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Conserved domains on  [gi|222831660|ref|NP_940877|]
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protein FAM171A2 precursor [Homo sapiens]

Protein Classification

FAM171 family protein( domain architecture ID 10566023)

FAM171 family protein such as Homo sapiens membrane protein astroprincin (FAM171A1), which plays a role in actin stress fiber formation

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
UPF0560 pfam10577
Uncharacterized protein family UPF0560; This family of proteins has no known function.
41-824 0e+00

Uncharacterized protein family UPF0560; This family of proteins has no known function.


:

Pssm-ID: 463154  Cd Length: 811  Bit Score: 1004.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660   41 ILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASV 120
Cdd:pfam10577   1 VTLKVQVSDNSTLQPLAGATVEVFGNQTSLASGTTGADGVATLRFPYRLGTWVIVTATKRGYVTNSVPWHPSRLPVYASV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  121 SLYLLPERPATLILYEDLVHILLGSPGARSQPLVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSG 200
Cdd:pfam10577  81 SLYLLPERPATLMLYEDVVQILSGSPGARSQPWVQFQRRALRLPPNSTYTNLTAFLTVASSQYEIGGFPYLQGLESNSTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  201 NGSWLELMPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSETrALTVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWT 280
Cdd:pfam10577 161 NESWFELTPVAAVSVHLLTSDGTEVQVSGPIHVSVPLPSDS-GLKENTSVPAWRFDPKLGLWVRSGTGYIQREGSQLTWT 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  281 FVSPQLGYWVAAMASPTAGLVTitsgIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPS 360
Cdd:pfam10577 240 YIAPQLGYWVAAMSPSSSGPVV----ARDITTYHTIFLLAILGGMALLVLILLCLLLYYCRRRCLKPRQQHRKLQLSSAL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  361 DGNKRDQATSMSQLHLICGGPLEPA-PSGDPEAPPPgPLHSAFSSSRDLASSRDDFFRTKPRSASRPAAEPS------GA 433
Cdd:pfam10577 316 DSSKKDQATSMSHLNLISGVHLESAsSSGEPDMHTP-MLKPSFSESRDFQSSRELFFKHKPADKSRHSLGNLtprskdYR 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  434 RGGESAGLKGARSAEGPGGLEPGL-EEHRRGPS--------------------GAAAFLHEPPSPPPPfdHYLGHKGAAE 492
Cdd:pfam10577 395 KSVESFPLKSARSAETSEGYEPLLhDDYRRSYTsvssssedkdslyhrrhltnDSKGYIQDPSPSPPP--PFPEREQGID 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  493 GKTPDFLLSQSVDQLARPPSLGQAGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRL-----GGEAGAAGVGDEPAPPEG 567
Cdd:pfam10577 473 RKPPDYLLSRSVDHLERPTSLSRPGQLIFCGSVDQMKDNMYRKVRPTLVIPAHYMRLpgehpLSGQALLLQTDQQSDLEG 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  568 -----TAPGPARafPQPDPQRPQMPGHSGPGGEGGGGGGEGWGAGRAAPVSGSVTIPVLFNESTMAQLNGELQALTEKKL 642
Cdd:pfam10577 553 iqaelSASHPHQ--PQQQPQQQQQLSQQGIGQQHLQGGEGEEWGSQSAGLSESVSIPVLFNDSTLAQMNGELQALTEKKL 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  643 LELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGGGARSTDASLDSGVDVHEARPARRRPAREERERAPPAAPPPPPAPP 722
Cdd:pfam10577 631 LELGVKPHPRAWFVSLDGRSNAHVRHSYIDLQRAGCNGSNDASLDSGVDMNEPKPGRRGREGRRERKGHGSPAPGATAYT 710
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  723 RLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVAAPEGRAatvpRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVG 802
Cdd:pfam10577 711 KLVYVDDTEQSSSESRTAVCSPEDNSLTPLLDEGAETRGGT----PRRGRSRGNSSRSSPSESRRDSLTSPEDELPDDDD 786
                         810       820
                  ....*....|....*....|....*
gi 222831660  803 ---DEAGDKKSPWQRREERPLMVFN 824
Cdd:pfam10577 787 ggdDQGENKKSPWQKREERPLMVFN 811
 
Name Accession Description Interval E-value
UPF0560 pfam10577
Uncharacterized protein family UPF0560; This family of proteins has no known function.
41-824 0e+00

Uncharacterized protein family UPF0560; This family of proteins has no known function.


Pssm-ID: 463154  Cd Length: 811  Bit Score: 1004.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660   41 ILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASV 120
Cdd:pfam10577   1 VTLKVQVSDNSTLQPLAGATVEVFGNQTSLASGTTGADGVATLRFPYRLGTWVIVTATKRGYVTNSVPWHPSRLPVYASV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  121 SLYLLPERPATLILYEDLVHILLGSPGARSQPLVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSG 200
Cdd:pfam10577  81 SLYLLPERPATLMLYEDVVQILSGSPGARSQPWVQFQRRALRLPPNSTYTNLTAFLTVASSQYEIGGFPYLQGLESNSTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  201 NGSWLELMPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSETrALTVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWT 280
Cdd:pfam10577 161 NESWFELTPVAAVSVHLLTSDGTEVQVSGPIHVSVPLPSDS-GLKENTSVPAWRFDPKLGLWVRSGTGYIQREGSQLTWT 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  281 FVSPQLGYWVAAMASPTAGLVTitsgIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPS 360
Cdd:pfam10577 240 YIAPQLGYWVAAMSPSSSGPVV----ARDITTYHTIFLLAILGGMALLVLILLCLLLYYCRRRCLKPRQQHRKLQLSSAL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  361 DGNKRDQATSMSQLHLICGGPLEPA-PSGDPEAPPPgPLHSAFSSSRDLASSRDDFFRTKPRSASRPAAEPS------GA 433
Cdd:pfam10577 316 DSSKKDQATSMSHLNLISGVHLESAsSSGEPDMHTP-MLKPSFSESRDFQSSRELFFKHKPADKSRHSLGNLtprskdYR 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  434 RGGESAGLKGARSAEGPGGLEPGL-EEHRRGPS--------------------GAAAFLHEPPSPPPPfdHYLGHKGAAE 492
Cdd:pfam10577 395 KSVESFPLKSARSAETSEGYEPLLhDDYRRSYTsvssssedkdslyhrrhltnDSKGYIQDPSPSPPP--PFPEREQGID 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  493 GKTPDFLLSQSVDQLARPPSLGQAGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRL-----GGEAGAAGVGDEPAPPEG 567
Cdd:pfam10577 473 RKPPDYLLSRSVDHLERPTSLSRPGQLIFCGSVDQMKDNMYRKVRPTLVIPAHYMRLpgehpLSGQALLLQTDQQSDLEG 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  568 -----TAPGPARafPQPDPQRPQMPGHSGPGGEGGGGGGEGWGAGRAAPVSGSVTIPVLFNESTMAQLNGELQALTEKKL 642
Cdd:pfam10577 553 iqaelSASHPHQ--PQQQPQQQQQLSQQGIGQQHLQGGEGEEWGSQSAGLSESVSIPVLFNDSTLAQMNGELQALTEKKL 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  643 LELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGGGARSTDASLDSGVDVHEARPARRRPAREERERAPPAAPPPPPAPP 722
Cdd:pfam10577 631 LELGVKPHPRAWFVSLDGRSNAHVRHSYIDLQRAGCNGSNDASLDSGVDMNEPKPGRRGREGRRERKGHGSPAPGATAYT 710
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  723 RLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVAAPEGRAatvpRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVG 802
Cdd:pfam10577 711 KLVYVDDTEQSSSESRTAVCSPEDNSLTPLLDEGAETRGGT----PRRGRSRGNSSRSSPSESRRDSLTSPEDELPDDDD 786
                         810       820
                  ....*....|....*....|....*
gi 222831660  803 ---DEAGDKKSPWQRREERPLMVFN 824
Cdd:pfam10577 787 ggdDQGENKKSPWQKREERPLMVFN 811
 
Name Accession Description Interval E-value
UPF0560 pfam10577
Uncharacterized protein family UPF0560; This family of proteins has no known function.
41-824 0e+00

Uncharacterized protein family UPF0560; This family of proteins has no known function.


Pssm-ID: 463154  Cd Length: 811  Bit Score: 1004.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660   41 ILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASV 120
Cdd:pfam10577   1 VTLKVQVSDNSTLQPLAGATVEVFGNQTSLASGTTGADGVATLRFPYRLGTWVIVTATKRGYVTNSVPWHPSRLPVYASV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  121 SLYLLPERPATLILYEDLVHILLGSPGARSQPLVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSG 200
Cdd:pfam10577  81 SLYLLPERPATLMLYEDVVQILSGSPGARSQPWVQFQRRALRLPPNSTYTNLTAFLTVASSQYEIGGFPYLQGLESNSTG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  201 NGSWLELMPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSETrALTVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWT 280
Cdd:pfam10577 161 NESWFELTPVAAVSVHLLTSDGTEVQVSGPIHVSVPLPSDS-GLKENTSVPAWRFDPKLGLWVRSGTGYIQREGSQLTWT 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  281 FVSPQLGYWVAAMASPTAGLVTitsgIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPS 360
Cdd:pfam10577 240 YIAPQLGYWVAAMSPSSSGPVV----ARDITTYHTIFLLAILGGMALLVLILLCLLLYYCRRRCLKPRQQHRKLQLSSAL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  361 DGNKRDQATSMSQLHLICGGPLEPA-PSGDPEAPPPgPLHSAFSSSRDLASSRDDFFRTKPRSASRPAAEPS------GA 433
Cdd:pfam10577 316 DSSKKDQATSMSHLNLISGVHLESAsSSGEPDMHTP-MLKPSFSESRDFQSSRELFFKHKPADKSRHSLGNLtprskdYR 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  434 RGGESAGLKGARSAEGPGGLEPGL-EEHRRGPS--------------------GAAAFLHEPPSPPPPfdHYLGHKGAAE 492
Cdd:pfam10577 395 KSVESFPLKSARSAETSEGYEPLLhDDYRRSYTsvssssedkdslyhrrhltnDSKGYIQDPSPSPPP--PFPEREQGID 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  493 GKTPDFLLSQSVDQLARPPSLGQAGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRL-----GGEAGAAGVGDEPAPPEG 567
Cdd:pfam10577 473 RKPPDYLLSRSVDHLERPTSLSRPGQLIFCGSVDQMKDNMYRKVRPTLVIPAHYMRLpgehpLSGQALLLQTDQQSDLEG 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  568 -----TAPGPARafPQPDPQRPQMPGHSGPGGEGGGGGGEGWGAGRAAPVSGSVTIPVLFNESTMAQLNGELQALTEKKL 642
Cdd:pfam10577 553 iqaelSASHPHQ--PQQQPQQQQQLSQQGIGQQHLQGGEGEEWGSQSAGLSESVSIPVLFNDSTLAQMNGELQALTEKKL 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  643 LELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGGGARSTDASLDSGVDVHEARPARRRPAREERERAPPAAPPPPPAPP 722
Cdd:pfam10577 631 LELGVKPHPRAWFVSLDGRSNAHVRHSYIDLQRAGCNGSNDASLDSGVDMNEPKPGRRGREGRRERKGHGSPAPGATAYT 710
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222831660  723 RLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVAAPEGRAatvpRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVG 802
Cdd:pfam10577 711 KLVYVDDTEQSSSESRTAVCSPEDNSLTPLLDEGAETRGGT----PRRGRSRGNSSRSSPSESRRDSLTSPEDELPDDDD 786
                         810       820
                  ....*....|....*....|....*
gi 222831660  803 ---DEAGDKKSPWQRREERPLMVFN 824
Cdd:pfam10577 787 ggdDQGENKKSPWQKREERPLMVFN 811
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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