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Conserved domains on  [gi|41053609|ref|NP_957147|]
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superkiller complex protein 8 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-302 9.46e-91

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 275.64  E-value: 9.46e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  13 HAHEDAIWTAAWGRsekDGSeTIVTGSLDDLVKVWKWSDEKLelQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:COG2319 117 TGHTGAVRSVAFSP---DGK-TLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  93 LETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSS 252
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 41053609 253 DKSIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-302 9.46e-91

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 275.64  E-value: 9.46e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  13 HAHEDAIWTAAWGRsekDGSeTIVTGSLDDLVKVWKWSDEKLelQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:COG2319 117 TGHTGAVRSVAFSP---DGK-TLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  93 LETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSS 252
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 41053609 253 DKSIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-302 2.63e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.22  E-value: 2.63e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  15 HEDAIWTAAWGrsekDGSETIVTGSLDDLVKVWKWSDEKLELqwTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWDLE 94
Cdd:cd00200   8 HTGGVTCVAFS----PDGKLLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  95 TGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDK 254
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 41053609 255 SIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-259 3.29e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.87  E-value: 3.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   80 ASSSLDAHIRLWDLETGKQIKSMDAGPVDAWTVAF-SPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSP 158
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSE 628

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  159 DGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIRSLTFSpDSQLLVTASDDGYIKIYDVQhANLAG-------TLSG 230
Cdd:PLN00181 629 SGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS-MSISGinetplhSFMG 706

                        170       180
                 ....*....|....*....|....*....
gi 41053609  231 HGSWVLSVAFSPDDTHFVSSSSDKSIKVW 259
Cdd:PLN00181 707 HTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 1.76e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 1.76e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053609    179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-218 1.59e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.59e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41053609   180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 169-267 1.95e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 42.33  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   169 DGIINIFDIATGKLLHTLEGHAMPiRSLTFSPDSQLL-VTASDDGYIKIYDVQHANLAGTL-SGHGSWVLsvAFSPDDTH 246
Cdd:TIGR03866  20 DNTISVIDTATLKVTRTFPVGQRP-RGITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLpSGPDPEQF--ALHPNGKI 96

                          90       100
                  ....*....|....*....|..
gi 41053609   247 -FVSSSSDKSIKVWDTSSRSCV 267
Cdd:TIGR03866  97 lYIANEDDALVTVIDIETRKVL 118
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-302 9.46e-91

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 275.64  E-value: 9.46e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  13 HAHEDAIWTAAWGRsekDGSeTIVTGSLDDLVKVWKWSDEKLelQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:COG2319 117 TGHTGAVRSVAFSP---DGK-TLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  93 LETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSS 252
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 41053609 253 DKSIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
13-302 1.08e-83

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 257.53  E-value: 1.08e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  13 HAHEDAIWTAAWGRsekdGSETIVTGSLDDLVKVWKWSDEklELQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:COG2319  75 LGHTAAVLSVAFSP----DGRLLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  93 LETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSS 252
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 41053609 253 DKSIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
21-302 2.01e-79

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 246.75  E-value: 2.01e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  21 TAAWGRSEKDGSETIVTGSLDDLVKVWKWSDEKLELQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWDLETGKQIK 100
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 101 SMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWD 260
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 41053609 261 TSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
13-263 5.65e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.89  E-value: 5.65e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  13 HAHEDAIWTAAWGRsekDGSeTIVTGSLDDLVKVWKWSDEKLelQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:COG2319 159 TGHSGAVTSVAFSP---DGK-LLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  93 LETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGII 172
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 173 NIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSS 252
Cdd:COG2319 313 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392

                       250
                ....*....|.
gi 41053609 253 DKSIKVWDTSS 263
Cdd:COG2319 393 DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-302 2.63e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.22  E-value: 2.63e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  15 HEDAIWTAAWGrsekDGSETIVTGSLDDLVKVWKWSDEKLELqwTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWDLE 94
Cdd:cd00200   8 HTGGVTCVAFS----PDGKLLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  95 TGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINI 174
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDK 254
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 41053609 255 SIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
36-302 9.04e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.40  E-value: 9.04e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  36 VTGSLDDLVKVWKWSDEKLELQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWDLETGKQIKSMDAGPVDAWTVAFS 115
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 116 PDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
Cdd:COG2319  88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWDTSSRSCVNTFFDHQD 275
Cdd:COG2319 168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                       250       260
                ....*....|....*....|....*..
gi 41053609 276 QVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 248 SVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-302 4.62e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.34  E-value: 4.62e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  59 TLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWDLETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESG 138
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 139 KKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 219 VQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAI 298
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243


                ....
gi 41053609 299 HIYD 302
Cdd:cd00200 244 RVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
73-302 1.74e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.72  E-value: 1.74e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  73 SQNGAIAASSSLDAHIRLWDLETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFIL 152
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 153 SIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHG 232
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 233 SWVLSVAFSPDDTHFVSSSSDKSIKVWDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
113-302 1.36e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.36e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 113 AFSPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP 192
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 193 IRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWDTSSRSCVNTFFD 272
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190
                ....*....|....*....|....*....|
gi 41053609 273 HQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-302 1.15e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.36  E-value: 1.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 182 LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWDT 261
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 41053609 262 SSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
14-212 1.22e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 68.95  E-value: 1.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  14 AHEDAIWTAAWGRSEKDGSETIVTGSLDDLVKVWKWSDEKLELQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWDL 93
Cdd:COG3391  18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  94 ETGKQIKSMDAGPvDAWTVAFSPDSKYI-ATGSHLGKVNIFGVESGKKEHSLDTrGKFILSIAYSPDGKYL-----ASGA 167
Cdd:COG3391  98 ATGKVVATIPVGG-GPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGKRLyvansGSNT 175

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 41053609 168 IDGIINIFDIATGKLLHTLEGHAMPIrSLTFSPD-SQLLVTASDDG 212
Cdd:COG3391 176 VSVIVSVIDTATGKVVATIPVGGGPV-GVAVSPDgRRLYVANRGSN 220
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 112-243 3.63e-13

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 70.07  E-value: 3.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  112 VAFSPDSKYIA-----TGSHlgKVNIFGVESGKKEHSL-DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK---L 182
Cdd:COG4946  348 PAWSPDGKSIAyfsdaSGEY--ELYIAPADGSGEPKQLtLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKvrkV 425

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41053609  183 LHtlEGHAMPIRSLTFSPDSQLLVTASDDGY----IKIYDVQhanlAGT---LSGHGSWVLSVAFSPD 243
Cdd:COG4946  426 DT--DGYGDGISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVE----TGKtvqLTDGRYDDGSPAFSPD 487
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
103-264 9.12e-12

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.56  E-value: 9.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 103 DAGPVDAWTVAFSPDSKYI-ATGSHLGKVNIFGVESGKKEHSLDTrGKFILSIAYSPDGKYL-ASGAIDGIINIFDIATG 180
Cdd:COG3391  64 AAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPV-GGGPRGLAVDPDGGRLyVADSGNGRVSVIDTATG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 181 KLLHTLEGHAMPiRSLTFSPDSQLLVTASDDG-----YIKIYDVQHANLAGTLSGhGSWVLSVAFSPDDTH-FV------ 248
Cdd:COG3391 143 KVVATIPVGAGP-HGIAVDPDGKRLYVANSGSntvsvIVSVIDTATGKVVATIPV-GGGPVGVAVSPDGRRlYVanrgsn 220

                       170
                ....*....|....*..
gi 41053609 249 -SSSSDKSIKVWDTSSR 264
Cdd:COG3391 221 tSNGGSNTVSVIDLATL 237
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 77-219 1.22e-10

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 58.92  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  77 AIAASSSLDAHIRLWDLETGKQIK-----SMDAGPvdawtvAFSPDSKYIA-TGSHLGKVNIFGVE-SGKKEHSLDTRGK 149
Cdd:COG0823   2 AFTLSRDGNSDIYVVDLDGGEPRRltnspGIDTSP------AWSPDGRRIAfTSDRGGGPQIYVVDaDGGEPRRLTFGGG 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41053609 150 FILSIAYSPDGKYLA-SGAIDGIINIF--DIATGKLLHTLEGHAMPirslTFSPDSQLLVTASD-DGYIKIYDV 219
Cdd:COG0823  76 YNASPSWSPDGKRLAfVSRSDGRFDIYvlDLDGGAPRRLTDGPGSP----SWSPDGRRIVFSSDrGGRPDLYVV 145
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-259 3.29e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.87  E-value: 3.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   80 ASSSLDAHIRLWDLETGKQIKSMDAGPVDAWTVAF-SPDSKYIATGSHLGKVNIFGVESGKKEHSLDTRGKFILSIAYSP 158
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSE 628

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  159 DGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIRSLTFSpDSQLLVTASDDGYIKIYDVQhANLAG-------TLSG 230
Cdd:PLN00181 629 SGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS-MSISGinetplhSFMG 706

                        170       180
                 ....*....|....*....|....*....
gi 41053609  231 HGSWVLSVAFSPDDTHFVSSSSDKSIKVW 259
Cdd:PLN00181 707 HTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 112-305 1.66e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.56  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  112 VAFSPDSKYIATGSHLGKVNIFGVES----GKKEH----SLDTRGKfILSIAYSPDGK-YLASGAIDGIINIFDIATGKL 182
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELASRSK-LSGICWNSYIKsQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  183 LHTLEGHAMPIRSLTF-SPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSwVLSVAFsPDDT--HFVSSSSDKSIKVW 259
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF-PSESgrSLAFGSADHKVYYY 645

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 41053609  260 D-TSSRSCVNTFFDHQDQVWSVKYNPTgSKIVSAGDDRAIHIYDCPM 305
Cdd:PLN00181 646 DlRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLWDLSM 691
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 1.76e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 1.76e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053609    179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 188-302 6.16e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.82  E-value: 6.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  188 GHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLAGTLS-------GHGSWVLSVAFSPDDTHFVSSS-SDKSIKV 258
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHTKKVGIVSFHPSAMNVLASAgADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 41053609  259 WDTSSRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-260 1.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.02e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 41053609    227 TLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWD 260
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-218 1.59e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.59e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41053609   180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 112-199 2.57e-08

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 50.74  E-value: 2.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   112 VAFSPDSKYIATGSHLGKVNIFGVeSGKK--EHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRL-NWQRvwTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79

                          90
                  ....*....|
gi 41053609   190 AMPIRSLTFS 199
Cdd:pfam12894  80 SDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
226-260 3.54e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.54e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 41053609   226 GTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWD 260
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
198-303 4.08e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 4.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWDTSSRSCVNTFFDHQDQV 277
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100
                ....*....|....*....|....*.
gi 41053609 278 WSVKYNPTGSKIVSAGDDRAIHIYDC 303
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDL 107
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 93-181 5.37e-08

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 54.27  E-value: 5.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   93 LETGKQIKSmdAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHsLDT--RGKFILSIAYSPDGKYLASGAIDG 170
Cdd:COG4946  377 SGEPKQLTL--GDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRK-VDTdgYGDGISDLAWSPDSKWLAYSKPGP 453

                         90
                 ....*....|....*
gi 41053609  171 ----IINIFDIATGK 181
Cdd:COG4946  454 nqlsQIFLYDVETGK 468
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 89-164 6.36e-08

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 53.89  E-value: 6.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   89 RLW--DLETGKQIKsMDAGP--VDAWTVAFSPDSKYIA----TGSHLGKVNIFGVESGKKeHSLdTRGKFI-LSIAYSPD 159
Cdd:COG4946  411 RLWvvDLASGKVRK-VDTDGygDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKT-VQL-TDGRYDdGSPAFSPD 487


                 ....*
gi 41053609  160 GKYLA 164
Cdd:COG4946  488 GKYLY 492
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 86-218 2.07e-07

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 51.90  E-value: 2.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  86 AHIRLWDLETGKQIKSMDAG------PVD------AWTVA----FSPdskyiATGSHlgKVNIFGVESGKKEHSLDTRGK 149
Cdd:cd20778 210 GLLDLWKPERGVRRILLDYGkgeeklPVYkmphleGWAVAgdkaFVP-----AVGEH--RVLVYDTNDWKFIKSIPLAGQ 282

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41053609 150 FILSIAySPDGKYLA---SGAIDGIINIFDIATGKLLHTLE--GHAMPIRsltFSPD-SQLLVTASDDGYIKIYD 218
Cdd:cd20778 283 PVFAVA-RPDGRYVWvnfSGPDNDTVQVIDTKTLKVVKTLEpgKRVLHME---FTPRgEAVYISVNDDNKVVVYD 353
PTZ00421 PTZ00421
coronin; Provisional
 112-261 4.74e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  112 VAFSP-DSKYIATGSHLGKVNIFGV-ESGKKEHSLD--------TRGKFILSIAYSPDGkYLASGAIDGIINIFDIATGK 181
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGIpEEGLTQNISDpivhlqghTKKVGIVSFHPSAMN-VLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  182 LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGS-------W------VLSVAFspddthfv 248
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaksqrclWakrkdlIITLGC-------- 231

                        170
                 ....*....|...
gi 41053609  249 SSSSDKSIKVWDT 261
Cdd:PTZ00421 232 SKSQQRQIMLWDT 244
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 123-259 1.81e-06

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 47.65  E-value: 1.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   123 TGSHLGKVNIFGVESGKKEhsLDTRGKfILSIAYSPDGK--YLASGAIDGIINIFDiATGKLLHTLEGHamPIRSLTFSP 200
Cdd:pfam08662  37 GETNLYLIGETGGPDCVVE--LDKEGP-IHDVAWSPNGKefAVIYGYMPAKVSFFD-LKGNVIHSFGEQ--PRNTIFWSP 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41053609   201 DSQLLVTA---SDDGYIKIYDVQHANLAGTLsgHGSWVLSVAFSPDDTHFVSSSS------DKSIKVW 259
Cdd:pfam08662 111 FGRLVLLAgfgNLAGDIEFWDVVNKKKIATA--EASNATLCEWSPDGRYFLTATTaprlrvDNGFKIW 176
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-302 3.04e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053609    263 SRSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 87-184 1.04e-05

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 46.47  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  87 HIRLWDLETG-KQIKSMDAGPvdawTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLdtRGKF---ILSIAYSPD--G 160
Cdd:cd22850 216 QVRLYDTSAGrRPVFSEKPIK----KPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRL--LGKYggsITGAVRHPElfD 289

                        90       100
                ....*....|....*....|....
gi 41053609 161 KYLASGAIDGIINIFDIATGKLLH 184
Cdd:cd22850 290 PYLASGGLDRYLRVFDIETRELLA 313
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-302 1.04e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  135 VESGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD----IATGKLLH----TLEGHAmPIRSLTFSPDSQLLV 206
Cdd:PLN00181 470 VKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRS-KLSGICWNSYIKSQV 548

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  207 TASD-DGYIKIYDVQHANLAGTLSGHGSWVLSVAF-SPDDTHFVSSSSDKSIKVWDTSSRSCVNTfFDHQDQVWSVKY-N 283
Cdd:PLN00181 549 ASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGT-IKTKANICCVQFpS 627

                        170
                 ....*....|....*....
gi 41053609  284 PTGSKIVSAGDDRAIHIYD 302
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYD 646
PTZ00421 PTZ00421
coronin; Provisional
 151-302 1.65e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  151 ILSIAYSP-DGKYLASGAIDGIINIFDIATGKL-------LHTLEGHAMPIRSLTFSPDSQ-LLVTASDDGYIKIYDVQH 221
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVER 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  222 ANLAGTLSGHGSWVLSVAFSPDDTHFVSSSSDKSIKVWDTSSRSCVNTFFDH-----QDQVWSVKYNPTGSKIVSAGDDR 296
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHasaksQRCLWAKRKDLIITLGCSKSQQR 237


                 ....*.
gi 41053609  297 AIHIYD 302
Cdd:PTZ00421 238 QIMLWD 243
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 116-220 4.32e-05

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 44.53  E-value: 4.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 116 PDSKYIATGSHLGKVNIFGVESGKKE-HSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHA-MPI 193
Cdd:cd22857 190 DDHRKIVTGTGYHQVRLYDTRAQRRPvVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCgGSI 269

                        90       100
                ....*....|....*....|....*..
gi 41053609 194 RSLTFSPDSQLLVTASDDGYIKIYDVQ 220
Cdd:cd22857 270 RSIARHPELPLIASCGLDRYLRIWDTE 296
PTZ00420 PTZ00420
coronin; Provisional
 186-302 4.83e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  186 LEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLA--------GTLSGHGSWVLSVAFSPDDTHFVSSSS-DKS 255
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESvkeikdpqCILKGHKKKISIIDWNPMNYYIMCSSGfDSF 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 41053609  256 IKVWDTSSRScvNTF-FDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:PTZ00420 150 VNIWDIENEK--RAFqINMPKKLSSLKWNIKGNLLSGTCVGKHMHIID 195
WD40 pfam00400
WD domain, G-beta repeat;
264-302 5.29e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41053609   264 RSCVNTFFDHQDQVWSVKYNPTGSKIVSAGDDRAIHIYD 302
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
55-92 1.74e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 41053609    55 ELQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 169-267 1.95e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 42.33  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   169 DGIINIFDIATGKLLHTLEGHAMPiRSLTFSPDSQLL-VTASDDGYIKIYDVQHANLAGTL-SGHGSWVLsvAFSPDDTH 246
Cdd:TIGR03866  20 DNTISVIDTATLKVTRTFPVGQRP-RGITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLpSGPDPEQF--ALHPNGKI 96

                          90       100
                  ....*....|....*....|..
gi 41053609   247 -FVSSSSDKSIKVWDTSSRSCV 267
Cdd:TIGR03866  97 lYIANEDDALVTVIDIETRKVL 118
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-176 2.28e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.28e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053609    137 SGKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 153-263 6.93e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 6.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  153 SIAYSPDGKYLA-----SGaIDGIInIFDIATG----KLLHTLEGHampIRSLTFSPDSQLLVTASDDGYIKIYDVqhAN 223
Cdd:COG4946  347 LPAWSPDGKSIAyfsdaSG-EYELY-IAPADGSgepkQLTLGDLGR---VFNPVWSPDGKKIAFTDNRGRLWVVDL--AS 419

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 41053609  224 laGTL-----SGHGSWVLSVAFSPDDTHFVSSSSDKS----IKVWDTSS 263
Cdd:COG4946  420 --GKVrkvdtDGYGDGISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVET 466
WD40 pfam00400
WD domain, G-beta repeat;
138-176 9.72e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 9.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 41053609   138 GKKEHSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 87-184 9.73e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 40.29  E-value: 9.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  87 HIRLWDLETGKQ-IKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHSLdtRGK---FILSIAYSPDGKY 162
Cdd:cd22857 203 QVRLYDTRAQRRpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCF--KGKcggSIRSIARHPELPL 280

                        90       100
                ....*....|....*....|..
gi 41053609 163 LASGAIDGIINIFDIATGKLLH 184
Cdd:cd22857 281 IASCGLDRYLRIWDTETRQLLS 302
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-92 1.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41053609     53 KLELQWTLEGHQLGVVSVNISQNGAIAASSSLDAHIRLWD 92
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
75-224 1.10e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 1.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  75 NGAIAASSSLDAHIRLWDLETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGK-KEHSLDTRGKFILS 153
Cdd:COG4257  27 DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGEiTTFALPGGGSNPHG 106

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053609 154 IAYSPDGKYLASGAIDGIINIFDIATGKL-LHTL-EGHAMPiRSLTFSPDSQLLVTASDDGYIKIYDVQHANL 224
Cdd:COG4257 107 IAFDPDGNLWFTDQGGNRIGRLDPATGEVtEFPLpTGGAGP-YGIAVDPDGNLWVTDFGANAIGRIDPDTGTL 178
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
154-235 1.53e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 39.89  E-value: 1.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 154 IAYSPDGKYL-ASGAIDGIINIFDI--ATGKLlhTLEGH-----AMPiRSLTFSPDSQLLVTAS-DDGYIKIYDVQHANl 224
Cdd:COG2706 256 IHISPDGRFLyVSNRGHNSIAVFAIdaDGGKL--TLVGHvptggKWP-RDFAIDPDGRFLLVANqKSDNITVFRIDADT- 331

                        90
                ....*....|.
gi 41053609 225 aGTLSGHGSWV 235
Cdd:COG2706 332 -GKLTPTGRSV 341
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 154-292 2.07e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 39.25  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609   154 IAYSPDGK--YLASGAIDgIINIFDIATGKLLHTLEGHAMPiRSLTFSPDSQLLVTAS-DDGYIKIYDVQHANLAGTLSg 230
Cdd:TIGR03866  46 ITFSKDGKllYVCASDSD-TIQVIDPATGEVLHTLPSGPDP-EQFALHPNGKILYIANeDDALVTVIDIETRKVLAQID- 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41053609   231 HGSWVLSVAFSPDDTHFVSSSSDKSIKVW-DTSSRSCV-NTFFDHQDQvwSVKYNPTGSKI-VSA 292
Cdd:TIGR03866 123 VGVEPEGMAVSPDGKIVVNTSETTNMAHWiDTATYEIVdNTLVDARPR--FAEFTADGKELwVSS 185
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 92-268 2.15e-03

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 39.24  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609  92 DLETGKQIKSMDAGPVDAWTVAFSPDSKYIATGSHLGKVNIFGVESGKKEHS----LDTRGkfilsIAYSPDGKYLASGA 167
Cdd:cd20718  44 DGSTHEVLGRIDDGGAQVHVVVFSPDGRFAYVISRDGWLTKIDLYTLRPVASirigVNSRG-----IALSDDGKYVIAGN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 168 ID-GIINIFDIATGKLLHTLEGHAM----PIRS-----LTFSPDSQLLVTASDDGYIKI--YDVQHANLAGTLSGHGSWV 235
Cdd:cd20718 119 YEpGHVVILDADTLEPLKVIPTTGVnddgIIESrvgaiLETPPGPYFLVALKDAGSVWVidYSDPDGNKVTDIGNIGRPL 198

                       170       180       190
                ....*....|....*....|....*....|....
gi 41053609 236 LSVAFSPDDTHF-VSSSSDKSIKVWDTSSRSCVN 268
Cdd:cd20718 199 HDAFLDPDGRYFiVASQGSNTMWVLDLKTGKVVA 232
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 123-252 2.67e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.73  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 123 TGSHLGKVNIFGVE-SGKKEHSLDTRGKFILSIAYSPDGKYLA-SGAIDGIINIF--DIATGK---LLHTLEGHAMPirs 195
Cdd:COG0823   4 TLSRDGNSDIYVVDlDGGEPRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGEprrLTFGGGYNASP--- 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41053609 196 lTFSPDSQLLVTASD-DGYIKIYDVqhanlagTLSGHGSWVLSV-----AFSPDDTHFVSSSS 252
Cdd:COG0823  81 -SWSPDGKRLAFVSRsDGRFDIYVL-------DLDGGAPRRLTDgpgspSWSPDGRRIVFSSD 135
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 186-241 4.30e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 4.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41053609   186 LEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHGSWVLSVAFS 241
Cdd:pfam12894  34 PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
112-247 5.34e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 37.96  E-value: 5.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 112 VAFSPDSKYIATGSHL--GKVNIFGVESGKKE----HSLDTRGKFILSIAYSPDGKYLASGA-IDGIINIFDI-ATGKLL 183
Cdd:COG2706  50 LALSPDGRFLYAVNEVddGGVSAFRIDPADGTltllNTVSSGGASPCHLSVDPDGRFLFVANyGGGSVSVFPIdADGSLG 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 184 -------HTLEGHAMP------IRSLTFSPDSQLLVtASDDG--YIKIYDVQHANlaGTLSGHGSWVLS-------VAFS 241
Cdd:COG2706 130 epvqviqHEGSGPNPErqegphAHSVVFDPDGRFLY-VPDLGtdRIYVYRLDPAT--GKLPEPPEVSLPpgsgprhLAFH 206


                ....*.
gi 41053609 242 PDDTHF 247
Cdd:COG2706 207 PNGRFA 212
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 107-260 6.21e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 37.65  E-value: 6.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 107 VDAWT---VAFSPDSKYIATGSHLGKVNifGVESGKKEHSLDTRGKFILSIAY-------SPDGKYLASgaidgiINIFD 176
Cdd:cd14956  76 ADYWGdriQVFTLTGELQTIGGSSGSGP--GQFNAPRGVAVDADGNLYVADFGnqriqkfDPDGSFLRQ------WGGTG 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41053609 177 IATGKLLHtleghamPiRSLTFSPDSQLLVTasdDGY---IKIYDVQHaNLAGTLSGHGS------WVLSVAFSPDDTHF 247
Cdd:cd14956 148 IEPGSFNY-------P-RGVAVDPDGTLYVA---DTYndrIQVFDNDG-AFLRKWGGRGTgpgqfnYPYGIAIDPDGNVF 215

                       170
                ....*....|...
gi 41053609 248 VSSSSDKSIKVWD 260
Cdd:cd14956 216 VADFGNNRIQKFT 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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