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Conserved domains on  [gi|33469922|ref|NP_877577|]
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DNA replication licensing factor MCM7 isoform 2 [Homo sapiens]

Protein Classification

minichromosome maintenance family protein( domain architecture ID 1003676)

minichromosome maintenance (MCM) family protein similar to minichromosome maintenance protein, a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication, and MCM domain-containing protein 2 (mcmdc2), which plays an important role in meiotic recombination and associated DNA double-strand break repair

Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 1-465 0e+00

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member smart00350:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 509  Bit Score: 682.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922      1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQTRgSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:smart00350  33 LKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHER-STFIDFQKIKLQESPEEVPVGQLPRSVDVI 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922     81 VEGENTRIAQPGDHVSVTGIFLPILrTGFRQVVQGLLSE--TYLEAHRIVK--MNKSEDDESGA----GELTREELRQIA 152
Cdd:smart00350 110 LDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANHVRKldYKRSFEDSSFSvqslSDEEEEEIRKLS 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    153 E-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG 230
Cdd:smart00350 189 KdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTG 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    231 RGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILA 310
Cdd:smart00350 269 KGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLA 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    311 AANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSR-QPPSQFE-PLDMKLMRRYIA 388
Cdd:smart00350 349 AANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIA 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    389 MCREK-QPMVPESLADYITAAYVEMRREAWASKDAT--YTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSK 465
Cdd:smart00350 429 YAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
1-465 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 682.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922      1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQTRgSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:smart00350  33 LKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHER-STFIDFQKIKLQESPEEVPVGQLPRSVDVI 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922     81 VEGENTRIAQPGDHVSVTGIFLPILrTGFRQVVQGLLSE--TYLEAHRIVK--MNKSEDDESGA----GELTREELRQIA 152
Cdd:smart00350 110 LDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANHVRKldYKRSFEDSSFSvqslSDEEEEEIRKLS 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    153 E-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG 230
Cdd:smart00350 189 KdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTG 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    231 RGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILA 310
Cdd:smart00350 269 KGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLA 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    311 AANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSR-QPPSQFE-PLDMKLMRRYIA 388
Cdd:smart00350 349 AANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIA 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    389 MCREK-QPMVPESLADYITAAYVEMRREAWASKDAT--YTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSK 465
Cdd:smart00350 429 YAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 159-464 0e+00

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 609.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 238
Cdd:cd17758   1 KLAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 239 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 318
Cdd:cd17758  81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 319 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVP 398
Cdd:cd17758 161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPKLLRAYIALAKRKRPTVP 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33469922 399 ESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17758 241 PALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 1-462 1.26e-161

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 475.83  E-value: 1.26e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQtnrsgGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:COG1241 124 ITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQ-----GPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQPQSIDVI 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  81 VEGENTRIAQPGDHVSVTGIflpiLRTGFRQVVQGLLS--ETYLEAHRIVKMNKSEDDEsgagELTREELRQIAE----E 154
Cdd:COG1241 199 LEDDLVGEVRPGDRVTVTGI----LRIEQRTSGRGKSTifDLYLEANSIEVEEKEFEEI----EITEEDEEKIKElskdP 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 155 DFYEKLAASIAPEIYGHEDVKKALLLllvggvdQ--------SPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQ 226
Cdd:COG1241 271 DIYEKIIASIAPSIYGYEEIKEAIAL-------QlfggvpkvLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGV 343

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 227 YTTGRGSSGVGLTAAVLRDSVS-GELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNAR 305
Cdd:COG1241 344 YTSGKGSTAAGLTAAAVRDDFGtGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNAR 423

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 306 CSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE--------P 377
Cdd:COG1241 424 CSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHRAGELLEQEIEeeteevkpE 503

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 378 LDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNE 456
Cdd:COG1241 504 IDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRLAEASARMRLSDTVTEEDAER 583


                ....*.
gi 33469922 457 AIRLME 462
Cdd:COG1241 584 AIRLVD 589
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
1-462 3.70e-153

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 454.00  E-value: 3.70e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    1 MVVATYTCDQCGAETYQPiQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:NF040949 128 IVKAVFRCRDCGCEFEWP-EEEEESYEIVEPPTVCPVCGKPGSFRLLQEKSKFIDWQKIVVQERPEELPPGQLPRSIEVV 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   81 VEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSeTYLEAHRIVKMNKsEDDESgagELTREELRQIAE----EDF 156
Cdd:NF040949 207 LEDDLVDTARPGDRVTVTGILRIKPDSSLKKGSRPIFK-NYIEANHIEVSQK-ELEEV---EITEEDEEKILElakdPWI 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  157 YEKLAASIAPEIYGHEDVKKALLLLL-VGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSG 235
Cdd:NF040949 282 REKIIASIAPSIYGHWEIKEAIALLLfGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTA 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  236 VGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPA 315
Cdd:NF040949 362 AGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPK 441

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  316 YGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSrqppSQFEP-LDMKLMRRYIAMCREK- 393
Cdd:NF040949 442 FGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGK----EKVKPeIDPDLLKKYIAYARKYv 517

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33469922  394 QPMVPESLADYITAAYVEMRREAWASKD---ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLME 462
Cdd:NF040949 518 RPKLTEEAKKLIEDFYVEMRKSSKSSEDpdsPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLML 589
MCM pfam00493
MCM P-loop domain;
146-365 1.07e-134

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 389.97  E-value: 1.07e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   146 EELRQIA-EEDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAP 223
Cdd:pfam00493   3 EEIKELAkRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGgVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   224 RSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN 303
Cdd:pfam00493  83 RAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLN 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33469922   304 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH 365
Cdd:pfam00493 163 ARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 91-464 1.66e-83

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 278.42  E-value: 1.66e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   91 PGDHVSVTGIF--LPIlRTGFRQVVQGLLSETYLEA-H-RIVKMNKSEDDESG------AGELTREELRQIAE----EDF 156
Cdd:PTZ00111 362 TGDRVTVVGILkvTPI-RTSTTRRTLKSLYTYFVNViHvKVINSTNANQPEKGlkylgnENDFSDLQVYKILElsrnPMI 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  157 YEKLAASIAPEIYGHEDVKK----------ALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQ 226
Cdd:PTZ00111 441 YRILLDSFAPSIKARNNVKIgllcqlfsgnKNSSDFNKSPDACYKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSI 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  227 YTTGRGSSGVGLTAAV-LRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNAR 305
Cdd:PTZ00111 521 YTSGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAE 600

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  306 CSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHI-----------------TY----- 363
Cdd:PTZ00111 601 TAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIakdfllphmtgsgndedTYdrsnt 680

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  364 --VHQHSRQPPSQFEPLDMKLMRRYIAMCR-EKQPMVPESLADYITAAYVEMRREAWASKD------------------- 421
Cdd:PTZ00111 681 mhVEDESLRSEKDYNKNDLDMLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQGNFQTSNldelehaqedddddlyyqs 760

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 33469922  422 ----ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:PTZ00111 761 sgtrMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
1-465 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 682.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922      1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQTRgSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:smart00350  33 LKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHER-STFIDFQKIKLQESPEEVPVGQLPRSVDVI 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922     81 VEGENTRIAQPGDHVSVTGIFLPILrTGFRQVVQGLLSE--TYLEAHRIVK--MNKSEDDESGA----GELTREELRQIA 152
Cdd:smart00350 110 LDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANHVRKldYKRSFEDSSFSvqslSDEEEEEIRKLS 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    153 E-EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTG 230
Cdd:smart00350 189 KdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGDINILLCGDPGTAKSQLLKYVEKTAPRAVYTTG 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    231 RGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILA 310
Cdd:smart00350 269 KGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVLA 348

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    311 AANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSR-QPPSQFE-PLDMKLMRRYIA 388
Cdd:smart00350 349 AANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIA 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    389 MCREK-QPMVPESLADYITAAYVEMRREAWASKDAT--YTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSK 465
Cdd:smart00350 429 YAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 159-464 0e+00

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 609.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 238
Cdd:cd17758   1 KLAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 239 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 318
Cdd:cd17758  81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 319 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVP 398
Cdd:cd17758 161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPKLLRAYIALAKRKRPTVP 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33469922 399 ESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17758 241 PALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 1-462 1.26e-161

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 475.83  E-value: 1.26e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   1 MVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQtnrsgGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:COG1241 124 ITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQ-----GPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQPQSIDVI 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  81 VEGENTRIAQPGDHVSVTGIflpiLRTGFRQVVQGLLS--ETYLEAHRIVKMNKSEDDEsgagELTREELRQIAE----E 154
Cdd:COG1241 199 LEDDLVGEVRPGDRVTVTGI----LRIEQRTSGRGKSTifDLYLEANSIEVEEKEFEEI----EITEEDEEKIKElskdP 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 155 DFYEKLAASIAPEIYGHEDVKKALLLllvggvdQ--------SPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQ 226
Cdd:COG1241 271 DIYEKIIASIAPSIYGYEEIKEAIAL-------QlfggvpkvLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGV 343

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 227 YTTGRGSSGVGLTAAVLRDSVS-GELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNAR 305
Cdd:COG1241 344 YTSGKGSTAAGLTAAAVRDDFGtGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNAR 423

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 306 CSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFE--------P 377
Cdd:COG1241 424 CSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHRAGELLEQEIEeeteevkpE 503

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 378 LDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNE 456
Cdd:COG1241 504 IDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRLAEASARMRLSDTVTEEDAER 583


                ....*.
gi 33469922 457 AIRLME 462
Cdd:COG1241 584 AIRLVD 589
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
1-462 3.70e-153

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 454.00  E-value: 3.70e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922    1 MVVATYTCDQCGAETYQPiQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:NF040949 128 IVKAVFRCRDCGCEFEWP-EEEEESYEIVEPPTVCPVCGKPGSFRLLQEKSKFIDWQKIVVQERPEELPPGQLPRSIEVV 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   81 VEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSeTYLEAHRIVKMNKsEDDESgagELTREELRQIAE----EDF 156
Cdd:NF040949 207 LEDDLVDTARPGDRVTVTGILRIKPDSSLKKGSRPIFK-NYIEANHIEVSQK-ELEEV---EITEEDEEKILElakdPWI 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  157 YEKLAASIAPEIYGHEDVKKALLLLL-VGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSG 235
Cdd:NF040949 282 REKIIASIAPSIYGHWEIKEAIALLLfGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTA 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  236 VGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPA 315
Cdd:NF040949 362 AGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPK 441

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  316 YGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSrqppSQFEP-LDMKLMRRYIAMCREK- 393
Cdd:NF040949 442 FGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGK----EKVKPeIDPDLLKKYIAYARKYv 517

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33469922  394 QPMVPESLADYITAAYVEMRREAWASKD---ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLME 462
Cdd:NF040949 518 RPKLTEEAKKLIEDFYVEMRKSSKSSEDpdsPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRLML 589
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 159-464 3.23e-141

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 410.20  E-value: 3.23e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 237
Cdd:cd17706   1 ILADSIAPSIYGHEDVKKAVLLQLFGGVQKIlEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 238 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 317
Cdd:cd17706  81 LTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 318 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHS-----RQPPSQFEPLDMKLMRRYIAMCRE 392
Cdd:cd17706 161 RYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSdpeeqVKPEEDGIPIDIELLRKYILYARQ 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33469922 393 KQPMVPESLADYITAAYVEMRREAwASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17706 241 IHPKISEEAREKLVRWYVELRKES-ERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
MCM pfam00493
MCM P-loop domain;
146-365 1.07e-134

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 389.97  E-value: 1.07e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   146 EELRQIA-EEDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAP 223
Cdd:pfam00493   3 EEIKELAkRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGgVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   224 RSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN 303
Cdd:pfam00493  83 RAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLN 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33469922   304 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH 365
Cdd:pfam00493 163 ARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 159-461 3.54e-123

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 364.06  E-value: 3.54e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLL--VGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 236
Cdd:cd17755   1 RLARSIAPSIYELEDVKKGILLQLfgGTRKDFTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 237 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 316
Cdd:cd17755  81 GLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 317 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREK-QP 395
Cdd:cd17755 161 SRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLYLEDTPEHIQDEVLDVEVLTDYISYAREHiHP 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33469922 396 MVPESLADYITAAYVEMRReAWASKDATYTSA-RTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 461
Cdd:cd17755 241 KLSEEAAQELVQAYVDMRK-MGSDARKRITATpRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLI 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 159-464 2.36e-122

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 362.09  E-value: 2.36e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 237
Cdd:cd17756   1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRlPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 238 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 317
Cdd:cd17756  81 LTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 318 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSR--QPPSQFEP-LDMKLMRRYIAMCREK- 393
Cdd:cd17756 161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARkaSQSQENEGeIPISKLKRYIAYCRAKc 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33469922 394 QPMVPESLADYITAAYVEMRREAWASKDATYTSA------RTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17756 241 APRLSEEAAEKLSNHYVTIRKDVRQNELESDNRSsipitvRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 158-461 5.92e-121

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 358.30  E-value: 5.92e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 158 EKLAASIAPEIYGHEDVKKALLLLL-VGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 236
Cdd:cd17761   1 EKIISSIAPSIYGHEDVKEAIALQLfGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 237 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 316
Cdd:cd17761  81 GLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 317 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRqpPSQFEP-LDMKLMRRYIAMCREK-Q 394
Cdd:cd17761 161 GRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGE--MREIKPeIDPDLLRKYIAYARKNvR 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33469922 395 PMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 461
Cdd:cd17761 239 PVLTEEAKQLIKDFYVEMRKSGQETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIM 305
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 159-461 4.57e-119

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 354.06  E-value: 4.57e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGM-KIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 237
Cdd:cd17753   1 RIINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKhRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 238 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 317
Cdd:cd17753  81 LTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 318 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHItyVHQHSRQPPS--------------------QFEP 377
Cdd:cd17753 161 RYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFV--VGSHVRSHPEndedregeeeknqrqrpketKVEP 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 378 LDMKLMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTsARTLLAILRLSTALARLRMVDVVEKEDVNE 456
Cdd:cd17753 239 IPQELLRKYIHYAREKvRPKLNQMDMDKVSRVYADLRKESMATGSLPIT-VRHLESIIRISEAHAKMHLREYVSEEDVDM 317


                ....*
gi 33469922 457 AIRLM 461
Cdd:cd17753 318 AIRVM 322
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 159-464 7.97e-119

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 352.83  E-value: 7.97e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 159 KLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 237
Cdd:cd17757   1 NLVRSIAPSIYGHEEVKKGILLMLLGgVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 238 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 317
Cdd:cd17757  81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 318 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHItyVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMV 397
Cdd:cd17757 161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHI--VDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKL 238

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33469922 398 PESLADYITAAYVEMR-REAWASKDATY-TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17757 239 TKEAKDELVEQYKELRqDDASGSTRSSYrITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 160-461 2.95e-114

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 340.60  E-value: 2.95e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 160 LAASIAPEIYGHEDVKKALLLLLVGGVDQS-PRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 238
Cdd:cd17754   2 LSKSLAPSIYGHEYIKKAILLMLLGGVEKNlENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 239 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 318
Cdd:cd17754  82 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYGR 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 319 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHsrqppsqfepldMKLMRRYIAMCREK-QPMV 397
Cdd:cd17754 162 YDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------IKFLRKYIHYAKERiKPKL 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33469922 398 PESLADYITAAYVEMRREAWASKDATYTS---ARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLM 461
Cdd:cd17754 230 TQEAAEYIAEEYADLRNDDNTKTDKARTSpitARTLETLIRLATAHAKARLSKTVDKVDAEVALNLL 296
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 91-464 1.66e-83

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 278.42  E-value: 1.66e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   91 PGDHVSVTGIF--LPIlRTGFRQVVQGLLSETYLEA-H-RIVKMNKSEDDESG------AGELTREELRQIAE----EDF 156
Cdd:PTZ00111 362 TGDRVTVVGILkvTPI-RTSTTRRTLKSLYTYFVNViHvKVINSTNANQPEKGlkylgnENDFSDLQVYKILElsrnPMI 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  157 YEKLAASIAPEIYGHEDVKK----------ALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQ 226
Cdd:PTZ00111 441 YRILLDSFAPSIKARNNVKIgllcqlfsgnKNSSDFNKSPDACYKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSI 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  227 YTTGRGSSGVGLTAAV-LRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNAR 305
Cdd:PTZ00111 521 YTSGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAE 600

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  306 CSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHI-----------------TY----- 363
Cdd:PTZ00111 601 TAILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIakdfllphmtgsgndedTYdrsnt 680

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922  364 --VHQHSRQPPSQFEPLDMKLMRRYIAMCR-EKQPMVPESLADYITAAYVEMRREAWASKD------------------- 421
Cdd:PTZ00111 681 mhVEDESLRSEKDYNKNDLDMLRMYIKFSKlHCFPKLSDEAKKVITREYVKMRQGNFQTSNldelehaqedddddlyyqs 760

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 33469922  422 ----ATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:PTZ00111 761 sgtrMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 160-464 1.99e-82

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 259.01  E-value: 1.99e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 160 LAASIAPEIYGHEDVKKALLLLLV---GGVDQSprGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 236
Cdd:cd17760   2 ILASLCPQVFGLYNVKLAVAMVLAggvQRIDAS--GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 237 GLTAAVLRDSvsGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAy 316
Cdd:cd17760  80 GLTVTAVKDG--GEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 317 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITyvhqHSRQPPSQFEPL-DMKLMRRYIAMCREKQP 395
Cdd:cd17760 157 GQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL----ENKGEPSKSSKLwSMEKMRTYFCLIKNLRP 232

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33469922 396 MVPESlADYITAAYVEMRREAwASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17760 233 VLSDE-ANAILLRYYQLQRQS-DCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 160-464 1.66e-74

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 238.20  E-value: 1.66e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 160 LAASIAPEIYGHEDVKKALLLL----LVGGVDQSPRgMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSG 235
Cdd:cd17759   2 IVNSLCPAIYGHELVKAGLLLSlfggKQKYADDKNR-IPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 236 VGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEaDRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPA 315
Cdd:cd17759  81 SGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 316 YGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHityvhqhsrqppsqfepldMKLMRRYIAMCR-EKQ 394
Cdd:cd17759 160 GGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH-------------------HQLLRKYISYARqYVN 220

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 395 PMVPESLADYITAAYVEMRREAwASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMS 464
Cdd:cd17759 221 PVLSKDASEALQEFYLELRKQN-QLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 1-104 1.39e-33

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 123.75  E-value: 1.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922     1 MVVATYTCDQCGAETYQPIQSPTfmpliMCPSQECQtnrSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVL 80
Cdd:pfam17207  30 LKKATFTCRKCGHTVGVKITEPT-----KCPNPECG---NKDPFKLVHEKSKFVDFQKIKIQESPEEVPAGELPRSLDVI 101

                          90       100
                  ....*....|....*....|....
gi 33469922    81 VEGENTRIAQPGDHVSVTGIFLPI 104
Cdd:pfam17207 102 LDDDLVDRVKPGDRVTVTGIYRVV 125
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 382-465 1.12e-26

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 103.39  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   382 LMRRYIAMCREK-QPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRL 460
Cdd:pfam17855   2 LLRKYIAYAREKiKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIRL 81


                  ....*
gi 33469922   461 MEMSK 465
Cdd:pfam17855  82 LKESL 86
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 200-339 7.43e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 45.75  E-value: 7.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922   200 NICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSgvGLTAAVLRDSVS---GELTLEGGALVLADQ--GVCCIDEFDKm 274
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTR--DTTEEDLFGRRNidpGGASWVDGPLVRAARegEIAVLDEINR- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33469922   275 AEADRTAI-HEVMEQQTISIAKAGILTTLNARC-SILAAANPAYGRYNPrrsleqniqLPAALLSRF 339
Cdd:pfam07728  78 ANPDVLNSlLSLLDERRLLLPDGGELVKAAPDGfRLIATMNPLDRGLNE---------LSPALRSRF 135
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 268-454 4.66e-05

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 45.54  E-value: 4.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 268 IDEFDKmaeAD-RT--AIHEVMEQQTISIAKAGIltTLNARCSILAAANP--AYGRYnprrsleqniQLPAALLSRFDL- 341
Cdd:COG0714 100 ADEINR---APpKTqsALLEAMEERQVTIPGGTY--KLPEPFLVIATQNPieQEGTY----------PLPEAQLDRFLLk 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469922 342 LWLiqDRPDRDNDLRLaqhityVHQHSRQPPSQFEPLdmkLMRRYIAMCRE--KQPMVPESLADYITAAYVEMRREAWAS 419
Cdd:COG0714 165 LYI--GYPDAEEEREI------LRRHTGRHLAEVEPV---LSPEELLALQElvRQVHVSEAVLDYIVDLVRATREHPDLR 233

                       170       180       190
                ....*....|....*....|....*....|....*
gi 33469922 420 KDAtytSARTLLAILRLSTALARLRMVDVVEKEDV 454
Cdd:COG0714 234 KGP---SPRASIALLRAARALALLDGRDYVTPDDV 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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