cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|....*...
gi 40805832 131 VSDLMRMEKIVLEKVCWK 148
Cdd:cd20583  81 VSDMMRMEKIILEKLCWK 98

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|....*...
gi 40805832 131 VSDLMRMEKIVLEKVCWK 148
Cdd:cd20583  81 VSDMMRMEKIILEKLCWK 98

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832     59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPlatDLIRISQYrFTVSDLMRME 138
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTK---ELVHYTGY-FTEEEILRME 78

                   ....*
gi 40805832    139 KIVLE 143
Cdd:smart00385  79 RLLLE 83

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20583   1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFT 80

                        90
                ....*....|....*...
gi 40805832 131 VSDLMRMEKIVLEKVCWK 148
Cdd:cd20583  81 VSDMMRMEKIILEKLCWK 98

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFT 130
Cdd:cd20584   1 LRDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCT 80

                        90
                ....*....|....*
gi 40805832 131 VSDLMRMEKIVLEKV 145
Cdd:cd20584  81 VSDLKRMEKIISEKL 95

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832    20 LLEQESRCQPKVCglrLIESAHDNGLRMTARLRDFevkdLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGL 99
Cdd:pfam00134   6 LRELELKYLPKPD---YMDQQPDINPKMRAILIDW----LVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 40805832   100 SCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKV 149
Cdd:pfam00134  79 TCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  47 MTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQ 126
Cdd:cd20507  32 ITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKY--EEIYPPEIKDFVYITD 109

                        90
                ....*....|....*...
gi 40805832 127 YRFTVSDLMRMEKIVLEK 144
Cdd:cd20507 110 NAYTREEILQMERDILKT 127

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20567  68 FELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKY--EEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTL 145

                ..
gi 40805832 146 CW 147
Cdd:cd20567 146 EF 147

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  20 LLEQESRCQPKVCGLRliesahdNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGL 99
Cdd:cd20561  12 LREMEVKCKPKVGYMK-------KQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 40805832 100 SCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLE 143
Cdd:cd20561  85 AAMLLASKF--EEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK 126

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40805832  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEK 144
Cdd:cd20568  55 FRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNT 131

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40805832  71 ETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20515  75 EVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKE---TIPLTAEKLCIyTDNSITLQELLDWELLVLTKLKW 149

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  66 FGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20559  13 LRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEELFIQMEMHILNTL 92

                ..
gi 40805832 146 CW 147
Cdd:cd20559  93 NW 94

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  59 LLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPlatDLIRISQYrfTVSDLMRME 138
Cdd:cd00043   6 IRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLK---EIAKVSGV--SEKELRKAE 80

                ..
gi 40805832 139 KI 140
Cdd:cd00043  81 KE 82

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 40805832  71 ETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKV 145
Cdd:cd20508  67 ETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKF--DERCPPCVDDFLYICDDAYTREELLKMEREILKTL 139

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  17 LNALLEQESRCQPKVCGLRLIESahdnglRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGC 96
Cdd:cd20573  26 LQTMLKAEETCLPSVSYFKCVQK------EILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQL 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 40805832  97 VGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20573 100 LGATCMFLASKMKE---TIPLTAEKLCIyTDNSIRPEELLQMELLVLNKLKW 148

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  17 LNALLEQESRCQPKVCGLRLIESahdnglRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGC 96
Cdd:cd20575  27 LQNLLRLEERYVPRVSYFQCVQR------EIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQL 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 40805832  97 VGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20575 101 LGAVCMLLASKLRE---TTPLTIEKLCIyTDNSISPRQLLDWEILVLGKLKW 149

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  69 DTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEeerNVPLATDLIRI-SQYRFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20574  73 EEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKE---TIPLTAEKLCIyTDNSIKPQELLEWELVVLGKLKW 149

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  21 LEQESRCQPKvcglrliesaHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLS 100
Cdd:cd20565  15 LEEEQAVRPK----------YLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 40805832 101 CFYLAVKSieEERNVPLATDLIRISQYRFTVSDLMRMEKIVL 142
Cdd:cd20565  85 AMFIASKY--EEMYPPEIGDFAFVTDNTYTKHQIRQMEMKIL 124

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40805832  68 FDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEE----RNVPLATDliriSQYRFtvSDLMRM 137
Cdd:cd20521  20 FSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDiltiREAAWLTD----NTYKY--EDVVRM 87

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805832  51 LRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFL---SKMKVQPKHlgcVGLSCFYLAVKSieEERNVPLATDLIRISQY 127
Cdd:cd20524  54 LVRYYEKKLLEFCRAFKLPDSVLATALTYFKRFYlknSVMEYHPKE---IMLTCLYLACKV--EEFNISIDQFVGNIKES 128

                        90       100
                ....*....|....*....|
gi 40805832 128 RFTVSDLMRMEKIVLEKVCW 147
Cdd:cd20524 129 EKTAEIILEYELLLLQGLNF 148