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Conserved domains on  [gi|33504539|ref|NP_878296|]
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wingless-type MMTV integration site family, member 2Ba [Danio rerio]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 63-376 0e+00

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19346:

Pssm-ID: 393294  Cd Length: 314  Bit Score: 600.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  63 GARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAIS 142
Cdd:cd19346   1 GARVICDNIPGLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 143 SAGVVYAITRACSQGELKICSCDSQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGR 222
Cdd:cd19346  81 SAGVVYAITRACSQGELKSCSCDPHKRGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARALMNLHNNRCGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 223 MAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIENSP 302
Cdd:cd19346 161 MAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKNFRKATKTDLVYFENSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19346 241 DYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
 
Name Accession Description Interval E-value
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 63-376 0e+00

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 600.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  63 GARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAIS 142
Cdd:cd19346   1 GARVICDNIPGLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 143 SAGVVYAITRACSQGELKICSCDSQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGR 222
Cdd:cd19346  81 SAGVVYAITRACSQGELKSCSCDPHKRGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARALMNLHNNRCGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 223 MAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIENSP 302
Cdd:cd19346 161 MAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKNFRKATKTDLVYFENSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19346 241 DYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 70-376 0e+00

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 523.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539    70 NIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAISSAGVVYA 149
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539   150 ITRACSQGELKICSCDSQRRGRASDEdGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGRMAVKRFM 229
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGKSSGE-GGWEWGGCSDNIDYGYKFSRKFVDAREKKRRDARALMNLHNNEAGRKAVKSNM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539   230 KTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEV-MMNQDGTGFMVADRDYKRTTKNDLVYIENSPDYCLMD 308
Cdd:pfam00110 160 RTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVnRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33504539   309 RSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:pfam00110 240 PKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
70-376 1.94e-166

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 467.57  E-value: 1.94e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539     70 NIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAISSAGVVYA 149
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLD-NASVFGKVLRQGTRETAFVYAISSAGVAHA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539    150 ITRACSQGELKICSCDSQRRGRASDEDgdFDWGGCSDNINYGIKFAKAFVDARERmVKDARALMNLHNNRCGRMAVKRFM 229
Cdd:smart00097  80 VTRACSEGELDSCGCDYRKRGRAGGRG--WKWGGCSDNIDFGIRFSREFVDARER-GKDARALMNLHNNEAGRLAVKKTM 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539    230 KTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVA--DRDYKRTTKNDLVYIENSPDYCLM 307
Cdd:smart00097 157 KRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVpkNSTFKPPTETDLVYLESSPDFCEK 236

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33504539    308 DRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:smart00097 237 NPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 63-376 0e+00

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 600.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  63 GARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAIS 142
Cdd:cd19346   1 GARVICDNIPGLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 143 SAGVVYAITRACSQGELKICSCDSQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGR 222
Cdd:cd19346  81 SAGVVYAITRACSQGELKSCSCDPHKRGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARALMNLHNNRCGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 223 MAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIENSP 302
Cdd:cd19346 161 MAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKNFRKATKTDLVYFENSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19346 241 DYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 63-376 0e+00

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 577.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  63 GARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAIS 142
Cdd:cd19334   1 GARVICDNIPGLVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDATVFGKVLLKGSREAAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 143 SAGVVYAITRACSQGELKICSCDSQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGR 222
Cdd:cd19334  81 SAGVVHAITRACSKGELLNCACDPTKRGKGRDSKGEFDWGGCSDNVKYGINFARKFVDARERRVRDARALMNLHNNRAGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 223 MAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIENSP 302
Cdd:cd19334 161 KAVKKNLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTNLLAANKGHKKPTRSDLVYFESSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19334 241 DYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 63-376 0e+00

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 553.00  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  63 GARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAIS 142
Cdd:cd19345   1 GSRVMCDNIPGLVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHSLFGRLLLRSSRESAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 143 SAGVVYAITRACSQGELKICSCDSQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGR 222
Cdd:cd19345  81 SAGVVFAITRACSQGELKSCSCDPKKKGSSKDSKGSFDWGGCSDNIDYGIRFARAFVDAKERKGKDARALMNLHNNRAGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 223 MAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIENSP 302
Cdd:cd19345 161 KAVKRFMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHFKKPTKNDLVYFENSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19345 241 DYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 70-376 0e+00

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 523.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539    70 NIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAISSAGVVYA 149
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539   150 ITRACSQGELKICSCDSQRRGRASDEdGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGRMAVKRFM 229
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGKSSGE-GGWEWGGCSDNIDYGYKFSRKFVDAREKKRRDARALMNLHNNEAGRKAVKSNM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539   230 KTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEV-MMNQDGTGFMVADRDYKRTTKNDLVYIENSPDYCLMD 308
Cdd:pfam00110 160 RTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVnRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERN 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33504539   309 RSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:pfam00110 240 PKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
70-376 1.94e-166

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 467.57  E-value: 1.94e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539     70 NIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAISSAGVVYA 149
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLD-NASVFGKVLRQGTRETAFVYAISSAGVAHA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539    150 ITRACSQGELKICSCDSQRRGRASDEDgdFDWGGCSDNINYGIKFAKAFVDARERmVKDARALMNLHNNRCGRMAVKRFM 229
Cdd:smart00097  80 VTRACSEGELDSCGCDYRKRGRAGGRG--WKWGGCSDNIDFGIRFSREFVDARER-GKDARALMNLHNNEAGRLAVKKTM 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539    230 KTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVA--DRDYKRTTKNDLVYIENSPDYCLM 307
Cdd:smart00097 157 KRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVpkNSTFKPPTETDLVYLESSPDFCEK 236

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33504539    308 DRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:smart00097 237 NPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 62-376 5.33e-160

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 451.68  E-value: 5.33e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  62 LGARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTlerDHTVFGRVMLRSSREAAFVYAI 141
Cdd:cd19338   1 MDPNSICRKTRRLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCST---SRKSFGKILKRDTRETAFVYAI 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 142 SSAGVVYAITRACSQGELKICSCDSQRRGRAsdEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCG 221
Cdd:cd19338  78 TSAGVTYSVTRACSMGELLQCGCDKSKRGKS--TEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRSDIRTLMNLHNNEAG 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 222 RMAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIENS 301
Cdd:cd19338 156 RLAVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKGSNDGKSLIPEGKTIKPPTKEDLVYLEES 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33504539 302 PDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19338 236 PDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 68-376 1.34e-147

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 420.11  E-value: 1.34e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  68 CDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTlERDHTVFGRVMLRSSREAAFVYAISSAGVV 147
Cdd:cd19337   1 CDQLRGLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCST-PDSSSVFGPVTNIGTREAAFTYAISAAGVV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 148 YAITRACSQGELKICSCDsqRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVKD-------ARALMNLHNNRC 220
Cdd:cd19337  80 HAIARACREGNLSTCGCS--RERRPKDLPRDWLWGGCGDNIEYGYKFAKEFIDARERETNYprhsrelARVLMNLHNNEA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 221 GRMAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRTTKNDLVYIEN 300
Cdd:cd19337 158 GRRAVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGTLLRRRNSRFNKPTKDDLVYLDD 237

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33504539 301 SPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19337 238 SPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHICK 313
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 88-375 8.88e-146

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 414.77  E-value: 8.88e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  88 LMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRACSQGELKICSCDSQ 167
Cdd:cd13113   1 LMESIAEGAQLALKECQRQFANRRWNCSTFN-EPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 168 RRGRasDEDGDFDWGGCSDNINYGIKFAKAFVDARERMVK-DARALMNLHNNRCGRMAVKRFMKTECKCHGVSGSCALRT 246
Cdd:cd13113  80 RQGP--EGQGDWTWGGCSDNIKFGIKFSRKFLDAREKKKGsDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 247 CWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDY--KRTTKNDLVYIENSPDYCLMDRSAGSLGTSGRVCNKS 324
Cdd:cd13113 158 CWRQLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRLVPKRSrfRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNPT 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 33504539 325 SRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd13113 238 SPGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 68-376 1.06e-144

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 412.86  E-value: 1.06e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  68 CDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHtVFGRVMLRSSREAAFVYAISSAGVV 147
Cdd:cd19336   1 CESLKGLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEP-VFGKVLNQGTREAAFVHAISSAGVA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 148 YAITRACSQGELKICSCDSQRRGRASDEdgdFDWGGCSDNINYGIKFAKAFVDARER---MVKDARALMNLHNNRCGRMA 224
Cdd:cd19336  80 HAVTRACSSGELEKCGCDRSVRGRSPEG---FQWSGCSDNVAYGVAFSKSFVDARERrkgRASSSRALMNLHNNEAGRKA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 225 VKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADR--DYKRTTKNDLVYIENSP 302
Cdd:cd19336 157 IEKNMRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRIGSRPVLVPKnpQFKPHTDADLVYLDSSP 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19336 237 DFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 67-376 1.96e-144

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 412.07  E-value: 1.96e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  67 ICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAISSAGV 146
Cdd:cd19339   1 ICNKIPGLTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLG-ERTVFGQELPVGSREAAFTYAITSAGV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 147 VYAITRACSQGELKICSCDSQRRGRASDEDGdFDWGGCSDNINYGIKFAKAFVDARErMVKDARALMNLHNNRCGRMAVK 226
Cdd:cd19339  80 AYAITQACSQGNLSDCGCDKSKKGYGKSDEG-WKWGGCSADVKYGLRFSRKFVDARE-VKRNARSLMNLHNNEAGRKAVE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 227 RFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAA--VEVMMNQDGTG----FMVADRDYKRTTKNDLVYIEN 300
Cdd:cd19339 158 ENLKLECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERArrVEPVRGRRRRRptflKLKISRKYKKPRPRDLVYLEK 237

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33504539 301 SPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19339 238 SPNYCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 66-376 3.94e-138

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 396.38  E-value: 3.94e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  66 VICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMLRSSREAAFVYAISSAG 145
Cdd:cd19335   2 ILCGSIPGLVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSVFGPVLDKASRESAFVHAIASAG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 146 VVYAITRACSQGELKICSCDSQRRGRAsdeDGDFDWGGCSDNINYGIKFAKAFVDARERMvKDARALMNLHNNRCGRMAV 225
Cdd:cd19335  82 VAHAVTRACAEGDSTSCGCDSRHKGPP---GEGWRWGGCSEDVEFGVRFSREFADARENR-PDARSAMNRHNNEAGRQAI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 226 KRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVE--VMMNQDGTGFMVADR----DYKRTTKNDLVYIE 299
Cdd:cd19335 158 LDNMELKCKCHGLSGSCELKTCWWAQPDFRKIGDYLKDKYDSASEmvVERHRESRGWVETLRpkykLFKPPTERDLIYYE 237

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 33504539 300 NSPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19335 238 ESPNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 74-376 3.22e-137

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 393.52  E-value: 3.22e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  74 LVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTlERDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRA 153
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCST-TNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 154 CSQGELKICSCDSQRRGRaSDEDGdFDWGGCSDNINYGIKFAKAFVDARER----MVKDARALMNLHNNRCGRMAVKRFM 229
Cdd:cd19344  80 CSAGNLTDCSCDSRRQGQ-SASEG-WKWGGCSDNVDYGIWFARKFVDAPEKserkRSRDVRSLMNLHNNEVGRQAIARLM 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 230 KTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRDYKRT--TKNDLVYIENSPDYCLM 307
Cdd:cd19344 158 KVKCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIATKKSKRRLRRRERRKRKVpiSKDELVYIHKSPNYCVR 237

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 33504539 308 DRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19344 238 DPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 65-376 2.30e-136

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 392.01  E-value: 2.30e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  65 RVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTV-FGRVML-RSSREAAFVYAIS 142
Cdd:cd19342   1 NTVCRTFPGLTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSSLETKNKNpHTSPILsRGYRETAFAYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 143 SAGVVYAITRACSQGELKICSCDSQRRGRASDEDgDFDWGGCSDNINYGIKFAKAFVDARERmVKDARALMNLHNNRCGR 222
Cdd:cd19342  81 AAGVAHQVARACSLGKLLSCGCDRSRRGKRSSGN-DWKWGGCSHNLDFGEKFSRKFLDSREK-ARDIHSRMNLHNNRAGR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 223 MAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGF----MVADRDYKRTTKNDLVYI 298
Cdd:cd19342 159 LAVSENMERKCKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQSNLNNGArrrrLTRRKRRRRPPKTDLVYY 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33504539 299 ENSPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19342 239 ERSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 74-376 7.79e-131

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 377.37  E-value: 7.79e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  74 LVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTvFGRVMLRSSREAAFVYAISSAGVVYAITRA 153
Cdd:cd19343   1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSIELAPN-FTPDLTRGTREQAFVYALSSAALTHTIARA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 154 CSQGELKICSCdsqrrGRASDE--DGDFDWGGCSDNINYGIKFAKAFVDARERMVKD----ARALMNLHNNRCGRMAVKR 227
Cdd:cd19343  80 CASGALPGCGC-----GRLPREppDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKKKKkkrqARALMNLHNNRVGRKAVRD 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 228 FMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTG--FMVADRDYKRTTKNDLVYIENSPDYC 305
Cdd:cd19343 155 SLETQCKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRrkLVPKSLKVRPYTKDDLIYLTKSPDYC 234

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 33504539 306 LMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19343 235 LPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 68-376 1.25e-126

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 367.08  E-value: 1.25e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  68 CDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAISSAGVV 147
Cdd:cd19347   1 CSQLAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVD-NTSVFGRVMQIGSRETAFTYAISAAGVV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 148 YAITRACSQGELKICSCdsQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARER-------MVKDARALMNLHNNRC 220
Cdd:cd19347  80 NAVSRACREGELSTCGC--SRAARPKDLPRDWLWGGCGDNLEYGYRFAKEFVDARERekiyqkgSYESARTLMNLHNNEA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 221 GRMAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRdYKRTTKNDLVYIEN 300
Cdd:cd19347 158 GRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQVNSR-FNPPTTLDLVYIDP 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33504539 301 SPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19347 237 SPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 68-376 8.89e-123

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 357.37  E-value: 8.89e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  68 CDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAISSAGVV 147
Cdd:cd19348   1 CSQLTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVD-NTSVFGRVMQIGSRETAFTYAVSAAGVV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 148 YAITRACSQGELKICSCdsQRRGRASDEDGDFDWGGCSDNINYGIKFAKAFVDARER-------MVKDARALMNLHNNRC 220
Cdd:cd19348  80 NAISRACREGELSTCGC--SRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREReknypkgSEEHARTLMNLQNNEA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 221 GRMAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFMVADRdYKRTTKNDLVYIEN 300
Cdd:cd19348 158 GRRAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRKGKLELVNSR-FNPPTAEDLVYIDP 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33504539 301 SPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19348 237 SPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 74-375 5.32e-121

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 352.81  E-value: 5.32e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  74 LVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDH--TVFGRVMLRSSREAAFVYAISSAGVVYAIT 151
Cdd:cd19333   1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRGgpNVFGKILNRGCRETAFIYAITSAAVTHSVA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 152 RACSQGELKICSCDSQRRGRAsdeDGDFDWGGCSDNINYGIKFAKAFVDARERMvKDARALMNLHNNRCGRMAVKRFMKT 231
Cdd:cd19333  81 RACSEGSIESCSCDYRRRGPG---GPDWEWGGCSDNIDFGRKFSREFVDAGEKG-RDLRYLMNLHNNEAGRVHVSSEMRQ 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 232 ECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDG----------TGFMVADRDYKRTTKNDLVYIENS 301
Cdd:cd19333 157 ECKCHGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNGnnrgsrrakkFLLEPENPNHKPPTSKDLVYFEES 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 302 PDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd19333 237 PNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 62-376 3.03e-119

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 348.58  E-value: 3.03e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  62 LGARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAI 141
Cdd:cd19349   1 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALG-ERTVFGKELKVGSREAAFTYAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 142 SSAGVVYAITRACSQGELKICSCDSQRRGRASDEDGdFDWGGCSDNINYGIKFAKAFVDARErMVKDARALMNLHNNRCG 221
Cdd:cd19349  80 IAAGVAHAITAACTQGNLSDCGCDKEKQGQYNQEEG-WKWGGCSADIRYGIGFSKVFVDARE-IKQNARTLMNLHNNEAG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 222 RMAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEV-----MMNQDGTGFMVADR-DYKRTTKNDL 295
Cdd:cd19349 158 RKILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVepvraSRNKRPTFLKIKKPlSYRKPMDTDL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 296 VYIENSPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd19349 238 VYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTC 317


                .
gi 33504539 376 K 376
Cdd:cd19349 318 K 318
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 62-376 2.70e-113

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 333.51  E-value: 2.70e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  62 LGARVICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLErDHTVFGRVMLRSSREAAFVYAI 141
Cdd:cd19350   1 LGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALG-ERTVFGQELRVGSREAAFTYAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 142 SSAGVVYAITRACSQGELKICSCDSQRRGRASDEDGdFDWGGCSDNINYGIKFAKAFVDARErMVKDARALMNLHNNRCG 221
Cdd:cd19350  80 TAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQEEG-WKWGGCSADIKYGIDFSRKFVDARE-IKKNARRLMNLHNNEAG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 222 RMAVKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEV------MMNQDGTGFMVADRDYKRTTKNDL 295
Cdd:cd19350 158 RKVLEERMKLECKCHGVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVevvrasRLRQPTFLKIKKRRSYQKPMETDL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 296 VYIENSPDYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd19350 238 VYIERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTC 317


                .
gi 33504539 376 K 376
Cdd:cd19350 318 K 318
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 80-375 2.30e-101

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 302.29  E-value: 2.30e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  80 QLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCStleRDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRACSQGEL 159
Cdd:cd19340   1 SGPKAYLSLSDSVAAGAQLAMEECQYQFKWDRWNCP---ESAFFSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHF 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 160 KICSCDSQRRGRASDEDgdFDWGGCSDNINYGIKFAKAFVDARERMvKDARALMNLHNNRCGRMAVKRFMKTECKCHGVS 239
Cdd:cd19340  78 EGCGCDDSKKGSKGGEG--WTWGGCSDNVKFGERVSKKFLDSLETG-QDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 240 GSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDG--TGFMVADRDYKRTTKNDLVYIENSPDYCLMDRSAGSLGTS 317
Cdd:cd19340 155 GSCSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGlrETNGSRAIKLLNIKKNDLVYLEKSPNYCRANVTLGWPGTL 234

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33504539 318 GRVCNKSS-RGMDGCEIMCCGR-----GYDTTRVNRM--TKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd19340 235 GRQCSRDKkESVSRWERKSCRRlcracGLKVRKKVVEvtSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 67-376 1.87e-99

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 297.66  E-value: 1.87e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  67 ICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTV--FGRVMLRSSREAAFVYAISSA 144
Cdd:cd19355   3 VCLTLPGLTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSSLETRNKIpyESVVFSRGFRESAFAYAIAAA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 145 GVVYAITRACSQGELKICSCDsqrrgrasdedgdFDWGGCSDNINYGIKFAKAFVDARErMVKDARALMNLHNNRCGRMA 224
Cdd:cd19355  83 GVVHAVSNACAMGKLKACGCD-------------WEWGGCSPDVEYGERFSKDFLDSRE-TYRDIHARMRLHNNRVGRQV 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 225 VKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGFM--VADRDYKRTTKNDLVYIENSP 302
Cdd:cd19355 149 VMDNMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLIKPHNRNTGQLepGHAPHRRRASINDLVYFEKSP 228

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33504539 303 DYCLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19355 229 DFCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 77-376 1.03e-94

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 285.34  E-value: 1.03e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  77 KQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRVMlrssREAAFVYAISSAGVVYAITRACSQ 156
Cdd:cd19341   4 RQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGKYRINLLKKGY----KETAFLYAISSAGLTHSVARACSS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 157 GELKICSCDSQRRGRASDEDgdFDWGGCSDNINYGIKFAKAFVDARERMVKDARALMNLHNNRCGRMAVKRFMKTECKCH 236
Cdd:cd19341  80 GRLDRCTCDESFSLEENRQT--WLWGGCGDNIKYGKKFTRRFLQLKKKSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCH 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 237 GVSGSCALRTCWLAMPDFRRTGDYLRKKYNAA--VEVMMNQDGTGFMV------ADRDYKRTTKNDLVYIENSPDYClmD 308
Cdd:cd19341 158 GVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAvkVVSENNAATGGSQLrkgksgSVKKKSRPRRKDLVYLEKSPSFC--R 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33504539 309 RSAGSLGTSGRVCNKSsrgmDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19341 236 STRYSPGTKGRRCLKG----DNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 67-376 1.04e-84

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 259.82  E-value: 1.04e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  67 ICDNIPGLVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVF--GRVMLRSSREAAFVYAISSA 144
Cdd:cd19356   3 VCLTLPGLSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSSLEGGGKLPhdSAILKRGFRESAFSFSLLAA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 145 GVVYAITRACSQGELKICSCDsqrrgrasdedgdFDWGGCSDNINYGIKFAKAFVDARERmVKDARALMNLHNNRCGRMA 224
Cdd:cd19356  83 GVMHSVATACSLGKLRGCGCE-------------WEWGGCSHDIEFGEKFSRDFLDSRES-PRDIQARMRIHNNRVGRQV 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 225 VKRFMKTECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVMMNQDGTGfMVADRDYKRTTKNDLVYIENSPDY 304
Cdd:cd19356 149 VTENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNKNSG-VFLPRLRPRRLARELVYFEKSPDF 227

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33504539 305 CLMDRSAGSLGTSGRVCNKSSRGMDGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19356 228 CERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 74-376 3.14e-82

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 253.28  E-value: 3.14e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  74 LVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCSTLERdhtvfGRVMLRSSREAAFVYAISSAGVVYAITRA 153
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGR-----GSLLKRGFKETAFLYAVSSAALTHSLAKA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 154 CSQGELKICSCDsQRRGRASDEDgdFDWGGCSDNINYGIKFAKAFVDAReRMVKDARALMNLHNNRCGRMAVKRFMKTEC 233
Cdd:cd19354  76 CSSGRMERCTCD-DSPGLENREA--WQWGVCGDNLKYSTKFLKNFLGQK-KGSKDLRARVDAHNTNVGIKAVKSGLKTTC 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 234 KCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEVM-MNQDGTG--FMVADRDYKRTTKN------DLVYIENSPDY 304
Cdd:cd19354 152 KCHGVSGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHsVTNDATGetELWSPERHGHTLKGhsprstDLVYLEDSPSF 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33504539 305 CLMDRSagSLGTSGRVCNKSSrgmdGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19354 232 CRPSKY--SPGTAGRTCSRET----NCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 91-375 4.96e-79

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 245.32  E-value: 4.96e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  91 SIGQGAKEWIRECQHQFRHHRWNCStlERDHTVFGRVMLRSS-REAAFVYAISSAGVVYAITRACSQGELKICSCDSQRR 169
Cdd:cd19352  13 SVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHSGLRSAnRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 170 GRASDEDgdFDWGGCSDNINYGIKFAKAFVDARERMvKDARALMNLHNNRCGRMAVKRFMKTECKCHGVSGSCALRTCWL 249
Cdd:cd19352  91 GQLGGQG--WLWGGCSDNVGFGEAISKQFVDALETG-QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 250 AMPDFRRTGDYLRKKYNAAVEVMMNQdGTGFMVADR-----DYKRTTKNDLVYIENSPDYCLMDRSAGSLGTSGRVCNKS 324
Cdd:cd19352 168 QLPEFREVGNYLKEKYHRALKVDLLQ-GAGNSAASRgaiaeTFRSISKKELVHLEDSPDYCLENKTLGLLGTEGRECLKR 246

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 33504539 325 SRGMD-----GCEIMC--CGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd19352 247 GKALSkwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 91-375 5.49e-78

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 242.89  E-value: 5.49e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  91 SIGQGAKEWIRECQHQFRHHRWNCSTLERDHTVFGRvmLRS-SREAAFVYAISSAGVVYAITRACSQGELKICSCDSQRR 169
Cdd:cd19351  12 SVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNG--LRSaTRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRN 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 170 GRASDEDgdFDWGGCSDNINYGIKFAKAFVDARERMvKDARALMNLHNNRCGRMAVKRFMKTECKCHGVSGSCALRTCWL 249
Cdd:cd19351  90 GRTGGRG--WIWGGCSDNVEFGERISKQFVDALETG-QDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 250 AMPDFRRTGDYLRKKYNAAVEVMMNQ---------DGTGFMVadRDYKRTTKNDLVYIENSPDYCLMDRSAGSLGTSGRV 320
Cdd:cd19351 167 QLADFREIGNYLKVKHDQALKLEMDKrrmragnsaDNRGAIA--EAFGSVAETELIYLEDSPDYCTKNASLGLQGTEGRE 244

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33504539 321 CNKSSRGMD-----GCEIMC--CGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTC 375
Cdd:cd19351 245 CLQSGKNLSqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 74-376 1.85e-73

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 231.08  E-value: 1.85e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539  74 LVNKQRQLCQRHPDLMQSIGQGAKEWIRECQHQFRHHRWNCsTLERDHTvfGRVMLRSSREAAFVYAISSAGVVYAITRA 153
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNC-TLEGRYR--ASLLKRGFKETAFLYAISSAGLTHAMAKA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 154 CSQGELKICSCDsqrrgRASDEDGD--FDWGGCSDNINYGIKFAKAFVDARERmvKDARALMNLHNNRCGRMAVKRFMKT 231
Cdd:cd19353  78 CSAGRMERCTCD-----EAPDLENReaWQWGGCGDNLKYSNKFVKEFLGRKSS--KDLRARVDFHNNLVGIKVIKAGVET 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33504539 232 ECKCHGVSGSCALRTCWLAMPDFRRTGDYLRKKYNAAVEV-MMNQDGTGFMVADRDYK----------RTTknDLVYIEN 300
Cdd:cd19353 151 TCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVgSTTNEATGEGDISPPKKsgaghsdqipRTT--DLVYIDD 228

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33504539 301 SPDYCLMDRSagSLGTSGRVCNKSSrgmdGCEIMCCGRGYDTTRVNRMTKCECKFKWCCAVECRDCEETVDVHTCK 376
Cdd:cd19353 229 SPSFCLMSRF--SPGTSGRRCYKDK----NCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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