|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
438-678 |
2.53e-71 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
:
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 231.40 E-value: 2.53e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 438 IIGGSDADIKNFPWQVFFDNP----WAGGALINEYWVLTAAHVVEGN--REPTMYVGSTSVqTSRLAKSKMLTPEHVFIH 511
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLQYTggrhFCGGSLISPRWVLTAAHCVYSSapSNYTVRLGSHDL-SSNEGGGQVIKVKKVIVH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 512 PGWKLlevpegrTNFDNDIALVRLKDPVKMGPTVSPICLPgtSSDYNLMDGDLGLISGWGRTEKRDR-AVRLKAARLPVA 590
Cdd:cd00190 80 PNYNP-------STYDNDIALLKLKRPVTLSDNVRPICLP--SSGYNLPAGTTCTVSGWGRTSEGGPlPDVLQEVNVPIV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 591 PLRKCKEvkvekptADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNdktKFYAAGLVSWGPQCG---TYGLYT 666
Cdd:cd00190 151 SNAECKR-------AYSYGGTITDNMLCAGGLEgGKDACQGDSGGPLVCNDNG---RGVLVGIVSWGSGCArpnYPGVYT 220
|
250
....*....|..
gi 41393602 667 RVKNYVDWIMKT 678
Cdd:cd00190 221 RVSSYLDWIQKT 232
|
|
| CUB |
pfam00431 |
CUB domain; |
175-287 |
3.34e-31 |
|
CUB domain;
:
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 117.40 E-value: 3.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 175 CSGdVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQvvVTLRREDFDVEAADSAGNclDSLVFVAGDR----QFGPY 250
Cdd:pfam00431 1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFR--VKLTFQDFELEDHDECGY--DYVEIRDGPSasspLLGRF 75
|
90 100 110
....*....|....*....|....*....|....*..
gi 41393602 251 CGHGfpGPLNIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:pfam00431 76 CGSG--IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
18-129 |
2.12e-27 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
:
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 106.73 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 18 TMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrsSNNPHS 93
Cdd:cd00041 8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSspllGRFCG---STLPPP 84
|
90 100 110
....*....|....*....|....*....|....*.
gi 41393602 94 piveeFQVPYNKLQVIFKSDFSNeeRFTGFAAYYVA 129
Cdd:cd00041 85 -----IISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
143-171 |
2.34e-07 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
:
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 47.24 E-value: 2.34e-07
10 20
....*....|....*....|....*....
gi 41393602 143 CSHFCNNFIGGYFCSCPPEYFLHDDMKNC 171
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
294-355 |
2.74e-07 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
:
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 47.84 E-value: 2.74e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41393602 294 CPK-EDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEgrvgatSFYSTCQSNGKWSNSKLKCQ 355
Cdd:cd00033 1 CPPpPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
359-421 |
7.09e-07 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
:
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 46.75 E-value: 7.09e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41393602 359 CGIPESIENGKVEDPEST-LFGSVIRYTCEEPYYYMengGGGEYHCAGNGSWVnevlgPELPKC 421
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLI---GSSTITCLENGTWS-----PPPPTC 56
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
438-678 |
2.53e-71 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 231.40 E-value: 2.53e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 438 IIGGSDADIKNFPWQVFFDNP----WAGGALINEYWVLTAAHVVEGN--REPTMYVGSTSVqTSRLAKSKMLTPEHVFIH 511
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLQYTggrhFCGGSLISPRWVLTAAHCVYSSapSNYTVRLGSHDL-SSNEGGGQVIKVKKVIVH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 512 PGWKLlevpegrTNFDNDIALVRLKDPVKMGPTVSPICLPgtSSDYNLMDGDLGLISGWGRTEKRDR-AVRLKAARLPVA 590
Cdd:cd00190 80 PNYNP-------STYDNDIALLKLKRPVTLSDNVRPICLP--SSGYNLPAGTTCTVSGWGRTSEGGPlPDVLQEVNVPIV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 591 PLRKCKEvkvekptADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNdktKFYAAGLVSWGPQCG---TYGLYT 666
Cdd:cd00190 151 SNAECKR-------AYSYGGTITDNMLCAGGLEgGKDACQGDSGGPLVCNDNG---RGVLVGIVSWGSGCArpnYPGVYT 220
|
250
....*....|..
gi 41393602 667 RVKNYVDWIMKT 678
Cdd:cd00190 221 RVSSYLDWIQKT 232
|
|
| Tryp_SPc |
smart00020 |
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ... |
437-675 |
9.78e-69 |
|
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Pssm-ID: 214473 Cd Length: 229 Bit Score: 224.48 E-value: 9.78e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 437 RIIGGSDADIKNFPWQVFFDNPWA----GGALINEYWVLTAAHVVEG--NREPTMYVGSTSVQTSRlaKSKMLTPEHVFI 510
Cdd:smart00020 1 RIVGGSEANIGSFPWQVSLQYGGGrhfcGGSLISPRWVLTAAHCVRGsdPSNIRVRLGSHDLSSGE--EGQVIKVSKVII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 511 HPGWKllevpegRTNFDNDIALVRLKDPVKMGPTVSPICLPgtSSDYNLMDGDLGLISGWGRTEKRDR--AVRLKAARLP 588
Cdd:smart00020 79 HPNYN-------PSTYDNDIALLKLKEPVTLSDNVRPICLP--SSNYNVPAGTTCTVSGWGRTSEGAGslPDTLQEVNVP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 589 VAPLRKCKEVKVEKPtadaeayVFTPNMICAGG-EKGMDSCKGDSGGAFAVQDPndktKFYAAGLVSWGPQCG---TYGL 664
Cdd:smart00020 150 IVSNATCRRAYSGGG-------AITDNMLCAGGlEGGKDACQGDSGGPLVCNDG----RWVLVGIVSWGSGCArpgKPGV 218
|
250
....*....|.
gi 41393602 665 YTRVKNYVDWI 675
Cdd:smart00020 219 YTRVSSYLDWI 229
|
|
| Trypsin |
pfam00089 |
Trypsin; |
438-675 |
1.19e-54 |
|
Trypsin;
Pssm-ID: 459667 [Multi-domain] Cd Length: 219 Bit Score: 186.49 E-value: 1.19e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 438 IIGGSDADIKNFPWQVFFDN----PWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQtSRLAKSKMLTPEHVFIHPG 513
Cdd:pfam00089 1 IVGGDEAQPGSFPWQVSLQLssgkHFCGGSLISENWVLTAAHCVSGASDVKVVLGAHNIV-LREGGEQKFDVEKIIVHPN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 514 WkllevpeGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDynLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLR 593
Cdd:pfam00089 80 Y-------NPDTLDNDIALLKLESPVTLGDTVRPICLPDASSD--LPVGTTCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 594 KCKEvkvekptadAEAYVFTPNMICAGGeKGMDSCKGDSGGAFAVQDPndktkfYAAGLVSWGPQCG---TYGLYTRVKN 670
Cdd:pfam00089 151 TCRS---------AYGGTVTDTMICAGA-GGKDACQGDSGGPLVCSDG------ELIGIVSWGYGCAsgnYPGVYTPVSS 214
|
....*
gi 41393602 671 YVDWI 675
Cdd:pfam00089 215 YLDWI 219
|
|
| COG5640 |
COG5640 |
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ... |
436-683 |
2.10e-50 |
|
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444365 [Multi-domain] Cd Length: 262 Bit Score: 176.38 E-value: 2.10e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 436 QRIIGGSDADIKNFPWQVF------FDNPWAGGALINEYWVLTAAHVVEGNREPTMYV--GSTSVQTSRlakSKMLTPEH 507
Cdd:COG5640 29 PAIVGGTPATVGEYPWMVAlqssngPSGQFCGGTLIAPRWVLTAAHCVDGDGPSDLRVviGSTDLSTSG---GTVVKVAR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 508 VFIHPGWkllevpeGRTNFDNDIALVRLKDPVkmgPTVSPICLPGTSSDYNlmDGDLGLISGWGRTE--KRDRAVRLKAA 585
Cdd:COG5640 106 IVVHPDY-------DPATPGNDIALLKLATPV---PGVAPAPLATSADAAA--PGTPATVAGWGRTSegPGSQSGTLRKA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 586 RLPVAPLRKCKevkvekptadAEAYVFTPNMICAGGEKG-MDSCKGDSGGAFAVQDPNDktkFYAAGLVSWGP-QC--GT 661
Cdd:COG5640 174 DVPVVSDATCA----------AYGGFDGGTMLCAGYPEGgKDACQGDSGGPLVVKDGGG---WVLVGVVSWGGgPCaaGY 240
|
250 260
....*....|....*....|..
gi 41393602 662 YGLYTRVKNYVDWIMKTMQENS 683
Cdd:COG5640 241 PGVYTRVSAYRDWIKSTAGGLG 262
|
|
| CUB |
pfam00431 |
CUB domain; |
175-287 |
3.34e-31 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 117.40 E-value: 3.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 175 CSGdVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQvvVTLRREDFDVEAADSAGNclDSLVFVAGDR----QFGPY 250
Cdd:pfam00431 1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFR--VKLTFQDFELEDHDECGY--DYVEIRDGPSasspLLGRF 75
|
90 100 110
....*....|....*....|....*....|....*..
gi 41393602 251 CGHGfpGPLNIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:pfam00431 76 CGSG--IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
18-129 |
2.12e-27 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 106.73 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 18 TMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrsSNNPHS 93
Cdd:cd00041 8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSspllGRFCG---STLPPP 84
|
90 100 110
....*....|....*....|....*....|....*.
gi 41393602 94 piveeFQVPYNKLQVIFKSDFSNeeRFTGFAAYYVA 129
Cdd:cd00041 85 -----IISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
21-127 |
1.39e-26 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 104.01 E-value: 1.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 21 GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrsSNNPHSPIV 96
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASspllGRFCG---SEAPPPVIS 77
|
90 100 110
....*....|....*....|....*....|.
gi 41393602 97 EEfqvpYNKLQVIFKSDFSNEERftGFAAYY 127
Cdd:smart00042 78 SS----SNSLTLTFVSDSSVQKR--GFSARY 102
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
175-287 |
9.35e-24 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 96.33 E-value: 9.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 175 CSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLrrEDFDVEaadSAGNC-LDSLVFVAGD----RQFGP 249
Cdd:cd00041 1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF--EDFDLE---SSPNCsYDYLEIYDGPstssPLLGR 75
|
90 100 110
....*....|....*....|....*....|....*...
gi 41393602 250 YCGHGFPGPlnIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:cd00041 76 FCGSTLPPP--IISSGNSLTVRFRSDSSVTGRGFKATY 111
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
185-287 |
1.20e-23 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 95.92 E-value: 1.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 185 GEIASPNYPKPYPENSRCEYQIRLEKGFQvvVTLRREDFDVEAADsagNCLDSLVFV-----AGDRQFGPYCGHGFPGPL 259
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYR--IELQFTDFDLESSD---NCEYDYVEIydgpsASSPLLGRFCGSEAPPPV 75
|
90 100
....*....|....*....|....*...
gi 41393602 260 nIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:smart00042 76 -ISSSSNSLTLTFVSDSSVQKRGFSARY 102
|
|
| CUB |
pfam00431 |
CUB domain; |
18-127 |
1.15e-20 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 87.74 E-value: 1.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 18 TMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrssnnphS 93
Cdd:pfam00431 7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASspllGRFCG--------S 78
|
90 100 110
....*....|....*....|....*....|....
gi 41393602 94 PIVEEFQVPYNKLQVIFKSDFSNEERftGFAAYY 127
Cdd:pfam00431 79 GIPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
143-171 |
2.34e-07 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 47.24 E-value: 2.34e-07
10 20
....*....|....*....|....*....
gi 41393602 143 CSHFCNNFIGGYFCSCPPEYFLHDDMKNC 171
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
294-355 |
2.74e-07 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 47.84 E-value: 2.74e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41393602 294 CPK-EDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEgrvgatSFYSTCQSNGKWSNSKLKCQ 355
Cdd:cd00033 1 CPPpPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
359-421 |
7.09e-07 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 46.75 E-value: 7.09e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41393602 359 CGIPESIENGKVEDPEST-LFGSVIRYTCEEPYYYMengGGGEYHCAGNGSWVnevlgPELPKC 421
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLI---GSSTITCLENGTWS-----PPPPTC 56
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
359-422 |
2.52e-06 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 45.15 E-value: 2.52e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41393602 359 CGIPESIENGKVEDP-ESTLFGSVIRYTCEEPYYYMengGGGEYHCAGNGSWVnevlgPELPKCV 422
Cdd:cd00033 1 CPPPPVPENGTVTGSkGSYSYGSTVTYSCNEGYTLV---GSSTITCTENGGWS-----PPPPTCE 57
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
294-354 |
3.00e-06 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 44.82 E-value: 3.00e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393602 294 CPKEDTP-NSVWEPAKAKYVFRDVVQITCLDGFEVVEgrvgatSFYSTCQSNGKWSNSKLKC 354
Cdd:smart00032 1 CPPPPDIeNGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
294-354 |
5.57e-06 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 44.03 E-value: 5.57e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393602 294 CPK-EDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVegrvgaTSFYSTCQSNGKWSNSKLKC 354
Cdd:pfam00084 1 CPPpPDIPNGKVSATKNEYNYGASVSYECDPGYRLV------GSPTITCQEDGTWSPPFPEC 56
|
|
| PHA02927 |
PHA02927 |
secreted complement-binding protein; Provisional |
301-428 |
6.50e-06 |
|
secreted complement-binding protein; Provisional
Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 48.11 E-value: 6.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 301 NSVWEPAKAKYVFRDVVQITCLDGFEvvEGRVGatSFYSTCQSNGkWSNSKlKCQPVDCGIPESIENGKVeDPESTLFGS 380
Cdd:PHA02927 34 NSVETDANANYNIGDTIEYLCLPGYR--KQKMG--PIYAKCTGTG-WTLFN-QCIKRRCPSPRDIDNGQL-DIGGVDFGS 106
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 41393602 381 VIRYTCEEPYYYMengGGGEYHCAgNGSWVNEVLGPELPKCVPV-CGVP 428
Cdd:PHA02927 107 SITYSCNSGYQLI---GESKSYCE-LGSTGSMVWNPEAPICESVkCQSP 151
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
131-171 |
1.97e-05 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.85 E-value: 1.97e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 41393602 131 DINECTDfvDVPCSH--FCNNFIGGYFCSCPPEYFlhdDMKNC 171
Cdd:smart00179 1 DIDECAS--GNPCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
131-171 |
1.15e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.93 E-value: 1.15e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 41393602 131 DINECTDFVdvPCSH--FCNNFIGGYFCSCPPEYFLhddmKNC 171
Cdd:cd00054 1 DIDECASGN--PCQNggTCVNTVGSYRCSCPPGYTG----RNC 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Tryp_SPc |
cd00190 |
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ... |
438-678 |
2.53e-71 |
|
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.
Pssm-ID: 238113 [Multi-domain] Cd Length: 232 Bit Score: 231.40 E-value: 2.53e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 438 IIGGSDADIKNFPWQVFFDNP----WAGGALINEYWVLTAAHVVEGN--REPTMYVGSTSVqTSRLAKSKMLTPEHVFIH 511
Cdd:cd00190 1 IVGGSEAKIGSFPWQVSLQYTggrhFCGGSLISPRWVLTAAHCVYSSapSNYTVRLGSHDL-SSNEGGGQVIKVKKVIVH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 512 PGWKLlevpegrTNFDNDIALVRLKDPVKMGPTVSPICLPgtSSDYNLMDGDLGLISGWGRTEKRDR-AVRLKAARLPVA 590
Cdd:cd00190 80 PNYNP-------STYDNDIALLKLKRPVTLSDNVRPICLP--SSGYNLPAGTTCTVSGWGRTSEGGPlPDVLQEVNVPIV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 591 PLRKCKEvkvekptADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNdktKFYAAGLVSWGPQCG---TYGLYT 666
Cdd:cd00190 151 SNAECKR-------AYSYGGTITDNMLCAGGLEgGKDACQGDSGGPLVCNDNG---RGVLVGIVSWGSGCArpnYPGVYT 220
|
250
....*....|..
gi 41393602 667 RVKNYVDWIMKT 678
Cdd:cd00190 221 RVSSYLDWIQKT 232
|
|
| Tryp_SPc |
smart00020 |
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ... |
437-675 |
9.78e-69 |
|
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Pssm-ID: 214473 Cd Length: 229 Bit Score: 224.48 E-value: 9.78e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 437 RIIGGSDADIKNFPWQVFFDNPWA----GGALINEYWVLTAAHVVEG--NREPTMYVGSTSVQTSRlaKSKMLTPEHVFI 510
Cdd:smart00020 1 RIVGGSEANIGSFPWQVSLQYGGGrhfcGGSLISPRWVLTAAHCVRGsdPSNIRVRLGSHDLSSGE--EGQVIKVSKVII 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 511 HPGWKllevpegRTNFDNDIALVRLKDPVKMGPTVSPICLPgtSSDYNLMDGDLGLISGWGRTEKRDR--AVRLKAARLP 588
Cdd:smart00020 79 HPNYN-------PSTYDNDIALLKLKEPVTLSDNVRPICLP--SSNYNVPAGTTCTVSGWGRTSEGAGslPDTLQEVNVP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 589 VAPLRKCKEVKVEKPtadaeayVFTPNMICAGG-EKGMDSCKGDSGGAFAVQDPndktKFYAAGLVSWGPQCG---TYGL 664
Cdd:smart00020 150 IVSNATCRRAYSGGG-------AITDNMLCAGGlEGGKDACQGDSGGPLVCNDG----RWVLVGIVSWGSGCArpgKPGV 218
|
250
....*....|.
gi 41393602 665 YTRVKNYVDWI 675
Cdd:smart00020 219 YTRVSSYLDWI 229
|
|
| Trypsin |
pfam00089 |
Trypsin; |
438-675 |
1.19e-54 |
|
Trypsin;
Pssm-ID: 459667 [Multi-domain] Cd Length: 219 Bit Score: 186.49 E-value: 1.19e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 438 IIGGSDADIKNFPWQVFFDN----PWAGGALINEYWVLTAAHVVEGNREPTMYVGSTSVQtSRLAKSKMLTPEHVFIHPG 513
Cdd:pfam00089 1 IVGGDEAQPGSFPWQVSLQLssgkHFCGGSLISENWVLTAAHCVSGASDVKVVLGAHNIV-LREGGEQKFDVEKIIVHPN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 514 WkllevpeGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDynLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLR 593
Cdd:pfam00089 80 Y-------NPDTLDNDIALLKLESPVTLGDTVRPICLPDASSD--LPVGTTCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 594 KCKEvkvekptadAEAYVFTPNMICAGGeKGMDSCKGDSGGAFAVQDPndktkfYAAGLVSWGPQCG---TYGLYTRVKN 670
Cdd:pfam00089 151 TCRS---------AYGGTVTDTMICAGA-GGKDACQGDSGGPLVCSDG------ELIGIVSWGYGCAsgnYPGVYTPVSS 214
|
....*
gi 41393602 671 YVDWI 675
Cdd:pfam00089 215 YLDWI 219
|
|
| COG5640 |
COG5640 |
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ... |
436-683 |
2.10e-50 |
|
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444365 [Multi-domain] Cd Length: 262 Bit Score: 176.38 E-value: 2.10e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 436 QRIIGGSDADIKNFPWQVF------FDNPWAGGALINEYWVLTAAHVVEGNREPTMYV--GSTSVQTSRlakSKMLTPEH 507
Cdd:COG5640 29 PAIVGGTPATVGEYPWMVAlqssngPSGQFCGGTLIAPRWVLTAAHCVDGDGPSDLRVviGSTDLSTSG---GTVVKVAR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 508 VFIHPGWkllevpeGRTNFDNDIALVRLKDPVkmgPTVSPICLPGTSSDYNlmDGDLGLISGWGRTE--KRDRAVRLKAA 585
Cdd:COG5640 106 IVVHPDY-------DPATPGNDIALLKLATPV---PGVAPAPLATSADAAA--PGTPATVAGWGRTSegPGSQSGTLRKA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 586 RLPVAPLRKCKevkvekptadAEAYVFTPNMICAGGEKG-MDSCKGDSGGAFAVQDPNDktkFYAAGLVSWGP-QC--GT 661
Cdd:COG5640 174 DVPVVSDATCA----------AYGGFDGGTMLCAGYPEGgKDACQGDSGGPLVVKDGGG---WVLVGVVSWGGgPCaaGY 240
|
250 260
....*....|....*....|..
gi 41393602 662 YGLYTRVKNYVDWIMKTMQENS 683
Cdd:COG5640 241 PGVYTRVSAYRDWIKSTAGGLG 262
|
|
| CUB |
pfam00431 |
CUB domain; |
175-287 |
3.34e-31 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 117.40 E-value: 3.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 175 CSGdVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQvvVTLRREDFDVEAADSAGNclDSLVFVAGDR----QFGPY 250
Cdd:pfam00431 1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFR--VKLTFQDFELEDHDECGY--DYVEIRDGPSasspLLGRF 75
|
90 100 110
....*....|....*....|....*....|....*..
gi 41393602 251 CGHGfpGPLNIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:pfam00431 76 CGSG--IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
18-129 |
2.12e-27 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 106.73 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 18 TMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrsSNNPHS 93
Cdd:cd00041 8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSspllGRFCG---STLPPP 84
|
90 100 110
....*....|....*....|....*....|....*.
gi 41393602 94 piveeFQVPYNKLQVIFKSDFSNeeRFTGFAAYYVA 129
Cdd:cd00041 85 -----IISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
21-127 |
1.39e-26 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 104.01 E-value: 1.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 21 GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrsSNNPHSPIV 96
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASspllGRFCG---SEAPPPVIS 77
|
90 100 110
....*....|....*....|....*....|.
gi 41393602 97 EEfqvpYNKLQVIFKSDFSNEERftGFAAYY 127
Cdd:smart00042 78 SS----SNSLTLTFVSDSSVQKR--GFSARY 102
|
|
| CUB |
cd00041 |
CUB domain; extracellular domain; present in proteins mostly known to be involved in ... |
175-287 |
9.35e-24 |
|
CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Pssm-ID: 238001 [Multi-domain] Cd Length: 113 Bit Score: 96.33 E-value: 9.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 175 CSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLrrEDFDVEaadSAGNC-LDSLVFVAGD----RQFGP 249
Cdd:cd00041 1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF--EDFDLE---SSPNCsYDYLEIYDGPstssPLLGR 75
|
90 100 110
....*....|....*....|....*....|....*...
gi 41393602 250 YCGHGFPGPlnIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:cd00041 76 FCGSTLPPP--IISSGNSLTVRFRSDSSVTGRGFKATY 111
|
|
| CUB |
smart00042 |
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ... |
185-287 |
1.20e-23 |
|
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 95.92 E-value: 1.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 185 GEIASPNYPKPYPENSRCEYQIRLEKGFQvvVTLRREDFDVEAADsagNCLDSLVFV-----AGDRQFGPYCGHGFPGPL 259
Cdd:smart00042 1 GTITSPNYPQSYPNNLDCVWTIRAPPGYR--IELQFTDFDLESSD---NCEYDYVEIydgpsASSPLLGRFCGSEAPPPV 75
|
90 100
....*....|....*....|....*...
gi 41393602 260 nIETKSNALDIIFQTDLTGQKKGWKLRY 287
Cdd:smart00042 76 -ISSSSNSLTLTFVSDSSVQKRGFSARY 102
|
|
| CUB |
pfam00431 |
CUB domain; |
18-127 |
1.15e-20 |
|
CUB domain;
Pssm-ID: 395345 [Multi-domain] Cd Length: 110 Bit Score: 87.74 E-value: 1.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 18 TMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEE----GRLCGqrssnnphS 93
Cdd:pfam00431 7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASspllGRFCG--------S 78
|
90 100 110
....*....|....*....|....*....|....
gi 41393602 94 PIVEEFQVPYNKLQVIFKSDFSNEERftGFAAYY 127
Cdd:pfam00431 79 GIPEDIVSSSNQMTIKFVSDASVQKR--GFKATY 110
|
|
| FXa_inhibition |
pfam14670 |
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
143-171 |
2.34e-07 |
|
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 47.24 E-value: 2.34e-07
10 20
....*....|....*....|....*....
gi 41393602 143 CSHFCNNFIGGYFCSCPPEYFLHDDMKNC 171
Cdd:pfam14670 8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
294-355 |
2.74e-07 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 47.84 E-value: 2.74e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41393602 294 CPK-EDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEgrvgatSFYSTCQSNGKWSNSKLKCQ 355
Cdd:cd00033 1 CPPpPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
359-421 |
7.09e-07 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 46.75 E-value: 7.09e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41393602 359 CGIPESIENGKVEDPEST-LFGSVIRYTCEEPYYYMengGGGEYHCAGNGSWVnevlgPELPKC 421
Cdd:smart00032 1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLI---GSSTITCLENGTWS-----PPPPTC 56
|
|
| CCP |
cd00033 |
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ... |
359-422 |
2.52e-06 |
|
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.
Pssm-ID: 153056 [Multi-domain] Cd Length: 57 Bit Score: 45.15 E-value: 2.52e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41393602 359 CGIPESIENGKVEDP-ESTLFGSVIRYTCEEPYYYMengGGGEYHCAGNGSWVnevlgPELPKCV 422
Cdd:cd00033 1 CPPPPVPENGTVTGSkGSYSYGSTVTYSCNEGYTLV---GSSTITCTENGGWS-----PPPPTCE 57
|
|
| CCP |
smart00032 |
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ... |
294-354 |
3.00e-06 |
|
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.
Pssm-ID: 214478 [Multi-domain] Cd Length: 56 Bit Score: 44.82 E-value: 3.00e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393602 294 CPKEDTP-NSVWEPAKAKYVFRDVVQITCLDGFEVVEgrvgatSFYSTCQSNGKWSNSKLKC 354
Cdd:smart00032 1 CPPPPDIeNGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
|
|
| Sushi |
pfam00084 |
Sushi repeat (SCR repeat); |
294-354 |
5.57e-06 |
|
Sushi repeat (SCR repeat);
Pssm-ID: 459664 [Multi-domain] Cd Length: 56 Bit Score: 44.03 E-value: 5.57e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393602 294 CPK-EDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVegrvgaTSFYSTCQSNGKWSNSKLKC 354
Cdd:pfam00084 1 CPPpPDIPNGKVSATKNEYNYGASVSYECDPGYRLV------GSPTITCQEDGTWSPPFPEC 56
|
|
| PHA02927 |
PHA02927 |
secreted complement-binding protein; Provisional |
301-428 |
6.50e-06 |
|
secreted complement-binding protein; Provisional
Pssm-ID: 222943 [Multi-domain] Cd Length: 263 Bit Score: 48.11 E-value: 6.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 301 NSVWEPAKAKYVFRDVVQITCLDGFEvvEGRVGatSFYSTCQSNGkWSNSKlKCQPVDCGIPESIENGKVeDPESTLFGS 380
Cdd:PHA02927 34 NSVETDANANYNIGDTIEYLCLPGYR--KQKMG--PIYAKCTGTG-WTLFN-QCIKRRCPSPRDIDNGQL-DIGGVDFGS 106
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 41393602 381 VIRYTCEEPYYYMengGGGEYHCAgNGSWVNEVLGPELPKCVPV-CGVP 428
Cdd:PHA02927 107 SITYSCNSGYQLI---GESKSYCE-LGSTGSMVWNPEAPICESVkCQSP 151
|
|
| EGF_CA |
smart00179 |
Calcium-binding EGF-like domain; |
131-171 |
1.97e-05 |
|
Calcium-binding EGF-like domain;
Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.85 E-value: 1.97e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 41393602 131 DINECTDfvDVPCSH--FCNNFIGGYFCSCPPEYFlhdDMKNC 171
Cdd:smart00179 1 DIDECAS--GNPCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
131-171 |
1.15e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.93 E-value: 1.15e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 41393602 131 DINECTDFVdvPCSH--FCNNFIGGYFCSCPPEYFLhddmKNC 171
Cdd:cd00054 1 DIDECASGN--PCQNggTCVNTVGSYRCSCPPGYTG----RNC 37
|
|
| EGF_CA |
pfam07645 |
Calcium-binding EGF domain; |
131-160 |
2.40e-04 |
|
Calcium-binding EGF domain;
Pssm-ID: 429571 Cd Length: 32 Bit Score: 38.76 E-value: 2.40e-04
10 20 30
....*....|....*....|....*....|.
gi 41393602 131 DINECTDFVDV-PCSHFCNNFIGGYFCSCPP 160
Cdd:pfam07645 1 DVDECATGTHNcPANTVCVNTIGSFECRCPD 31
|
|
| eMpr |
COG3591 |
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ... |
452-681 |
1.22e-03 |
|
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 442810 [Multi-domain] Cd Length: 194 Bit Score: 40.43 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 452 QVFFDNPWAG--GALINEYWVLTAAHVV---EGNREPTMYV----------GSTSVQTsrlakskmltpehVFIHPGWKL 516
Cdd:COG3591 4 RLETDGGGGVctGTLIGPNLVLTAGHCVydgAGGGWATNIVfvpgynggpyGTATATR-------------FRVPPGWVA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 517 levpegRTNFDNDIALVRLKDPVkmGPTVSPIclpGTSSDYNLMDGDLGLISGWGrtekRDRAVRLKAARlpvaplrkck 596
Cdd:COG3591 71 ------SGDAGYDYALLRLDEPL--GDTTGWL---GLAFNDAPLAGEPVTIIGYP----GDRPKDLSLDC---------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393602 597 evkvekptaDAEAYVFTPNMICAggekGMDSCKGDSGGAFAVQDPNdktKFYAAGLVSWGPqCGTYGLYTRV-KNYVDWI 675
Cdd:COG3591 126 ---------SGRVTGVQGNRLSY----DCDTTGGSSGSPVLDDSDG---GGRVVGVHSAGG-ADRANTGVRLtSAIVAAL 188
|
....*.
gi 41393602 676 MKTMQE 681
Cdd:COG3591 189 RAWASA 194
|
|
| |
