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Conserved domains on  [gi|118766347|ref|NP_940983|]
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zinc finger CCCH domain-containing protein 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 278-296 2.63e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


:

Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 44.72  E-value: 2.63e-06
                           10
                   ....*....|....*....
gi 118766347   278 CKYFLEGRCIKGDQCKFDH 296
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 307-325 4.50e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


:

Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.94  E-value: 4.50e-06
                           10
                   ....*....|....*....
gi 118766347   307 CKFYLQGYCTKGENCIYMH 325
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH_3 super family cl25863
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 300-359 5.61e-06

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


The actual alignment was detected with superfamily member pfam15663:

Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 46.30  E-value: 5.61e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118766347   300 LEKRKEICKFYLQGYCTKGENCIYMH------NEFPCKFYHSGaKCYQgDNCKFSHDDLTKETKKL 359
Cdd:pfam15663    1 MENKGDDCYFFYYSTCTKGDSCPFRHceaalgNETVCTLWQEG-RCFR-PVCRFRHMEIDKNRKEI 64
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1006-1162 9.21e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118766347 1006 SQPSGAGTSNSGSGALPPYAPKLSSSAGLPLGTSTSVLSGISlyDPRDHGSSSTSELATASSGEnSKNQKKSGGLKSSDK 1085
Cdd:PHA03307  759 SNPSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPG--RLRRSGPAADAASRTASKRK-SRSHTPDGGSESSGP 835

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118766347 1086 TEPSPGEAilpqkPSPNVGVTLEGPADPQADVPRSSGKVQVPAVHSLPVQALTGLIRPQYSDPRQARQPGQGSPTPD 1162
Cdd:PHA03307  836 ARPPGAAA-----RPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRP 907
 
Name Accession Description Interval E-value
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 278-296 2.63e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 44.72  E-value: 2.63e-06
                           10
                   ....*....|....*....
gi 118766347   278 CKYFLEGRCIKGDQCKFDH 296
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 307-325 4.50e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.94  E-value: 4.50e-06
                           10
                   ....*....|....*....
gi 118766347   307 CKFYLQGYCTKGENCIYMH 325
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 300-359 5.61e-06

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 46.30  E-value: 5.61e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118766347   300 LEKRKEICKFYLQGYCTKGENCIYMH------NEFPCKFYHSGaKCYQgDNCKFSHDDLTKETKKL 359
Cdd:pfam15663    1 MENKGDDCYFFYYSTCTKGDSCPFRHceaalgNETVCTLWQEG-RCFR-PVCRFRHMEIDKNRKEI 64
ZnF_C3H1 smart00356
zinc finger;
303-327 2.57e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 42.23  E-value: 2.57e-05
                            10        20
                    ....*....|....*....|....*
gi 118766347    303 RKEICKFYLQGYCTKGENCIYMHNE 327
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 277-351 6.58e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 46.40  E-value: 6.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118766347  277 ICKYFLEGRCI-KGDQCKFDHDAELEKRKEICKFYLQGYCTKGENCIYMHN-------EFPCKFYHSGAKCYQGDNCKFS 348
Cdd:COG5084    76 ACISRNFNSIRgSRLSTPNNHVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEydlrssqGPPCRSFSLKGSCSSGPSCGYS 155


                  ...
gi 118766347  349 HDD 351
Cdd:COG5084   156 HID 158
ZnF_C3H1 smart00356
zinc finger;
276-297 3.46e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.76  E-value: 3.46e-04
                            10        20
                    ....*....|....*....|..
gi 118766347    276 QICKYFLEGRCIKGDQCKFDHD 297
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1006-1162 9.21e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118766347 1006 SQPSGAGTSNSGSGALPPYAPKLSSSAGLPLGTSTSVLSGISlyDPRDHGSSSTSELATASSGEnSKNQKKSGGLKSSDK 1085
Cdd:PHA03307  759 SNPSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPG--RLRRSGPAADAASRTASKRK-SRSHTPDGGSESSGP 835

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118766347 1086 TEPSPGEAilpqkPSPNVGVTLEGPADPQADVPRSSGKVQVPAVHSLPVQALTGLIRPQYSDPRQARQPGQGSPTPD 1162
Cdd:PHA03307  836 ARPPGAAA-----RPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRP 907
 
Name Accession Description Interval E-value
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 278-296 2.63e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 44.72  E-value: 2.63e-06
                           10
                   ....*....|....*....
gi 118766347   278 CKYFLEGRCIKGDQCKFDH 296
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 307-325 4.50e-06

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 43.94  E-value: 4.50e-06
                           10
                   ....*....|....*....
gi 118766347   307 CKFYLQGYCTKGENCIYMH 325
Cdd:pfam18345    1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 300-359 5.61e-06

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 46.30  E-value: 5.61e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118766347   300 LEKRKEICKFYLQGYCTKGENCIYMH------NEFPCKFYHSGaKCYQgDNCKFSHDDLTKETKKL 359
Cdd:pfam15663    1 MENKGDDCYFFYYSTCTKGDSCPFRHceaalgNETVCTLWQEG-RCFR-PVCRFRHMEIDKNRKEI 64
ZnF_C3H1 smart00356
zinc finger;
303-327 2.57e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 42.23  E-value: 2.57e-05
                            10        20
                    ....*....|....*....|....*
gi 118766347    303 RKEICKFYLQGYCTKGENCIYMHNE 327
Cdd:smart00356    3 KTELCKFFKRGYCPRGDRCKFAHPL 27
YTH1 COG5084
Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin ...
 277-351 6.58e-05

Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only];


Pssm-ID: 227416 [Multi-domain]  Cd Length: 285  Bit Score: 46.40  E-value: 6.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118766347  277 ICKYFLEGRCI-KGDQCKFDHDAELEKRKEICKFYLQGYCTKGENCIYMHN-------EFPCKFYHSGAKCYQGDNCKFS 348
Cdd:COG5084    76 ACISRNFNSIRgSRLSTPNNHVNPVLSSSVVCKFFLRGLCKSGFSCEFLHEydlrssqGPPCRSFSLKGSCSSGPSCGYS 155


                  ...
gi 118766347  349 HDD 351
Cdd:COG5084   156 HID 158
ZnF_C3H1 smart00356
zinc finger;
276-297 3.46e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.76  E-value: 3.46e-04
                            10        20
                    ....*....|....*....|..
gi 118766347    276 QICKYFLEGRCIKGDQCKFDHD 297
Cdd:smart00356    5 ELCKFFKRGYCPRGDRCKFAHP 26
zf-CCCH_3 pfam15663
Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically ...
 271-350 5.92e-04

Zinc-finger containing family; zf-CCCH_3 family is found in eukaryotes, and is typically between 155 and 169 amino acids in length.


Pssm-ID: 464787 [Multi-domain]  Cd Length: 110  Bit Score: 40.52  E-value: 5.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118766347   271 EHKGKQiCKYFLEGRCIKGDQCKFDHDAELEKRKEICKFYLQGYCTKgENCIYMH-------NEFPCKFYHSGAKCyQGD 343
Cdd:pfam15663    2 ENKGDD-CYFFYYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFR-PVCRFRHmeidknrKEIPCYWENQPGGC-QKP 78


                   ....*..
gi 118766347   344 NCKFSHD 350
Cdd:pfam15663   79 HCAFHHT 85
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
273-297 1.09e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 37.56  E-value: 1.09e-03
                           10        20
                   ....*....|....*....|....*.
gi 118766347   273 KGKQICKYFLE-GRCIKGDQCKFDHD 297
Cdd:pfam00642    1 YKTELCRFFLRtGYCKYGDRCKFAHG 26
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 277-297 1.97e-03

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 36.80  E-value: 1.97e-03
                           10        20
                   ....*....|....*....|.
gi 118766347   277 ICKYFLEGRCIKGDQCKFDHD 297
Cdd:pfam18044    2 LCRYFQKGGCRYGDNCRFSHD 22
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 330-349 3.50e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 35.86  E-value: 3.50e-03
                           10        20
                   ....*....|....*....|
gi 118766347   330 CKFYHSGaKCYQGDNCKFSH 349
Cdd:pfam18345    1 CKFFLKG-RCRYGDKCRFAH 19
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 329-350 3.80e-03

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 36.03  E-value: 3.80e-03
                           10        20
                   ....*....|....*....|..
gi 118766347   329 PCKFYHSGaKCYQGDNCKFSHD 350
Cdd:pfam18044    2 LCRYFQKG-GCRYGDNCRFSHD 22
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1006-1162 9.21e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118766347 1006 SQPSGAGTSNSGSGALPPYAPKLSSSAGLPLGTSTSVLSGISlyDPRDHGSSSTSELATASSGEnSKNQKKSGGLKSSDK 1085
Cdd:PHA03307  759 SNPSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPG--RLRRSGPAADAASRTASKRK-SRSHTPDGGSESSGP 835

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118766347 1086 TEPSPGEAilpqkPSPNVGVTLEGPADPQADVPRSSGKVQVPAVHSLPVQALTGLIRPQYSDPRQARQPGQGSPTPD 1162
Cdd:PHA03307  836 ARPPGAAA-----RPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRP 907
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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