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Conserved domains on  [gi|45333909|ref|NP_987093|]
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COMM domain-containing protein 6 isoform a [Homo sapiens]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 1-96 2.02e-46

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04754:

Pssm-ID: 471425  Cd Length: 86  Bit Score: 143.52  E-value: 2.02e-46
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45333909  1 MEASSEPPLDAKSDvTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQpqllatsslls 80
Cdd:cd04754  5 KLLTASDSVDQVLN-IGQLVDFKWKLGMAVSSDTCRSLNSPYVAVTLKVADPSGQVVTKSFEMTIPEFQ----------- 72

                       90
               ....*....|....*.
gi 45333909 81 asNFYRQFKEIAAVIE 96
Cdd:cd04754 73 --NFSRQFKEMAAVLE 86
 
Name Accession Description Interval E-value
Commd6 cd04754
COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of ...
 1-96 2.02e-46

COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240102  Cd Length: 86  Bit Score: 143.52  E-value: 2.02e-46
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45333909  1 MEASSEPPLDAKSDvTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQpqllatsslls 80
Cdd:cd04754  5 KLLTASDSVDQVLN-IGQLVDFKWKLGMAVSSDTCRSLNSPYVAVTLKVADPSGQVVTKSFEMTIPEFQ----------- 72

                       90
               ....*....|....*.
gi 45333909 81 asNFYRQFKEIAAVIE 96
Cdd:cd04754 73 --NFSRQFKEMAAVLE 86
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 17-91 6.06e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 63.34  E-value: 6.06e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45333909   17 NQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQpqllatssllsasNFYRQFKEI 91
Cdd:pfam07258  3 PQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSSEEVTFELSKEQLQ-------------DLLNELEEA 64
 
Name Accession Description Interval E-value
Commd6 cd04754
COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of ...
 1-96 2.02e-46

COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240102  Cd Length: 86  Bit Score: 143.52  E-value: 2.02e-46
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45333909  1 MEASSEPPLDAKSDvTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQpqllatsslls 80
Cdd:cd04754  5 KLLTASDSVDQVLN-IGQLVDFKWKLGMAVSSDTCRSLNSPYVAVTLKVADPSGQVVTKSFEMTIPEFQ----------- 72

                       90
               ....*....|....*.
gi 45333909 81 asNFYRQFKEIAAVIE 96
Cdd:cd04754 73 --NFSRQFKEMAAVLE 86
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 1-95 1.38e-19

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 75.81  E-value: 1.38e-19
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45333909  1 MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPY--VAVMLKVADHSgQVKTKCFEMTIPQFQpqllatssl 78
Cdd:cd04748  5 NKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTilVQLKLQVGDNN-SSEKICFEMTKEELQ--------- 74

                       90
               ....*....|....*..
gi 45333909 79 lsasNFYRQFKEIAAVI 95
Cdd:cd04748 75 ----NFLNKLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 17-91 6.06e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 63.34  E-value: 6.06e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45333909   17 NQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQpqllatssllsasNFYRQFKEI 91
Cdd:pfam07258  3 PQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSSEEVTFELSKEQLQ-------------DLLNELEEA 64
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 18-63 2.06e-05

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 40.86  E-value: 2.06e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 45333909  18 QLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADhSGQVKTKCFEM 63
Cdd:cd04756 110 QLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKE-NGILKPVSIEM 154
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 18-79 8.49e-03

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 32.80  E-value: 8.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45333909  18 QLVDFQWKLGMAVS-SDTCRSLKyPYVAVMLKVADHsgqvKTKCFEMTIPQFQPQLLATSSLL 79
Cdd:cd04753  37 HLEDFKWRVDVAIStSSLSRVLQ-PSILMEMKLSDG----KSHRFEVPVAKFHELRYNVALIL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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