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Conserved domains on  [gi|32698864|ref|NP_872323|]
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type III endosome membrane protein TEMP [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR19-TM super family cl21041
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 16-97 7.24e-18

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


The actual alignment was detected with superfamily member pfam15176:

Pssm-ID: 464545  Cd Length: 115  Bit Score: 72.63  E-value: 7.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698864    16 TASAVAPGPGTGaRAWPVLVGFVLGAVVLSLLIALAAKCHLCRRYHASYRHRPLPETG--------RG---GRPQV-AED 83
Cdd:pfam15176   1 NLTPNSEHERSG-KSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEaetyesgdTGnpsSLSQLqATN 79

                          90       100
                  ....*....|....*....|....*....
gi 32698864    84 E---------------DDDGFIEDNYIQP 97
Cdd:pfam15176  80 PddttvifeqlhsfvvDDDGFIEDKYIDT 108
 
Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 16-97 7.24e-18

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


Pssm-ID: 464545  Cd Length: 115  Bit Score: 72.63  E-value: 7.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698864    16 TASAVAPGPGTGaRAWPVLVGFVLGAVVLSLLIALAAKCHLCRRYHASYRHRPLPETG--------RG---GRPQV-AED 83
Cdd:pfam15176   1 NLTPNSEHERSG-KSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEaetyesgdTGnpsSLSQLqATN 79

                          90       100
                  ....*....|....*....|....*....
gi 32698864    84 E---------------DDDGFIEDNYIQP 97
Cdd:pfam15176  80 PddttvifeqlhsfvvDDDGFIEDKYIDT 108
 
Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 16-97 7.24e-18

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


Pssm-ID: 464545  Cd Length: 115  Bit Score: 72.63  E-value: 7.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698864    16 TASAVAPGPGTGaRAWPVLVGFVLGAVVLSLLIALAAKCHLCRRYHASYRHRPLPETG--------RG---GRPQV-AED 83
Cdd:pfam15176   1 NLTPNSEHERSG-KSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEaetyesgdTGnpsSLSQLqATN 79

                          90       100
                  ....*....|....*....|....*....
gi 32698864    84 E---------------DDDGFIEDNYIQP 97
Cdd:pfam15176  80 PddttvifeqlhsfvvDDDGFIEDKYIDT 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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