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Conserved domains on  [gi|45580696|ref|NP_996261|]
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ER membrane protein complex subunit 10 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMC10 cd22209
ER membrane protein complex subunit 10 and similar proteins; Endoplasmic reticulum (ER) ...
 54-196 3.64e-52

ER membrane protein complex subunit 10 and similar proteins; Endoplasmic reticulum (ER) membrane protein complex subunit 10 (EMC10), also called hematopoietic signal peptide-containing membrane domain-containing protein 1 (HSM1) or INM02, is a bone marrow-derived angiogenic growth factor promoting angiogenesis and tissue repair in the heart after myocardial infarction. It stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK, and MAPK2 signaling pathways. Yeast EMC10 is a non-essential component of the ER membrane protein complex (EMC), which may be involved in ER-associated degradation (ERAD) and proper assembly of multi-pass transmembrane proteins.


:

Pssm-ID: 412067  Cd Length: 141  Bit Score: 166.45  E-value: 3.64e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580696  54 LLLEHSFeiDDSANFRKRGSLLWN--QQDGTLSLSQRQLSEEERGRLRDVAALNGLYRVRIPRRPGAldglEAGGYVSSF 131
Cdd:cd22209   3 LPLEHSL--DGGATFTPRGTITIRssSKSGSLSLEQNQLLEEEEKKLKKLAAADGLYRIRIPSDGGN----PSDSYVSSS 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45580696 132 VPACSLVESHLSDQLTLHVDVAGNVVGVSVVTHPGGCRGHEVEDVDLELFNTSVQLQPPTTAPGP 196
Cdd:cd22209  77 VKACSLLESNLSDDITLHLDDSGNVIGVSYSTPPGPCAGAEVSDPKLSTFNTTVSVRQPTTGPVP 141
 
Name Accession Description Interval E-value
EMC10 cd22209
ER membrane protein complex subunit 10 and similar proteins; Endoplasmic reticulum (ER) ...
 54-196 3.64e-52

ER membrane protein complex subunit 10 and similar proteins; Endoplasmic reticulum (ER) membrane protein complex subunit 10 (EMC10), also called hematopoietic signal peptide-containing membrane domain-containing protein 1 (HSM1) or INM02, is a bone marrow-derived angiogenic growth factor promoting angiogenesis and tissue repair in the heart after myocardial infarction. It stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK, and MAPK2 signaling pathways. Yeast EMC10 is a non-essential component of the ER membrane protein complex (EMC), which may be involved in ER-associated degradation (ERAD) and proper assembly of multi-pass transmembrane proteins.


Pssm-ID: 412067  Cd Length: 141  Bit Score: 166.45  E-value: 3.64e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580696  54 LLLEHSFeiDDSANFRKRGSLLWN--QQDGTLSLSQRQLSEEERGRLRDVAALNGLYRVRIPRRPGAldglEAGGYVSSF 131
Cdd:cd22209   3 LPLEHSL--DGGATFTPRGTITIRssSKSGSLSLEQNQLLEEEEKKLKKLAAADGLYRIRIPSDGGN----PSDSYVSSS 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45580696 132 VPACSLVESHLSDQLTLHVDVAGNVVGVSVVTHPGGCRGHEVEDVDLELFNTSVQLQPPTTAPGP 196
Cdd:cd22209  77 VKACSLLESNLSDDITLHLDDSGNVIGVSYSTPPGPCAGAEVSDPKLSTFNTTVSVRQPTTGPVP 141
 
Name Accession Description Interval E-value
EMC10 cd22209
ER membrane protein complex subunit 10 and similar proteins; Endoplasmic reticulum (ER) ...
 54-196 3.64e-52

ER membrane protein complex subunit 10 and similar proteins; Endoplasmic reticulum (ER) membrane protein complex subunit 10 (EMC10), also called hematopoietic signal peptide-containing membrane domain-containing protein 1 (HSM1) or INM02, is a bone marrow-derived angiogenic growth factor promoting angiogenesis and tissue repair in the heart after myocardial infarction. It stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK, and MAPK2 signaling pathways. Yeast EMC10 is a non-essential component of the ER membrane protein complex (EMC), which may be involved in ER-associated degradation (ERAD) and proper assembly of multi-pass transmembrane proteins.


Pssm-ID: 412067  Cd Length: 141  Bit Score: 166.45  E-value: 3.64e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45580696  54 LLLEHSFeiDDSANFRKRGSLLWN--QQDGTLSLSQRQLSEEERGRLRDVAALNGLYRVRIPRRPGAldglEAGGYVSSF 131
Cdd:cd22209   3 LPLEHSL--DGGATFTPRGTITIRssSKSGSLSLEQNQLLEEEEKKLKKLAAADGLYRIRIPSDGGN----PSDSYVSSS 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45580696 132 VPACSLVESHLSDQLTLHVDVAGNVVGVSVVTHPGGCRGHEVEDVDLELFNTSVQLQPPTTAPGP 196
Cdd:cd22209  77 VKACSLLESNLSDDITLHLDDSGNVIGVSYSTPPGPCAGAEVSDPKLSTFNTTVSVRQPTTGPVP 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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