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Conserved domains on  [gi|41327785|ref|NP_951047|]
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform b [Homo sapiens]

Protein Classification

Mth938-like domain-containing protein( domain architecture ID 10142263)

Mth938-like domain-containing protein similar to human NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 1-114 2.26e-65

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


:

Pssm-ID: 240161  Cd Length: 114  Bit Score: 193.57  E-value: 2.26e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   1 MYIDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWLLEPRIEIVVVGTGDRTERLQSQVLQAMRQR 80
Cdd:cd05125   1 NYIDAYSENGFRLNNNKVIGSGAILPKEVFSWNVSSFEDITEESLSLFELLEPRPEILVIGTGRKSRPLSPELRKYFKKL 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 41327785  81 GIAVEVQDTPNACATFNFLCHEGRVTGAALIPPP 114
Cdd:cd05125  81 GIAVEVVDTRNACATFNFLAEEGRRVAAALIPPG 114
 
Name Accession Description Interval E-value
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 1-114 2.26e-65

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


Pssm-ID: 240161  Cd Length: 114  Bit Score: 193.57  E-value: 2.26e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   1 MYIDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWLLEPRIEIVVVGTGDRTERLQSQVLQAMRQR 80
Cdd:cd05125   1 NYIDAYSENGFRLNNNKVIGSGAILPKEVFSWNVSSFEDITEESLSLFELLEPRPEILVIGTGRKSRPLSPELRKYFKKL 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 41327785  81 GIAVEVQDTPNACATFNFLCHEGRVTGAALIPPP 114
Cdd:cd05125  81 GIAVEVVDTRNACATFNFLAEEGRRVAAALIPPG 114
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 3-111 1.37e-42

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 135.73  E-value: 1.37e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785     3 IDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWllePRIEIVVVGTGDRTERLQSQVLQAMRQRGI 82
Cdd:pfam04430   1 IDGYGFGGFRVNGVRYRGSLLVLPGGVFAWDVTKGEDLTPEDLALLL---ADPEVLIIGTGARVLFLPPELREALRKRGI 77

                          90       100
                  ....*....|....*....|....*....
gi 41327785    83 AVEVQDTPNACATFNFLCHEGRVTGAALI 111
Cdd:pfam04430  78 GVEVMDTRAACRTYNVLASEGRRVAAALI 106
COG3737 COG3737
Uncharacterized protein, contains Mth938-like domain [Function unknown];
3-111 3.08e-29

Uncharacterized protein, contains Mth938-like domain [Function unknown];


Pssm-ID: 442951  Cd Length: 121  Bit Score: 102.14  E-value: 3.08e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   3 IDSYNSRGFMINGNRVLGPCALLPHSVVQ-WNVGSHQDITEDSFSLfwLLEPRIEIVVVGTGDRTERLQSQVLQAMRQRG 81
Cdd:COG3737  14 ITAYGDGGFRINGMRYRGSLLVLPDGLVEdWPVTSFEDLTAAHLEP--LLALKPEVVLLGTGARQRFPPPALLAALREAG 91

                        90       100       110
                ....*....|....*....|....*....|
gi 41327785  82 IAVEVQDTPNACATFNFLCHEGRVTGAALI 111
Cdd:COG3737  92 IGVEVMDTGAACRTYNILLAEGRRVAAALI 121
 
Name Accession Description Interval E-value
Mth938_2P1-like cd05125
Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially ...
 1-114 2.26e-65

Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the Mth938 family, for which structures, but no functional data are available.


Pssm-ID: 240161  Cd Length: 114  Bit Score: 193.57  E-value: 2.26e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   1 MYIDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWLLEPRIEIVVVGTGDRTERLQSQVLQAMRQR 80
Cdd:cd05125   1 NYIDAYSENGFRLNNNKVIGSGAILPKEVFSWNVSSFEDITEESLSLFELLEPRPEILVIGTGRKSRPLSPELRKYFKKL 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 41327785  81 GIAVEVQDTPNACATFNFLCHEGRVTGAALIPPP 114
Cdd:cd05125  81 GIAVEVVDTRNACATFNFLAEEGRRVAAALIPPG 114
DUF498 pfam04430
Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized ...
 3-111 1.37e-42

Protein of unknown function (DUF498/DUF598); This is a large family of uncharacterized proteins found in all domains of life. The structure shows a novel fold with three beta sheets. A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid.


Pssm-ID: 461305  Cd Length: 106  Bit Score: 135.73  E-value: 1.37e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785     3 IDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWllePRIEIVVVGTGDRTERLQSQVLQAMRQRGI 82
Cdd:pfam04430   1 IDGYGFGGFRVNGVRYRGSLLVLPGGVFAWDVTKGEDLTPEDLALLL---ADPEVLIIGTGARVLFLPPELREALRKRGI 77

                          90       100
                  ....*....|....*....|....*....
gi 41327785    83 AVEVQDTPNACATFNFLCHEGRVTGAALI 111
Cdd:pfam04430  78 GVEVMDTRAACRTYNVLASEGRRVAAALI 106
Mth938-like cd00248
Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and ...
 2-111 7.34e-39

Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. 2P1 is a partially characterized nuclear protein which is homologous to E3-3 from rat and known to be alternately spliced. Xcr35 and Rpa2829 are hypothetical proteins of unknown function from the Xanthomonas campestris and Rhodopseudomonas palustris genomes, respectively, for which the crystal structures have been determined.


Pssm-ID: 238152  Cd Length: 109  Bit Score: 126.21  E-value: 7.34e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   2 YIDSYNSRGFMINGNRVLGPCALLPHSVVQWNVGSHQDITEDSFSLFWLLEpRIEIVVVGTGDRTERLQSQVLQAMRQRG 81
Cdd:cd00248   1 PIDGYGPGGFRIAGQVYRGPLLVLPDGVVPWDGTSLSDLDPEALLPLLAED-RPDILLIGTGAEIAFLPRALRAALRAAG 79

                        90       100       110
                ....*....|....*....|....*....|
gi 41327785  82 IAVEVQDTPNACATFNFLCHEGRVTGAALI 111
Cdd:cd00248  80 IGVEVMSTGAACRTYNVLLSEGRRVAAALI 109
COG3737 COG3737
Uncharacterized protein, contains Mth938-like domain [Function unknown];
3-111 3.08e-29

Uncharacterized protein, contains Mth938-like domain [Function unknown];


Pssm-ID: 442951  Cd Length: 121  Bit Score: 102.14  E-value: 3.08e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   3 IDSYNSRGFMINGNRVLGPCALLPHSVVQ-WNVGSHQDITEDSFSLfwLLEPRIEIVVVGTGDRTERLQSQVLQAMRQRG 81
Cdd:COG3737  14 ITAYGDGGFRINGMRYRGSLLVLPDGLVEdWPVTSFEDLTAAHLEP--LLALKPEVVLLGTGARQRFPPPALLAALREAG 91

                        90       100       110
                ....*....|....*....|....*....|
gi 41327785  82 IAVEVQDTPNACATFNFLCHEGRVTGAALI 111
Cdd:COG3737  92 IGVEVMDTGAACRTYNILLAEGRRVAAALI 121
Xcc1710_like cd05560
Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from ...
 3-111 1.06e-17

Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. Their three-dimensional structures have been determined, but their functions are unknown.


Pssm-ID: 240187  Cd Length: 109  Bit Score: 72.61  E-value: 1.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327785   3 IDSYNSRGFMINGNRVLGPCALLPHSVV-QWNVGSHQDITEDSFSlfWLLEPRIEIVVVGTGDRTERLQSQVLQAMRQRG 81
Cdd:cd05560   2 ITAYGDGYVEINDQRYEHSLIVTPDELItDWPVARFEDLTAAHFE--ALLALQPEVILLGTGERQRFPPPALLAPLLARG 79

                        90       100       110
                ....*....|....*....|....*....|
gi 41327785  82 IAVEVQDTPNACATFNFLCHEGRVTGAALI 111
Cdd:cd05560  80 IGVEVMDTQAACRTYNILMGEGRRVVAALL 109
Mth938 cd05126
Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium ...
 50-110 2.26e-03

Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the protein has not been determined.


Pssm-ID: 240162  Cd Length: 117  Bit Score: 35.39  E-value: 2.26e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41327785  50 LLEPRIEIVVVGTGdRTERLQ--SQVLQAMRQRGIAVEVQDTPNACATFNFLCHEGRVTGAAL 110
Cdd:cd05126  54 LLEEGVEVIVIGTG-QSGALKvpPETVEKLEKRGVEVLVLPTEEAVKRYNELAGKGRRVLAVI 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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