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Conserved domains on  [gi|41152273|ref|NP_957020|]
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neuroendocrine protein 7B2 precursor [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Secretogranin_V super family cl05037
Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a ...
 30-199 7.98e-14

Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.


The actual alignment was detected with superfamily member pfam05281:

Pssm-ID: 368368  Cd Length: 230  Bit Score: 68.00  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152273    30 TVDQVSEADIQRLLHG---VMEQLGIARPRV---EYPAHqaTNIVGPLSIQGGAHEGLQHLGPygnipnIVAelTGDSVP 103
Cdd:pfam05281  34 NVDLVSRSEYARLCDGgsdCLLQSNNPNPSLrdqEFLQH--SSLWGHQFVSGGMGEGPNRYKT------IVK--TDASLP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152273   104 kdfsedhGYPDPPNPCPLG---KTAADGCLENSPDTAEFSREFQKHQ-------HLFD-PEHDYPALAKWNKGL------ 166
Cdd:pfam05281 104 -------AYCNPPNPCPEGydvETQGGGCIMDFENTAIFSREFQAAQdctcdseHMFDcSQENAADVGEGDGDLdsaveq 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 41152273   167 -----------------LYEKLKGGPKRRKRSVPNPYLMGQRLDnVVAKK 199
Cdd:pfam05281 177 filhqfgnenslnnhnnLVKKAGHMPDPRIKAVINPFLQGDRLP-IAAKK 225
 
Name Accession Description Interval E-value
Secretogranin_V pfam05281
Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a ...
 30-199 7.98e-14

Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.


Pssm-ID: 368368  Cd Length: 230  Bit Score: 68.00  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152273    30 TVDQVSEADIQRLLHG---VMEQLGIARPRV---EYPAHqaTNIVGPLSIQGGAHEGLQHLGPygnipnIVAelTGDSVP 103
Cdd:pfam05281  34 NVDLVSRSEYARLCDGgsdCLLQSNNPNPSLrdqEFLQH--SSLWGHQFVSGGMGEGPNRYKT------IVK--TDASLP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152273   104 kdfsedhGYPDPPNPCPLG---KTAADGCLENSPDTAEFSREFQKHQ-------HLFD-PEHDYPALAKWNKGL------ 166
Cdd:pfam05281 104 -------AYCNPPNPCPEGydvETQGGGCIMDFENTAIFSREFQAAQdctcdseHMFDcSQENAADVGEGDGDLdsaveq 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 41152273   167 -----------------LYEKLKGGPKRRKRSVPNPYLMGQRLDnVVAKK 199
Cdd:pfam05281 177 filhqfgnenslnnhnnLVKKAGHMPDPRIKAVINPFLQGDRLP-IAAKK 225
 
Name Accession Description Interval E-value
Secretogranin_V pfam05281
Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a ...
 30-199 7.98e-14

Neuroendocrine protein 7B2 precursor (Secretogranin V); The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia.


Pssm-ID: 368368  Cd Length: 230  Bit Score: 68.00  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152273    30 TVDQVSEADIQRLLHG---VMEQLGIARPRV---EYPAHqaTNIVGPLSIQGGAHEGLQHLGPygnipnIVAelTGDSVP 103
Cdd:pfam05281  34 NVDLVSRSEYARLCDGgsdCLLQSNNPNPSLrdqEFLQH--SSLWGHQFVSGGMGEGPNRYKT------IVK--TDASLP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41152273   104 kdfsedhGYPDPPNPCPLG---KTAADGCLENSPDTAEFSREFQKHQ-------HLFD-PEHDYPALAKWNKGL------ 166
Cdd:pfam05281 104 -------AYCNPPNPCPEGydvETQGGGCIMDFENTAIFSREFQAAQdctcdseHMFDcSQENAADVGEGDGDLdsaveq 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 41152273   167 -----------------LYEKLKGGPKRRKRSVPNPYLMGQRLDnVVAKK 199
Cdd:pfam05281 177 filhqfgnenslnnhnnLVKKAGHMPDPRIKAVINPFLQGDRLP-IAAKK 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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