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Conserved domains on  [gi|40018564|ref|NP_954523|]
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origin recognition complex subunit 4 [Rattus norvegicus]

Protein Classification

origin recognition complex subunit 4( domain architecture ID 13386334)

origin recognition complex subunit 4 is a component of the origin recognition complex (ORC), an ATP-dependent DNA-binding complex that binds origins of replication

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
226-413 4.53e-57

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


:

Pssm-ID: 464223  Cd Length: 212  Bit Score: 187.16  E-value: 4.53e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   226 KIFKEQLSLPAEF----PDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLM 301
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   302 EAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKP 368
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 40018564   369 VVMKAFEHLQQLELIKPMERTSVNS-------QREYQLVKLLLDNTQIMNAL 413
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 super family cl34277
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-224 4.12e-18

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1474:

Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 85.67  E-value: 4.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  41 QYKHLIELLkRTAIYGES-NSLLIVGPRGSGKTTLLNHALKELMQIGDMSE-NVLQVHLNGLLQTNDKIALKEITRQLNL 118
Cdd:COG1474  34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEAEERGvDVRVVYVNCRQASTRYRVLSRILEELGS 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564 119 ENVVGDKvfG-SFAENLSFLLEALQKGNRtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQS-AQTPIAVIGLTCRLDI 196
Cdd:COG1474 113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDLEF 186
                       170       180
                ....*....|....*....|....*...
gi 40018564 197 LELLEKRVKSRFSHRQIHlmnsfdFPQY 224
Cdd:COG1474 187 LENLDPRVKSSLGEEEIV------FPPY 208
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
226-413 4.53e-57

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 187.16  E-value: 4.53e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   226 KIFKEQLSLPAEF----PDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLM 301
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   302 EAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKP 368
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 40018564   369 VVMKAFEHLQQLELIKPMERTSVNS-------QREYQLVKLLLDNTQIMNAL 413
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-224 4.12e-18

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 85.67  E-value: 4.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  41 QYKHLIELLkRTAIYGES-NSLLIVGPRGSGKTTLLNHALKELMQIGDMSE-NVLQVHLNGLLQTNDKIALKEITRQLNL 118
Cdd:COG1474  34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEAEERGvDVRVVYVNCRQASTRYRVLSRILEELGS 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564 119 ENVVGDKvfG-SFAENLSFLLEALQKGNRtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQS-AQTPIAVIGLTCRLDI 196
Cdd:COG1474 113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDLEF 186
                       170       180
                ....*....|....*....|....*...
gi 40018564 197 LELLEKRVKSRFSHRQIHlmnsfdFPQY 224
Cdd:COG1474 187 LENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
56-224 2.28e-12

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 68.04  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    56 GESNSLLIVGPRGSGKTTLLNHALKELMQI-GDMSENVLQVHLNGLLQTNDKIALKEITRQLNlenVVGDKV--FG-SFA 131
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaEDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   132 ENLSFLLEALQKGNRTsscpVIFILDEFDLFAhQKNQTLLYNLFDISQSAQT---PIAVIGLTCRLDILELLEKRVKSRF 208
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGISNDLKFRENLDPRVKSSL 189
                         170
                  ....*....|....*.
gi 40018564   209 SHRQIHlmnsfdFPQY 224
Cdd:TIGR02928 190 CEEEII------FPPY 199
cdc6 PRK00411
ORC1-type DNA replication protein;
46-224 3.34e-11

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 64.48  E-value: 3.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   46 IELLK---RTAIYGESNS-LLIVGPRGSGKTTLLNHALKELMQIgdmSENVLQVHLNGLLQTNDKIALKEITRQLNLENV 121
Cdd:PRK00411  39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI---AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPP 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  122 --VG---DKVFGSFAEnlsflleALQKGNRTsscpVIFILDEFDLFAHQKNQTLLYNLFDISQSAQ-TPIAVIGLTCRLD 195
Cdd:PRK00411 116 psSGlsfDELFDKIAE-------YLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHEEYPgARIGVIGISSDLT 184
                        170       180
                 ....*....|....*....|....*....
gi 40018564  196 ILELLEKRVKSRFSHRQIHlmnsfdFPQY 224
Cdd:PRK00411 185 FLYILDPRVKSVFRPEEIY------FPPY 207
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
44-211 4.19e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.93  E-value: 4.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  44 HLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELmqiGDMSENVLQVHLNGLlqtndkialkeitrqlnLENVVG 123
Cdd:cd00009   5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDL-----------------LEGLVV 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564 124 DKVFGSFAENLSFLLEALQKgnrtsscPVIFILDEFDLFAHQKNQTLLYNL--FDISQSAQTPIAVIGLTCRLDILELLE 201
Cdd:cd00009  65 AELFGHFLVRLLFELAEKAK-------PGVLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNRPLLGDLDR 137
                       170
                ....*....|
gi 40018564 202 KRvKSRFSHR 211
Cdd:cd00009 138 AL-YDRLDIR 146
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
34-188 8.97e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 51.74  E-value: 8.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    34 NLFGVQVQYKHLIELLKRTAIyGESNSLLIVGPRGSGKTTLLNHALKelmQIGDMSENVLQ---VHLNGLLQTNDKIALK 110
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLR---ALERDGGYFLRgkcDENLPYSPLLEALTRE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   111 EITRQLNLENVV----------------GDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQkNQTLLYNL 174
Cdd:pfam13191  77 GLLRQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAAL 155
                         170
                  ....*....|....
gi 40018564   175 FDISQsaQTPIAVI 188
Cdd:pfam13191 156 LRLLE--SLPLLVV 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
59-215 2.15e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.06  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564     59 NSLLIVGPRGSGKTTLLNHALKElmqigdmsenvLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLL 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE-----------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    139 EALQKGNrtsscPVIFILDEFDLFAHQKNQTLL----YNLFDISQSAQTPIAVIGLTcrLDILELLEKRVKSRFSHRQIH 214
Cdd:smart00382  72 ALARKLK-----PDVLILDEITSLLDAEQEALLllleELRLLLLLKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVL 144

                   .
gi 40018564    215 L 215
Cdd:smart00382 145 L 145
 
Name Accession Description Interval E-value
ORC4_C pfam14629
Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of ...
226-413 4.53e-57

Origin recognition complex (ORC) subunit 4 C-terminus; This entry represents the C-terminus of origin recognition complex subunit 4.


Pssm-ID: 464223  Cd Length: 212  Bit Score: 187.16  E-value: 4.53e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   226 KIFKEQLSLPAEF----PDKIFAEKWNENAHCLSEDSTVLEVLQKHFNVNKNLQSLHMLLMLALNRVTVTHPFMTSADLM 301
Cdd:pfam14629   1 EICKSLLSLPSDEssseGDKKFLEQWNASIEELLEDSTVQDILKRLYYTTKSVRSLLNSLILPVSKLSPDSPLLTAESLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   302 EAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRK-------------AHSVYNFEKP 368
Cdd:pfam14629  81 SALSSQSPDSKLSLLRSLSVLELCLLIAAARLSEIYDTDTFNFEMVYDEYKKLAKRSkvspssatsqssaASGIRVWGRP 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 40018564   369 VVMKAFEHLQQLELIKPMERTSVNS-------QREYQLVKLLLDNTQIMNAL 413
Cdd:pfam14629 161 VALKAWEHLLSLELLVPVGAVSTGGassgsggGKEFRMVRLDITLEEIREAV 212
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
41-224 4.12e-18

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 85.67  E-value: 4.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  41 QYKHLIELLkRTAIYGES-NSLLIVGPRGSGKTTLLNHALKELMQIGDMSE-NVLQVHLNGLLQTNDKIALKEITRQLNL 118
Cdd:COG1474  34 EIEELASAL-RPALRGERpSNVLIYGPTGTGKTAVAKYVLEELEEEAEERGvDVRVVYVNCRQASTRYRVLSRILEELGS 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564 119 ENVVGDKvfG-SFAENLSFLLEALQKGNRtsscPVIFILDEFDLFAHQKNQTLLYNLFDISQS-AQTPIAVIGLTCRLDI 196
Cdd:COG1474 113 GEDIPST--GlSTDELFDRLYEALDERDG----VLVVVLDEIDYLVDDEGDDLLYQLLRANEElEGARVGVIGISNDLEF 186
                       170       180
                ....*....|....*....|....*...
gi 40018564 197 LELLEKRVKSRFSHRQIHlmnsfdFPQY 224
Cdd:COG1474 187 LENLDPRVKSSLGEEEIV------FPPY 208
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
56-224 2.28e-12

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 68.04  E-value: 2.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    56 GESNSLLIVGPRGSGKTTLLNHALKELMQI-GDMSENVLQVHLNGLLQTNDKIALKEITRQLNlenVVGDKV--FG-SFA 131
Cdd:TIGR02928  38 SRPSNVFIYGKTGTGKTAVTKYVMKELEEAaEDRDVRVVTVYVNCQILDTLYQVLVELANQLR---GSGEEVptTGlSTS 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   132 ENLSFLLEALQKGNRTsscpVIFILDEFDLFAhQKNQTLLYNLFDISQSAQT---PIAVIGLTCRLDILELLEKRVKSRF 208
Cdd:TIGR02928 115 EVFRRLYKELNERGDS----LIIVLDEIDYLV-GDDDDLLYQLSRARSNGDLdnaKVGVIGISNDLKFRENLDPRVKSSL 189
                         170
                  ....*....|....*.
gi 40018564   209 SHRQIHlmnsfdFPQY 224
Cdd:TIGR02928 190 CEEEII------FPPY 199
cdc6 PRK00411
ORC1-type DNA replication protein;
46-224 3.34e-11

ORC1-type DNA replication protein;


Pssm-ID: 234751 [Multi-domain]  Cd Length: 394  Bit Score: 64.48  E-value: 3.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   46 IELLK---RTAIYGESNS-LLIVGPRGSGKTTLLNHALKELMQIgdmSENVLQVHLNGLLQTNDKIALKEITRQLNLENV 121
Cdd:PRK00411  39 IEELAfalRPALRGSRPLnVLIYGPPGTGKTTTVKKVFEELEEI---AVKVVYVYINCQIDRTRYAIFSEIARQLFGHPP 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  122 --VG---DKVFGSFAEnlsflleALQKGNRTsscpVIFILDEFDLFAHQKNQTLLYNLFDISQSAQ-TPIAVIGLTCRLD 195
Cdd:PRK00411 116 psSGlsfDELFDKIAE-------YLDERDRV----LIVALDDINYLFEKEGNDVLYSLLRAHEEYPgARIGVIGISSDLT 184
                        170       180
                 ....*....|....*....|....*....
gi 40018564  196 ILELLEKRVKSRFSHRQIHlmnsfdFPQY 224
Cdd:PRK00411 185 FLYILDPRVKSVFRPEEIY------FPPY 207
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
44-211 4.19e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 57.93  E-value: 4.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  44 HLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHALKELmqiGDMSENVLQVHLNGLlqtndkialkeitrqlnLENVVG 123
Cdd:cd00009   5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDL-----------------LEGLVV 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564 124 DKVFGSFAENLSFLLEALQKgnrtsscPVIFILDEFDLFAHQKNQTLLYNL--FDISQSAQTPIAVIGLTCRLDILELLE 201
Cdd:cd00009  65 AELFGHFLVRLLFELAEKAK-------PGVLFIDEIDSLSRGAQNALLRVLetLNDLRIDRENVRVIGATNRPLLGDLDR 137
                       170
                ....*....|
gi 40018564 202 KRvKSRFSHR 211
Cdd:cd00009 138 AL-YDRLDIR 146
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
57-285 3.17e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 3.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  57 ESNSLLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNgllqtndkiaLKEITRQLNLENVVGDKVFGSFAENLSF 136
Cdd:COG5635 179 KKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIE----------LRDLAEEASLEDLLAEALEKRGGEPEDA 248
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564 137 LLEALQKGNrtsscpVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIgLTCRLDILEllekrvKSRFSHRQIHLM 216
Cdd:COG5635 249 LERLLRNGR------LLLLLDGLDEVPDEADRDEVLNQLRRFLERYPKARVI-ITSRPEGYD------SSELEGFEVLEL 315
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40018564 217 NSFDFPQylkIFKeqlslpaefpdkiFAEKWNENAHCLSEDstvlevLQKHFNVNKNLQSL----HMLLMLAL 285
Cdd:COG5635 316 APLSDEQ---IEE-------------FLKKWFEATERKAER------LLEALEENPELRELarnpLLLTLLAL 366
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
34-188 8.97e-08

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 51.74  E-value: 8.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    34 NLFGVQVQYKHLIELLKRTAIyGESNSLLIVGPRGSGKTTLLNHALKelmQIGDMSENVLQ---VHLNGLLQTNDKIALK 110
Cdd:pfam13191   1 RLVGREEELEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLR---ALERDGGYFLRgkcDENLPYSPLLEALTRE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   111 EITRQLNLENVV----------------GDKVFGSFAENLSFLLEALQKGNRTSSCPVIFILDEFDLFAHQkNQTLLYNL 174
Cdd:pfam13191  77 GLLRQLLDELESslleawraallealapVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEA-SLQLLAAL 155
                         170
                  ....*....|....
gi 40018564   175 FDISQsaQTPIAVI 188
Cdd:pfam13191 156 LRLLE--SLPLLVV 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
59-215 2.15e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.06  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564     59 NSLLIVGPRGSGKTTLLNHALKElmqigdmsenvLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLL 138
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARE-----------LGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLAL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    139 EALQKGNrtsscPVIFILDEFDLFAHQKNQTLL----YNLFDISQSAQTPIAVIGLTcrLDILELLEKRVKSRFSHRQIH 214
Cdd:smart00382  72 ALARKLK-----PDVLILDEITSLLDAEQEALLllleELRLLLLLKSEKNLTVILTT--NDEKDLGPALLRRRFDRRIVL 144

                   .
gi 40018564    215 L 215
Cdd:smart00382 145 L 145
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
46-159 7.76e-06

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 47.60  E-value: 7.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  46 IELLKRtAIYGESNSLLIV-GPRGSGKTTLLNHALKElmqigdmsENVlqVHLNgLLQTNDKIALKEITRQLN--LENVV 122
Cdd:COG1672   9 LEELEK-LYESDGGELVVVyGRRRVGKTSLIKEFLKE--------KPA--IYFD-AREESERESLRDFSEALAeaLGDPL 76
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 40018564 123 GDKVFGSFAENLSFLLEALQKGnrtsscPVIFILDEF 159
Cdd:COG1672  77 SKKEFESWEEAFEYLAELAEGK------RLVIVIDEF 107
AAA_22 pfam13401
AAA domain;
60-188 1.29e-05

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 44.64  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    60 SLLIVGPRGSGKTTLLNHALKELMQigdmsENVLQVHLNGLLQTNDKIALKEITRQLNLEnvvgdkvfGSFAENLSFLLE 139
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLPE-----VRDSVVFVDLPSGTSPKDLLRALLRALGLP--------LSGRLSKEELLA 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 40018564   140 ALQKGNRTSSCPVIFILDEFDLFahqkNQTLLYNLFDISQSAQTPIAVI 188
Cdd:pfam13401  74 ALQQLLLALAVAVVLIIDEAQHL----SLEALEELRDLLNLSSKLLQLI 118
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
61-212 1.50e-05

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.12  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    61 LLIVGPRGSGKTTLLnHALkelmqIGDMSENVLQVHLNGLLqtndkialkeitrqlnlenvvgDKVFGSFAENLSFLLEA 140
Cdd:pfam00004   1 LLLYGPPGTGKTTLA-KAV-----AKELGAPFIEISGSELV----------------------SKYVGESEKRLRELFEA 52
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   141 LQKGNrtsscPVIFILDEFDLFA----------HQKNQTLLYNLFDISQSAQTPIAVIGLTCRLDileLLEKRVKSRFSH 210
Cdd:pfam00004  53 AKKLA-----PCVIFIDEIDALAgsrgsggdseSRRVVNQLLTELDGFTSSNSKVIVIAATNRPD---KLDPALLGRFDR 124

                  ..
gi 40018564   211 RQ 212
Cdd:pfam00004 125 II 126
ATPase_2 pfam01637
ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is ...
61-249 3.66e-04

ATPase domain predominantly from Archaea; This family contain a conserved P-loop motif that is involved in binding ATP. There are eukaryote members as well as archaeal members in this family.


Pssm-ID: 376582 [Multi-domain]  Cd Length: 222  Bit Score: 41.54  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    61 LLIVGPRGSGKTTLLNHALKELMQIGDMSENVLQVHLNGLLQTNDKIALKEitrqlnLENVVGDKVFGSFAE-------N 133
Cdd:pfam01637  23 YVIYGPEGCGKTALLRESIENLLDLGYYVIYYDPLRRYFISKLDRFEEVRR------LAEALGIAVPKAELEesklaflA 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   134 LSFLLEALqkgNRTSSCPVIFILDEFDLFAHQKNQTL---LYNLFDISQSAQTPIAVIGLTC------RLDILELLEKRv 204
Cdd:pfam01637  97 IELLLEAL---KRRGKKIAIIIDEVQQAIGLNGAELLvkeLLNLIEYLTKEYHLCHVICLSSeglfieLVYYKSPLIGR- 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 40018564   205 ksrfsHRQIHLMnSFDFPQYLKIFKEQLSLPAEFPDKIFAEKWNE 249
Cdd:pfam01637 173 -----HRWALVD-PLDKETAWNFLKEGFKELYELSKEDFEEIWRY 211
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
42-158 4.54e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 42.24  E-value: 4.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564  42 YKHLIELLKRTAIygesnsLLIVGPRGSGKTTLLNHALKELMQIgdmsenvlqvhlngllqtndkialkeitRQLNLENv 121
Cdd:COG1373  10 LDKLLKLLDNRKA------VVITGPRQVGKTTLLKQLAKELENI----------------------------LYINLDD- 54
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 40018564 122 vgDKVFGSFAENLSFLLEALQKGNRTsscPVIFILDE 158
Cdd:COG1373  55 --PRLRALAEEDPDDLLEALKELYPG---KTYLFLDE 86
AAA_19 pfam13245
AAA domain;
57-99 5.79e-04

AAA domain;


Pssm-ID: 433059 [Multi-domain]  Cd Length: 136  Bit Score: 39.89  E-value: 5.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 40018564    57 ESNSLLIVGPrGSGKTTLLNHALKELMQIGDMSENVLQVHLNG 99
Cdd:pfam13245  11 SKVVLLTGGP-GTGKTTTIRHIVALLVALGGVSFPILLAAPTG 52
PTZ00112 PTZ00112
origin recognition complex 1 protein; Provisional
56-232 8.83e-04

origin recognition complex 1 protein; Provisional


Pssm-ID: 240274 [Multi-domain]  Cd Length: 1164  Bit Score: 41.90  E-value: 8.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    56 GESNSLLIVGPRGSGKTT-------LLNHALKELMQigdMSENVLQVhlNGLLQTNDKIALKEITRQLNleNVVGDKVFG 128
Cdd:PTZ00112  779 GSNQILYISGMPGTGKTAtvysviqLLQHKTKQKLL---PSFNVFEI--NGMNVVHPNAAYQVLYKQLF--NKKPPNALN 851
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564   129 SFaENLSFLLEALQKGNRTSScpvIFILDEFDlFAHQKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILELLEKRVKSRF 208
Cdd:PTZ00112  852 SF-KILDRLFNQNKKDNRNVS---ILIIDEID-YLITKTQKVLFTLFDWPTKINSKLVLIAISNTMDLPERLIPRCRSRL 926
                         170       180
                  ....*....|....*....|....
gi 40018564   209 SHRQIhLMNSFDFPQYLKIFKEQL 232
Cdd:PTZ00112  927 AFGRL-VFSPYKGDEIEKIIKERL 949
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
61-158 1.51e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 38.34  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    61 LLIVGPRGSGKTTLLNHALKELMQigdmSENVLQVHLngllqtnDKIALKEItrqlnlenvvgdkvfgSFAENLSFLLEA 140
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKELLP----PENILYINL-------DDPRLLKL----------------ADFELLELFLEL 57
                          90
                  ....*....|....*...
gi 40018564   141 LQKGNRtsscpvIFILDE 158
Cdd:pfam13173  58 LYPGKT------YLFLDE 69
VI_IcmF TIGR03348
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
38-78 2.56e-03

type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]


Pssm-ID: 274531 [Multi-domain]  Cd Length: 1169  Bit Score: 40.40  E-value: 2.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 40018564     38 VQVQYKHLIELLKRTAIYGEsNSL------LIVGPRGSGKTTLLNHA 78
Cdd:TIGR03348   86 LRARFNEALALLKRSRLGGR-RYLydlpwyLVIGPPGSGKTTLLQNS 131
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
60-122 2.72e-03

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 40.06  E-value: 2.72e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40018564  60 SLLIVGPRGSGKTTLLNhALkeLMqigdmsenvlqvhlngLLQTNDKIALKEITRQLNL--ENVV 122
Cdd:COG0630 292 SVLVAGGTASGKTTLLN-AL--LS----------------FIPPDAKIVTIEDTRELNLphENWI 337
DAP3 pfam10236
Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins ...
45-79 4.54e-03

Mitochondrial ribosomal death-associated protein 3; This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).


Pssm-ID: 431160  Cd Length: 310  Bit Score: 38.82  E-value: 4.54e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 40018564    45 LIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHAL 79
Cdd:pfam10236  10 LIKKLKAADKSKKVVRFVLTGEPGSGKSVLLLQAM 44
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
61-115 4.83e-03

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 39.02  E-value: 4.83e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40018564  61 LLIVGPRGSGKTTLLNHALKELMQIGDmseNVLQV------HLNGLLQT--NDKI------ALKEITRQ 115
Cdd:COG2804 316 ILVTGPTGSGKTTTLYAALNELNTPER---NIITVedpveyQLPGINQVqvNPKIgltfasALRSILRQ 381
AAA_35 pfam14516
AAA-like domain; This family of proteins are part of the AAA superfamily.
63-164 4.99e-03

AAA-like domain; This family of proteins are part of the AAA superfamily.


Pssm-ID: 373105  Cd Length: 331  Bit Score: 38.65  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40018564    63 IVGPRGSGKTTLLNHALKELMQIGDMSenvlqVHLNglLQTNDKIALK-----------EITRQLNLENVVG---DKVFG 128
Cdd:pfam14516  36 IKAPRQMGKTSLLLRILAYAQQQGYRT-----VYLD--FQLADKAILTdldkflrwfcaNISRQLGLPPKLDdywDEDLG 108
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 40018564   129 SfaeNLS-------FLLEALQKgnrtsscPVIFILDEFD-LFAH 164
Cdd:pfam14516 109 S---KVSctiyfedYLLPQIDR-------PLVLALDEVDrLFEY 142
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
60-115 5.19e-03

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 38.42  E-value: 5.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40018564    60 SLLIVGPRGSGKTTLLNHALKEL-------MQIGDMSENVL----QVHLN--GLLQTNDkiALKEITRQ 115
Cdd:pfam00437 132 NILVTGPTGSGKTTTLYAALGELntrdeniVTVEDPVEIQLeginQVQLNarAGVTFAD--LLRAILRQ 198
LolD COG1136
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];
56-76 6.44e-03

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440751 [Multi-domain]  Cd Length: 227  Bit Score: 38.10  E-value: 6.44e-03
                        10        20
                ....*....|....*....|.
gi 40018564  56 GESnsLLIVGPRGSGKTTLLN 76
Cdd:COG1136  34 GEF--VAIVGPSGSGKSTLLN 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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