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Conserved domains on  [gi|840083309|ref|NP_991273|]
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interferon regulatory factor 9 [Danio rerio]

Protein Classification

IRF and IRF-3 domain-containing protein( domain architecture ID 10457094)

IRF and IRF-3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 11-115 2.37e-60

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 191.62  E-value: 2.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309   11 RLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDFRSEEDAAIFKAWAAFKGKLMENGN-SDPASWKTRLRCALN 89
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDkPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 840083309   90 KSPEFSEVTERSQLDISEPYKVYRLV 115
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF-3 super family cl11061
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 213-385 1.57e-30

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


The actual alignment was detected with superfamily member pfam10401:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 115.82  E-value: 1.57e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  213 LHTFHITVHYIGQEVLRQEVMRND-VRISYLPrsPVPPSLPSLSGSNfHRIFLPePPSDISTDSslapRLNALKSLLPFM 291
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEgCRLSYGP--PDPQVALYGPVAL-QQVRFP-DPDGIPDER----QREYTRRLLNVL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  292 EWGVALTSLSGGIYAKRFCQGRVFWRGPHSSTT-GPCKMERSGTpTQLFNREIFQQEL-ECFRNGGKQPQSEIILCFGEE 369
Cdd:pfam10401  73 ERGLLLWVAGQGLYAKRLCQSRVFWSGPEAPGGdKPNKLERDAT-VKLFDLAKFLRELiLFQEGRGRSPDYTITLCFGEE 151

                         170
                  ....*....|....*.
gi 840083309  370 LLEGDNISDKHIIIKI 385
Cdd:pfam10401 152 WPDDKPREKKLITVQV 167
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 11-115 2.37e-60

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 191.62  E-value: 2.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309   11 RLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDFRSEEDAAIFKAWAAFKGKLMENGN-SDPASWKTRLRCALN 89
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDkPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 840083309   90 KSPEFSEVTERSQLDISEPYKVYRLV 115
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 10-116 1.33e-50

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 166.31  E-value: 1.33e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  10 RRLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDfRSEEDAAIFKAWAAFKGKLMENGNSDPASWKTRLRCALN 89
Cdd:cd00103    2 MRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTPDPAEWKARLLCALR 80

                         90       100
                 ....*....|....*....|....*..
gi 840083309  90 KSPEFSEVTERSQLDISEPYKVYRLVP 116
Cdd:cd00103   81 SSRGFEEVKDKSKDTPGDPHRVYRLLP 107
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 11-117 1.25e-49

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 163.66  E-value: 1.25e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309    11 RLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDFRSEEDAAIFKAWAAFKGKLMENGNS-DPASWKTRLRCALN 89
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSpDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 840083309    90 KSPEFSEVTERSQlDISEPYKVYRLVPP 117
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 213-385 1.57e-30

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 115.82  E-value: 1.57e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  213 LHTFHITVHYIGQEVLRQEVMRND-VRISYLPrsPVPPSLPSLSGSNfHRIFLPePPSDISTDSslapRLNALKSLLPFM 291
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEgCRLSYGP--PDPQVALYGPVAL-QQVRFP-DPDGIPDER----QREYTRRLLNVL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  292 EWGVALTSLSGGIYAKRFCQGRVFWRGPHSSTT-GPCKMERSGTpTQLFNREIFQQEL-ECFRNGGKQPQSEIILCFGEE 369
Cdd:pfam10401  73 ERGLLLWVAGQGLYAKRLCQSRVFWSGPEAPGGdKPNKLERDAT-VKLFDLAKFLRELiLFQEGRGRSPDYTITLCFGEE 151

                         170
                  ....*....|....*.
gi 840083309  370 LLEGDNISDKHIIIKI 385
Cdd:pfam10401 152 WPDDKPREKKLITVQV 167
 
Name Accession Description Interval E-value
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 11-115 2.37e-60

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 191.62  E-value: 2.37e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309   11 RLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDFRSEEDAAIFKAWAAFKGKLMENGN-SDPASWKTRLRCALN 89
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDkPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 840083309   90 KSPEFSEVTERSQLDISEPYKVYRLV 115
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 10-116 1.33e-50

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 166.31  E-value: 1.33e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  10 RRLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDfRSEEDAAIFKAWAAFKGKLMENGNSDPASWKTRLRCALN 89
Cdd:cd00103    2 MRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTPDPAEWKARLLCALR 80

                         90       100
                 ....*....|....*....|....*..
gi 840083309  90 KSPEFSEVTERSQLDISEPYKVYRLVP 116
Cdd:cd00103   81 SSRGFEEVKDKSKDTPGDPHRVYRLLP 107
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 11-117 1.25e-49

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 163.66  E-value: 1.25e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309    11 RLRSWIVEQVNSGKYLGLVWDNPEKTMFRIPWKHAGKQDFRSEEDAAIFKAWAAFKGKLMENGNS-DPASWKTRLRCALN 89
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSpDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 840083309    90 KSPEFSEVTERSQlDISEPYKVYRLVPP 117
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 213-385 1.57e-30

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 115.82  E-value: 1.57e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  213 LHTFHITVHYIGQEVLRQEVMRND-VRISYLPrsPVPPSLPSLSGSNfHRIFLPePPSDISTDSslapRLNALKSLLPFM 291
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEgCRLSYGP--PDPQVALYGPVAL-QQVRFP-DPDGIPDER----QREYTRRLLNVL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 840083309  292 EWGVALTSLSGGIYAKRFCQGRVFWRGPHSSTT-GPCKMERSGTpTQLFNREIFQQEL-ECFRNGGKQPQSEIILCFGEE 369
Cdd:pfam10401  73 ERGLLLWVAGQGLYAKRLCQSRVFWSGPEAPGGdKPNKLERDAT-VKLFDLAKFLRELiLFQEGRGRSPDYTITLCFGEE 151

                         170
                  ....*....|....*.
gi 840083309  370 LLEGDNISDKHIIIKI 385
Cdd:pfam10401 152 WPDDKPREKKLITVQV 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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