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progressive ankylosis protein homolog B [Danio rerio]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||||
ANKH super family | cl09432 | Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis ... |
1-345 | 0e+00 | ||||||
Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters. The actual alignment was detected with superfamily member pfam07260: Pssm-ID: 429370 Cd Length: 344 Bit Score: 689.80 E-value: 0e+00
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MATE_like super family | cl09326 | Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
327-438 | 2.65e-03 | ||||||
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. The actual alignment was detected with superfamily member cd13123: Pssm-ID: 447704 [Multi-domain] Cd Length: 420 Bit Score: 40.13 E-value: 2.65e-03
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Name | Accession | Description | Interval | E-value | ||||||
ANKH | pfam07260 | Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis ... |
1-345 | 0e+00 | ||||||
Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters. Pssm-ID: 429370 Cd Length: 344 Bit Score: 689.80 E-value: 0e+00
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MATE_MurJ_like | cd13123 | MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
327-438 | 2.65e-03 | ||||||
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR). Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 40.13 E-value: 2.65e-03
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Name | Accession | Description | Interval | E-value | ||||||
ANKH | pfam07260 | Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis ... |
1-345 | 0e+00 | ||||||
Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters. Pssm-ID: 429370 Cd Length: 344 Bit Score: 689.80 E-value: 0e+00
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MATE_MurJ_like | cd13123 | MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
327-438 | 2.65e-03 | ||||||
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR). Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 40.13 E-value: 2.65e-03
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