NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|41393079|ref|NP_958865|]
View 

replication factor C subunit 3 [Danio rerio]

Protein Classification

replication factor C small subunit( domain architecture ID 1001945)

replication factor C small subunit is part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
rfc super family cl35099
replication factor C small subunit; Reviewed
3-345 3.23e-48

replication factor C small subunit; Reviewed


The actual alignment was detected with superfamily member PRK00440:

Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 165.05  E-value: 3.23e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGagvEKLRiehqsittpskkkl 82
Cdd:PRK00440   6 IWVEKYRPRTLDEIVGQEEIVERLKSYVKEKNMPHLLFAGPPGTGKTTAALALARELYG---EDWR-------------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   83 eintiasNYHLEVNPSDAGNSDrvVIQELIKTVAQSQQIQSSaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLI 162
Cdd:PRK00440  69 -------ENFLELNASDERGID--VIRNKIKEFARTAPVGGA---PFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFI 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  163 LCCNSTSKVIAPIRSRCLAVRV-PLPSvEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALlmceacRVQQYPFS 241
Cdd:PRK00440 137 LSCNYSSKIIDPIQSRCAVFRFsPLKK-EAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAI------NALQAAAA 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  242 PDQDIPEtdwevylrETANAIVSQQSPQ------------RLLEVRARLYELLT-HCISPEVIMKGLVTELLS-NCDGHL 307
Cdd:PRK00440 210 TGKEVTE--------EAVYKITGTARPEeiremielalngDFTEAREKLRDLMIdYGLSGEDIIKQIHREVWSlDIPEEL 281
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 41393079  308 KAEVAQMAAYYEHRLQLGNKAIYHLEAFVAKFMAIYKK 345
Cdd:PRK00440 282 KVELIDAIGEADFRITEGANERIQLEALLAKLALLGKK 319
 
Name Accession Description Interval E-value
rfc PRK00440
replication factor C small subunit; Reviewed
3-345 3.23e-48

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 165.05  E-value: 3.23e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGagvEKLRiehqsittpskkkl 82
Cdd:PRK00440   6 IWVEKYRPRTLDEIVGQEEIVERLKSYVKEKNMPHLLFAGPPGTGKTTAALALARELYG---EDWR-------------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   83 eintiasNYHLEVNPSDAGNSDrvVIQELIKTVAQSQQIQSSaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLI 162
Cdd:PRK00440  69 -------ENFLELNASDERGID--VIRNKIKEFARTAPVGGA---PFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFI 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  163 LCCNSTSKVIAPIRSRCLAVRV-PLPSvEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALlmceacRVQQYPFS 241
Cdd:PRK00440 137 LSCNYSSKIIDPIQSRCAVFRFsPLKK-EAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAI------NALQAAAA 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  242 PDQDIPEtdwevylrETANAIVSQQSPQ------------RLLEVRARLYELLT-HCISPEVIMKGLVTELLS-NCDGHL 307
Cdd:PRK00440 210 TGKEVTE--------EAVYKITGTARPEeiremielalngDFTEAREKLRDLMIdYGLSGEDIIKQIHREVWSlDIPEEL 281
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 41393079  308 KAEVAQMAAYYEHRLQLGNKAIYHLEAFVAKFMAIYKK 345
Cdd:PRK00440 282 KVELIDAIGEADFRITEGANERIQLEALLAKLALLGKK 319
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
19-342 5.11e-34

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 127.01  E-value: 5.11e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  19 HKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKTRIMCLLRELYGagveklrieHQSITTPSKKKLEINTIASNYH---LE 94
Cdd:COG0470   1 QEEAWEQLLAAAESGRLPHaLLLHGPPGIGKTTLALALARDLLC---------ENPEGGKACGQCHSRLMAAGNHpdlLE 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  95 VNPSDAGNSDRV-VIQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIA 173
Cdd:COG0470  72 LNPEEKSDQIGIdQIRELGEFLSLTPLEG-----GRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLP 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 174 PIRSRCLAVRVPLPSVEEVCSVLsgvcRKEGllLPPELAKQIAEKSGRNLRKALLMCEAcrvqqypfspdqdipetdWEV 253
Cdd:COG0470 147 TIRSRCQVIRFRPPSEEEALAWL----REEG--VDEDALEAILRLAGGDPRAAINLLQA------------------LAG 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 254 Y--LRETANAIVSQQSPQRLLEV--RARLYELLthcispEVIMKGLVTELLSNCDGHLKAEVAQMAAYYEHRLQLG-NKA 328
Cdd:COG0470 203 RkeLLEDLAALLSRDRALELLDAllKAEALELL------DWLLKWLLDNLPLEYAGEDLARAYEALSEADRRLGRYaNDR 276
                       330
                ....*....|....
gi 41393079 329 IyHLEAFVAKFMAI 342
Cdd:COG0470 277 L-LLEALLAKLGRL 289
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
21-179 7.44e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 50.99  E-value: 7.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  21 EQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGAGVEklriehqsittpskkkleintiasnyHLEVNPSDA 100
Cdd:cd00009   5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAP--------------------------FLYLNASDL 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 101 GNSDrvVIQELIKTVAQSQQIQSSAQREFKVVLLTEVDRLTKDAQHALRRTMEKYM------ATCRLILCCNSTS--KVI 172
Cdd:cd00009  59 LEGL--VVAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNdlridrENVRVIGATNRPLlgDLD 136

                ....*..
gi 41393079 173 APIRSRC 179
Cdd:cd00009 137 RALYDRL 143
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
18-185 1.35e-05

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 44.89  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    18 YHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKTRIMCLLRELYGagveklriEHQSITTPSKKKLEINTIASNYHLEVN 96
Cdd:pfam13177   1 GQPEAIQLLQNSLENGRLSHaYLFSGPEGVGKLELALAFAKALFC--------EEPGDDLPCGQCRSCRRIESGNHPDLV 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    97 P-SDAGNSDRV-VIQELIKTVAQSQQIQSsaqreFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAP 174
Cdd:pfam13177  73 IiEPEGQSIKIdQIRELQKEFSKSPYEGK-----KKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPT 147
                         170
                  ....*....|.
gi 41393079   175 IRSRCLAVRVP 185
Cdd:pfam13177 148 IRSRCQIIRFK 158
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
3-59 5.05e-05

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 44.95  E-value: 5.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393079     3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-----LLVYGPSGAGKKTRIMCLLREL 59
Cdd:TIGR00602  73 PWVEKYKPETQHELAVHKKKIEEVETWLKAQVLENapkriLLITGPSGCGKSTTIKILSKEL 134
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
37-190 2.08e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.20  E-value: 2.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079     37 HLLVYGPSGAGKKTRIMCLLRELYGAGVEKLRIEHQSITTPSKKKLEINTIASNYHlevnPSDAGNSDRVVIQELIKtva 116
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKA----SGSGELRLRLALALARK--- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    117 qsqqiqssaqREFKVVLLTEVDRLTKDAQHALRR--------TMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPS 188
Cdd:smart00382  77 ----------LKPDVLILDEITSLLDAEQEALLLlleelrllLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146

                   ..
gi 41393079    189 VE 190
Cdd:smart00382 147 IL 148
 
Name Accession Description Interval E-value
rfc PRK00440
replication factor C small subunit; Reviewed
3-345 3.23e-48

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 165.05  E-value: 3.23e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGagvEKLRiehqsittpskkkl 82
Cdd:PRK00440   6 IWVEKYRPRTLDEIVGQEEIVERLKSYVKEKNMPHLLFAGPPGTGKTTAALALARELYG---EDWR-------------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   83 eintiasNYHLEVNPSDAGNSDrvVIQELIKTVAQSQQIQSSaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLI 162
Cdd:PRK00440  69 -------ENFLELNASDERGID--VIRNKIKEFARTAPVGGA---PFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFI 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  163 LCCNSTSKVIAPIRSRCLAVRV-PLPSvEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALlmceacRVQQYPFS 241
Cdd:PRK00440 137 LSCNYSSKIIDPIQSRCAVFRFsPLKK-EAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAI------NALQAAAA 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  242 PDQDIPEtdwevylrETANAIVSQQSPQ------------RLLEVRARLYELLT-HCISPEVIMKGLVTELLS-NCDGHL 307
Cdd:PRK00440 210 TGKEVTE--------EAVYKITGTARPEeiremielalngDFTEAREKLRDLMIdYGLSGEDIIKQIHREVWSlDIPEEL 281
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 41393079  308 KAEVAQMAAYYEHRLQLGNKAIYHLEAFVAKFMAIYKK 345
Cdd:PRK00440 282 KVELIDAIGEADFRITEGANERIQLEALLAKLALLGKK 319
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
3-339 8.94e-48

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 164.39  E-value: 8.94e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGAGVEKLRIEHQSITTPSKKKL 82
Cdd:PRK12402   4 LWTEKYRPALLEDILGQDEVVERLSRAVDSPNLPHLLVQGPPGSGKTAAVRALARELYGDPWENNFTEFNVADFFDQGKK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   83 EINTIASNYHLEVNPSDAGNSDRVVIQELIKtvaqSQQIQSSAQREFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLI 162
Cdd:PRK12402  84 YLVEDPRFAHFLGTDKRIRSSKIDNFKHVLK----EYASYRPLSADYKTILLDNAEALREDAQQALRRIMEQYSRTCRFI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  163 LCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALLMCEAcRVQQYPFSP 242
Cdd:PRK12402 160 IATRQPSKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYYAGGDLRKAILTLQT-AALAAGEIT 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  243 DQDIPETDWEVYLRETANAIVSQQSPQRLLEVRARLYELL-THCISPEVIMKGLVTELLSNCDGHLKAEVAQMAAYYEHR 321
Cdd:PRK12402 239 MEAAYEALGDVGTDEVIESLLDAAEAGDFTDARKTLDDLLiDEGLSGGEVLEELLRVARSRYRGDNLARLHRLAADADAR 318
                        330
                 ....*....|....*...
gi 41393079  322 LQLGNKAIYHLEAFVAKF 339
Cdd:PRK12402 319 LTDGANDRIQLEALLAEL 336
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
19-342 5.11e-34

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 127.01  E-value: 5.11e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  19 HKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKTRIMCLLRELYGagveklrieHQSITTPSKKKLEINTIASNYH---LE 94
Cdd:COG0470   1 QEEAWEQLLAAAESGRLPHaLLLHGPPGIGKTTLALALARDLLC---------ENPEGGKACGQCHSRLMAAGNHpdlLE 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  95 VNPSDAGNSDRV-VIQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIA 173
Cdd:COG0470  72 LNPEEKSDQIGIdQIRELGEFLSLTPLEG-----GRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLP 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 174 PIRSRCLAVRVPLPSVEEVCSVLsgvcRKEGllLPPELAKQIAEKSGRNLRKALLMCEAcrvqqypfspdqdipetdWEV 253
Cdd:COG0470 147 TIRSRCQVIRFRPPSEEEALAWL----REEG--VDEDALEAILRLAGGDPRAAINLLQA------------------LAG 202
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 254 Y--LRETANAIVSQQSPQRLLEV--RARLYELLthcispEVIMKGLVTELLSNCDGHLKAEVAQMAAYYEHRLQLG-NKA 328
Cdd:COG0470 203 RkeLLEDLAALLSRDRALELLDAllKAEALELL------DWLLKWLLDNLPLEYAGEDLARAYEALSEADRRLGRYaNDR 276
                       330
                ....*....|....
gi 41393079 329 IyHLEAFVAKFMAI 342
Cdd:COG0470 277 L-LLEALLAKLGRL 289
PLN03025 PLN03025
replication factor C subunit; Provisional
4-227 2.85e-32

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 122.92  E-value: 2.85e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    4 WVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGAgveklriehqsittpskkkle 83
Cdd:PLN03025   3 WVEKYRPTKLDDIVGNEDAVSRLQVIARDGNMPNLILSGPPGTGKTTSILALAHELLGP--------------------- 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   84 intiasNYH---LEVNPSDAGNSDrvVIQELIKTVAQSQQIQSSAQRefKVVLLTEVDRLTKDAQHALRRTMEKYMATCR 160
Cdd:PLN03025  62 ------NYKeavLELNASDDRGID--VVRNKIKMFAQKKVTLPPGRH--KIVILDEADSMTSGAQQALRRTMEIYSNTTR 131
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41393079  161 LILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKAL 227
Cdd:PLN03025 132 FALACNTSSKIIEPIQSRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQAL 198
PRK04132 PRK04132
replication factor C small subunit; Provisional
93-344 1.35e-23

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 102.22  E-value: 1.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   93 LEVNPSDAGNSDrvVIQELIKTVAQSQQIQSSaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVI 172
Cdd:PRK04132 600 LELNASDERGIN--VIREKVKEFARTKPIGGA---SFKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKII 674
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  173 APIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALlmceacRVQQYPFSPDQDIpeTDWE 252
Cdd:PRK04132 675 EPIQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAI------NILQAAAALDDKI--TDEN 746
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  253 VYLretanaIVSQQSPQ------------RLLEVRARLYE-LLTHCISPEVIMKGLVTELLS-NCDGHLKAEVAQMAAYY 318
Cdd:PRK04132 747 VFL------VASRARPEdiremmllalkgNFLKAREKLREiLLKQGLSGEDVLVQMHREVFNlPIDEPKKVELADKIGEY 820
                        250       260
                 ....*....|....*....|....*.
gi 41393079  319 EHRLQLGNKAIYHLEAFVAKFMAIYK 344
Cdd:PRK04132 821 NFRLVEGANEMIQLEALLAQFTLMGK 846
44 PHA02544
clamp loader, small subunit; Provisional
3-204 9.38e-18

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 82.73  E-value: 9.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPS-GAGKKTRIMCLLRELyGAGVeklriehqsittpskkk 81
Cdd:PHA02544  10 MWEQKYRPSTIDECILPAADKETFKSIVKKGRIPNMLLHSPSpGTGKTTVAKALCNEV-GAEV----------------- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   82 leintiasnyhLEVNPSDagnsDRVviqELIKTVAQSQQIQSSAQREFKVVLLTEVDRL-TKDAQHALRRTMEKYMATCR 160
Cdd:PHA02544  72 -----------LFVNGSD----CRI---DFVRNRLTRFASTVSLTGGGKVIIIDEFDRLgLADAQRHLRSFMEAYSKNCS 133
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 41393079  161 LILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLS-------GVCRKEG 204
Cdd:PHA02544 134 FIITANNKNGIIEPLRSRCRVIDFGVPTKEEQIEMMKqmivrckGILEAEG 184
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
10-342 6.70e-17

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 80.62  E-value: 6.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  10 PTSLAKLDYHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKT--RIM-----CllrelygagveklriEHQSITTP---- 77
Cdd:COG2812   6 PQTFDDVVGQEHVVRTLKNALASGRLAHaYLFTGPRGVGKTTlaRILakalnC---------------ENGPTGEPcgec 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  78 -SKKKleintIASNYHLEVNPSDAGNSDRVV--IQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTME- 153
Cdd:COG2812  71 eSCRA-----IAAGSHPDVIEIDAEASNIGVddIRELIEKVSYAPVEG-----RYKVYIIDEAHMLTTEAFNALLKTLEe 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 154 -----KymatcrLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALL 228
Cdd:COG2812 141 ppphvV------FILATTEPQKLLPTILSRCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALS 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 229 MCeacrvqqypfspDQDIP--ETDWEVYLRETANAIVsQQSPQRLLEVRARLYE-----------LLTHCIspEVIMKGL 295
Cdd:COG2812 215 LL------------DQAIAfgLLDRRELLLDLLEALL-AGDVAALLALAEELAKrgrdlkrflddLLSLLR--DLLLLKL 279
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 41393079 296 VTELLSNCDGHLKAEVAQMAAYY-----EHRLQLGNKAIYHLEAFVAKFMAI 342
Cdd:COG2812 280 GPDAELLVNEDERERLQELARRLsperlLRAIQILLEARRELERNVNPRLAL 331
PRK07940 PRK07940
DNA polymerase III subunit delta'; Validated
129-226 7.99e-09

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236134 [Multi-domain]  Cd Length: 394  Bit Score: 56.46  E-value: 7.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSgvcRKEGllLP 208
Cdd:PRK07940 118 WRIVVIEDADRLTERAANALLKAVEEPPPRTVWLLCAPSPEDVLPTIRSRCRHVALRTPSVEAVAEVLV---RRDG--VD 192
                         90
                 ....*....|....*...
gi 41393079  209 PELAKQIAEKSGRNLRKA 226
Cdd:PRK07940 193 PETARRAARASQGHIGRA 210
PRK04195 PRK04195
replication factor C large subunit; Provisional
1-232 2.05e-08

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 55.70  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    1 MSLWVDKYRPTSLAKLDYHKEQANQLKNLVQcgDFPH------LLVYGPSGAGKKTRIMCLLRELygagveklriehqsi 74
Cdd:PRK04195   1 MMPWVEKYRPKTLSDVVGNEKAKEQLREWIE--SWLKgkpkkaLLLYGPPGVGKTSLAHALANDY--------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   75 ttpskkKLEIntiasnyhLEVNPSDAGNSDrvVIQeliKTVAQSQQIQSSAQREFKVVLLTEVDRL--TKDA--QHALRR 150
Cdd:PRK04195  64 ------GWEV--------IELNASDQRTAD--VIE---RVAGEAATSGSLFGARRKLILLDEVDGIhgNEDRggARAILE 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  151 TMEKymATCRLILCCN---STSKviAPIRSRCLAV---RVPLPSVEEVcsvLSGVCRKEGLLLPPELAKQIAEKSGRNLR 224
Cdd:PRK04195 125 LIKK--AKQPIILTANdpyDPSL--RELRNACLMIefkRLSTRSIVPV---LKRICRKEGIECDDEALKEIAERSGGDLR 197

                 ....*...
gi 41393079  225 KALLMCEA 232
Cdd:PRK04195 198 SAINDLQA 205
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
7-229 7.41e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 53.72  E-value: 7.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVY-GPSGAGKKTRIMCLLRelygagveklRIEHQSITTPSKkklein 85
Cdd:PRK14970  10 KYRPQTFDDVVGQSHITNTLLNAIENNHLAQALLFcGPRGVGKTTCARILAR----------KINQPGYDDPNE------ 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   86 tiasNYHLEVNPSDAGNSDRVV-IQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILC 164
Cdd:PRK14970  74 ----DFSFNIFELDAASNNSVDdIRNLIDQVRIPPQTG-----KYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILA 144
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41393079  165 CNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALLM 229
Cdd:PRK14970 145 TTEKHKIIPTILSRCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSI 209
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
21-179 7.44e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 50.99  E-value: 7.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  21 EQANQLKNLVQCGDFPHLLVYGPSGAGKKTRIMCLLRELYGAGVEklriehqsittpskkkleintiasnyHLEVNPSDA 100
Cdd:cd00009   5 EAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAP--------------------------FLYLNASDL 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079 101 GNSDrvVIQELIKTVAQSQQIQSSAQREFKVVLLTEVDRLTKDAQHALRRTMEKYM------ATCRLILCCNSTS--KVI 172
Cdd:cd00009  59 LEGL--VVAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSRGAQNALLRVLETLNdlridrENVRVIGATNRPLlgDLD 136

                ....*..
gi 41393079 173 APIRSRC 179
Cdd:cd00009 137 RALYDRL 143
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
7-231 1.22e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 53.23  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVY-GPSGAGKKT--RIMcllrelygagVEKLRIEHQSITTPSKKKLE 83
Cdd:PRK14962   7 KYRPKTFSEVVGQDHVKKLIINALKKNSISHAYIFaGPRGTGKTTvaRIL----------AKSLNCENRKGVEPCNECRA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   84 INTIASNYHLEVNPSDAGnSDRVV--IQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRL 161
Cdd:PRK14962  77 CRSIDEGTFMDVIELDAA-SNRGIdeIRKIRDAVGYRPMEG-----KYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVF 150
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  162 ILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALLMCE 231
Cdd:PRK14962 151 VLATTNLEKVPPTIISRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLE 220
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
7-231 3.44e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 51.87  E-value: 3.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVY-GPSGAGKKT--RIMcllrelygagVEKLRIEHQSITTPSKKK-- 81
Cdd:PRK14956  11 KYRPQFFRDVIHQDLAIGALQNALKSGKIGHAYIFfGPRGVGKTTiaRIL----------AKRLNCENPIGNEPCNECts 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   82 -LEINTIASNYHLEVNPsdAGNSDRVVIQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCR 160
Cdd:PRK14956  81 cLEITKGISSDVLEIDA--ASNRGIENIRELRDNVKFAPMGG-----KYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIV 153
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41393079  161 LILCCNSTSKVIAPIRSRC---LAVRVPLPSVEEVCSVLsgvCRKEGLLLPPELAKQIAEKSGRNLRKALLMCE 231
Cdd:PRK14956 154 FILATTEFHKIPETILSRCqdfIFKKVPLSVLQDYSEKL---CKIENVQYDQEGLFWIAKKGDGSVRDMLSFME 224
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
7-227 7.88e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 50.82  E-value: 7.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVY-GPSGAGKKT--RIMcllrelygagVEKLRIEHQSITTPSKKKLE 83
Cdd:PRK14960   8 KYRPRNFNELVGQNHVSRALSSALERGRLHHAYLFtGTRGVGKTTiaRIL----------AKCLNCETGVTSTPCEVCAT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   84 INTIASNYHLEVNPSDAGNSDRVV-IQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLI 162
Cdd:PRK14960  78 CKAVNEGRFIDLIEIDAASRTKVEdTRELLDNVPYAPTQG-----RFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFL 152
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41393079  163 LCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKAL 227
Cdd:PRK14960 153 FATTDPQKLPITVISRCLQFTLRPLAVDEITKHLGAILEKEQIAADQDAIWQIAESAQGSLRDAL 217
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
7-227 8.60e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 50.58  E-value: 8.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKTrimcllrelygagVEKLRIEHQSITTPSKKKLEIN 85
Cdd:PRK14950   9 KWRSQTFAELVGQEHVVQTLRNAIAEGRVAHaYLFTGPRGVGKTS-------------TARILAKAVNCTTNDPKGRPCG 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   86 T------IASNYHLEVNPSDAGNSDRVV-IQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMAT 158
Cdd:PRK14950  76 TcemcraIAEGSAVDVIEMDAASHTSVDdAREIIERVQFRPALA-----RYKVYIIDEVHMLSTAAFNALLKTLEEPPPH 150
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393079  159 CRLILCCNSTSKVIAPIRSRC---LAVRVplpSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKAL 227
Cdd:PRK14950 151 AIFILATTEVHKVPATILSRCqrfDFHRH---SVADMAAHLRKIAAAEGINLEPGALEAIARAATGSMRDAE 219
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
7-231 1.86e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 49.40  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKT--RI--MCLlrelygagveklRIEHQSITTPSKKK 81
Cdd:PRK14964   6 KYRPSSFKDLVGQDVLVRILRNAFTLNKIPQsILLVGASGVGKTTcaRIisLCL------------NCSNGPTSDPCGTC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   82 LEINTIASNYHLEVNPSDAGNSDRVviqELIKTVAQSQQIQSSAQReFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRL 161
Cdd:PRK14964  74 HNCISIKNSNHPDVIEIDAASNTSV---DDIKVILENSCYLPISSK-FKVYIIDEVHMLSNSAFNALLKTLEEPAPHVKF 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  162 ILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALLMCE 231
Cdd:PRK14964 150 ILATTEVKKIPVTIISRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDEESLKLIAENSSGSMRNALFLLE 219
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
129-227 8.69e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 47.51  E-value: 8.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLP 208
Cdd:PRK14953 120 YKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTILSRCQRFIFSKPTKEQIKEYLKRICNEEKIEYE 199
                         90
                 ....*....|....*....
gi 41393079  209 PELAKQIAEKSGRNLRKAL 227
Cdd:PRK14953 200 EKALDLLAQASEGGMRDAA 218
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
18-185 1.35e-05

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 44.89  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    18 YHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKTRIMCLLRELYGagveklriEHQSITTPSKKKLEINTIASNYHLEVN 96
Cdd:pfam13177   1 GQPEAIQLLQNSLENGRLSHaYLFSGPEGVGKLELALAFAKALFC--------EEPGDDLPCGQCRSCRRIESGNHPDLV 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    97 P-SDAGNSDRV-VIQELIKTVAQSQQIQSsaqreFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAP 174
Cdd:pfam13177  73 IiEPEGQSIKIdQIRELQKEFSKSPYEGK-----KKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPT 147
                         170
                  ....*....|.
gi 41393079   175 IRSRCLAVRVP 185
Cdd:pfam13177 148 IRSRCQIIRFK 158
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
7-227 1.95e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 46.23  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVY-GPSGAGKKTrimcllrelYGAGVEKLRIEHQSITTPSKKKLEiN 85
Cdd:PRK14957   9 KYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFtGTRGVGKTT---------LGRLLAKCLNCKTGVTAEPCNKCE-N 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   86 TIASNYHLEVNPSDAGNSDRVVIQElIKTVAQSQQIQSSAQReFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCC 165
Cdd:PRK14957  79 CVAINNNSFIDLIEIDAASRTGVEE-TKEILDNIQYMPSQGR-YKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILAT 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393079  166 NSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKAL 227
Cdd:PRK14957 157 TDYHKIPVTILSRCIQLHLKHISQADIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDAL 218
PRK04132 PRK04132
replication factor C small subunit; Provisional
4-48 2.47e-05

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 46.37  E-value: 2.47e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 41393079    4 WVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVYGPSGAGK 48
Cdd:PRK04132   9 WVEKYRPQRLDDIVGQEHIVKRLKHYVKTGSMPHLLFAGPPGVGK 53
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
7-273 2.80e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 45.85  E-value: 2.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKT--RIMcllrelygagVEKLRIEHQSITTPSKKKLE 83
Cdd:PRK08691   9 KWRPKTFADLVGQEHVVKALQNALDEGRLHHaYLLTGTRGVGKTTiaRIL----------AKSLNCENAQHGEPCGVCQS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   84 INTIASNYHLEVNPSDAG-NSDRVVIQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLI 162
Cdd:PRK08691  79 CTQIDAGRYVDLLEIDAAsNTGIDNIREVLENAQYAPTAG-----KYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  163 LCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKAL-LMCEACRVQQYPFS 241
Cdd:PRK08691 154 LATTDPHKVPVTVLSRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAAAGSMRDALsLLDQAIALGSGKVA 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 41393079  242 PD---QDIPETDWEvYLRETANAIVSQQSPQRLLE 273
Cdd:PRK08691 234 ENdvrQMIGAVDKQ-YLYELLTGIINQDGAALLAK 267
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
187-252 4.07e-05

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 40.98  E-value: 4.07e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41393079 187 PSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALLMCEACRVQqypfspDQDIPETDWE 252
Cdd:cd18140   1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAG------GGVITEEDVY 60
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
3-59 5.05e-05

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 44.95  E-value: 5.05e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393079     3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-----LLVYGPSGAGKKTRIMCLLREL 59
Cdd:TIGR00602  73 PWVEKYKPETQHELAVHKKKIEEVETWLKAQVLENapkriLLITGPSGCGKSTTIKILSKEL 134
Rad17 pfam03215
Rad17 P-loop domain;
3-59 5.98e-05

Rad17 P-loop domain;


Pssm-ID: 367398 [Multi-domain]  Cd Length: 186  Bit Score: 43.41  E-value: 5.98e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41393079     3 LWVDKYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-----LLVYGPSGAGKKTRIMCLLREL 59
Cdd:pfam03215   8 QWYEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENakhriLLISGPSGCGKSTVIKELSKEL 69
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
6-232 8.56e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 43.92  E-value: 8.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    6 DKYRPTSLAklDY----H---KEQAnqLKNLVQCGDFPHLLVYGPSGAGKKT--RIMcllrelygAGVEKLRIEHQSITT 76
Cdd:PRK13342   4 ERMRPKTLD--EVvgqeHllgPGKP--LRRMIEAGRLSSMILWGPPGTGKTTlaRII--------AGATDAPFEALSAVT 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   77 PSKKklEINTIASNYhlevnpsdagnsdRVVIQELIKTVaqsqqiqssaqrefkvVLLTEVDRLTKDAQHALRRTMEKYM 156
Cdd:PRK13342  72 SGVK--DLREVIEEA-------------RQRRSAGRRTI----------------LFIDEIHRFNKAQQDALLPHVEDGT 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  157 ATcrLILCcnSTS----KVIAPIRSRClavRV----PLpSVEEVCSVLS-GVCRKEGLL--LPPELAKQIAEKSGRNLRK 225
Cdd:PRK13342 121 IT--LIGA--TTEnpsfEVNPALLSRA---QVfelkPL-SEEDIEQLLKrALEDKERGLveLDDEALDALARLANGDARR 192

                 ....*..
gi 41393079  226 ALLMCEA 232
Cdd:PRK13342 193 ALNLLEL 199
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
7-229 8.69e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.38  E-value: 8.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPH-LLVYGPSGAGKKT--RIM-----CLLRelyGAGVEKLRiEHQSIttps 78
Cdd:PRK14971  10 KYRPSTFESVVGQEALTTTLKNAIATNKLAHaYLFCGPRGVGKTTcaRIFaktinCQNL---TADGEACN-ECESC---- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   79 kkkLEINTIAS-NYHlEVnpsDAGNSDRVV-IQELIKTVAQSQQIQssaqrEFKVVLLTEVDRLTKDAQHALRRTMEKYM 156
Cdd:PRK14971  82 ---VAFNEQRSyNIH-EL---DAASNNSVDdIRNLIEQVRIPPQIG-----KYKIYIIDEVHMLSQAAFNAFLKTLEEPP 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41393079  157 ATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKALLM 229
Cdd:PRK14971 150 SYAIFILATTEKHKILPTILSRCQIFDFNRIQVADIVNHLQYVASKEGITAEPEALNVIAQKADGGMRDALSI 222
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
7-226 1.19e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 43.73  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    7 KYRPTSLAKLDYHKEQANQLKNLVQCGDFPHLLVY-GPSGAGKKTRIMCLLRELYGAGVEKLRIEHQSITTPSKKKLEIN 85
Cdd:PRK14955   9 KYRPKKFADITAQEHITRTIQNSLRMGRVGHGYIFsGLRGVGKTTAARVFAKAVNCQRMIDDADYLQEVTEPCGECESCR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079   86 TIASNYHLEVNPSDAGNSDRVviqELIKTVAQSQQIQSSAQReFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCC 165
Cdd:PRK14955  89 DFDAGTSLNISEFDAASNNSV---DDIRLLRENVRYGPQKGR-YRVYIIDEVHMLSIAAFNAFLKTLEEPPPHAIFIFAT 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41393079  166 NSTSKVIAPIRSRCLAV---RVPLPSVEEvcsVLSGVCRKEGLLLPPELAKQIAEKSGRNLRKA 226
Cdd:PRK14955 165 TELHKIPATIASRCQRFnfkRIPLEEIQQ---QLQGICEAEGISVDADALQLIGRKAQGSMRDA 225
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
37-190 2.08e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.20  E-value: 2.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079     37 HLLVYGPSGAGKKTRIMCLLRELYGAGVEKLRIEHQSITTPSKKKLEINTIASNYHlevnPSDAGNSDRVVIQELIKtva 116
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKA----SGSGELRLRLALALARK--- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079    117 qsqqiqssaqREFKVVLLTEVDRLTKDAQHALRR--------TMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPS 188
Cdd:smart00382  77 ----------LKPDVLILDEITSLLDAEQEALLLlleelrllLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146

                   ..
gi 41393079    189 VE 190
Cdd:smart00382 147 IL 148
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
129-227 4.99e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.97  E-value: 4.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLP 208
Cdd:PRK14959 120 YKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPHKFPVTIVSRCQHFTFTRLSEAGLEAHLTKVLGREGVDYD 199
                         90
                 ....*....|....*....
gi 41393079  209 PELAKQIAEKSGRNLRKAL 227
Cdd:PRK14959 200 PAAVRLIARRAAGSVRDSM 218
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
129-226 6.41e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 41.68  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLP 208
Cdd:PRK06647 120 YRVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVHKLPATIKSRCQHFNFRLLSLEKIYNMLKKVCLEDQIKYE 199
                         90
                 ....*....|....*...
gi 41393079  209 PELAKQIAEKSGRNLRKA 226
Cdd:PRK06647 200 DEALKWIAYKSTGSVRDA 217
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
128-234 7.68e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 41.38  E-value: 7.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  128 EFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLL 207
Cdd:PRK06645 128 KHKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATIISRCQRYDLRRLSFEEIFKLLEYITKQENLKT 207
                         90       100
                 ....*....|....*....|....*..
gi 41393079  208 PPELAKQIAEKSGRNLRKALLMCEACR 234
Cdd:PRK06645 208 DIEALRIIAYKSEGSARDAVSILDQAA 234
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
130-179 7.96e-04

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 40.79  E-value: 7.96e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 41393079  130 KVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRC 179
Cdd:PRK05564  95 KVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRC 144
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
129-226 8.77e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.08  E-value: 8.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAV---RVPLpsvEEVCSVLSGVCRKEGL 205
Cdd:PRK14954 128 YRVYIIDEVHMLSTAAFNAFLKTLEEPPPHAIFIFATTELHKIPATIASRCQRFnfkRIPL---DEIQSQLQMICRAEGI 204
                         90       100
                 ....*....|....*....|.
gi 41393079  206 LLPPELAKQIAEKSGRNLRKA 226
Cdd:PRK14954 205 QIDADALQLIARKAQGSMRDA 225
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
129-227 1.10e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 40.89  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLP 208
Cdd:PRK14969 120 FKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNLKQMPPPLIVSHLQHILEQENIPFD 199
                         90
                 ....*....|....*....
gi 41393079  209 PELAKQIAEKSGRNLRKAL 227
Cdd:PRK14969 200 ATALQLLARAAAGSMRDAL 218
PRK05707 PRK05707
DNA polymerase III subunit delta'; Validated
129-192 1.16e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180215 [Multi-domain]  Cd Length: 328  Bit Score: 40.46  E-value: 1.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41393079  129 FKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEV 192
Cdd:PRK05707 107 RKVVLIEPAEAMNRNAANALLKSLEEPSGDTVLLLISHQPSRLLPTIKSRCQQQACPLPSNEES 170
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
130-226 1.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 40.21  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  130 KVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRVPLPSVEEVCSVLSGVCRKEGLLLPP 209
Cdd:PRK14963 118 KVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPTILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEP 197
                         90
                 ....*....|....*..
gi 41393079  210 ELAKQIAEKSGRNLRKA 226
Cdd:PRK14963 198 EALQLVARLADGAMRDA 214
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
128-229 4.81e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 38.48  E-value: 4.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41393079  128 EFKVVLLTEVDRLTKDAQHALRRTMEKYMATCRLILCCNSTSKVIAPIRSRCLAVRV-PLpSVEEVCSVLSGVcrkeGLL 206
Cdd:PRK09112 141 NWRIVIIDPADDMNRNAANAILKTLEEPPARALFILISHSSGRLLPTIRSRCQPISLkPL-DDDELKKALSHL----GSS 215
                         90       100
                 ....*....|....*....|....*
gi 41393079  207 LPP--ELAKQIAEKSGRNLRKALLM 229
Cdd:PRK09112 216 QGSdgEITEALLQRSKGSVRKALLL 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH