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Conserved domains on  [gi|40806219|ref|NP_954994|]
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thymocyte nuclear protein 1 isoform 2 [Homo sapiens]

Protein Classification

EVE domain-containing protein( domain architecture ID 15340151)

EVE domain-containing protein belongs to the PUA superfamily and may bind RNA, similar to human thymocyte nuclear protein 1 that specifically binds 5-hydroxymethylcytosine

CATH:  3.10.590.10
Gene Ontology:  GO:0003723
PubMed:  19191354

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EVE cd21133
EVE domains are putative RNA-binding domains that belong to the PUA superfamily; The EVE ...
 55-160 4.28e-66

EVE domains are putative RNA-binding domains that belong to the PUA superfamily; The EVE domain, formerly known as DUF55, has been revealed via structural similarity to be part of the PUA superfamily. It is most similar in three-dimensional fold to the YTH (YT521-B homology) domain, and is thought to be involved in RNA-binding.


:

Pssm-ID: 410978  Cd Length: 148  Bit Score: 198.17  E-value: 4.28e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219  55 SHWLMKSEPESrlekgvdvkFSIEDLKAQPkQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAY 134
Cdd:cd21133   1 AYWLMKSEPDV---------FSIDDLKAEP-GTTPWDGVRNYQARNFMRDMKVGDLAFFYHSNCKEPGIVGIVEVVREAY 70

                        90       100
                ....*....|....*....|....*.
gi 40806219 135 PDHTQFEKNNPHYDPSSKEDNPKWSM 160
Cdd:cd21133  71 PDPTAFDPKSPYYDPKSTPENPRWYM 96
 
Name Accession Description Interval E-value
EVE cd21133
EVE domains are putative RNA-binding domains that belong to the PUA superfamily; The EVE ...
 55-160 4.28e-66

EVE domains are putative RNA-binding domains that belong to the PUA superfamily; The EVE domain, formerly known as DUF55, has been revealed via structural similarity to be part of the PUA superfamily. It is most similar in three-dimensional fold to the YTH (YT521-B homology) domain, and is thought to be involved in RNA-binding.


Pssm-ID: 410978  Cd Length: 148  Bit Score: 198.17  E-value: 4.28e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219  55 SHWLMKSEPESrlekgvdvkFSIEDLKAQPkQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAY 134
Cdd:cd21133   1 AYWLMKSEPDV---------FSIDDLKAEP-GTTPWDGVRNYQARNFMRDMKVGDLAFFYHSNCKEPGIVGIVEVVREAY 70

                        90       100
                ....*....|....*....|....*.
gi 40806219 135 PDHTQFEKNNPHYDPSSKEDNPKWSM 160
Cdd:cd21133  71 PDPTAFDPKSPYYDPKSTPENPRWYM 96
EVE COG2947
Predicted RNA-binding protein, contains EVE domain [General function prediction only];
56-160 8.07e-52

Predicted RNA-binding protein, contains EVE domain [General function prediction only];


Pssm-ID: 442190  Cd Length: 135  Bit Score: 161.81  E-value: 8.07e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219  56 HWLMKSEPEsrlekgvdvKFSIEDLKAqpKQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNcKEPGIAGLMKIVKEAYP 135
Cdd:COG2947   2 YWLMKSEPD---------VYSIDDLVA--DGTTPWDGVRNYQARNFLRAMKVGDLVFFYHSN-KEPGIVGIAEVVREAYP 69

                        90       100
                ....*....|....*....|....*
gi 40806219 136 DHTQFeknnphydpsskeDNPKWSM 160
Cdd:COG2947  70 DPTQF-------------DTPRWVM 81
EVE pfam01878
EVE domain; This domain was formerly known as DUF55. Crystal structures have shown that this ...
 55-160 2.10e-50

EVE domain; This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.


Pssm-ID: 396449  Cd Length: 146  Bit Score: 158.62  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219    55 SHWLMKSEPEsrlekgvdvKFSIEDLKaqPKQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAY 134
Cdd:pfam01878   1 AYWLMKSEPD---------VYSIDDLK--RGGTTGWDGVRNYQARNFLRAMKPGDLVFFYHSGCKPPAIVGIAEVVSEAY 69

                          90       100
                  ....*....|....*....|....*.
gi 40806219   135 PDHTQFEKNNPHYDPSSKEDNPKWSM 160
Cdd:pfam01878  70 PDPTQFDPKSPYYDPKSTPENPRWYR 95
 
Name Accession Description Interval E-value
EVE cd21133
EVE domains are putative RNA-binding domains that belong to the PUA superfamily; The EVE ...
 55-160 4.28e-66

EVE domains are putative RNA-binding domains that belong to the PUA superfamily; The EVE domain, formerly known as DUF55, has been revealed via structural similarity to be part of the PUA superfamily. It is most similar in three-dimensional fold to the YTH (YT521-B homology) domain, and is thought to be involved in RNA-binding.


Pssm-ID: 410978  Cd Length: 148  Bit Score: 198.17  E-value: 4.28e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219  55 SHWLMKSEPESrlekgvdvkFSIEDLKAQPkQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAY 134
Cdd:cd21133   1 AYWLMKSEPDV---------FSIDDLKAEP-GTTPWDGVRNYQARNFMRDMKVGDLAFFYHSNCKEPGIVGIVEVVREAY 70

                        90       100
                ....*....|....*....|....*.
gi 40806219 135 PDHTQFEKNNPHYDPSSKEDNPKWSM 160
Cdd:cd21133  71 PDPTAFDPKSPYYDPKSTPENPRWYM 96
EVE COG2947
Predicted RNA-binding protein, contains EVE domain [General function prediction only];
56-160 8.07e-52

Predicted RNA-binding protein, contains EVE domain [General function prediction only];


Pssm-ID: 442190  Cd Length: 135  Bit Score: 161.81  E-value: 8.07e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219  56 HWLMKSEPEsrlekgvdvKFSIEDLKAqpKQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNcKEPGIAGLMKIVKEAYP 135
Cdd:COG2947   2 YWLMKSEPD---------VYSIDDLVA--DGTTPWDGVRNYQARNFLRAMKVGDLVFFYHSN-KEPGIVGIAEVVREAYP 69

                        90       100
                ....*....|....*....|....*
gi 40806219 136 DHTQFeknnphydpsskeDNPKWSM 160
Cdd:COG2947  70 DPTQF-------------DTPRWVM 81
EVE pfam01878
EVE domain; This domain was formerly known as DUF55. Crystal structures have shown that this ...
 55-160 2.10e-50

EVE domain; This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.


Pssm-ID: 396449  Cd Length: 146  Bit Score: 158.62  E-value: 2.10e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40806219    55 SHWLMKSEPEsrlekgvdvKFSIEDLKaqPKQTTCWDGVRNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAY 134
Cdd:pfam01878   1 AYWLMKSEPD---------VYSIDDLK--RGGTTGWDGVRNYQARNFLRAMKPGDLVFFYHSGCKPPAIVGIAEVVSEAY 69

                          90       100
                  ....*....|....*....|....*.
gi 40806219   135 PDHTQFEKNNPHYDPSSKEDNPKWSM 160
Cdd:pfam01878  70 PDPTQFDPKSPYYDPKSTPENPRWYR 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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