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Conserved domains on  [gi|45643135|ref|NP_996670|]
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mortality factor 4-like protein 1 isoform 2 [Homo sapiens]

Protein Classification

MRG family protein( domain architecture ID 13040224)

MRG (MORF4 related gene) family protein similar to human mortality factor 4-like protein 1, also called MORF-related gene 15 protein (MRG15), and Schizosaccharomyces pombe chromatin modification-related protein eaf3, both of which are components of the NuA4 histone acetyltransferase complex that is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRG pfam05712
MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4 ...
 176-351 1.11e-78

MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.


:

Pssm-ID: 461721  Cd Length: 185  Bit Score: 239.04  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135   176 RARVDPTvenEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSR----GNTDNKEY 251
Cdd:pfam05712   1 RARDSES---EDEFSKRPEIKLDIPDELKKILVDDWENITKNNQLVPLPAKPPVDEILEDYVEHEKVKrangSNKTRDED 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135   252 AVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILA-------DHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLA 324
Cdd:pfam05712  78 LLEEVVAGLREYFDKALGRILLYRFERPQYAELRKkwasgpnDDQGKEPSDIYGAEHLLRLFVKLPELLAQTNMDEQSLN 157

                         170       180
                  ....*....|....*....|....*..
gi 45643135   325 LLLNYLHDFLKYLAKNSATLFSASDYE 351
Cdd:pfam05712 158 RLREHLEDFLEFLAKNHERYFSKQEYE 184
CBD_MSL3_like cd18983
chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins; ...
 15-110 1.74e-23

chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins; This subgroup includes human male-specific lethal (MSL) complex subunit 3 (MSL3, also known as MSL3L1). The MSL3 chromodomain specifically recognizes the H4K20 monomethyl mark, in a DNA-dependent manner, and may be involved in chromosomal targeting of the MSL complex. Also included is MORF-related gene on chromosome 15 (MRG15, also known as MORF4L1) which specifically binds to Lys36-methylated histone H3 and plays a role in transcriptional regulation and in DNA repair. This subgroup also includes Arabidopsis thaliana Morf Related Gene 2 (MRG2) which acts as a H3K4me3/H3K36me3 reader involved in the regulation of Arabidopsis flowering. SH3-fold-beta-barrel domains of the chromo-like superfamily include chromodomains, chromo shadow domains and chromo barrel domains, and are implicated in the recognition of lysine-methylated histone tails and nucleic acids. The chromodomain differs, in that it lacks the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


:

Pssm-ID: 350846  Cd Length: 57  Bit Score: 91.74  E-value: 1.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135  15 ERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKksavrprrsekslkthedivalfpvpegapsvhhplltsSWDE 94
Cdd:cd18983   1 ERVLCFHGPLLYEAKILDVIPDKKEWKYFIHYNGWNK---------------------------------------SWDE 41

                        90
                ....*....|....*.
gi 45643135  95 WVPESRVLKYVDTNLQ 110
Cdd:cd18983  42 WVPEDRVLKYTDENLR 57
 
Name Accession Description Interval E-value
MRG pfam05712
MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4 ...
 176-351 1.11e-78

MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.


Pssm-ID: 461721  Cd Length: 185  Bit Score: 239.04  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135   176 RARVDPTvenEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSR----GNTDNKEY 251
Cdd:pfam05712   1 RARDSES---EDEFSKRPEIKLDIPDELKKILVDDWENITKNNQLVPLPAKPPVDEILEDYVEHEKVKrangSNKTRDED 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135   252 AVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILA-------DHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLA 324
Cdd:pfam05712  78 LLEEVVAGLREYFDKALGRILLYRFERPQYAELRKkwasgpnDDQGKEPSDIYGAEHLLRLFVKLPELLAQTNMDEQSLN 157

                         170       180
                  ....*....|....*....|....*..
gi 45643135   325 LLLNYLHDFLKYLAKNSATLFSASDYE 351
Cdd:pfam05712 158 RLREHLEDFLEFLAKNHERYFSKQEYE 184
CBD_MSL3_like cd18983
chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins; ...
 15-110 1.74e-23

chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins; This subgroup includes human male-specific lethal (MSL) complex subunit 3 (MSL3, also known as MSL3L1). The MSL3 chromodomain specifically recognizes the H4K20 monomethyl mark, in a DNA-dependent manner, and may be involved in chromosomal targeting of the MSL complex. Also included is MORF-related gene on chromosome 15 (MRG15, also known as MORF4L1) which specifically binds to Lys36-methylated histone H3 and plays a role in transcriptional regulation and in DNA repair. This subgroup also includes Arabidopsis thaliana Morf Related Gene 2 (MRG2) which acts as a H3K4me3/H3K36me3 reader involved in the regulation of Arabidopsis flowering. SH3-fold-beta-barrel domains of the chromo-like superfamily include chromodomains, chromo shadow domains and chromo barrel domains, and are implicated in the recognition of lysine-methylated histone tails and nucleic acids. The chromodomain differs, in that it lacks the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 350846  Cd Length: 57  Bit Score: 91.74  E-value: 1.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135  15 ERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKksavrprrsekslkthedivalfpvpegapsvhhplltsSWDE 94
Cdd:cd18983   1 ERVLCFHGPLLYEAKILDVIPDKKEWKYFIHYNGWNK---------------------------------------SWDE 41

                        90
                ....*....|....*.
gi 45643135  95 WVPESRVLKYVDTNLQ 110
Cdd:cd18983  42 WVPEDRVLKYTDENLR 57
Tudor-knot pfam11717
RNA binding activity-knot of a chromodomain; This is a novel knotted tudor domain which is ...
 11-103 1.78e-10

RNA binding activity-knot of a chromodomain; This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilization of Ht2 is essential for RNA binding.


Pssm-ID: 432022 [Multi-domain]  Cd Length: 55  Bit Score: 56.06  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135    11 FQEGERVLCFH-GPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKsavrprrsekslkthedivalfpvpegapsvhhpllt 89
Cdd:pfam11717   1 IEIGCKVLVRKrDGEWRLAEILSIRPKKGKYEYYVHYVGFNKR------------------------------------- 43

                          90
                  ....*....|....
gi 45643135    90 ssWDEWVPESRVLK 103
Cdd:pfam11717  44 --LDEWVPEDRIDL 55
 
Name Accession Description Interval E-value
MRG pfam05712
MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4 ...
 176-351 1.11e-78

MRG; This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation. It contains 2 chromo domains and a leucine zipper motif.


Pssm-ID: 461721  Cd Length: 185  Bit Score: 239.04  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135   176 RARVDPTvenEETFMNRVEVKVKIPEELKPWLVDDWDLITRQKQLFYLPAKKNVDSILEDYANYKKSR----GNTDNKEY 251
Cdd:pfam05712   1 RARDSES---EDEFSKRPEIKLDIPDELKKILVDDWENITKNNQLVPLPAKPPVDEILEDYVEHEKVKrangSNKTRDED 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135   252 AVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILA-------DHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLA 324
Cdd:pfam05712  78 LLEEVVAGLREYFDKALGRILLYRFERPQYAELRKkwasgpnDDQGKEPSDIYGAEHLLRLFVKLPELLAQTNMDEQSLN 157

                         170       180
                  ....*....|....*....|....*..
gi 45643135   325 LLLNYLHDFLKYLAKNSATLFSASDYE 351
Cdd:pfam05712 158 RLREHLEDFLEFLAKNHERYFSKQEYE 184
CBD_MSL3_like cd18983
chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins; ...
 15-110 1.74e-23

chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins; This subgroup includes human male-specific lethal (MSL) complex subunit 3 (MSL3, also known as MSL3L1). The MSL3 chromodomain specifically recognizes the H4K20 monomethyl mark, in a DNA-dependent manner, and may be involved in chromosomal targeting of the MSL complex. Also included is MORF-related gene on chromosome 15 (MRG15, also known as MORF4L1) which specifically binds to Lys36-methylated histone H3 and plays a role in transcriptional regulation and in DNA repair. This subgroup also includes Arabidopsis thaliana Morf Related Gene 2 (MRG2) which acts as a H3K4me3/H3K36me3 reader involved in the regulation of Arabidopsis flowering. SH3-fold-beta-barrel domains of the chromo-like superfamily include chromodomains, chromo shadow domains and chromo barrel domains, and are implicated in the recognition of lysine-methylated histone tails and nucleic acids. The chromodomain differs, in that it lacks the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 350846  Cd Length: 57  Bit Score: 91.74  E-value: 1.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135  15 ERVLCFHGPLLYEAKCVKVAIKDKQVKYFIHYSGWNKksavrprrsekslkthedivalfpvpegapsvhhplltsSWDE 94
Cdd:cd18983   1 ERVLCFHGPLLYEAKILDVIPDKKEWKYFIHYNGWNK---------------------------------------SWDE 41

                        90
                ....*....|....*.
gi 45643135  95 WVPESRVLKYVDTNLQ 110
Cdd:cd18983  42 WVPEDRVLKYTDENLR 57
Tudor-knot pfam11717
RNA binding activity-knot of a chromodomain; This is a novel knotted tudor domain which is ...
 11-103 1.78e-10

RNA binding activity-knot of a chromodomain; This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilization of Ht2 is essential for RNA binding.


Pssm-ID: 432022 [Multi-domain]  Cd Length: 55  Bit Score: 56.06  E-value: 1.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45643135    11 FQEGERVLCFH-GPLLYEAKCVKVAIKDKQVKYFIHYSGWNKKsavrprrsekslkthedivalfpvpegapsvhhpllt 89
Cdd:pfam11717   1 IEIGCKVLVRKrDGEWRLAEILSIRPKKGKYEYYVHYVGFNKR------------------------------------- 43

                          90
                  ....*....|....
gi 45643135    90 ssWDEWVPESRVLK 103
Cdd:pfam11717  44 --LDEWVPEDRIDL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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