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Conserved domains on  [gi|162417982|ref|NP_955459|]
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zinc finger protein 64 isoform d [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-603 1.39e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 172 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 249
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 250 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 326
Cdd:COG5048  100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 327 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 401
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 402 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 480
Cdd:COG5048  249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 481 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 546
Cdd:COG5048  318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 162417982 547 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 603
Cdd:COG5048  388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-603 1.39e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 172 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 249
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 250 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 326
Cdd:COG5048  100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 327 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 401
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 402 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 480
Cdd:COG5048  249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 481 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 546
Cdd:COG5048  318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 162417982 547 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 603
Cdd:COG5048  388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-341 3.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.97e-05
                          10        20
                  ....*....|....*....|....*.
gi 162417982  316 DLDRHLRIHTGDKPHKCEFCDKCFSR 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-603 1.39e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 172 DKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKC--KTCDYAAADSSSLNKHLRIHSderpfkcqicpYASRNSSQLTVH 249
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH-----------NNPSDLNSKSLP 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 250 LRSHTASELDDDVPkanclSTESTDTPKAPVITLPSEAREQMATLGERT---FNCCYPGCHFKTVHGMKDLDRHLRIHTG 326
Cdd:COG5048  100 LSNSKASSSSLSSS-----SSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 327 DKPHKCEFCDKCFSRKDNLtmhmrcHTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDE-----RPYKCQLCPYASRNSSQL 401
Cdd:COG5048  175 SLSKDPSSNLSLLISSNVS------TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpltTNSQLSPKSLLSQSPSSL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 402 TVHLRSHTGDTPFQCWLCSAKFKISSDLKRHMIVHSG-EKPFKCEFCDVRCTMKANLKSHIRIKHTfkclhcafqgrDRA 480
Cdd:COG5048  249 SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNH-----------SGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 481 DLLEHSrlhqadhpekCPE--CSYSCSSAAALRVHSRVHCKDRPFKCDFCSFDTKRPSSLAK------------HVDKVH 546
Cdd:COG5048  318 SLKPFS----------CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqqykdlKNDKKS 387

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 162417982 547 RDEAKTENRAPLGKEGLREGSSQHVAKivTQRAFRCETCGASFVRDDSLRCHKKQHS 603
Cdd:COG5048  388 ETLSNSCIRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
115-538 3.90e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 115 SNENQTATVISLPAKSRTKKPTTPPAQKRLNCCypGCQFKTAYGMKdmeRHLKIHTGDKPHKCEV--CGKCFSRKDKLKT 192
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNC--TDSFSRLEHLT---RHIRSHTGEKPSQCSYsgCDKSFSRPLELSR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 193 HMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHS-DERPFKCQICPYASRNSSQLTVHLRSHTASELDDDVPKANCLSTE 271
Cdd:COG5048   82 HLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSnSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 272 STDTPKAPVITLPseareqmatlgertfnccypgCHFKTVHGMKDLDRHLRIHTGDKPHKCEFCDKCFSRKDNLTMHMRC 351
Cdd:COG5048  162 PQSNSLHPPLPAN---------------------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 352 HTSVKPHKCHLCDYAAVDSSSLKKHLRIHSDERPYKCQLCPYASR------NSSQLTVHLRSHTG-DTPFQCWLCSAKFK 424
Cdd:COG5048  221 ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptassqSSSPNESDSSSEKGfSLPIKSKQCNISFS 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 425 ISSDLKRHM--IVHSGE--KPFKC--EFCDVRCTMKANLKSHIRIkHTFKCLHCA--------FQGRDRADLLEHSRLHQ 490
Cdd:COG5048  301 RSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL-HTSISPAKEkllnssskFSPLLNNEPPQSLQQYK 379

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 162417982 491 ADHPEKCPECSYSCSSAAALR-----VHSRVHCKDRP--FKCDFCSFDTKRPSSL 538
Cdd:COG5048  380 DLKNDKKSETLSNSCIRNFKRdsnlsLHIITHLSFRPynCKNPPCSKSFNRHYNL 434
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-341 3.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.97e-05
                          10        20
                  ....*....|....*....|....*.
gi 162417982  316 DLDRHLRIHTGDKPHKCEFCDKCFSR 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
314-445 1.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 314 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 383
Cdd:COG5048  302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 162417982 384 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 445
Cdd:COG5048  382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 2.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 162417982  161 DMERHLKIHTGDKPHKCEVCGKCFSR 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 382-465 3.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 382 DERPYKCQL--CPYASRNSSQLTVH-LRSHtgdtpfqcwlCSAKFKISSDLKRHMIVHSGEKPFKCEFCDVRCTMKANLK 458
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 162417982 459 SHIRIKH 465
Cdd:COG5189  416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
190-211 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|..
gi 162417982  190 LKTHMRCHTGVKPYKCKTCDYA 211
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-452 2.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.65e-03
                          10        20
                  ....*....|....*....|....*
gi 162417982  428 DLKRHMIVHSGEKPFKCEFCDVRCT 452
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
201-371 2.75e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 201 KPYKCKTCDYAAADSSSLNKHLR--IHSDE--RPFKC--QICPYASRNSSQLTVHLRSHTaselddDVPKANCLSTESTD 274
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT------SISPAKEKLLNSSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162417982 275 TPKAPVITLPSEAREQMATL-GERTFNCCYPGC--HFKTVHGMKdldRHLRIHTGDKPHKCEF--CDKCFSRKDNLTMHM 349
Cdd:COG5048  362 KFSPLLNNEPPQSLQQYKDLkNDKKSETLSNSCirNFKRDSNLS---LHIITHLSFRPYNCKNppCSKSFNRHYNLIPHK 438

                        170       180
                 ....*....|....*....|..
gi 162417982 350 RCHTSVKPHKCHLCDYAAVDSS 371
Cdd:COG5048  439 KIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-366 5.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.26e-03
                          10        20
                  ....*....|....*....|...
gi 162417982  344 NLTMHMRCHTSVKPHKCHLCDYA 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
203-226 7.08e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.45  E-value: 7.08e-03
                          10        20
                  ....*....|....*....|....
gi 162417982  203 YKCKTCDYAAADSSSLNKHLRIHS 226
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHT 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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