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Conserved domains on  [gi|32698954|ref|NP_872371|]
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UBA-like domain-containing protein 2 [Homo sapiens]

Protein Classification

ubiquitin-like domain-containing protein( domain architecture ID 10198660)

ubiquitin-like (UBL) domain-containing protein similar to vertebrate UBA-like domain-containing protein 1/2

PubMed:  22201813

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBA_F100B_like cd14343
UBA-like domain found in protein FAM100B; The family corresponds to the uncharacterized ...
 10-48 4.29e-20

UBA-like domain found in protein FAM100B; The family corresponds to the uncharacterized protein FAM100B and its homologs mainly found in Metazoa. Although their biological roles remain unclear, all family members contain a ubiquitin-associated (UBA)-like domain that may be involved in the binding of ubiquitin.


:

Pssm-ID: 270528  Cd Length: 39  Bit Score: 77.90  E-value: 4.29e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 32698954  10 HQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQ 48
Cdd:cd14343   1 EQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSAFFQ 39
 
Name Accession Description Interval E-value
UBA_F100B_like cd14343
UBA-like domain found in protein FAM100B; The family corresponds to the uncharacterized ...
 10-48 4.29e-20

UBA-like domain found in protein FAM100B; The family corresponds to the uncharacterized protein FAM100B and its homologs mainly found in Metazoa. Although their biological roles remain unclear, all family members contain a ubiquitin-associated (UBA)-like domain that may be involved in the binding of ubiquitin.


Pssm-ID: 270528  Cd Length: 39  Bit Score: 77.90  E-value: 4.29e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 32698954  10 HQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQ 48
Cdd:cd14343   1 EQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSAFFQ 39
UBA_4 pfam14555
UBA-like domain;
11-53 5.29e-07

UBA-like domain;


Pssm-ID: 464207  Cd Length: 43  Bit Score: 43.98  E-value: 5.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 32698954    11 QVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIP 53
Cdd:pfam14555   1 DELIAQFQAITGADEEVARQYLEAHNWDLEAAVNAFFDDGEAS 43
 
Name Accession Description Interval E-value
UBA_F100B_like cd14343
UBA-like domain found in protein FAM100B; The family corresponds to the uncharacterized ...
 10-48 4.29e-20

UBA-like domain found in protein FAM100B; The family corresponds to the uncharacterized protein FAM100B and its homologs mainly found in Metazoa. Although their biological roles remain unclear, all family members contain a ubiquitin-associated (UBA)-like domain that may be involved in the binding of ubiquitin.


Pssm-ID: 270528  Cd Length: 39  Bit Score: 77.90  E-value: 4.29e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 32698954  10 HQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQ 48
Cdd:cd14343   1 EQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSAFFQ 39
UBA_p47 cd14348
UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX ...
 13-47 2.35e-09

UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX domain-containing protein 2C, is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. p47, together with p97, forms the p97-p47 complex that plays an important role in regulation of membrane fusion events. p47 contains an N-terminal ubiquitin-associated (UBA)-like domain, a central SEP (named after shp1, eyc and p47) domain, and a ubiquitin-like (UBX) domain. UBA-like domain is responsible for forming a highly stable complex with ubiquitin. SEP domain and UBX domain may involve in p47 trimerization or forms a stable complex with the p97 N-terminal domain.


Pssm-ID: 270533  Cd Length: 40  Bit Score: 50.23  E-value: 2.35e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 32698954  13 MINQFVLAAGCAADQAKQLLQAAHWQFETALSTFF 47
Cdd:cd14348   3 LIAQFVSVTGADEDRAKFFLESAGWDLEAALSSFF 37
UBA_4 pfam14555
UBA-like domain;
11-53 5.29e-07

UBA-like domain;


Pssm-ID: 464207  Cd Length: 43  Bit Score: 43.98  E-value: 5.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 32698954    11 QVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIP 53
Cdd:pfam14555   1 DELIAQFQAITGADEEVARQYLEAHNWDLEAAVNAFFDDGEAS 43
UBA_TAP-C_like cd14273
UBA-like domain found in the NXF family of mRNA nuclear export factors and similar proteins; ...
 17-47 2.03e-03

UBA-like domain found in the NXF family of mRNA nuclear export factors and similar proteins; This family includes nuclear RNA export factors (NXF1/NXF2), FAS-associated factors (FAF1/2), tyrosyl-DNA phosphodiesterase 2 (TDP2), OTU domain-containing proteins (OTU7A/OTU7B), NSFL1 cofactor p47, defective in cullin neddylation protein 1 (DCN1)-like protein (DCNL1/DCNL2), yeast defective in cullin neddylation protein 1 (DCN1) and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. FAF2 is the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. Its biological function remains unclear. TDP2 is a 5'-Tyr-DNA phosphodiesterase required for the efficient repair of topoisomerase II-induced DNA double strand breaks. OTU7A and OTU7B are zinc finger proteins that function as deubiquitinating enzymes. p47 is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. DCNL1 plays an essential role in the neddylation E3 complex and participates in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. The biological function of DCNL2 remains unclear. Yeast DCN1 is a scaffold-type E3 ligase for cullin neddylation. It can bind directly to cullins and the ubiquitin-like protein Nedd8-specific E2 (Ubc12), and regulate cullin neddylation and thus display ubiquitin ligase activity.


Pssm-ID: 270459  Cd Length: 31  Bit Score: 34.30  E-value: 2.03e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 32698954  17 FVLAAGCAADQAKQLLQAAHWQFETALSTFF 47
Cdd:cd14273   1 FMEITGADPETARQYLESNNWDLEAAINLYF 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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