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Conserved domains on  [gi|32698982|ref|NP_872386|]
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probable transmembrane reductase CYB561D1 isoform 2 [Homo sapiens]

Protein Classification

cytochrome b561 domain-containing protein( domain architecture ID 10171790)

cytochrome b561 domain-containing protein (CYB561D) similar to mammalian CYB561D2, also called transmembrane ascorbate ferrireductase, a two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 32-212 3.31e-51

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


:

Pssm-ID: 176491  Cd Length: 183  Bit Score: 164.38  E-value: 3.31e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  32 LVALGFTIFLTALSRPGTSLFSWHPVFMALAFCLCMAEAILLFSPEHSLFFfCSRKARIRLHWAGQTLAILCAALGLGFI 111
Cdd:cd08761   1 LVAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982 112 ISSRTRSELPHLVSWHSWVGALTLLATAVQALCGLCLLCPRAAR--VSRVARLKLYHLTCGLVVYLMATVTVLLGMYSVW 189
Cdd:cd08761  80 YYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRrgESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159

                       170       180
                ....*....|....*....|....
gi 32698982 190 F-QAQIKGAAWYLCLALPVYPALV 212
Cdd:cd08761 160 FsKNVTHVALWYLALAVALALAGV 183
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 32-212 3.31e-51

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 164.38  E-value: 3.31e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  32 LVALGFTIFLTALSRPGTSLFSWHPVFMALAFCLCMAEAILLFSPEHSLFFfCSRKARIRLHWAGQTLAILCAALGLGFI 111
Cdd:cd08761   1 LVAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982 112 ISSRTRSELPHLVSWHSWVGALTLLATAVQALCGLCLLCPRAAR--VSRVARLKLYHLTCGLVVYLMATVTVLLGMYSVW 189
Cdd:cd08761  80 YYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRrgESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159

                       170       180
                ....*....|....*....|....
gi 32698982 190 F-QAQIKGAAWYLCLALPVYPALV 212
Cdd:cd08761 160 FsKNVTHVALWYLALAVALALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 54-191 1.14e-40

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 135.81  E-value: 1.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982    54 WHPVFMALAFCLCMAEAILLFSpeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGAL 133
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 32698982   134 TLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM-YSVWFQ 191
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 54-185 1.55e-31

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 111.94  E-value: 1.55e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982     54 WHPVFMALAFCLCMAEAILLFspeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGAL 133
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVA---RPLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLA 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 32698982    134 TLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
PLN02680 PLN02680
carbon-monoxide oxygenase
 51-185 8.38e-05

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 42.48  E-value: 8.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982   51 LFSWHPVFMALAFCLCMAEAILLFSPEHSlfffcSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWV 130
Cdd:PLN02680  46 IFNVHPVLMVIGLVLLNGEAMLAYKTVPG-----TKNLKKLVHLTLQFLAFCLSLIGVWAALKFHNEKGIDNFYSLHSWL 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 32698982  131 GALTLLATAVQALCGLCLL-CPRAARVSRvARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:PLN02680 121 GLACLFLFSLQWAAGFVTFwYPGGSRNSR-ASLLPWHVFFGIYIYALAVATATTGI 175
 
Name Accession Description Interval E-value
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 32-212 3.31e-51

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 164.38  E-value: 3.31e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  32 LVALGFTIFLTALSRPGTSLFSWHPVFMALAFCLCMAEAILLFSPEHSLFFfCSRKARIRLHWAGQTLAILCAALGLGFI 111
Cdd:cd08761   1 LVAVVFAAFLLYIARPGTSLFSWHPLLMSLGFLLLMTEALLLLQPTSSLTK-LARKTKVRLHWILQLLALLCILAGLVAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982 112 ISSRTRSELPHLVSWHSWVGALTLLATAVQALCGLCLLCPRAAR--VSRVARLKLYHLTCGLVVYLMATVTVLLGMYSVW 189
Cdd:cd08761  80 YYNKERNGKPHFTSWHGILGLVTVILIVLQALGGLALLYPPGLRrgESKAKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159

                       170       180
                ....*....|....*....|....
gi 32698982 190 F-QAQIKGAAWYLCLALPVYPALV 212
Cdd:cd08761 160 FsKNVTHVALWYLALAVALALAGV 183
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 54-191 1.14e-40

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 135.81  E-value: 1.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982    54 WHPVFMALAFCLCMAEAILLFSpeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGAL 133
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYR--VNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 32698982   134 TLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM-YSVWFQ 191
Cdd:pfam03188  79 TVILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLlEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 54-185 1.55e-31

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 111.94  E-value: 1.55e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982     54 WHPVFMALAFCLCMAEAILLFspeHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVGAL 133
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVA---RPLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLA 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 32698982    134 TLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:smart00665  78 AFVLAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 52-185 2.30e-22

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 88.49  E-value: 2.30e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  52 FSWHPVFMALAFCLCMAEAILlfspEHSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVG 131
Cdd:cd08554   2 FNWHPLLMVIGFVFLMGEALL----VYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLG 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 32698982 132 ALTLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:cd08554  78 LATVLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 52-185 2.42e-12

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 63.89  E-value: 2.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  52 FSWHPVFMALAFCLCMAEAILLFSpehslFFFCSRKARIR-LHWAGQTLAILCAALGLGFIISSRT--RSELPHLVSWHS 128
Cdd:cd08764  24 FNWHPLLMVLGLIFLYGNSILVYR-----VFRNTRKKRLKlLHAVLHLLAFILAVIGLKAVFDSHNlaKPPIPNMYSLHS 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32698982 129 WVGALTLLATAVQALCGLC-LLCPRAARVSRVARLKLyHLTCGLVVYLMATVTVLLGM 185
Cdd:cd08764  99 WLGLTAVILFSLQWVGGFVsFLFPGLPETLRAAYLPL-HVFFGLFIFVLAVATALLGI 155
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 52-185 3.84e-10

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 56.16  E-value: 3.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  52 FSWHPVFMALAFCLCMAEAILLFSpehslFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWVG 131
Cdd:cd08766   8 FNVHPVLMVIGFIFLAGEAILAYK-----TVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSWLG 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32698982 132 ALTLLATAVQALCG-LCLLCPRAARVSRvARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:cd08766  83 IGTISLFGLQWLFGfVTFWFPGASRNTR-AALLPWHVFLGLAIYYLAIATAETGL 136
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 50-186 9.73e-09

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 53.12  E-value: 9.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  50 SLFSWHPVFMALAFCLCMAEAILLfspehSLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELpHLVSWHSW 129
Cdd:cd08760  34 TLIKAHGVLMAIAWGILMPIGALL-----ARYFLLGDPVWFYLHAGLQLLAVLLAIAGFVLGIVLVQGGGG-SLNNAHAI 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 32698982 130 VGALTLLATAVQALCGLcLLCPRAARVSRVarLKLYHLTCGLVVYLMATVTVLLGMY 186
Cdd:cd08760 108 LGIIVLALAILQPLLGL-LRPHPGSKKRSI--WNWAHRWLGRAALILAIVNIFLGLD 161
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 48-185 1.28e-06

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 46.81  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  48 GTSLFSWHPVFMALAFCLCMAEAILLFSPEHSlfFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWH 127
Cdd:cd08765   8 GAAEFNWHPVLMVIGFIFIQGIAIIVYRLPWT--WKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNMYSLH 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32698982 128 SWVGALTLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:cd08765  86 SWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGI 143
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 48-185 6.18e-06

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 44.42  E-value: 6.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982  48 GTSLFSWHPVFMALAFCLCMAEAILLFSpehsLFFFCSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWH 127
Cdd:cd08763   3 GPLQFNVHPLCMVLGLVFLCGEALLVYR----VFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLH 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32698982 128 SWVGALTLLATAVQALCGLCLLCPRAARVSRVARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:cd08763  79 SWCGILTFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGL 136
PLN02680 PLN02680
carbon-monoxide oxygenase
 51-185 8.38e-05

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 42.48  E-value: 8.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982   51 LFSWHPVFMALAFCLCMAEAILLFSPEHSlfffcSRKARIRLHWAGQTLAILCAALGLGFIISSRTRSELPHLVSWHSWV 130
Cdd:PLN02680  46 IFNVHPVLMVIGLVLLNGEAMLAYKTVPG-----TKNLKKLVHLTLQFLAFCLSLIGVWAALKFHNEKGIDNFYSLHSWL 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 32698982  131 GALTLLATAVQALCGLCLL-CPRAARVSRvARLKLYHLTCGLVVYLMATVTVLLGM 185
Cdd:PLN02680 121 GLACLFLFSLQWAAGFVTFwYPGGSRNSR-ASLLPWHVFFGIYIYALAVATATTGI 175
PLN02351 PLN02351
cytochromes b561 family protein
 24-185 9.40e-04

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 39.12  E-value: 9.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982   24 RGSGILAHLVALGFTIFLTA------LSRPGTSLFSWHPVFMALAFCLCMAEAILLFSpehslFFFCSRKARIRLHWAGQ 97
Cdd:PLN02351  17 RLSGLVVAVLVLYWALFFKSsflpqsTSQEDLVYAVLHPLLMVIGFILISGEAILVHR-----WLPGSRKTKKSVHLWLQ 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32698982   98 TLAILCAALGLgFIISSRTRSELPHLVSWHSWVGALTLLATAVQALCGLCLLCPRA-ARVSRVARLKlYHLTCGLVVYLM 176
Cdd:PLN02351  92 GLALASGVFGI-WTKFHGQDGIVANFYSLHSWMGLICVSLFGAQWLTGFMSFWHRGeMRTTRTTVLP-WHVFLGLYTYGL 169


                 ....*....
gi 32698982  177 ATVTVLLGM 185
Cdd:PLN02351 170 AVATAETGL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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