NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|922580764|ref|NP_872194|]
View 

Lipid droplet localized protein [Caenorhabditis elegans]

Protein Classification

saccharopine dehydrogenase family protein( domain architecture ID 708574)

saccharopine dehydrogenase family protein similar to saccharopine dehydrogenase (SDH), also named saccharopine reductase, which catalyses the condensation of l-alpha-aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH to give saccharopine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG3268 super family cl25614
Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown];
1-301 1.81e-23

Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown];


The actual alignment was detected with superfamily member COG3268:

Pssm-ID: 442499 [Multi-domain]  Cd Length: 368  Bit Score: 98.76  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764   1 MQQKYSKQAKEQGVYVVSACGWDSIPADLGVNFLKKNFHGDlNHVESFVQLLTGPSGysfnaGTYQTLILGLSGAATD-K 79
Cdd:COG3268  115 MIDRYDAAARAAGARIVPACGFDSVPSDLGAALLQERLPEA-DRLTLAVRAKGGFSG-----GTAASMLEALAAGGADrR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764  80 LGavrkeimpeKIVRGAVKLPKRPTLWEIKEKElNGVAVPFPGADKSIINRSqyydatsRQVRPIhmETYIRLSSQFYGY 159
Cdd:COG3268  189 NG---------RLVRVPYALRTREDFPDGGPQQ-GAWTAPWGDVNTAVVRRS-------NALLNY--EEYMAVPKGAARA 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764 160 LIGLWIMFLSIFVKYPFTRRILQQYPDQcsfymfKNSGPSARQMAEASFVYWFFGygyketlpldqqhEGKINRKVLATC 239
Cdd:COG3268  250 LALAAGLGALLAAAVPPLRRLLKRVLPK------PGEGPSEEERERGRFVVWGEA-------------RTAGGRRVRARV 310

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922580764 240 KGPDaGYIATSGCVLSAALTLIRDKdnlPKDGGVYTTAAAFGNSKIYDYLASFGITYQLESE 301
Cdd:COG3268  311 RGPG-GYGLTAKMLAEAALRLLADD---PVRGGFLTPATAFGAALVLRLLAVAGLTFEVEEL 368
 
Name Accession Description Interval E-value
COG3268 COG3268
Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown];
1-301 1.81e-23

Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown];


Pssm-ID: 442499 [Multi-domain]  Cd Length: 368  Bit Score: 98.76  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764   1 MQQKYSKQAKEQGVYVVSACGWDSIPADLGVNFLKKNFHGDlNHVESFVQLLTGPSGysfnaGTYQTLILGLSGAATD-K 79
Cdd:COG3268  115 MIDRYDAAARAAGARIVPACGFDSVPSDLGAALLQERLPEA-DRLTLAVRAKGGFSG-----GTAASMLEALAAGGADrR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764  80 LGavrkeimpeKIVRGAVKLPKRPTLWEIKEKElNGVAVPFPGADKSIINRSqyydatsRQVRPIhmETYIRLSSQFYGY 159
Cdd:COG3268  189 NG---------RLVRVPYALRTREDFPDGGPQQ-GAWTAPWGDVNTAVVRRS-------NALLNY--EEYMAVPKGAARA 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764 160 LIGLWIMFLSIFVKYPFTRRILQQYPDQcsfymfKNSGPSARQMAEASFVYWFFGygyketlpldqqhEGKINRKVLATC 239
Cdd:COG3268  250 LALAAGLGALLAAAVPPLRRLLKRVLPK------PGEGPSEEERERGRFVVWGEA-------------RTAGGRRVRARV 310

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922580764 240 KGPDaGYIATSGCVLSAALTLIRDKdnlPKDGGVYTTAAAFGNSKIYDYLASFGITYQLESE 301
Cdd:COG3268  311 RGPG-GYGLTAKMLAEAALRLLADD---PVRGGFLTPATAFGAALVLRLLAVAGLTFEVEEL 368
 
Name Accession Description Interval E-value
COG3268 COG3268
Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown];
1-301 1.81e-23

Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown];


Pssm-ID: 442499 [Multi-domain]  Cd Length: 368  Bit Score: 98.76  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764   1 MQQKYSKQAKEQGVYVVSACGWDSIPADLGVNFLKKNFHGDlNHVESFVQLLTGPSGysfnaGTYQTLILGLSGAATD-K 79
Cdd:COG3268  115 MIDRYDAAARAAGARIVPACGFDSVPSDLGAALLQERLPEA-DRLTLAVRAKGGFSG-----GTAASMLEALAAGGADrR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764  80 LGavrkeimpeKIVRGAVKLPKRPTLWEIKEKElNGVAVPFPGADKSIINRSqyydatsRQVRPIhmETYIRLSSQFYGY 159
Cdd:COG3268  189 NG---------RLVRVPYALRTREDFPDGGPQQ-GAWTAPWGDVNTAVVRRS-------NALLNY--EEYMAVPKGAARA 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580764 160 LIGLWIMFLSIFVKYPFTRRILQQYPDQcsfymfKNSGPSARQMAEASFVYWFFGygyketlpldqqhEGKINRKVLATC 239
Cdd:COG3268  250 LALAAGLGALLAAAVPPLRRLLKRVLPK------PGEGPSEEERERGRFVVWGEA-------------RTAGGRRVRARV 310

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922580764 240 KGPDaGYIATSGCVLSAALTLIRDKdnlPKDGGVYTTAAAFGNSKIYDYLASFGITYQLESE 301
Cdd:COG3268  311 RGPG-GYGLTAKMLAEAALRLLADD---PVRGGFLTPATAFGAALVLRLLAVAGLTFEVEEL 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH