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Conserved domains on  [gi|238859649|ref|NP_941968|]
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keratin-associated protein 10-8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 46-180 3.25e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.28  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   46 CQESCCEPRSCASSCCTPSCCAPAPCLALVCAPVSCEPSPCQSGCTDSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCK 125
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 238859649  126 SNCCKPVCCVSICSGAssPCCQQSSCQSACCTFSPCQQACCVPICCKPICCVPVC 180
Cdd:pfam01500 100 TRWCRPDCRVEGTCLP--PCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
160-206 5.51e-06

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238859649  160 PCQQACCVPICCKPICCVPVCSGasSLCCQKSSCQPACCTTSCCRPS 206
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQ--PSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
187-232 1.90e-04

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238859649  187 CCQKSSCQPACCTTSCCRPSSSVSLLCRPV-CRPACCvpVPSCCVPA 232
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCC--RSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 46-180 3.25e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.28  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   46 CQESCCEPRSCASSCCTPSCCAPAPCLALVCAPVSCEPSPCQSGCTDSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCK 125
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 238859649  126 SNCCKPVCCVSICSGAssPCCQQSSCQSACCTFSPCQQACCVPICCKPICCVPVC 180
Cdd:pfam01500 100 TRWCRPDCRVEGTCLP--PCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
160-206 5.51e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238859649  160 PCQQACCVPICCKPICCVPVCSGasSLCCQKSSCQPACCTTSCCRPS 206
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQ--PSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
187-232 1.90e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238859649  187 CCQKSSCQPACCTTSCCRPSSSVSLLCRPV-CRPACCvpVPSCCVPA 232
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCC--RSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 46-180 3.25e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.28  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   46 CQESCCEPRSCASSCCTPSCCAPAPCLALVCAPVSCEPSPCQSGCTDSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCK 125
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 238859649  126 SNCCKPVCCVSICSGAssPCCQQSSCQSACCTFSPCQQACCVPICCKPICCVPVC 180
Cdd:pfam01500 100 TRWCRPDCRVEGTCLP--PCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPAC 152
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 58-224 4.03e-14

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 68.28  E-value: 4.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   58 SSCCTPSCCAPAPCLALVCAPVSCEPSPCQSGCtdsCTPSCCQQSSCQPACCTSSPCQ---QACCVPVCCKSNCCKPVCC 134
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSC---CRPSCCQTSCCQPTTFQSSCCRptcQPCCQTSCCQPTCCQTSSC 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649  135 VSICSGASSPccQQSSCQSACCTFSPCQQACCVPICCKPICCVPVCsgasslcCQKSSCQPACCTTSCCRPSSSVSLLCR 214
Cdd:pfam01500  79 QTGCGGIGYG--QEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSC-------TPPTCCQLHHAQASCCRPSYCGQSCCR 149

                         170
                  ....*....|
gi 238859649  215 PVCRPACCVP 224
Cdd:pfam01500 150 PACCCQCSEP 159
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-181 3.89e-11

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 60.22  E-value: 3.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   10 YVIAASTMSVCSSDVGHVSRVSSPSTCTGSSWQVDNCQESCCEPRSCASSCCTPSCCAPAPclalvcapvsCEPSPCQSG 89
Cdd:pfam05287  20 HYPVSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSY----------CVPSPCQRS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   90 CTDSCTPSCCqqSSCQPACCTSSPCQQACCVPVCCKSNCCKPVCCVSicSGASSPCCQQSSCQSACCTFSPCQQACCVPI 169
Cdd:pfam05287  90 CYSPRTSCVC--SPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGS--SGFRPLGCLSKGFQSLGYGSSFCRPSYVSSR 165

                         170
                  ....*....|..
gi 238859649  170 CCKPICCVPVCS 181
Cdd:pfam05287 166 SYQPSCFRPSCG 177
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
98-138 3.19e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 3.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238859649   98 CCQQSSCQPACCTSSPCQQACCVPVCCKSNCCKPVCCVSIC 138
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
93-134 6.23e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 47.76  E-value: 6.23e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 238859649   93 SCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKSNCCKPVCC 134
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
93-132 1.14e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 1.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 238859649   93 SCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKSNCCKPV 132
Cdd:pfam13885   6 CCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
160-206 5.51e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 5.51e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238859649  160 PCQQACCVPICCKPICCVPVCSGasSLCCQKSSCQPACCTTSCCRPS 206
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQ--PSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
142-180 1.57e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.21  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 238859649  142 SSPCCQQSSCQSACCTFSPCQQACCVPICCKPICCVPVC 180
Cdd:pfam13885   3 QPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
103-147 2.29e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.83  E-value: 2.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 238859649  103 SCQPACCTSSPCQQACCVPVCCKSNCCKPVCCVSICSgaSSPCCQ 147
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCC--RSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
46-87 1.16e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 1.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 238859649   46 CQESCCEPRSCASSCCTPSCCAPAPCLALVCAPVSCEPSPCQ 87
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
187-232 1.90e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238859649  187 CCQKSSCQPACCTTSCCRPSSSVSLLCRPV-CRPACCvpVPSCCVPA 232
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPScCRPSCC--RSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 93-255 2.98e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 37.49  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   93 SCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKSNCCKPVCCvsicsgaSSPCCQQSSCQSACCTFSPCQQACCVP-ICC 171
Cdd:pfam05287  25 SCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSC-------QTSSCEPCTSSTSYCVPSPCQRSCYSPrTSC 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649  172 KPICCVPVCSGASSLCcqKSSCQPACCTTSCCRPSSSVSLLCRPVCRPACCVPVPSCcvPASSCQPSCCHPASCLSFLCR 251
Cdd:pfam05287  98 VCSPCQTTSAGSLGFG--SSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGY--GSSFCRPSYVSSRSYQPSCFR 173


                  ....
gi 238859649  252 PACS 255
Cdd:pfam05287 174 PSCG 177
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 93-259 7.81e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 36.33  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649   93 SCTPSCCQQSSCQPACCTS-SPCQQACCVPVCCKSNCCKPVCC---VSICSGASSPCCQQSSCQSACCTFSPCQQACCVP 168
Cdd:pfam05287   4 NCCSGNFSSRSLRNHLHYPvSSCGSSCPSNLSYSTDLCSPSSCqlgSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859649  169 ICCKPICCVPVCSGASSlCCQKSSCQPACCTTSCCRPSSSVSLLCRPV-CRPACCVPVP--SCCVPASSCQPSCCHPASC 245
Cdd:pfam05287  84 SPCQRSCYSPRTSCVCS-PCQTTSAGSLGFGSSSCQSLGYGSNSCQPLgCGSSGFRPLGclSKGFQSLGYGSSFCRPSYV 162

                         170
                  ....*....|....
gi 238859649  246 LSFLCRPACSRLAC 259
Cdd:pfam05287 163 SSRSYQPSCFRPSC 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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