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Conserved domains on  [gi|40805858|ref|NP_954993|]
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isthmin-2 isoform 1 precursor [Homo sapiens]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 11259316)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMOP smart00723
Adhesion-associated domain present in MUC4 and other proteins;
396-559 4.51e-45

Adhesion-associated domain present in MUC4 and other proteins;


:

Pssm-ID: 128962  Cd Length: 154  Bit Score: 156.60  E-value: 4.51e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858    396 MHDQDVDSCEKWLNCKSDFLiKYLSqMLRDLPSCPCAYPLEAMDSpvslqdehqGRsFRWRDASGPRER-LDIYQPTARF 474
Cdd:smart00723   1 ERPWDRDMCLRWLECDGQLP-NFLW-DLEDLPSCPCSLPQAVADS---------GR-FRPDDACDPDERiLCTYHPGARH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858    475 CLRSMLSGESsTLAAQHCCYDEDSRLLT----------RGKGAGMPNLI-STDFSPKLHFKFDTTPWILCKGDWSRLhav 543
Cdd:smart00723  69 CIRSMQSVES-TGAGQVCCYDAWGQLMTtddqpvikprRGHGAGTPPYIgSTEVPGLSHFKNDVEPYILCCKWADRP--- 144

                          170
                   ....*....|....*.
gi 40805858    544 lppnngRACTDNPLEE 559
Cdd:smart00723 145 ------QRCTMYYWRR 154
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 331-371 5.87e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.20  E-value: 5.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 40805858    331 EWSPWSPCSGNCSTGKQQRTRPC--------GYGCT--ATETRTCDLPSCP 371
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTRSCcspppqngGGPCTgeDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
AMOP smart00723
Adhesion-associated domain present in MUC4 and other proteins;
396-559 4.51e-45

Adhesion-associated domain present in MUC4 and other proteins;


Pssm-ID: 128962  Cd Length: 154  Bit Score: 156.60  E-value: 4.51e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858    396 MHDQDVDSCEKWLNCKSDFLiKYLSqMLRDLPSCPCAYPLEAMDSpvslqdehqGRsFRWRDASGPRER-LDIYQPTARF 474
Cdd:smart00723   1 ERPWDRDMCLRWLECDGQLP-NFLW-DLEDLPSCPCSLPQAVADS---------GR-FRPDDACDPDERiLCTYHPGARH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858    475 CLRSMLSGESsTLAAQHCCYDEDSRLLT----------RGKGAGMPNLI-STDFSPKLHFKFDTTPWILCKGDWSRLhav 543
Cdd:smart00723  69 CIRSMQSVES-TGAGQVCCYDAWGQLMTtddqpvikprRGHGAGTPPYIgSTEVPGLSHFKNDVEPYILCCKWADRP--- 144

                          170
                   ....*....|....*.
gi 40805858    544 lppnngRACTDNPLEE 559
Cdd:smart00723 145 ------QRCTMYYWRR 154
AMOP pfam03782
AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after ...
 400-539 1.75e-27

AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.


Pssm-ID: 461048  Cd Length: 143  Bit Score: 107.83  E-value: 1.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858   400 DVDSCEKWLNCKsdfliKYLSQMLRDLPSCPCAYPLEAMDSPVSLQDehQGRSFRWRdasgPRERLDiYQPTARFCLRSM 479
Cdd:pfam03782   1 AHDMCDNWYNCD-----RFLKNFLAELPSCPCTLPQALLDKGRFMPD--PRCDLDWN----PKETCT-YHPGAVHCVRSG 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40805858   480 LSGESstLAAQHCCYDEDSRLL-----------TRGKGAGMPNLISTDFSPKL-HFKFDTTPWILCK----GDWSR 539
Cdd:pfam03782  69 LPSFS--GSGQQCCYDDDGYLMltydsfwgstpDRGHDWGAPPYRSPPFVPGLsHWLHDVMPFYYCClwadEDCER 142
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 331-371 5.87e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.20  E-value: 5.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 40805858    331 EWSPWSPCSGNCSTGKQQRTRPC--------GYGCT--ATETRTCDLPSCP 371
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTRSCcspppqngGGPCTgeDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 331-370 1.16e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.43  E-value: 1.16e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 40805858   331 EWSPWSPCSGNCSTGKQQRTR-----------PCGygcTATETRTCDLPSC 370
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRtvivepqnggrPCP---ELLERRPCNLPPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 332-371 6.61e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 6.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 40805858  332 WSPWSPCSGNCSTGKQQRTRPCGY-GCTATETRTCDLPSCP 371
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILHeGCTTHMVEECEEEECP 283
 
Name Accession Description Interval E-value
AMOP smart00723
Adhesion-associated domain present in MUC4 and other proteins;
396-559 4.51e-45

Adhesion-associated domain present in MUC4 and other proteins;


Pssm-ID: 128962  Cd Length: 154  Bit Score: 156.60  E-value: 4.51e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858    396 MHDQDVDSCEKWLNCKSDFLiKYLSqMLRDLPSCPCAYPLEAMDSpvslqdehqGRsFRWRDASGPRER-LDIYQPTARF 474
Cdd:smart00723   1 ERPWDRDMCLRWLECDGQLP-NFLW-DLEDLPSCPCSLPQAVADS---------GR-FRPDDACDPDERiLCTYHPGARH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858    475 CLRSMLSGESsTLAAQHCCYDEDSRLLT----------RGKGAGMPNLI-STDFSPKLHFKFDTTPWILCKGDWSRLhav 543
Cdd:smart00723  69 CIRSMQSVES-TGAGQVCCYDAWGQLMTtddqpvikprRGHGAGTPPYIgSTEVPGLSHFKNDVEPYILCCKWADRP--- 144

                          170
                   ....*....|....*.
gi 40805858    544 lppnngRACTDNPLEE 559
Cdd:smart00723 145 ------QRCTMYYWRR 154
AMOP pfam03782
AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after ...
 400-539 1.75e-27

AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.


Pssm-ID: 461048  Cd Length: 143  Bit Score: 107.83  E-value: 1.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40805858   400 DVDSCEKWLNCKsdfliKYLSQMLRDLPSCPCAYPLEAMDSPVSLQDehQGRSFRWRdasgPRERLDiYQPTARFCLRSM 479
Cdd:pfam03782   1 AHDMCDNWYNCD-----RFLKNFLAELPSCPCTLPQALLDKGRFMPD--PRCDLDWN----PKETCT-YHPGAVHCVRSG 68

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40805858   480 LSGESstLAAQHCCYDEDSRLL-----------TRGKGAGMPNLISTDFSPKL-HFKFDTTPWILCK----GDWSR 539
Cdd:pfam03782  69 LPSFS--GSGQQCCYDDDGYLMltydsfwgstpDRGHDWGAPPYRSPPFVPGLsHWLHDVMPFYYCClwadEDCER 142
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 331-371 5.87e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.20  E-value: 5.87e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 40805858    331 EWSPWSPCSGNCSTGKQQRTRPC--------GYGCT--ATETRTCDLPSCP 371
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTRSCcspppqngGGPCTgeDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 331-370 1.16e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.43  E-value: 1.16e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 40805858   331 EWSPWSPCSGNCSTGKQQRTR-----------PCGygcTATETRTCDLPSC 370
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRtvivepqnggrPCP---ELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
331-370 5.12e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 5.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 40805858   331 EWSPWSPCSGNCSTGKQQRTRPC------GYGCTA--TETRTCDLPSC 370
Cdd:pfam00090   2 PWSPWSPCSVTCGKGIQVRQRTCkspfpgGEPCTGddIETQACKMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 332-371 6.61e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 6.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 40805858  332 WSPWSPCSGNCSTGKQQRTRPCGY-GCTATETRTCDLPSCP 371
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILHeGCTTHMVEECEEEECP 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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