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Conserved domains on  [gi|41327736|ref|NP_958441|]
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epidermal growth factor receptor isoform d precursor [Homo sapiens]

Protein Classification

Recep_L_domain and FU domain-containing protein( domain architecture ID 12013602)

Recep_L_domain and FU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 505-627 2.66e-60

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


:

Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 198.75  E-value: 2.66e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   505 VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTATCSGPGADNCTKCAH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   585 YIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 627
Cdd:pfam14843  81 FRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.06e-39

Furin-like cysteine rich region;


:

Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 142.96  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327736   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 6.01e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 122.73  E-value: 6.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327736   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-481 9.48e-31

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


:

Pssm-ID: 460032  Cd Length: 112  Bit Score: 116.56  E-value: 9.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITGFLLIQAWpeNRTDLHAFENLEIIRGRTKQHGQFSLAV 440
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   441 VSL-NITSLGLRSLKEISDGDVIISGNKNLCYANT-INWKKLF 481
Cdd:pfam01030  70 LDNpNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 505-627 2.66e-60

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 198.75  E-value: 2.66e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   505 VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTATCSGPGADNCTKCAH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   585 YIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 627
Cdd:pfam14843  81 FRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.06e-39

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 142.96  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327736   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 6.01e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 122.73  E-value: 6.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327736   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-481 9.48e-31

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 116.56  E-value: 9.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITGFLLIQAWpeNRTDLHAFENLEIIRGRTKQHGQFSLAV 440
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   441 VSL-NITSLGLRSLKEISDGDVIISGNKNLCYANT-INWKKLF 481
Cdd:pfam01030  70 LDNpNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU smart00261
Furin-like repeats;
552-598 1.90e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 45.19  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 41327736    552 NSECIQCHPECLpqamniTCTGRGPDNCIQCAH--YIDGPHCVKTCPAG 598
Cdd:smart00261   1 DGECKPCHPECA------TCTGPGPDDCTSCKHgfFLDGGKCVSECPPG 43
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 558-598 4.53e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 41.35  E-value: 4.53e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 41327736 558 CHPECLpqamniTCTGRGPDNCIQCAHYI--DGPHCVKTCPAG 598
Cdd:cd00064   2 CHPSCA------TCTGPGPDQCTSCRHGFylDGGTCVSECPEG 38
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 231-274 1.52e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 39.81  E-value: 1.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41327736 231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPPLMLYNPTT 274
Cdd:cd00064   1 PCHPSCA-TCTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEG 45
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 505-627 2.66e-60

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 198.75  E-value: 2.66e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   505 VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
Cdd:pfam14843   1 VCDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNILQGEPREYVVNSTCVPCHPECLPQNGTATCSGPGADNCTKCAH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   585 YIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 627
Cdd:pfam14843  81 FRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
Furin-like pfam00757
Furin-like cysteine rich region;
185-335 1.06e-39

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 142.96  E-value: 1.06e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   185 GSCQKCDPSCPNGSCWGAGeeNCQKltkiICAQQCSGRCRgkSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 264
Cdd:pfam00757  10 GTMEKCHSCCNNGYCWGPG--HCQK----VCPEQCKKRCT--KPGECCHEQCLGGCTGPNDSDCLACRHFNDEGTCVDQC 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327736   265 PPlmlynpttyqmdvnpeGKYSFGATCV--KKCPR------NYVVTDHGSCVRACGADsYEMEEDGVRKCKKCEGPCRK 335
Cdd:pfam00757  82 PP----------------GTYQFGWRCVtfKECPKshlpgyNPLVIHNGECVRECPSG-YTEVENNSRKCEPCEGLCPK 143
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 57-168 6.01e-33

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 122.73  E-value: 6.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736    57 NCEVVLGNLEITYVQRN---YDLSFLKTIQEVAGYVLIAL-NTVERIPLENLQIIRGNMYYENSYALAVLSNYDanktgL 132
Cdd:pfam01030   1 NCTVIYGNLEITLIDENndsELLSFLSNVEEITGYLLIANtNLVSLSFLPNLRIIRGRNLFDDNYALYILDNPN-----L 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 41327736   133 KELPMRNLQEILHGAVRFSNNPALCNVES-IQWRDIV 168
Cdd:pfam01030  76 TELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
Recep_L_domain pfam01030
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ...
 361-481 9.48e-31

Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain.


Pssm-ID: 460032  Cd Length: 112  Bit Score: 116.56  E-value: 9.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   361 NCTSISGDLHILPVAFRGDSFthtppldpqELDILKTVKEITGFLLIQAWpeNRTDLHAFENLEIIRGRTKQHGQFSLAV 440
Cdd:pfam01030   1 NCTVIYGNLEITLIDENNDSE---------LLSFLSNVEEITGYLLIANT--NLVSLSFLPNLRIIRGRNLFDDNYALYI 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 41327736   441 VSL-NITSLGLRSLKEISDGDVIISGNKNLCYANT-INWKKLF 481
Cdd:pfam01030  70 LDNpNLTELGLPSLKEITSGGVYIHNNPKLCYTETeILWKLLL 112
FU smart00261
Furin-like repeats;
552-598 1.90e-06

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 45.19  E-value: 1.90e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 41327736    552 NSECIQCHPECLpqamniTCTGRGPDNCIQCAH--YIDGPHCVKTCPAG 598
Cdd:smart00261   1 DGECKPCHPECA------TCTGPGPDDCTSCKHgfFLDGGKCVSECPPG 43
Furin-like pfam00757
Furin-like cysteine rich region;
497-598 1.72e-05

Furin-like cysteine rich region;


Pssm-ID: 395614 [Multi-domain]  Cd Length: 143  Bit Score: 45.12  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   497 NSCKATGQVCHALCSPEGCWGPEprDCVS-CRnvsrgRECVDKCNllegeprefvENSECiqCHPECLPQamnitCTGRG 575
Cdd:pfam00757   6 DVCPGTMEKCHSCCNNGYCWGPG--HCQKvCP-----EQCKKRCT----------KPGEC--CHEQCLGG-----CTGPN 61

                          90       100
                  ....*....|....*....|...
gi 41327736   576 PDNCIQCAHYIDGPHCVKTCPAG 598
Cdd:pfam00757  62 DSDCLACRHFNDEGTCVDQCPPG 84
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 190-265 2.82e-05

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 44.29  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327736   190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG--------KSPSDC--CHNQCA-----AGCTGPRESDCLVCRKF 254
Cdd:pfam14843   2 CDPLCSSEGCWGPGPDQCLSCRNFSRGGTCVESCNIlqgepreyVVNSTCvpCHPECLpqngtATCSGPGADNCTKCAHF 81

                          90
                  ....*....|.
gi 41327736   255 RDEATCKDTCP 265
Cdd:pfam14843  82 RDGPHCVSSCP 92
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 558-598 4.53e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 41.35  E-value: 4.53e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 41327736 558 CHPECLpqamniTCTGRGPDNCIQCAHYI--DGPHCVKTCPAG 598
Cdd:cd00064   2 CHPSCA------TCTGPGPDQCTSCRHGFylDGGTCVSECPEG 38
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 231-274 1.52e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 39.81  E-value: 1.52e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 41327736 231 CCHNQCAaGCTGPRESDCLVCRKFR--DEATCKDTCPPLMLYNPTT 274
Cdd:cd00064   1 PCHPSCA-TCTGPGPDQCTSCRHGFylDGGTCVSECPEGTYADTEG 45
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 506-559 7.09e-03

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 35.19  E-value: 7.09e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41327736 506 CHALCspEGCWGPEPRDCVSCRNVS--RGRECVDKCnllegePREFVENSECIQCH 559
Cdd:cd00064   2 CHPSC--ATCTGPGPDQCTSCRHGFylDGGTCVSEC------PEGTYADTEGGVCL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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