDKVTQLDQRLALITDMLHQLL 490
Cdd:pfam03520 150 gelvedlsmmgRVVKVEKQVQSIEKKLDFLLDIYSQCL 187
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
167-222 3.15e-11

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 429715 [Multi-domain]  Cd Length: 73  Bit Score: 59.14  E-value: 3.15e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 32479525   167 VEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGS 222
Cdd:pfam07885  15 LEGWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGR 70
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
172-248 1.04e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.78  E-value: 1.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32479525  172 YADALWWGVVTVTTIGYGDKVPQTwvgkTIASCFSVFAISF-FALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLI 248
Cdd:PLN03192 251 YISAIYWSITTMTTVGYGDLHAVN----TIEMIFIIFYMLFnLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFV 324
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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