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actin-histidine N-methyltransferase isoform b [Homo sapiens]
SET domain-containing protein( domain architecture ID 14442821)
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
SET_SETD3 | cd19176 | SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ... |
80-282 | 8.01e-132 | ||||
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1. : Pssm-ID: 380953 Cd Length: 251 Bit Score: 374.28 E-value: 8.01e-132
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Name | Accession | Description | Interval | E-value | ||||
SET_SETD3 | cd19176 | SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ... |
80-282 | 8.01e-132 | ||||
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1. Pssm-ID: 380953 Cd Length: 251 Bit Score: 374.28 E-value: 8.01e-132
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
105-137 | 3.90e-03 | ||||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 36.35 E-value: 3.90e-03
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Name | Accession | Description | Interval | E-value | ||||
SET_SETD3 | cd19176 | SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2. ... |
80-282 | 8.01e-132 | ||||
SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins; SETD3 (EC 2.1.1.43) is a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). It functions as a transcriptional activator that plays an important role in the transcriptional regulation of muscle cell differentiation via interaction with MYOD1. Pssm-ID: 380953 Cd Length: 251 Bit Score: 374.28 E-value: 8.01e-132
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SET_LSMT | cd10527 | SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ... |
95-281 | 1.80e-49 | ||||
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain. Pssm-ID: 380925 [Multi-domain] Cd Length: 236 Bit Score: 164.16 E-value: 1.80e-49
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SET_SpSET10-like | cd19180 | SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and ... |
84-282 | 4.34e-36 | ||||
SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; Schizosaccharomyces pombe SETD10 is a ribosomal S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b). Pssm-ID: 380957 Cd Length: 252 Bit Score: 129.77 E-value: 4.34e-36
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SET_SETD4 | cd19177 | SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ... |
99-286 | 4.12e-34 | ||||
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed. Pssm-ID: 380954 [Multi-domain] Cd Length: 245 Bit Score: 124.33 E-value: 4.12e-34
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SET_RBCMT | cd19179 | SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large ... |
96-279 | 6.22e-32 | ||||
SET domain found in chloroplastic ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase (RBCMT) and similar proteins; RBCMT (EC 2.1.1.127; also termed [Ribulose-bisphosphate carboxylase]-lysine N-methyltransferase, RuBisCO LSMT, RuBisCO methyltransferase, or rbcMT) methylates 'Lys-14' of the large subunit of RuBisCO. Pssm-ID: 380956 Cd Length: 237 Bit Score: 118.57 E-value: 6.22e-32
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SET_SETD6 | cd19178 | SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ... |
105-279 | 1.65e-23 | ||||
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Pssm-ID: 380955 [Multi-domain] Cd Length: 250 Bit Score: 96.22 E-value: 1.65e-23
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SET | pfam00856 | SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ... |
105-137 | 3.90e-03 | ||||
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure. Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 36.35 E-value: 3.90e-03
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Blast search parameters | ||||
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