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Conserved domains on  [gi|38027914|ref|NP_937832|]
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COP9 signalosome complex subunit 8 isoform 2 [Homo sapiens]

Protein Classification

CSN8/PSMD8/EIF3K family protein( domain architecture ID 10562241)

CSN8/PSMD8/EIF3K family protein is a component of a multi-protein complex, such as human COP9 signalosome complex subunit 8 (CSN8), 26S proteasome non-ATPase regulatory subunit 8 (PSD8) and eukaryotic translation initiation factor 3 subunit K (EIF3K)

Gene Ontology:  GO:0032991

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSN8_PSD8_EIF3K pfam10075
CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature ...
 1-117 6.51e-40

CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.


:

Pssm-ID: 462954  Cd Length: 137  Bit Score: 131.22  E-value: 6.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38027914     1 MNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSII 80
Cdd:pfam10075  20 LADFRLLLKRIPPDIKQSNPEIQQLLTLEQLLWQGDYAKFYQTLKSNDWSEDYTPFVSGLEDTIRDEIAALVGKAYESIS 99

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 38027914    81 ADDFAAFVGLP-VEEAVKGILEQGWQADSTTRMVLPRK 117
Cdd:pfam10075 100 ADDLAELLGLDtPEELKKFAKARGWTLDADGVILPFNP 137
 
Name Accession Description Interval E-value
CSN8_PSD8_EIF3K pfam10075
CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature ...
 1-117 6.51e-40

CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.


Pssm-ID: 462954  Cd Length: 137  Bit Score: 131.22  E-value: 6.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38027914     1 MNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSII 80
Cdd:pfam10075  20 LADFRLLLKRIPPDIKQSNPEIQQLLTLEQLLWQGDYAKFYQTLKSNDWSEDYTPFVSGLEDTIRDEIAALVGKAYESIS 99

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 38027914    81 ADDFAAFVGLP-VEEAVKGILEQGWQADSTTRMVLPRK 117
Cdd:pfam10075 100 ADDLAELLGLDtPEELKKFAKARGWTLDADGVILPFNP 137
 
Name Accession Description Interval E-value
CSN8_PSD8_EIF3K pfam10075
CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature ...
 1-117 6.51e-40

CSN8/PSMD8/EIF3K family; This domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome) where it functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development. It is found in Eukaryotic translation initiation factor 3 subunit K, a component of the eukaryotic translation initiation factor 3 (eIF-3) complex required for the initiation of protein synthesis. It is also found in 26S proteasome non-ATPase regulatory subunit 8 (PSMD8), a regulatory subunit of the 26S proteasome.


Pssm-ID: 462954  Cd Length: 137  Bit Score: 131.22  E-value: 6.51e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38027914     1 MNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSII 80
Cdd:pfam10075  20 LADFRLLLKRIPPDIKQSNPEIQQLLTLEQLLWQGDYAKFYQTLKSNDWSEDYTPFVSGLEDTIRDEIAALVGKAYESIS 99

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 38027914    81 ADDFAAFVGLP-VEEAVKGILEQGWQADSTTRMVLPRK 117
Cdd:pfam10075 100 ADDLAELLGLDtPEELKKFAKARGWTLDADGVILPFNP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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