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Conserved domains on  [gi|1677530034|ref|NP_937884|]
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eukaryotic translation initiation factor 4 gamma 1 isoform 5 [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 4 gamma 1( domain architecture ID 20299391)

eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0003723|GO:0031369|GO:0003729|GO:0006446|GO:0008135|GO:0008190|GO:0005524
PubMed:  10872469|12867079|9019810|27694156
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 761-986 5.14e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.14e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  761 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 840
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  841 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 920
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1677530034  921 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 986
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1438-1570 7.36e-58

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 195.97  E-value: 7.36e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1438 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1516
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1677530034 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1570
Cdd:cd11559     81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1242-1354 4.51e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1677530034 1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 20-452 1.19e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   20 QPAFPPGQTAPVV----FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVY--PAGSQVMMiPSQ 93
Cdd:PHA03247  2588 RPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSR-PRR 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   94 ISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIap 173
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-- 2744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  174 krerktirirdPNQGGKDITEeimsgARTASTPTPPQTGGGLEPQANGETPQVAViVRPDDRSQGAIIADRPGLPGPEHS 253
Cdd:PHA03247  2745 -----------PAGPATPGGP-----ARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADP 2807

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  254 PSESQPSSPSPTPSPSPVlePGSEPNLAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILE 326
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPP 2882

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  327 VEvTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNG 406
Cdd:PHA03247  2883 VR-RLARPAVSRSTESFALPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1677530034  407 APSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
405-573 1.26e-05

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  405 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 484
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  485 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 560
Cdd:PRK12323   449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                          170
                   ....*....|...
gi 1677530034  561 SGVPPRPEEADET 573
Cdd:PRK12323   523 AESIPDPATADPD 535
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 761-986 5.14e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.14e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  761 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 840
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  841 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 920
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1677530034  921 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 986
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1438-1570 7.36e-58

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 195.97  E-value: 7.36e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1438 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1516
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1677530034 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1570
Cdd:cd11559     81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 762-989 1.78e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.78e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   762 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 841
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   842 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 921
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1677530034   922 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 989
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1242-1354 4.51e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1677530034 1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1242-1354 4.55e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 132.75  E-value: 4.55e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1677530034  1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1509-1592 1.27e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.27e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  1509 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1588
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 1677530034  1589 LREA 1592
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1521-1597 1.05e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 96.06  E-value: 1.05e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677530034 1521 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1597
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 20-452 1.19e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   20 QPAFPPGQTAPVV----FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVY--PAGSQVMMiPSQ 93
Cdd:PHA03247  2588 RPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSR-PRR 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   94 ISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIap 173
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-- 2744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  174 krerktirirdPNQGGKDITEeimsgARTASTPTPPQTGGGLEPQANGETPQVAViVRPDDRSQGAIIADRPGLPGPEHS 253
Cdd:PHA03247  2745 -----------PAGPATPGGP-----ARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADP 2807

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  254 PSESQPSSPSPTPSPSPVlePGSEPNLAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILE 326
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPP 2882

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  327 VEvTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNG 406
Cdd:PHA03247  2883 VR-RLARPAVSRSTESFALPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1677530034  407 APSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
405-573 1.26e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  405 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 484
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  485 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 560
Cdd:PRK12323   449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                          170
                   ....*....|...
gi 1677530034  561 SGVPPRPEEADET 573
Cdd:PRK12323   523 AESIPDPATADPD 535
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 328-513 1.64e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  328 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
Cdd:pfam05109  418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  403 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 465
Cdd:pfam05109  497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1677530034  466 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 513
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
368-450 1.92e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 46.15  E-value: 1.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  368 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 447
Cdd:COG5373     31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106


                   ...
gi 1677530034  448 ATS 450
Cdd:COG5373    107 FEE 109
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 761-986 5.14e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.46  E-value: 5.14e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  761 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 840
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  841 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 920
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1677530034  921 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 986
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1438-1570 7.36e-58

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 195.97  E-value: 7.36e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1438 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1516
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1677530034 1517 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1570
Cdd:cd11559     81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 762-989 1.78e-53

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 186.03  E-value: 1.78e-53
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   762 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 841
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   842 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 921
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1677530034   922 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 989
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1242-1354 4.51e-37

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 135.48  E-value: 4.51e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1677530034 1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1242-1354 4.55e-36

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 132.75  E-value: 4.55e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  1242 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1321
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1677530034  1322 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1354
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1509-1592 1.27e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.27e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  1509 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1588
Cdd:smart00515    2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79


                    ....
gi 1677530034  1589 LREA 1592
Cdd:smart00515   80 LQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1521-1597 1.05e-23

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 96.06  E-value: 1.05e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1677530034 1521 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1597
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1439-1564 2.25e-23

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 97.16  E-value: 2.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1439 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1513
Cdd:cd11473      2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1677530034 1514 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1564
Cdd:cd11473     82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1508-1597 3.13e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 74.99  E-value: 3.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1508 AKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFK 1587
Cdd:cd11558     80 GPLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIE 159

                           90
                   ....*....|
gi 1677530034 1588 WLREAEEESD 1597
Cdd:cd11558    160 WLEEAEEESD 169
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1439-1597 2.50e-09

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 57.63  E-value: 2.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1439 PSEELNR--QLEKLLKEGSSNQRVFDwIEANLSEQQIVSNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYL 1515
Cdd:cd11561      1 EEEEDERvdELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLV 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1516 CDEQKELQALYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWL 1589
Cdd:cd11561     73 TDEKAQKALLGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWL 149


                   ....*...
gi 1677530034 1590 REAEEESD 1597
Cdd:cd11561    150 EEAEEEEE 157
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1435-1595 3.72e-08

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 55.30  E-value: 3.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1435 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1503
Cdd:cd11560     29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034 1504 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1580
Cdd:cd11560    105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179

                          170
                   ....*....|....*
gi 1677530034 1581 SVTAFFKWLREAEEE 1595
Cdd:cd11560    180 QMEPFVEWLQEAEEE 194
PHA03247 PHA03247
large tegument protein UL36; Provisional
 20-452 1.19e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   20 QPAFPPGQTAPVV----FSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVY--PAGSQVMMiPSQ 93
Cdd:PHA03247  2588 RPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRddPAPGRVSR-PRR 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   94 ISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIap 173
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-- 2744

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  174 krerktirirdPNQGGKDITEeimsgARTASTPTPPQTGGGLEPQANGETPQVAViVRPDDRSQGAIIADRPGLPGPEHS 253
Cdd:PHA03247  2745 -----------PAGPATPGGP-----ARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADP 2807

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  254 PSESQPSSPSPTPSPSPVlePGSEPNLAVL-------SIPGDTMTTIQMSVEESTPISREtgePYRLSPEPTPLAEPILE 326
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPA--GPLPPPTSAQptappppPGPPPPSLPLGGSVAPGGDVRRR---PPSRSPAAKPAAPARPP 2882

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  327 VEvTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPngmvPSEDLEPEVESSPELAPPPacPSESPVPIAPTAQPEELLNG 406
Cdd:PHA03247  2883 VR-RLARPAVSRSTESFALPPDQPERPPQPQAPPP----PQPQPQPPPPPQPQPPPPP--PPRPQPPLAPTTDPAGAGEP 2955

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1677530034  407 APSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPA 452
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
PHA03247 PHA03247
large tegument protein UL36; Provisional
 21-576 2.94e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 2.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   21 PAFPPGQTAPVVFSTPQATQMNTPS----QPRQHFYPSR------------------AQPPSSAASRVQSAAPARPGPAA 78
Cdd:PHA03247  2494 AAPDPGGGGPPDPDAPPAPSRLAPAilpdEPVGEPVHPRmltwirgleelasddagdPPPPLPPAAPPAAPDRSVPPPRP 2573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034   79 HVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGA-SPTEFGTYAGAYYPAQgvqqfptg 157
Cdd:PHA03247  2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpSPSPAANEPDPHPPPT-------- 2645

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  158 vAPTPVLMNQPPqiAPKRERKTIRIRDPnqggkditeeimsgARTASTPTPPQtgGGLEPQANGETPQVAVIVRPDDRSQ 237
Cdd:PHA03247  2646 -VPPPERPRDDP--APGRVSRPRRARRL--------------GRAAQASSPPQ--RPRRRAARPTVGSLTSLADPPPPPP 2706

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  238 GAIIADRPGLPGPEHSPSESQPSspsptpspspvlepGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEP 317
Cdd:PHA03247  2707 TPEPAPHALVSATPLPPGPAAAR--------------QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG---PPAP 2769

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  318 TPLAEPILEVEVTLSKPVPESEFSSSP-LQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAP 396
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESREsLPSPWDPADPPAAVLAPAAALP-----PAASPAGPLPPPTSAQPTAPPPPPG 2844

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  397 TAQPEELLNGAPSPPAvDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAES 476
Cdd:PHA03247  2845 PPPPSLPLGGSVAPGG-DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP 2923

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  477 EKGGEELLPPESTPIP-ANLSQNLEAAAATQVAVSVPKRRrkikelnkkeavgdlLDAFKEANPAVPEVENQPPAGSNPG 555
Cdd:PHA03247  2924 PPPPQPQPPPPPPPRPqPPLAPTTDPAGAGEPSGAVPQPW---------------LGALVPGRVAVPRFRVPQPAPSREA 2988

                          570       580
                   ....*....|....*....|.
gi 1677530034  556 PESEGSGVPPRPEEADETWDS 576
Cdd:PHA03247  2989 PASSTPPLTGHSLSRVSSWAS 3009
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-572 6.21e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 6.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  116 PTQQYPVQPGAPgFYPGASPTEFGTyagayyPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDpnqggkdiTEE 195
Cdd:PHA03247  2478 PVYRRPAEARFP-FAAGAAPDPGGG------GPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRG--------LEE 2542

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  196 IMSGarTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIiADRPGLPgPEHSPSESQPSSPSPTPSPspvLEPG 275
Cdd:PHA03247  2543 LASD--DAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSR-ARRPDAP-PQSARPRAPVDDRGDPRGP---APPS 2615

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  276 SEPnlavlsiPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEvEVTLSKPV---PESEFSSSPLQAPTPLA 352
Cdd:PHA03247  2616 PLP-------PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPG-RVSRPRRArrlGRAAQASSPPQRPRRRA 2687

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  353 shtveIHEPNGMVPSEDLEPEVESSPELAPPPACPSeSPVPIAPTAQ-----PEELLNGAPSPPAVDLSPVSEPEEQAKE 427
Cdd:PHA03247  2688 -----ARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAArqaspALPAAPAPPAVPAGPATPGGPARPARPP 2761

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  428 VTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPI-----PANLSQNLEAA 502
Cdd:PHA03247  2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplppPTSAQPTAPPP 2841

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  503 AATQVAVSVP-----------KRRRKIKELNKKEAVGDLLDAFKEANPAV---PEVENQPPAGSNPGPESEgSGVPPRPE 568
Cdd:PHA03247  2842 PPGPPPPSLPlggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLARPAVsrsTESFALPPDQPERPPQPQ-APPPPQPQ 2920


                   ....
gi 1677530034  569 EADE 572
Cdd:PHA03247  2921 PQPP 2924
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
405-573 1.26e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 49.87  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  405 NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELL 484
Cdd:PRK12323   369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  485 PPESTPIPANLSQNLEAAAATQ----VAVSVPKRRRKIKElnkKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEG 560
Cdd:PRK12323   449 APAPAPAAAPAAAARPAAAGPRpvaaAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASP---APAQPDAAPAGWV 522

                          170
                   ....*....|...
gi 1677530034  561 SGVPPRPEEADET 573
Cdd:PRK12323   523 AESIPDPATADPD 535
rne PRK10811
ribonuclease E; Reviewed
 300-453 2.55e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 49.27  E-value: 2.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  300 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEFSSSPLQAPT-PLASHTVEIHEPNGMVPSEDLEPEVESS 377
Cdd:PRK10811   844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVVSAPVVEAVAEvVEEPVVVAEPQPEEVVVVETTHPEVIAA 922

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  378 PELAPPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATS 450
Cdd:PRK10811   923 PVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVA 1002


                   ...
gi 1677530034  451 PAQ 453
Cdd:PRK10811  1003 PAQ 1005
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
318-564 9.36e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 9.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  318 TPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPT 397
Cdd:PRK07003   416 AAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPR 495

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  398 AQPEELLNGAPSPPAVDLSPVSEPEEqakevTASMAPPTiPSATPAtAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESE 477
Cdd:PRK07003   496 AAAPSAATPAAVPDARAPAAASREDA-----PAAAAPPA-PEARPP-TPAAAAPAARAGGAAAALDVLRNAGMRVSSDRG 568

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  478 KGgeellpPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPE 557
Cdd:PRK07003   569 AR------AAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSA 642


                   ....*..
gi 1677530034  558 SEGSGVP 564
Cdd:PRK07003   643 DEGFGGP 649
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 328-513 1.64e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 1.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  328 EVTLSKpVPESEFSSSPLQ-----APTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
Cdd:pfam05109  418 KVIFSK-APESTTTSPTLNttgfaAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRD 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  403 llNG----------------APSPPAVDLSP-VSEPEEQAKEVTASMAPPTIPSATPatAPSATSPAQEEEMEEEEEEEE 465
Cdd:pfam05109  497 --NGteskapdmtsptsavtTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTP--TPNATSPTPAVTTPTPNATIP 572

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1677530034  466 GEAGEAGEAESEKGGEELLPP---ESTPIPANLSQNLEAAAATQVAVSVPK 513
Cdd:pfam05109  573 TLGKTSPTSAVTTPTPNATSPtvgETSPQANTTNHTLGGTSSTPVVTSPPK 623
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 184-445 1.72e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  184 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 245
Cdd:PRK10263   308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  246 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlsPEPTPLAE 322
Cdd:PRK10263   384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  323 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELAP---PPACPSESPVP 393
Cdd:PRK10263   460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAAwyqPIPEPVKEPEP 539

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1677530034  394 IAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATA 445
Cdd:PRK10263   540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANS 591
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
368-450 1.92e-04

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 46.15  E-value: 1.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  368 EDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEllngAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPS 447
Cdd:COG5373     31 EELEAELAEAAEAASAPAEPEPEAAAAATAAAPEA----APAPVPEAPAAPPAAAEAPAPAAAAPPAEAEPAAAPAAASS 106


                   ...
gi 1677530034  448 ATS 450
Cdd:COG5373    107 FEE 109
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 140-453 2.35e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.72  E-value: 2.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  140 TYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 217
Cdd:pfam17823  116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  218 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMTTIQMSV 297
Cdd:pfam17823  195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  298 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPL-----QAPTPLASHTVEihepngmvpsedlEP 372
Cdd:pfam17823  271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAapmgaQAQGPIIQVSTD-------------QP 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  373 EVESSPELAPPPACPSESPvpiaptaqpeellNGAPSPPAVDLSPVSEPEEQAKEVTASMAP-------PTIPSATPATA 445
Cdd:pfam17823  316 VHNTAGEPTPSPSNTTLEP-------------NTPKSVASTNLAVVTTTKAQAKEPSASPVPvlhtsmiPEVEATSPTTQ 382


                   ....*...
gi 1677530034  446 PSATSPAQ 453
Cdd:pfam17823  383 PSPLLPTQ 390
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
276-452 3.92e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 3.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  276 SEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPyrlSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHT 355
Cdd:PRK12323   341 SELALAPDEYAGFTMTLLRMLAFRPGQSGGGAGPA---TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAAR 417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  356 VEIHEPNGMVPSEDLEPEVESSPELAP-----PPACPSESPVPIAPTAQPeellnGAPSPPAVDLSPVSEPEEQAKEVTA 430
Cdd:PRK12323   418 AVAAAPARRSPAPEALAAARQASARGPggapaPAPAPAAAPAAAARPAAA-----GPRPVAAAAAAAPARAAPAAAPAPA 492

                          170       180
                   ....*....|....*....|....*
gi 1677530034  431 SMAPP---TIPSATPATAPSATSPA 452
Cdd:PRK12323   493 DDDPPpweELPPEFASPAPAQPDAA 517
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 344-452 4.62e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.92  E-value: 4.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  344 PLQAPTPLASHTVEIHEPngmVPSEDLEPEVESSPELAPPPAC------------------PSESPVPIAPTAQPEEL-- 403
Cdd:PLN03209   324 PSQRVPPKESDAADGPKP---VPTKPVTPEAPSPPIEEEPPQPkavvprplspytayedlkPPTSPIPTPPSSSPASSks 400

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1677530034  404 LNGAPSPPAVDLSPVSE-----PEEQAKEVTASMA-------------PPTIPSATPATA--PSATSPA 452
Cdd:PLN03209   401 VDAVAKPAEPDVVPSPGsasnvPEVEPAQVEAKKTrplspyaryedlkPPTSPSPTAPTGvsPSVSSTS 469
PHA03377 PHA03377
EBNA-3C; Provisional
 303-613 5.25e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 45.04  E-value: 5.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  303 ISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIhEPNGMVPSEdlepevESSPELAP 382
Cdd:PHA03377   408 VSRVPWRKPRTLPWPTPKTHPVKRTLVKTSGRSDEAEQAQSTPERPGPSDQPSVPV-EPAHLTPVE------HTTVILHQ 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  383 PPacPSESPVPIAPTAQPEELLNGA-----------------------PSPPAVDLSPVSEPEEQAKEVTASMAPPTIPS 439
Cdd:PHA03377   481 PP--QSPPTVAIKPAPPPSRRRRGAcvvydddiievidvetteeeesvTQPAKPHRKVQDGFQRSGRRQKRATPPKVSPS 558

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  440 atpATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIK 519
Cdd:PHA03377   559 ---DRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPSVVRMFLR 635

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  520 ELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSgvPPRPEEADETWDSkedKIHNAENIQPGEQKYEYKSD 599
Cdd:PHA03377   636 ERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQST--PPRPSWLPSVFVL---PSVDAGRAQPSEESHLSSMS 710

                          330
                   ....*....|....
gi 1677530034  600 QWKPLNLEEKKRYD 613
Cdd:PHA03377   711 PTQPISHEEQPRYE 724
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 308-451 9.81e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 9.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  308 GEPYRLSPEPTPLAEPilevEVTLSKPVPESEFSSSPLQAPTPLAShtveihepngMVPSEDLEPEVESSPELAPPPACP 387
Cdd:PRK14951   369 AAEAAAPAEKKTPARP----EAAAPAAAPVAQAAAAPAPAAAPAAA----------ASAPAAPPAAAPPAPVAAPAAAAP 434

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1677530034  388 SESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEeqakevTASMAPPTIPSATPATAPSATSP 451
Cdd:PRK14951   435 AAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE------PAVASAAPAPAAAPAAARLTPTE 492
rne PRK10811
ribonuclease E; Reviewed
 344-512 2.71e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.72  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  344 PLQAPTPL---------ASHTVEIHEP-----------NGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEEL 403
Cdd:PRK10811   820 PTQSPMPLtvacaspemASGKVWIRYPvvrpqdvqveeQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPV 899

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  404 LNGAPSPPAVDlsPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEEL 483
Cdd:PRK10811   900 VVAEPQPEEVV--VVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVA 977

                          170       180
                   ....*....|....*....|....*....
gi 1677530034  484 LPPESTPIPANLSQNLEAAAATQVAVSVP 512
Cdd:PRK10811   978 QPAAPVVAEVAAEVETVTAVEPEVAPAQV 1006
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 332-453 3.90e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 3.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  332 SKPVPESEfSSSPLQAPTPLASHTVEIHEPNGMVPsedlePEVESSPELAPPPACPSESPVPIAPTAQPEELlnGAPSPP 411
Cdd:PRK14951   372 AAAPAEKK-TPARPEAAAPAAAPVAQAAAAPAPAA-----APAAAASAPAAPPAAAPPAPVAAPAAAAPAAA--PAAAPA 443

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1677530034  412 AVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQ 453
Cdd:PRK14951   444 AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 359-452 5.28e-03

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 38.95  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  359 HEPNGMVPSEDLEPEVESSP-ELAPPPACPSESPVPiAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTI 437
Cdd:pfam05104   44 EKPNGKLPESEQADESEEEPrEFKTPDEAPSAALEP-EPVPTPVPAPVEPEPAPPSESPAPSPKEKKKKEKKSAKVEPAE 122

                           90
                   ....*....|....*
gi 1677530034  438 PSATPATAPSATSPA 452
Cdd:pfam05104  123 TPEAVQPKPALEKEE 137
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
274-450 6.46e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 6.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  274 PGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPileVEVTLSKPVPESEFSSSPLQAPTPLAS 353
Cdd:PRK12323   387 PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA---RQASARGPGGAPAPAPAPAAAPAAAAR 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  354 HTVeihepngmvpsedlepevessPELAPPPACPSESPVPIAPTAQP----------EELLNGAPSPPAVDLSPVSEPEE 423
Cdd:PRK12323   464 PAA---------------------AGPRPVAAAAAAAPARAAPAAAPapadddpppwEELPPEFASPAPAQPDAAPAGWV 522

                          170       180
                   ....*....|....*....|....*..
gi 1677530034  424 QAKEVTASMAPPTIPSATPATAPSATS 450
Cdd:PRK12323   523 AESIPDPATADPDDAFETLAPAPAAAP 549
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
323-436 8.92e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 40.72  E-value: 8.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1677530034  323 PILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEE 402
Cdd:PRK14948   348 PRLWLEVTLLGLLPSAFISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPT 427

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1677530034  403 llngaPSPPAVDLSPVSEPEEQAKEVTASMAPPT 436
Cdd:PRK14948   428 -----PPANAANAPPSLNLEELWQQILAKLELPS 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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