NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|613410251|ref|NP_941967|]
View 

keratin-associated protein 10-5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 67-237 1.43e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251   67 SSCTPSCCQPACCASSPCQQACCVPVCCKPVCCLPTCskdsssccqqsscqptccaSSSCQQSCCVPVCCKPVCCVPTCS 146
Cdd:pfam01500  23 GCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC-------------------QPCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251  147 edSSSCCQHSSCQPTCCTSSPCQQSCYVPVCCKPVCCKPICCVPVCsgastsccqqssCQPACCTTSCCRPSSSVSLLCR 226
Cdd:pfam01500  84 --GIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC------------CQLHHAQASCCRPSYCGQSCCR 149

                         170
                  ....*....|.
gi 613410251  227 PICRPACCLPI 237
Cdd:pfam01500 150 PACCCQCSEPT 160
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 67-237 1.43e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251   67 SSCTPSCCQPACCASSPCQQACCVPVCCKPVCCLPTCskdsssccqqsscqptccaSSSCQQSCCVPVCCKPVCCVPTCS 146
Cdd:pfam01500  23 GCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC-------------------QPCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251  147 edSSSCCQHSSCQPTCCTSSPCQQSCYVPVCCKPVCCKPICCVPVCsgastsccqqssCQPACCTTSCCRPSSSVSLLCR 226
Cdd:pfam01500  84 --GIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC------------CQLHHAQASCCRPSYCGQSCCR 149

                         170
                  ....*....|.
gi 613410251  227 PICRPACCLPI 237
Cdd:pfam01500 150 PACCCQCSEPT 160
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 67-237 1.43e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 1.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251   67 SSCTPSCCQPACCASSPCQQACCVPVCCKPVCCLPTCskdsssccqqsscqptccaSSSCQQSCCVPVCCKPVCCVPTCS 146
Cdd:pfam01500  23 GCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC-------------------QPCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251  147 edSSSCCQHSSCQPTCCTSSPCQQSCYVPVCCKPVCCKPICCVPVCsgastsccqqssCQPACCTTSCCRPSSSVSLLCR 226
Cdd:pfam01500  84 --GIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC------------CQLHHAQASCCRPSYCGQSCCR 149

                         170
                  ....*....|.
gi 613410251  227 PICRPACCLPI 237
Cdd:pfam01500 150 PACCCQCSEPT 160
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 118-271 1.45e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251  118 PTCCASSSCQQSCCVPVCCKPVCCVPTCSEDSSSCCQHSSCQPTCCTSSPCQQScyvpVCCKPVCCKPICCVPVCSGasT 197
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQT----SCCQPTCCQTSSCQTGCGG--I 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 613410251  198 SCCQQSSCQPACCTTSCCRPSSSVSLLCRPICRPACCLPISscCAPASSYQASCCRPASCVSLLCRPACSPLAC 271
Cdd:pfam01500  86 GYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPT--CCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 22-192 1.12e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.95  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251   22 CPESCCEPPCGTAPCltlvCTPVSCVSSPCCQAACEPSPCQSGCTSSCTPSCCQPACCASSPCQQACCvpvcckpvcclp 101
Cdd:pfam01500  20 CGSGCCQPCCCQSSC----CRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCG------------ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251  102 tcskdSSSCCQQSSCQPTCCASSSCQQSCCVPVCCKPVCCVPTCsedsssccqhssCQPTCCTSSPCQQSCYVPVCCKPV 181
Cdd:pfam01500  84 -----GIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSC------------TPPTCCQLHHAQASCCRPSYCGQS 146

                         170
                  ....*....|.
gi 613410251  182 CCKPICCVPVC 192
Cdd:pfam01500 147 CCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
56-102 2.58e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.22  E-value: 2.58e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 613410251   56 CEPSPCQSGCtssCTPSCCQPACCASSPCQQACCVPVCCKPVCCLPT 102
Cdd:pfam13885   2 CQPSCCQPSC---CQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
177-228 9.65e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 44.68  E-value: 9.65e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 613410251  177 CCKPVCCKPICCVPvcsgastSCCQQSSCQPACCTTSCCRPSSSVSLLCRPI 228
Cdd:pfam13885   1 CCQPSCCQPSCCQP-------SCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
66-103 1.22e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 44.30  E-value: 1.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 613410251   66 TSSCTPSCCQPACCASSPCQQACCVPVCCKPVCCLPTC 103
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
135-191 5.95e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.95e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 613410251  135 CCKPVCCVPTCSEdsssccqhsscqPTCCTSSPCQQSCYVPVCCKPVCCKPICCVPV 191
Cdd:pfam13885   1 CCQPSCCQPSCCQ------------PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
93-145 1.73e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.21  E-value: 1.73e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 613410251   93 CCKPVCCLPTCSKdsssccqqsscqPTCCASSSCQQSCCVPVCCKPVCCVPTC 145
Cdd:pfam13885   1 CCQPSCCQPSCCQ------------PSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
160-192 1.50e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.52  E-value: 1.50e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 613410251  160 PTCCTSSPCQQSCYVPVCCKPVCCKPICCVPVC 192
Cdd:pfam13885   9 PSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-146 2.66e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 37.87  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410251   10 SSACSDSWRVDDCPESCCEPPCgtapcltlvCTPVSCVSSPCCQAACEPSPCQSGC--------TSSCTPSCCQPACCAS 81
Cdd:pfam05287  44 SSCQLGSSLRDNCQETCGEPTS---------CQTSSCEPCTSSTSYCVPSPCQRSCysprtscvCSPCQTTSAGSLGFGS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 613410251   82 SPCQQACCVPVCCKPVCCLPTCSKdsSSCCQQSSCQPTCCASSSCQQSCCVPVCCKPVCCVPTCS 146
Cdd:pfam05287 115 SSCQSLGYGSNSCQPLGCGSSGFR--PLGCLSKGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSCG 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH